Proficiency Assessment H.1L.3 Heredity Standard: Explain and apply laws of heredity and their relationship to the structure and function of DNA. Title: You Must Choose, But Choose Wisely Introduction Mendelian Genetics Dominant/recessive inheritance X-linked inheritance Codominant/Incomplete dominance Polygenic inheritance Punnett Squares (monohybrid) Homozygous/Heterozygous DNA and Heredity DNA makes up a chromosome Chromosomes are organized into segments called genes Genes code for proteins Proteins produce traits of an organism Genotype/Phenotype Vocabulary: homozygous, heterozygous, phenotype, genotype, pedigree, Punnett Square, carrier, color-blindness, crossover, genetic expression, generation (P1, F1, F2), hemophilia, karyotype, mutation, non-disjunction, polygenic, sequence, sex-linked, endomorph, ectomorph, mesomorph Possible learning targets: Explain the laws of heredity. Explain the relationship of the laws of heredity to the structure of DNA. Explain the relationship of the laws of heredity to the function of DNA. Apply laws of heredity. Assessment In the role of a genetic counselor at a sperm bank, students must identify genetic traits, including phenotype and genotype, for individuals in the bank and evaluate the “best” match for a fictitious couple, Bella and Edward. They must know basic laws of heredity and what causes some deviations from those laws. It is essential that students have some exposure to human genetic traits and likely should have experienced the process of genetically constructing a child following simplified rules. Type: Case Study/Essay Time needed: 1-2 class periods Materials: Paper and pencil – can be typed at teacher’s discretion, copies of Face Trait Key and donor tables Curriculum, Instruction, and Assessment September 4, 2012 Directions: Deliver student task description, donor files, trait key, and scoring guide to students. Give them time to process and write. Curriculum, Instruction, and Assessment September 4, 2012 Student Handout You Must Choose, But Choose Wisely You are a genetic counselor at the local fertility clinic, The Michael Phelps Memorial Sperm Bank. A young couple, Bella and Edward, has been referred to you after discovering that Edward has an extraordinarily low sperm count and cannot successfully impregnate Bella. In your database, you have hundreds of sperm donors’ characteristics listed. You must select the appropriate donor for Edward and Bella. Face Shape Hair Color Hair Shape Hairline Eyebrow Color Eyebrow Thickness Eyelash Length Eye Color Eye Shape Eye Spacing Eye Size Nose Size Nose Shape Mouth Size Lip Thickness Chin Size Chin Shape Cleft Chin Dimples Freckles Earlobe Attachment Skin Color Blood Type Body Type Bella Round Brown Wavy Straight Lighter than hair Thin Movie type Hazel Almond Medium Medium Average Rounded Narrow Thick Very Prominent Round No No No Attached Pasty white ABEctomorph Edward Square Brown Wavy Widow’s Peak Same as hair Thick Not movie type Dark blue Almond Wide Small Average Rounded Average Thick Very Prominent Square No Yes No Attached Pasty white OMesomorph Use your body traits key to establish possible genotypes for each trait, then prepare a report for Edward and Bella detailing what traits you would recommend looking for in a sperm donor. Explain why you would recommend those traits. Explain why the selection of a sperm donor may not result in the desired traits appearing in their child and what might cause unexpected traits to appear. Curriculum, Instruction, and Assessment September 4, 2012 Face Traits Key Face Shape Hairline Eyebrow Color Hair Color Darker than hair color (W1W1) Same as hair color (W1W2) Lighter than hair color (W2W2) Eyebrow Thickness Eye Color Genotypes Protein Phenotypes Hair Shape Curriculum, Instruction, and Assessment FFBB Dark brown FFBb Brown FFbb Brown FfBB Brown FfBb Dark Blue Ffbb Dark Blue ffBB Light Blue ffBb Light Blue September 4, 2012 ffbb Pale blue Eyelash Length Eye Shape Eye Spacing Eye Size Nose Size Curriculum, Instruction, and Assessment September 4, 2012 Nose Shape Cleft Chin Cheek Dimples Mouth Size Lip Thickness Freckles Chin Size Chin Shape *Adapted from an activity produced by the Woodrow Wilson National Fellowship Foundation. Ideograms from Dropping Your Genes March 1991 in the National Association of Biology Teachers' journal - American Biology Teacher. Thomas Atkins tsa01@csufresno.edu and Joyce Roderick jmr49@cvip.fresno.edu Curriculum, Instruction, and Assessment September 4, 2012 Earlobe Attachment Skin Color Curriculum, Instruction, and Assessment September 4, 2012 Donor #1 Donor #2 Steven Face Shape Round Hair Color Brown Hair Shape Wavy Hairline Straight Eyebrow Color Lighter than hair Eyebrow Thickness Thin Eyelash Length Not movie type Eye Color Brown Eye Shape Almond Eye Spacing Close Eye Size Small Nose Size Small Nose Shape Rounded Mouth Size Wide Lip Thickness Thick Chin Size Very Prominent Chin Shape Round Cleft Chin No Dimples Yes Freckles No Earlobe Attachment Free Skin Color Pasty white Blood Type BBody Type Ectomorph Charles Face Shape Round Hair Color Red Hair Shape Wavy Hairline Widow’s Peak Eyebrow Color Darker than hair Eyebrow Thickness Thick Eyelash Length Not movie type Eye Color Blue Eye Shape Almond Eye Spacing Average Eye Size Small Nose Size Big Nose Shape Rounded Mouth Size Medium Lip Thickness Thin Chin Size Very Prominent Chin Shape Square Cleft Chin No Dimples No Freckles No Earlobe Attachment Attached Skin Color Pasty white Blood Type A+ Body Type Mesomorph Curriculum, Instruction, and Assessment September 4, 2012 Donor #3 Donor #4 Jonathan Face Shape Round Hair Color Brown Hair Shape Straight Hairline Straight Eyebrow Color Darker than hair Eyebrow Thickness Thick Eyelash Length Not movie type Eye Color Dark blue Eye Shape Almond Eye Spacing Average Eye Size Medium Nose Size Big Nose Shape Rounded Mouth Size Medium Lip Thickness Thick Chin Size Very Prominent Chin Shape Round Cleft Chin Yes Dimples No Freckles No Earlobe Attachment Attached Skin Color Light brown Blood Type O+ Body Type Mesomorph Ryan Face Shape Round Hair Color Brown Hair Shape Wavy Hairline Straight Eyebrow Color Same as hair Eyebrow Thickness Thick Eyelash Length Movie type Eye Color Light blue Eye Shape Almond Eye Spacing Close Eye Size Medium Nose Size Average Nose Shape Pointed Mouth Size Narrow Lip Thickness Thick Chin Size Very Prominent Chin Shape Round Cleft Chin No Dimples Yes Freckles No Earlobe Attachment Attached Skin Color Pasty white Blood Type ABody Type Mesomorph Curriculum, Instruction, and Assessment September 4, 2012 Donor #5 Donor #6 Taylor Face Shape Round Hair Color Dark Brown Hair Shape Straight Hairline Straight Eyebrow Color Same as hair Eyebrow Thickness Thick Eyelash Length Movie type Eye Color Dark brown Eye Shape Almond Eye Spacing Far Eye Size Small Nose Size Average Nose Shape Rounded Mouth Size Wide Lip Thickness Thick Chin Size Very Prominent Chin Shape Round Cleft Chin Yes Dimples Yes Freckles No Earlobe Attachment Free Skin Color Light brown Blood Type ABBody Type Mesomorph Isaiah Face Shape Round Hair Color Dark Brown Hair Shape Curly Hairline Straight Eyebrow Color Same as hair Eyebrow Thickness Thick Eyelash Length Not movie type Eye Color Dark brown Eye Shape Almond Eye Spacing Average Eye Size Medium Nose Size Average Nose Shape Rounded Mouth Size Medium Lip Thickness Thick Chin Size Very Prominent Chin Shape Round Cleft Chin No Dimples Yes Freckles No Earlobe Attachment Free Skin Color Dark brown Blood Type O+ Body Type Mesomorph Curriculum, Instruction, and Assessment September 4, 2012 Donor #7 Donor #8 Jackie Face Shape Round Hair Color Dark Brown Hair Shape Straight Hairline Straight Eyebrow Color Same as hair Eyebrow Thickness Thick Eyelash Length Not movie type Eye Color Dark brown Eye Shape Almond Eye Spacing Medium Eye Size Small Nose Size Big Nose Shape Rounded Mouth Size Wide Lip Thickness Thin Chin Size Very Prominent Chin Shape Round Cleft Chin No Dimples Yes Freckles No Earlobe Attachment Attached Skin Color Light brown Blood Type B+ Body Type Mesomorph Seth Face Shape Round Hair Color Brown Hair Shape Curly Hairline Widow’s Peak Eyebrow Color Lighter than hair Eyebrow Thickness Thin Eyelash Length Not movie type Eye Color Light brown Eye Shape Almond Eye Spacing Medium Eye Size Medium Nose Size Average Nose Shape Rounded Mouth Size Narrow Lip Thickness Thin Chin Size Very Prominent Chin Shape Round Cleft Chin No Dimples No Freckles Yes Earlobe Attachment Attached Skin Color Pasty white Blood Type ABody Type Endomorph Curriculum, Instruction, and Assessment September 4, 2012 Check list H.1L.3 Laws of Heredity Include the Following Heading Title Name (First and Last) Date Class Elements Spelling Conventions (capitalization, punctuation, paragraphs) Use vocabulary from state standard: homozygous, heterozygous, phenotype, genotype, pedigree, Punnett Square, carrier, colorblindness, crossover, genetic expression, generation (P1, F1, F2), hemophilia, karyotype, mutation, non-disjunction, polygenic, sequence, sex-linked See Directions/procedures Scoring See rubric Format Use trait keys to create genotype/phenotype crosses Written explanation Curriculum, Instruction, and Assessment Evidence = X September 4, 2012 Scoring Guide H.1L.3 Heredity Standard: Explain and apply laws of heredity and their relationship to the structure and function of DNA. Score Description: 4.0 Exceeds Explain how changes in DNA sequence and other factors change the expressed traits of organisms in subsequent generations. 3.5 Can complete level 3.0 and can partially complete level 4.0. 3.0 Meets Explain and apply the laws of heredity. Explain the relationship of the structure and function of DNA to the laws of heredity. 2.5 Can complete level 2.0 and can partially complete level 3.0 or 4.0 2.0 Nearly meets Recognize that there are laws of heredity and that heredity is controlled by the structure of DNA. 1.5 Can complete level 1.0 and can partially complete level 2.0, 3.0, or 4.0. 1.0 Beginning Recognize that characteristics of organisms are related to DNA and are passed from one generation to the next, with help. 0.5 Can produce some evidence of basic knowledge, with help. 0.0 Has no understanding Cannot provide any evidence of knowledge or understanding, even with help. Curriculum, Instruction, and Assessment September 4, 2012