C-reactive protein and risk of cardiovascular mortality in Korean men and women
eTable 1. Causes of death
Causes
Number
%
Cardiovascular disease
187
17.9%
Cancer
480
45.8%
Respiratory disease
22
2.1%
Digestive system disease
20
1.9%
Endocrine, nutritional, and metabolic disease
21
2.0%
Nervous system disorder
16
1.5%
External causes
(violence, suicide, trauma)
222
21.2%
Other/unclassified deaths
79
7.5%
1
eTable 2. All-cause death according to baseline CRP and CRP change in the total population
CRP group
Person-years
Number of
Mortality rate
Age-sex adjusted HR
events
(10,000 person-year)
(95% CI)
Multivariate HR*(95% CI)
Model 1
Model 2
Total (N=129,344)
Low baseline (<0.5 mg/dL),
81,096.9
20
0.4
1.00 (reference)
1.00 (reference)
1.00 (reference)
304,013.9
94
0.5
1.35 (0.83-2.18)
1.24 (0.75-2.03)
1.35 (0.80-2.27)
181,395.8
88
0.9
1.67 (1.03-2.72)
1.60 (0.97-2.66)
1.69 (0.99-2.87)
120,034.5
59
0.3
1.68 (1.01-2.80)
1.53 (0.90-2.61)
1.45 (0.82-2.55)
CRP change <0 mg/L
81,096.9
20
0.3
1.00 (reference)
1.00 (reference)
1.00 (reference)
CRP change ≥0 mg/L
304,013.9
94
0.5
1.35 (0.83-2.18)
1.23 (0.75-2.03)
1.34 (0.79-2.25)
CRP change <0 mg/L
181,395.8
88
0.9
1.00 (reference)
1.00 (reference)
1.00 (reference)
CRP change ≥0 mg/L
120,034.5
59
0.3
1.00 (0.72-1.39)
0.95 (0.67-1.35)
0.84 (0.58-1.21)
CRP change <0 mg/L
Low baseline (<0.5 mg/dL),
CRP change ≥0 mg/L
High baseline (≥0.5mg/L) CRP change <0
mg/L
High baseline (≥0.5mg/L) CRP change ≥0
mg/L
Low baseline CRP <0.5mg/L (N=71,673)
High baseline CRP ≥0.5mg/L (N=57,671)
Cox proportional hazard models were used to estimate HRs and 95 percent confidence intervals (95% CIs)
*
Model 1: adjustment for age, smoking status, alcohol intake, regular exercise, BMI, history of hypertension, history of diabetes, history of coronary disease and
education level; model 2: model 1 plus adjustment for glucose, LDL-cholesterol, HDL-cholesterol, triglyceride and systolic blood pressure.
2
eTable 3. CVD death according to baseline CRP and CRP change in the total population
CRP group (mg/L)
Person-years
Number of
Mortality rate
Age-sex adjusted HR
events
(10,000 person-year)
(95% CI)
Multivariate HR*(95% CI)
Model 1
Model 2
Total (N=129,344)
Low baseline (<0.5 mg/dL),
CRP change <0 mg/L
Low baseline (<0.5 mg/dL),
CRP change ≥0 mg/L
High baseline (≥0.5mg/L) CRP change
<0 mg/L
High baseline (≥0.5mg/L) CRP change
≥0 mg/L
81,096.9
3
0.4
1.00 (reference)
1.00 (reference)
1.00 (reference)
304,013.9
15
0.5
1.40 (0.41-4.85)
1.26 (0.36-4.39)
1.88 (0.43-8.30)
181,395.8
17
0.9
2.23 (0.65-7.65)
2.01 (0.58-7.01)
2.65 (0.60-11.82)
120,034.5
4
0.3
0.79 (0.18-3.54)
0.73 (0.16-3.32)
0.49 (0.07-3.55)
Low baseline CRP <0.5mg/L (N=71,673)
CRP change <0 mg/L
81,096.9
3
0.4
1.00 (reference)
1.00 (reference)
1.00 (reference)
CRP change ≥0 mg/L
304,013.9
15
0.5
1.42 (0.41-4.90)
1.32 (0.38-4.62)
1.96 (0.44-8.66)
CRP change <0 mg/L
181,395.8
17
0.9
1.00 (reference)
1.00 (reference)
1.00 (reference)
CRP change ≥0 mg/L
120,034.5
4
0.3
0.35 (0.12-1.04)
0.35 (0.12-1.05)
0.18 (0.04-0.77)
High baseline CRP ≥0.5mg/L (N=57,671)
Cox proportional hazard models were used to estimate HRs and 95 percent confidence intervals (95% CIs)
*
Model 1: adjustment for age, smoking status, alcohol intake, regular exercise, BMI, history of hypertension, history of diabetes, history of coronary disease and
education level; model 2: model 1 plus adjustment for glucose, LDL-cholesterol, HDL-cholesterol, triglyceride and systolic blood pressure.
3