Unit 1: DNA and the Genome
1.8 Genomic Sequencing
(a) Genomic Sequencing
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2
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2.
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4.
Explain the term ‘genomic sequencing’.
Describe what ‘bioinformatics’ is why they are used.
(b) Evolution
Define the term ‘phylogenetics ’.
Describe what a molecular clock is.
Describe how evidence is used to determine the main
sequence of events in evolution.
Explain how the sequence of events can be determined
using sequence data and fossil evidence.
Name the three domains and describe how the comparison
of sequences provides evidence of these.
(c) Comparison of genomes
Compare genomes from different species.
Names some examples of genomes that have been
sequenced for research purposes.
Describe how comparison of genomes reveals that many
genes are highly conserved across different organisms.
(d) Personal Genomics and Health
Describe the term ‘pharmogenetics’ .
Understand how pharmogenetics can lead to personalised
medicine.
State that there are difficulties in distinguishing between
neutral and harmful mutations in both genes and regulatory
sequences, and in understanding the complex nature of
many diseases.
Understand the difficulties with personalised medicine
Unit 1: DNA and the Genome
1.8 Genomic Sequencing
(b)Genomic Sequencing
1
2
1
2
3
4
5
1
2
3
1.
2.
3.
4.
Explain the term ‘genomic sequencing’.
Describe what ‘bioinformatics’ is why they are used.
(b) Evolution
Define the term ‘phylogenetics ’.
Describe what a molecular clock is.
Describe how evidence is used to determine the main
sequence of events in evolution.
Explain how the sequence of events can be determined
using sequence data and fossil evidence.
Name the three domains and describe how the comparison
of sequences provides evidence of these.
(d)Comparison of genomes
Compare genomes from different species.
Names some examples of genomes that have been
sequenced for research purposes.
Describe how comparison of genomes reveals that many
genes are highly conserved across different organisms.
(d) Personal Genomics and Health
Describe the term ‘pharmogenetics’ .
Understand how pharmogenetics can lead to personalised
medicine.
State that there are difficulties in distinguishing between
neutral and harmful mutations in both genes and regulatory
sequences, and in understanding the complex nature of
many diseases.
Understand the difficulties with personalised medicine