All data are valid for the academic year 2014/2015
PROFESSORS AND ASSOCIATES
• Prof. dr. sc. Zoran Đogaš
, MD, PhD; full professor ; Head of Department e-mail: zoran.dogas@mefst.hr, tel. 557-905
Individual consultation: THURSDAY 14,00 - 15,00
• Prof. dr. sc. Ivica Grković
, MD, PhD; full professor e-mail: ivica.grkovic@mefst.hr, tel. 557-803
Individual consultation: WEDNESDAY 13,00 - 14,00
• Prof. dr. sc.
Maja Valić , MD, PhD; Head of laboratory e-mail: maja.valic@mefst.hr, tel. 557-860
Individual consultation: THURSDAY 14,00 - 15,00
• Doc. dr. sc. Renata Pecotić
, MD,PhD; Head of educational department e-mail: renata.pecotic@mefst.hr, tel. 557-857
Individual consultation: THURSDAY 14,00 - 15,00
• Ivana Pavlinac Dodig , MD, PhD; research fellow e-mail: ivana.pavlinac@mefst.hr, tel. 557-862
Individual consultation: THURSDAY 14,00 - 15,00
•
Ivona Stipica , MD; research fellow e-mail: ivona.stipica@mefst.hr, tel. 557-858
Individual consultation: THURSDAY 14,00 - 15,00
•
Linda Lušić, MS ; research fellow e-mail: linda.lusic@mefst.hr, tel. 557-858
Individual consultation: THURSDAY 14,00 - 15,00
•
Maja Rogić Vidaković, PhD; research fellow; Head of Laboratory for Human and
Experimental Neurophysiology (LAHEN) e-mail: maja.rogic@mefst.hr, tel. 557-876
Individual consultation: THURSDAY 14,00 - 15,00

Neuroscience is one of the basic medical sciences studying morphology and function of a healthy nervous system, with an emphasis on the mechanisms responsible for achieving its role as a central organism control and management system. This course will introduce students to and enable them to approach problems in this area using scientific methods. The aim of the Basic neuroscience course is to teach a student how to use the acquired knowledge on physics, chemistry, biochemistry, biology, anatomy, histology and physiology in acquiring knowledge on the normal function of the nervous system to the extent necessary for further successful studying.

The Basic neuroscience course lectures will be held during the 4th semester with a total duration of 115 hours.


Neuroscience is tested in the form of written exam that consists of 100 multiple answer questions with only one answer being correct. Each correct answer carries one point.

Topics to be covered through lectures, seminars and practical lessons, including an indication of the prescribed literature, will be announced on the beginning of the course.
Attendance of all forms of instruction is MANDATORY (except the attendance of individual consultations), and all students are obligated to study the prescribed material IN
ADVANCE for seminars and practical lessons, using the main textbook and/or the additional literature.

The course Basic neuroscience is consisted of:
•LECTURES • SEMINARS • PRACTICAL LABORATORY WORK • INDIVIDUAL TEACHING
CONSULTATIONS
CURICCULUM
The course content is divided into six units :
A Neuroanatomy
LECTURES
Research methods of the CNS structure and the structure of gray and white matter of the spinal cord
SEMINARES
The structure of gray and white matter of the spinal cord, brainstem and cerebellum, diencephalon and telencephalon
PRACTICAL WORK
Review of the CNS structures
Appearance and distribution of gray and white matter of the spinal cord and brainstem
Clinical-anatomic syndromes of the spinal cord
B Basics of neuron electrophysiology
LECTURES
Neuron is a basic structural-functional unit of CNS
The biophysical basics of excitability
SEMINARS
The cell membrane, ion channels, passive and active neuron properties
PRACTICAL WORK
Computational models of the membrane resting potential and the action potential
Computational models of the postsynaptic potential
C Intercellular signaling
LECTURES
Signaling mechanisms, signaling molecules and their receptors
SEMINARS
Structure and function of the synapse and the cellular basis of behavior (neuron sequences, pathways, circles, networks, systems)

Neurotransmitters, neuropeptides and their receptors
PRACTICAL WORK
Signalization, Web site
D Sensory system
LECTURES
Principles of sensory systems organization, types of stimuli and sensory receptors
Olfaction and gustation – chemical senses
Physiology of the eye and phototransduction
SEMINARS
Pain, heat and cold – anterolateral sensory system
Touch, pressure, and kinesthesia - the dorsal column system
Ear - organ of hearing and balance
Auditory and vestibular system
Organization of the retina, primary visual pathway and primary visual cortex
Perception of colours, shapes, depth and movement; and the organization of the associative visual fields of the cerebral cortex
PRACTICAL WORK
Physiology of sensation
E Motor system
LECTURES
General structure of the motor systems
Role of the motor cortex in voluntary movements
SEMINARES
Spinal motor mechanisms and reflexes
Role of the descending pathways from the brainstem in maintaining posture and muscle tone; spinal shock
Motor functions of the cerebellum
Motor functions of the basal ganglia
The hypothalamus controls the endocrine and the autonomic nervous system
F General brain functions
LECTURES
Development of the CNS and processes of development reorganization and plasticity
Stages of wakefulness and sleep; Sleep Medicine
Physiology of intracranial pressure and cerebral circulation
The structure of neurotransmitter systems and reticular formation
SEMINARS
General brain function: ascending activating system, EEG, alertness levels and levels of consciousness
Neurobiology of biological rhythms and motivational states
Neurobiology of emotion and sexuality
Neurobiology of attention and association functions of the prefrontal and posterior parietal cortex
Anatomy and psychology of learning and memory
Cellular mechanisms of learning and memory

• LECTURES:
Lecture
P-1
Topic
Introductory lecture
Hours Lecturer
1 Đogaš
P-2 Neuron is a basic structural-functional unit of the CNS 2 Đogaš
P-3 CNS research methods
Development of the CNS and processes of development reorganization and plasticity
2
Grković
P-4 1 Grković Peripheral nervous system and the spinal cord
P-5
P-6
P-7
Diencephalon and telenchephalon
Biophysical basics of excitability
Neurotransmitters in health and disease
2
2
2
Grković
Đogaš
Đogaš
P-8
P-9
P-10
General brain function and sleep
Serotonin (web)
Control of breathing during wakefulness and during sleep (web)
2
1
Đogaš
2
Pecotić
Valić
P-11 1
Đogaš
P-12
P-13
General organization of the sensory systems (Ch 15, 18)
Physiology of the eye and phototransduction
General structure of the motor systems
Clinical importance and basic research
2
2
Đogaš
Valić/Pecotić
TOTAL: 22 hours

• SEMINARS:
Seminar Subject Hours Lecturer
S1 The structure of gray and white matter of the spinal cord (Ch 9)
S2 The structure of gray and white matter of the brainstem and cerebellum (Ch 10, 11, 12, 14)
S3 The structure of gray and white matter of the diencephalon (Ch 13)
S4 Telencephalon (Ch 13)
(2 hours) Pavlinac Dodig
(2 hours) Pavlinac Dodig
(2 hours) Pavlinac Dodig
(2 hours) Pavlinac Dodig
S5 Cell membrane, ion channels, passive and active neuron properties (Ch 6)
S6 Structure and function of the synapse and the cellular basis of behavior (neuron sequences, pathways, circles, networks, systems) (Ch 7)
(2 hours) Đogaš/ Valić
(3 hours) Đogaš/ Pecotić
S7 Neurotransmitters, neuropeptides and their receptor (Ch 8) (3 hours) Valić/Pecotić
S8 Electrophysiology of neurons and types of potential (Ch 6-8) (2 hours)Valić/Pecotić
S9 General brain functions; EEG, evoked potentials (2 hours) Đogaš
S10 Stages of wakefulness and alertness; sleep
S11 Clinical seminar
(2 hours)
(2 hours)
Đogaš/Pecotić
Valić/Pecotić
S12 Pain, heat and cold – anterolateral sensory system (2 hours) Valić
Touch, pressure, and kinesthesia - the dorsal column system (Ch 15)
S13 Ear - organ of hearing and balance
Auditory and vestibular system (Ch 17)
(2 hours) Pecotić
S14 Organization of the retina, primary visual pathway (2 hours) and primary visual cortex (Ch 16)
S15 Perception of colors, shapes, depth and movement; (1 hour) and the organization of associative visual fields (part Ch 26)
Valić
Valić/Pavlinac Dodig
S16 Sensory system (2 hours) Pecotić
S17 Role of motor cortex in voluntary movements (2 hours)
Eye movement and eye gaze direction system (Ch 19, 14, p242-50)
Valić/Pecotić

S18 Neuroanatomy and neurophysiology of
eloquent brain areas (motor, speech, language) (2 hours)
Rogić Vidaković
S19 Spinal motor mechanisms and reflexes (Ch 9)
S20 Role of the descending pathways from the brainstem in maintaining posture and muscle tone; spinal shock (Ch 9)
S21 Motor functions of the cerebellum and the basal ganglia (Ch 20)
(1 sat)
(1 sat)
Pecotić
Valić/Pavlinac Dodig
(2 hours)
Pecotić
S22 Organization and structure functions of the limbic system (Ch 25)
(1 sat)
Valić
S23 Neurobiology of emotion and sexuality (2 hours)
Lušić
S24 Neurobiology of attention and associative functions (2 hours)
Đogaš of the prefrontal and posterior parietal cortex
S25 Anatomy and psychology of learning and memory (2 hours)
Lušić
S26 Cellular mechanisms of learning and memory (2 hours)
Đogaš
S27 General brain function (2 hours)
Đogaš/Lušić
TOTAL: 52 hours
The materials are chapters of the textbook by

Allan Siegel and Hreday N. Sapru: Essential Neuroscience, 2 nd
/3 rd
Edition.

Purves et al Neuroscience 5 th
edition published by Sinauer Associates
The text for exercise is an Interactive Tutorial by John Huguenard and David A. McCormick:
Electrophysiology of the Neuron, Windows Version
All absences and minuses have to be compensated through a colloquium at least 2 days before the exam.
Students not taking the exam in the first examination period, to compensate their absences and minuses, have to take a colloquium in a 10 days period after the end of the Basic neuroscience course.

• PRACTICAL LESSONS:
Practical Hours Title Chapter
Venue Lecturer
V1 2
V2 2
Review of the CNS structures
PAK IS/IPD/RP
Appearance and distribution of gray and white matter of the spinal cord
V3 2
IT. IS/IPD/RP
V7 3
V8 3
Appearance and distribution of gray and white matter of the brainstem
V4
V5 3
V6
2
3
Clinical-anatomic syndromes of the spinal cord (CD-ROM)
Neuron electrophysiology
Resting potential
Neuron electrophysiology
Action potential
Neuron electrophysiology
Synaptic potential
Neuron electrophysiology
Signalization
PowerLab
EEG and evoked potential
IT.
IT.
IT.
IT.
S L
IT. RP/IPD
IS/IPD
Valić/Pecotić
Valić/Pecotić
Valić/Pecotić
Pecotić/Valić
V9 2
*V10 4 SleepLab
Polysomnography SL
Pecotić/Valić/IPD
ZĐ/RP/MV/IPD
*V11 3
V12 3
SleepLab
Polysomnography report
PowerLab
Physiology of sensation
SL
ZĐ/RP/MV/IPD
ZĐ/RP/MV/IPD
V13 1 Transcranial magnetic stimulation (TMS) LAHEN Rogić Vidaković
Motor evoked potentials (MEP)
Mapping eloquent brain functions (speech)
L
V14 2
V15 3
*V16 3
PowerLab
Muscle and electromyography
PowerLab
Reflexes and reaction time
PowerLab
L
L
RP/MV/IPD
Lušić

Animal neurophysiological research in vivo L
TOTAL: 41 hours
RP/MV/IPD
PAK - dissection hall;
I.T. - IT classroom (BSB building; 2 nd floor, 4 th
floor, 5 th
floor)
L - Neuroscience laboratory, 5 th floor
LAHEN- Laboratory for Human and Experimental Neurophysiology- Department of
Neuroscience, 5 th
floor (lab 26)
SL - Sleep medicine centre (Sleep Lab)
TEXTBOOK AND INSTRUCTIONAL MATERIALS
OBLIGATORY TEXTBOOK AND PRACTICUM FOR PRACTICAL LESSONS
 •Siegel, A. and Sapru, H.: ESSENTIAL NEUROSCIENCE, Wolters Kluwer / Lippincott
Williams & Wilkins

Purves et al Neuroscience 5 th
edition published by Sinauer Associates
 •John Huguenard and David A. McCormick:
Electrophysiology of the Neuron, Windows
Version, A Companion to Neurobiology by Gordon Shepard
ADDITIONAL LITERATURE
•Kandel, E.R., Schwartz, J.H. and Jessel, T.M.: PRINCIPLES OF NEURAL SCIENCE, 4th edition,
McGraw-Hill; New York, SAD, 2000.
•Zigmond, MJ et all.: Fundamental Neuroscience, Academic Press; San Diego, SAD, 1999.
•Guyton, A.C. and Hall: MEDICAL PHYSIOLOGY, 11th edition. 2006.
Department of neuroscience
School of medicine
University of Split
21 000 Split, Šoltanska 2 phone 021/ 557-858 fax. 021/ 557-955