会员号：S423101054A
A bi-directional neural interface system for use in Deep Brain
Stimulation
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Man-zhao HAO , Xiao-Xing XING , Ling-Feng CHEN , Ping Shi , Guo-Xing WANG , Ning LAN
1,*
1
Institue of Rehabilitation Engineering, Med-X Research Institute, School of Biomedical
Engineering, Shanghai Jiao Tong University
2School of Microelectronics, Shanghai Jiao Tong University
*Ning LAN
ninglan@sjtu.edu.cn
Abstract: With the development of neuroscience, engineering and computing, the
possibilities of interpreting brain activities and restoring functions for various
disabilities seem endless. Extracellular recording of the cortical activity with
electrophysiological signals provides complementary information about the neural
activity. While passive recording provides useful data, active electrical
microstimulation is required in further research and applications. Electrical
microstimulation could serve as artificial input to the neural network or serve to
modulate neural activity, particularly in the relief of Parkinsonian symptoms by
deep brain stimulation (DBS) of subthalamic nucleus. We are developing a
bi-directional neural interface system that combines recording and stimulation in
one system. Microprobe with multiple channels can be designed with various
geometrical shapes for placement in different locations, regions and layers in the
brain. The recording hardware is composed of a recording headstage, which amplifies
signals from the microprobe, a recording interface board is capable of further signal
amplifying and filtering. A data acquisition card is connected to the system
controller. The stimulation hardware contains a stimulation interface board, which
generates micro current/voltage. A stimulation headstage is used to generate
stimulation patterns by switching channels. The software of the system controller
consists of graphical user interface (GUI), algorithms of signal processing and
stimulation patterns generator. The channel capacity of this system can be expanded
as needed. This makes recording high frequency neural activity possible. Spikes
activity of individual neurons and local field potentials in the vicinity of the
probe can be recorded. This recording technique is designed with the highest spatial
resolution. The potential applications of this bidirectional system are broad. As
a research tool, we will use it to provide stimulus to subthalamic nucleus and record
the neural activities in any parts of the cerebro-basal ganglia-thalamus circuits.
With this system, we can study the mechanism of deep brain stimulation (DBS) to
further understand the motor behaviors of the cerebo-basal ganglia-thalamus system
under normal, pathological and neuromodulation conditions.
Keywords: Recording; Microstimulation; Neuromodulation; Deep brain stimulation;
The cerebo-basal ganglia-thalamus system; Motor control