Conference Session B11
Paper #6028
Disclaimer — This paper partially fulfills a writing requirement for first year (freshman) engineering students at the University of Pittsburgh Swanson School of Engineering. This paper is a student, not a professional , paper. This paper is based on publicly available information and may not be provide complete analyses of all relevant data. If this paper is used for any purpose other than these authors’ partial fulfillment of a writing requirement for first year (freshman) engineering students at the University of Pittsburgh Swanson School of Engineering, the user does so at his or her own risk.
Katherine Moore, kjm131@pitt.edu, Mahboobin 4:00, Corrin Rogers, cer57@pitt.edu, Mahboobin 4:00
Revised Proposal – Reservoir-based polymer drug delivery systems are an important innovation in cancer treatment.
Reservoir-based drug delivery systems store pharmaceuticals area we will be sure to research is the ethics behind these devices and how they could affect people physically, economically and the technologies overall impact on the within the body and release them at specific times. This process known as zero order kinetics, is preferable to orally consumed medications which cause inconsistent quantities of medication levels over time in the body. The placement of the systems ensures that the drugs affect the targeted area, with minimal effects towards other organs or systems. Reservoir systems typically have a solid core containing the wanted pharmaceutical surrounded by a thin film made up of drugs and polymers. Polymers used must be biocompatible and possess specific qualities, such as elasticity, that allow the best assembly for the device. We chose to focus on how using these delivery systems to reduce cancer effects. Sudden dosages of current anti-cancer treatments are toxic to other organs. However, low concentrations of pharmaceutical drugs through zero-order kinetic processing have more effective results especially with diseases such as cancer.
Reservoir-based drug delivery works best for areas hard to reach through systemic administration or for drugs requiring long-term dosage [1].
In the future this technology could provide aid towards other diseases aside from cancer. With the use of reservoirbased technology, engineers and scientists can work towards designing more effective drug delivery systems. For example, reservoir-based systems that release specific pharmaceuticals over long periods of time can target defects in eyes that would be otherwise difficult to reach [2]. Not only could this technology help in defeating diseases, such as cancer, but could open new doors for the future of all pharmaceutical delivery.
We have already begun to find a multitude of information on reservoir-based polymer drug delivery systems and their aid in cancer treatment. We will continue to use our resources in the University of Pittsburgh’s library centers and through other scholarly databases. We may attempt to contact
Biomedical Engineers in our community that may be investigating this topic: professors and engineers at the
Swanson School of Engineering and researchers at local hospitals. We will focus our research on specific polymers used in reservoirs, how the drugs reach zero-order kinetics, and specific and overall effects of this technology. Another world. By continuing our research, we will adequately be able to discuss the need for reservoir-based polymer drug delivery systems and their effects on cancer treatment. In
2012, 8.2 million people diagnosed with cancer died. With further development in this technology, we can hope to reduce this number drastically [3].
[1] E. Pierstorff, W. Yang. (2012). “Reservoir-Based Polymer
Drug Delivery Systems”. Journal of Laboratory Automation.
(Print Article). pp. 50-58
[2] P. Alves, J. Coelho, R. Cordeiro, P. Ferreira, A. Fonseca,
M. Gil, J. Gois. (2010). “Drug delivery systems: Advanced technologies potentially applicable in personalized treatments”. The EPMA Journal.
(Print Article). pp. 164-209
[3] H. Gensler, P. Li, R. Lo, R. Masood, E. Meng, P. Prasad,
I. Roy, R. Sheybani, U. Sinha, K. Yong, S. Zhu. (2010).
“IMPLANTABLE MEMS DRUG DELIVERY DEVICE
FOR CANCER RADIATION REDUCTION.” Micro Electro
Mechanical Systems (MEMS), 2010 IEEE 23 rd
International
Conference. (Print Article). pp. 23-26
Y. Danyuo, J.D. Obayemi, S. Dozie-Nwachukwa, C.J. Ani,
O.S. Odusanya, Y. Oni, N. Anuku, K. Malatesta, W.O.
Soboyejo. (2014). “Prodigiosin Release from an Implantable
Biomedical Device: Kinetics of Localized Cancer Drug
Release.”
Materials Science and Engineering: C . (Print
Article). pp. 734-745.
This article, from a distinguished journal on material science and engineering, focuses on localized hypothermia and controlling concentrations of the cancer drug prodigiosin.
Its in-depth analysis of fluid release and swelling mechanisms, as well as its surplus of kinetic statistical data, will help us analyze localized cancer treatment on a primarysource level.
University of Pittsburgh, Swanson School of Engineering
2016-01-29
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Katherine Moore
Corrin Rogers
H. Gensler, P. Li, R. Lo, R. Masood, E. Meng, P. Prasad, I.
Roy, R. Sheybani, U. Sinha, K. Yong, S. Zhu. (2010).
“IMPLANTABLE MEMS DRUG DELIVERY DEVICE
FOR CANCER RADIATION REDUCTION.” Micro Electro
Mechanical Systems (MEMS), 2010 IEEE 23 rd International
Conference. (Conference Paper). pp. 23-26
In this paper from the 2010 IEEE International
Conference, the authors describe a small implanted device and administers medications for cancer treatment at selected dosages and times. This piece discusses the composition of the device, as well as the mechanisms in place so that the proper amounts of medication are administered. This article will be used to describe how the delivery system is made and what comprises it.
S. Hassenbusch, G. Mueller-Schwefe, E. Reig. (1999). “Cost
Effectiveness of Intrathecal Therapy for Pain.”
Neuromodulation Volume 2.
(Print Article). pp. 77-84
This article from a scientific journal entitled
Neuromodulation , is about using a device inside the body that dispenses pain medication for cancer patients with constant pain. It mainly focuses on the whether this implantable device or oral medications are more cost effective and which one better improves the patient’s quality of life. We will use this article to help support why implantable reservoir-based devices are more beneficial to the patient compared to oral contraceptives.
R. Hu, I. Roy, P. Song, D. Tng, K. Yong. (2012). “Approaches and Challenges of Engineering Implantable
Microelectromechanical Systems (MEMS) Drug Delivery
Systems for in Vitro and in Vivo Applications.”
Micromachines.
(Print Article). pp 615-631
This article from a journal entitled Micromachines , debates the many qualities and possible issues that need to be taken into account when discussing implantable drug delivery systems. It focusses on qualities of the device such as biocompatibility, most effective delivery method and how long it will last. This article will be used to confer the possible issues with implantable drug delivery systems as well as how those problems can be solved.
R. Langer, D. LaVan, Terry McGuire. (2003). “Small-scale systems for in vivo drug delivery.” Nature Biotechnology.
(Print Article). pp. 1184-1191
This article, from a peer-reviewed journal specializing in nature biotechnology, provides details about the making of microscopic drug delivery, particularly implanted chambers.
This source describes the release rates for drugs in these chambers for long-term delivery; its details on how to construct the best chamber will serve our paper’s paragraph on how the makeup of the devices affects the stability of the zero-order kinetics.
K. Mohan, D. Nadarajan, M. Ramesh. (2014). “An In-Body
Wireless Communication System for Targeted Drug
Delivery: Design and Simulation.” International Symposium on Technology Management and Emerging Technologies.
(Conference Paper).
This paper presented at a conference in Indonesia, is about a wireless drug delivery system implanted in the human body that can be controlled from outside the body through radio frequency communication. Within the script, the authors talk about the importance of achieving and finding the optimum frequency in which to communicate with the device. We will be using this piece to explain the mechanisms behind the systems as well as one way of communication externally with the device.
E. Pierstorff, W. Yang. (2012). “Reservoir-Based Polymer
Drug Delivery Systems.” Journal of Laboratory Automation.
(Print Article). pp. 50-58
This article, from a Journal of Laboratory Automation, provides detailed descriptions about polymers, such as silicone, that allow a stable release rate of drugs. Its descriptions on release area, polymeric membrane thickness, and drug solubility will allow us to focus on the chemical effectiveness of these drug delivery systems. For example, this article describes hydrogel systems, made up of watersoluble polymers, and how their porosity can be easily manipulated.
V. P. Torchilin. (2001). “Structure and Design of Polymeric
Surfactant-based Drug Delivery System.” Journal of
Controlled Release . (Print article). pp. 137-172.
This article, from Elsevier’s Journal of Controlled
Diseases, details the structure of a polymer-based reservoir system that creates the best mechanism for durability and protection in vivo devices. This knowledge, and other information on the physiology-based targeting tumors, will help us properly relate the structure of reservoir-based systems with chemical kinetics.
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