The list of knowledge and practical skills
students must master studying the course "Medical
Chemistry"
(specialties:
"General
Medicine",
"Pediatrics", "Prophylactic medicine")
Content module 1. Thermodynamic and kinetic laws of processes.
Chemistry of biogenic elements. Complexes in biological fluids. Acid-base
balance in body fluids.
Students must be able to:
 characterize the quantitative composition of solutions;
 prepare solutions with a given quantitative composition;
 analyze the relationship between colligative properties and
concentration of solutions;
 interpret chemical and biochemical processes with the position of the
thermal effects;
 use thermodynamic functions for assessing orientation of processes
and to explain the energy coupling in living systems;
 analyze the dependence of reaction rate on the concentration and
temperature;
 interpret the dependence of the reaction on the activation energy;
 analyze characteristics of catalysts and explain the mechanism of
homogeneous and heterogeneous catalysis;
 explain the mechanism of action of enzymes and analyze the
dependence of enzymatic processes on the concentration of enzyme
and substrate;
 analyze chemical equilibrium and explain it from the standpoint of
thermodynamics and kinetics;
 explain the impact of external factors on chemical equilibrium;
 interpret the relationship between the biological role of biogenic s-, p-,
d-elements and finding their form in the body;
 interpret the structural features of complex compounds as the basis for
their use in helatotherapy;
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make conclusions about the acidity of body fluids on the basis of
pH;
 explain the mechanism of action of buffer systems and their role in
maintaining acid-base balance in biosystems;
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Content module 2. Electrokinetic phenomena in biological systems.
Physics and chemistry of surface phenomena. Lyophobic and
lyophilic disperse systems.
Students must be able to:
analyze the principles of titrimetric methods;
analyze quantitative content in the solution of acids and bases by
methods of acid-base titration;
analyze conditions of creation and dissolution of precipitate,
explaining the role of heterogeneous equilibria involving salts in
general homeostasis of the organism;
explain the mechanism of electrode potentials;
analyze the principles of potentiometry method and draw conclusions
about its use in biomedical research;
measure the red-ox potentials and predict the direction of red-ox
reactions;
make conclusions about the surface activity of substances on the basis
of their structure;
analyze the structural features of the surface layer of surface-adsorbed
molecules of compounds, explain the principles of the structure of
biological membranes;
analyze adsorption equations and limits of their use, distinguish
between unimolecular and polymolekular adsorption;
interpret patterns of adsorption of substances from solutions on solid
surfaces;
explain the physical and chemical basis of adsorption methods of
therapy;
distinguish between selective ion exchange and adsorption of
electrolytes;
interpret chromatographic analysis methods and their role in
biomedical research;
analyze the principles and methods for the treatment of colloiddisperse solutions;
explain the physical and chemical basis of hemodialysis;
interpret the physicochemical properties of proteins;
make conclusions about the charge of dissolved biopolymers based on
their isoelectric point.
The list of knowledge and practical skills
students must master studying the course "Medical
Chemistry" (specialty "Dentistry")
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Content modul 1. Homogeneous equilibrium in biological fluids.
Students must be able to:
characterize the quantitative composition of solutions;
prepare solutions with a given quantitative composition;
analyze the relationship between colligative properties and
concentration of solutions;
interpret chemical and biochemical processes from the position of the
thermal effects;
use thermodynamic functions for assessing of processes orientation,
explain energy coupling in living systems;
analyze the dependence of reaction rate on the concentration and
temperature;
interpret the dependence of the reaction on activation energy;
analyze characteristics of catalysts and explain the mechanism of
homogeneous and heterogeneous catalysis;
explain the mechanism of action of enzymes and analyze the
dependence of enzymatic processes on the concentration of an
enzyme and a substrate;
analyze chemical equilibrium and explain it from the standpoint of
thermodynamics and kinetics;
explain the impact of external factors on chemical equilibrium;
interpret the relationship between the biological role of biogenic s-, p-,
d-elements and finding their form in the body;
analyze the relationship between the chemical properties of the
compounds of s-, p-, d-elements and their application in the dental
practice;
explain the principles of the structure of complex compounds;
interpret the structural features of complex compounds for their
application in helatotherapy.
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Content module 2. Heterogeneous equilibria in biological fluids
Students must be able to:
make conclusions about the acidity of body fluids on the basis of pH;
explain the mechanism of action of buffer systems and their role in
maintaining of the acid-base balance in biosystems;
analyze the principles of titrimetric methods;
analyze quantitative content in the solution of acids and bases by
methods of acid-base titration;
analyze conditions of creation and dissolution of precipitate, explain
the role of heterogeneous equilibria involving salts in general
homeostasis of the organism;
explain the mechanism of electrode potentials;
analyze the electrochemical processes in the mouth;
analyze the principles of potentiometry method and make conclusions
about its use in biomedical research;
measure the red-ox potentials and predict the direction of red-ox
reactions;
analyze the structural features of the surface layer of surface-adsorbed
molecules of compounds, explain the principles of the structure of
biological membranes;
analyze adsorption equations and limits of their use, distinguish
between unimolecular and polymolekular adsorption;
explain the physical and chemical basis of adsorption methods of
therapy;
distinguish between selective ion exchange and adsorption of
electrolytes;
interpret chromatographic analysis methods and their role in
biomedical research;
analyze the principles and methods for the treatment of superfine
systems;
explain the physical and chemical basis of hemodialysis;
interpret the physicochemical properties of proteins, structural
components of all tissues;
make conclusions about the charge of dissolved biopolymers based on
their isoelectric point.
The list of knowledge and practical skills
students must master studying course "Bioorganic
Chemistry" (specialty "Dentistry")
Content module 1. The theoretical basis of the structure and
reactivity of bioorganic compounds. Carbohydrates.
Students must be able to:
 explain the basic rules of IUPAC nomenclature and use it for giving
the names to bioorganic compounds;
 make conclusions and analyze the relationship between the structure,
configuration and conformation of bioorganic compounds;
 interpret reactivity of bioorganic compounds on the nature of the
chemical bond and mutual influence of atoms in a molecule;
 interpret the mechanisms of the various classes of bioorganic
compounds and their transformation in biological systems;
 make conclusions about the existence of monosaccharides in different
tautomeric forms that affect their reactivity and enables laboratory
research sugars in biological fluids;
 interpret the structural features and changes of homopolisaccharides energy for life processes in the body;
 analyze the principles of methods for detection and determination of
sugars in the blood, urine and saliva;
 explain the mechanisms of biological roles heteropolysaccharides
(glycosaminoglycans) in biological fluids and tissues.
Content module 3. α-Amino Acids. Peptides. Proteins.
Students must be able to:
 interpret the structural features of a-amino acids as the basis of biopolymers - proteins that are structural components of all tissues;
 make conclusions about the different changes of amino acids in the
body and analyze the dependence of the formation of these
physiologically active compounds (FAC) on the structure and
reactivity;
 explain the mechanism of formation of biogenic amines and their
influence on the physiological functions of the body;
 explain the relationship between the physical and chemical properties
of proteins and their amino acid composition;
 analyze qualitative reactions for the detection of a-amino acids,
determine the amino acid composition of proteins and use of the
Biuret reaction for the quantitative determination of proteins.
Content module 3. Carboxylic acids and their functional derivatives.
Lipids
Students must be able to:
 explain the dependence of the biological activity of carboxylic acids
on the spatial structure of the molecule;
 interpret the mechanisms of reaction characteristics of carboxylic
acids and lipids, their conversion in the biological systems;
 explain the biological role of different classes of lipids in the
processes of life.
Content module 4. Biologically active heterocyclic compounds.
Nucleosides, nucleotides and nucleic acids.
Students must be able to:
 explain the dependence of the reactivity of organic compounds on
their structure, that contributes to their biosynthesis in the body and
laboratory synthesis to obtain drugs;
 make conclusions about the biological activity of heterofunctional
derivatives of heterocyclic compounds in terms of the features of their
structure and chemical behavior;
 analyze the value of mononucleotides for the building of nucleic acids
and nucleotide coenzymes;
 interpret the mechanisms of participation of vitamins coenzymes in
the biochemical reactions of the body.
The calendar-themed plan of lectures on "Medical Chemistry"
for students on the specialty "Dentistry"
№
1
2
3
4
5
Theme of the lecture
Chemistry and dentistry. Fundamentals of bioenergrtics.
Protolytic equilibrium in chemical and biological
systems.
Chelation and sedimentation processes in biological
fluids.
Electrode processes and their biological role in
dentistry.
Physics and chemistry of surface phenomena.
Week
02.02-07.02
16.02-20.02
The calendar-themed plan of practical lessons on "Medical
Chemistry" for students on specialty "Dentistry"
№
1
2
3
4
02.03-07.03
16.03-20.03
5
30.03-03.04
The list of individual tasks for the self-dependent work of
Preparation of the review of scientific literature and creation of electronic schemes
to topics:
(1) Hypo-, hyper- and isotonic solutions in medical practice. The role of osmosis
in biological systems
(2) ATP as a universal source of energy for biochemical reactions. Characteristic
of macroergic bonds.
(3) Thermochemical calculations and their use for the energy characteristics of
biochemical processes..
(4) Exergonic and endergonic processes that occur in the human body.
(5) Buffer capacity and factors on which it depends. Buffer systems of blood.
(6) Complex compounds in biological systems. The idea about the hemoglobin
structure.
(7) Using of chromatography in biomedical research.
(8) Dialysis, electrodialysis, ultrafiltration. "Artificial kidney".
6
7
8
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Theme of the lesson
Methods for the expression of the solutions
concentrations. Colligative properties of solutions.
Thermodynamic laws of biochemical processes.
Kinetic laws of biochemical processes.
Biogenic elements in medicine and dentistry.
Complexes in heterogeneous systems. Reactions of
sedimentation and dissolution.
Acid-base equilibrium and pH of biological fluids.
Properties of buffer solutions and their role in
biological systems. Titrimetric analysis. The method
of acid-base titration.
Determination of electrode potentials.
Adsorption and ion exchange processes in biological
systems. Chromatography.
The preparation, purification and properties of
colloidal solutions. Coagulation of colloidal
solutions. Physical chemistry of solutions of
biopolymers.
The final module control
Week
02.02-07.02
09.02-13.02
16.02-20.02
23.02-27.03
02.03-07.03
09.03-13.03
16.03-20.03
23.03-27.03
30.03-03.04