Cleveland Clinic • Business: Implantable artificial kidney for patients with end-stage renal disease • Challenge: Achieve optimal collaboration among domain experts in multiple geographic locations • Solution: SoftMEMS’ flexible design environment enabled effective multi-site information exchange • Value: Unified co-design environment enables innovation that saves human lives Implantable artificial kidney uses MEMS membranes to filter blood just like kidneys do 1 Cleveland Clinic – Artificial Kidney A potential High Volume Application Red Blood Cells • MEMS filters are replaced every year • 100s of filters are used in each device White Blood Cells Silicon Membranes Close up shows two membranes - real device uses 100s of membranes MEMS-Silicon membrane filters out salts and small molecules