Supplemental Table 1. Cohort characteristics by anatomical site(s) radiated in breast-conserving surgery (n=319,003) and mastectomy (n=75,331) cohort
Radiation after Breast-Conserving Surgery
Anatomical site(s)
Variable
Total
Breast/chest
N=319003
(100%)
N=277063
(86.9%)
N (col %)
Race/ethnicity
Non-Hispanic
white
Non-Hispanic
black
Hispanic
Other
Age at diagnosis (years)
18-49
50-64
65-79
80+
Comorbidity score
0
1
≥2
Insurance
Uninsured
Medicaid
Medicare
Private
Median income, $‡
<30,000
30,000-34,999
35,000-45,999
46,000+
Missing
Diagnosis year
2004
2005
2006
2007
2008
2009
2010
2011
2012
Pathologic stage†
I
II
Postmastectomy Radiation
radiated¥
Breast/chest with
nodes
N=41940
(13.1%)
Total
p-value*
N (row %)
N=75331
(100%)
Anatomical site(s) radiated¥
Breast/chest with
Breast/chest
nodes
N=27225
N=48106
(36.1%)
(63.9%)
N (col %)
260957 (81.8)
228438 (87.5)
32519 (12.5)
33202 (10.4)
13536 (4.2)
11308 (3.5)
27454 (82.7)
11291 (83.4)
9880 (87.4)
5748 (17.3)
2245 (16.6)
1428 (12.6)
70030 (22)
139177 (43.6)
94691 (29.7)
15105 (4.7)
58402 (83.4)
120765 (86.8)
84538 (89.3)
13358 (88.4)
11628 (16.6)
18412 (13.2)
10153 (10.7)
1747 (11.6)
277448 (87)
34435 (10.8)
7120 (2.2)
241092 (86.9)
29813 (86.6)
6158 (86.5)
5682 (1.8)
16936 (5.3)
100845 (31.6)
195540 (61.3)
p<0.0001
p-value*
N (row %)
57391 (76.2)
20710 (36.1)
36681 (63.9)
p<0.0001
10187 (13.5)
4518 (6)
3235 (4.3)
3855 (37.8)
1515 (33.5)
1145 (35.4)
6332 (62.2)
3003 (66.5)
2090 (64.6)
p<0.0001
28711 (38.1)
29388 (39)
14206 (18.9)
3026 (4)
10165 (35.4)
10542 (35.9)
5346 (37.6)
1172 (38.7)
18546 (64.6)
18846 (64.1)
8860 (62.4)
1854 (61.3)
p<0.0001
36356 (13.1)
4622 (13.4)
962 (13.5)
p=0.17
64725 (85.9)
8567 (11.4)
2039 (2.7)
23437 (36.2)
3068 (35.8)
720 (35.3)
41288 (63.8)
5499 (64.2)
1319 (64.7)
p=0.56
4616 (81.2)
13612 (80.4)
89537 (88.8)
169298 (86.6)
1066 (18.8)
3324 (19.6)
11308 (11.2)
26242 (13.4)
p<0.0001
2596 (3.4)
7567 (10)
17208 (22.8)
47960 (63.7)
946 (36.4)
2669 (35.3)
6440 (37.4)
17170 (35.8)
1650 (63.6)
4898 (64.7)
10768 (62.6)
30790 (64.2)
p=0.0006
29212 (9.2)
46572 (14.6)
84702 (26.6)
146722 (46)
11795 (3.7)
24713 (84.6)
39958 (85.8)
72988 (86.2)
129182 (88)
10222 (86.7)
4499 (15.4)
6614 (14.2)
11714 (13.8)
17540 (12)
1573 (13.3)
p<0.0001
8805 (11.7)
12191 (16.2)
19798 (26.3)
31537 (41.9)
3000 (4)
3427 (38.9)
4404 (36.1)
6790 (34.3)
11550 (36.6)
1054 (35.1)
5378 (61.1)
7787 (63.9)
13008 (65.7)
19987 (63.4)
1946 (64.9)
p<0.0001
30000 (9.4)
31602 (9.9)
34014 (10.7)
33810 (10.6)
35104 (11)
37317 (11.7)
38291 (12)
40957 (12.8)
37908 (11.9)
25795 (86)
27225 (86.1)
29364 (86.3)
29340 (86.8)
30670 (87.4)
32556 (87.2)
33581 (87.7)
35412 (86.5)
33120 (87.4)
4205 (14)
4377 (13.9)
4650 (13.7)
4470 (13.2)
4434 (12.6)
4761 (12.8)
4710 (12.3)
5545 (13.5)
4788 (12.6)
p<0.0001
5962 (7.9)
6267 (8.3)
6937 (9.2)
7689 (10.2)
8573 (11.4)
9295 (12.3)
10212 (13.6)
10797 (14.3)
9599 (12.7)
2394 (40.2)
2444 (39)
2734 (39.4)
2953 (38.4)
3094 (36.1)
3307 (35.6)
3649 (35.7)
3481 (32.2)
3169 (33)
3568 (59.8)
3823 (61)
4203 (60.6)
4736 (61.6)
5479 (63.9)
5988 (64.4)
6563 (64.3)
7316 (67.8)
6430 (67)
p<0.0001
202378 (63.4)
101251 (31.7)
193003 (95.4)
78083 (77.1)
9375 (4.6)
23168 (22.9)
p<0.0001
5629 (7.5)
29930 (39.7)
3562 (63.3)
12228 (40.9)
2067 (36.7)
17702 (59.1)
p<0.0001
III
15374 (4.8)
Grade
1
84116 (26.4)
2
138149 (43.3)
3
96738 (30.3)
Hormone receptor status
Positive
265013 (83.1)
Negative
53990 (16.9)
Tumor size
<2 cm
224224 (70.3)
2 cm to <5 cm
88959 (27.9)
≥5 cm
5820 (1.8)
Node status
Positive
74856 (23.5)
Negative
244147 (76.5)
Division
New England
25066 (7.9)
Middle Atlantic
47625 (14.9)
South Atlantic
68939 (21.6)
East North Central
61413 (19.3)
East South Central
15633 (4.9)
West North Central
23119 (7.2)
West South Central
16815 (5.3)
Mountain
15496 (4.9)
Pacific
44897 (14.1)
Facility category
Community cancer
program
36434 (11.4)
Comprehensive
community cancer
program
169189 (53)
NCI/teaching/resea
rch center
87167 (27.3)
Other programs
26213 (8.2)
Facility case volume
Low
24581 (7.7)
Medium
79968 (25.1)
High
214454 (67.2)
Reconstruction
Yes
-No
-Completeness of radiotherapy
Complete
313745 (98.4)
Incomplete
5258 (1.6)
No. of Radiation sessions
1-8 sessions
3823 (1.2)
9-16 sessions
14855 (4.7)
17-24 sessions
13343 (4.2)
25-40 sessions
286982 (90)
5977 (38.9)
9397 (61.1)
39772 (52.8)
11435 (28.8)
28337 (71.2)
77175 (91.7)
120283 (87.1)
79605 (82.3)
6941 (8.3)
17866 (12.9)
17133 (17.7)
p<0.0001
7252 (9.6)
31299 (41.5)
36780 (48.8)
3065 (42.3)
11540 (36.9)
12620 (34.3)
4187 (57.7)
19759 (63.1)
24160 (65.7)
p<0.0001
231885 (87.5)
45178 (83.7)
33128 (12.5)
8812 (16.3)
p<0.0001
57078 (75.8)
18253 (24.2)
20673 (36.2)
6552 (35.9)
36405 (63.8)
11701 (64.1)
p=0.43
203330 (90.7)
70055 (78.7)
3678 (63.2)
20894 (9.3)
18904 (21.3)
2142 (36.8)
p<0.0001
14216 (18.9)
36805 (48.9)
24310 (32.3)
6170 (43.4)
12800 (34.8)
8255 (34)
8046 (56.6)
24005 (65.2)
16055 (66)
p<0.0001
44177 (59)
232886 (95.4)
30679 (41)
11261 (4.6)
p<0.0001
61091 (81.1)
14240 (18.9)
18278 (29.9)
8947 (62.8)
42813 (70.1)
5293 (37.2)
p<0.0001
21876 (87.3)
42643 (89.5)
58868 (85.4)
53679 (87.4)
13035 (83.4)
20207 (87.4)
14486 (86.1)
13024 (84)
39245 (87.4)
3190 (12.7)
4982 (10.5)
10071 (14.6)
7734 (12.6)
2598 (16.6)
2912 (12.6)
2329 (13.9)
2472 (16)
5652 (12.6)
p<0.0001
4322 (5.7)
9529 (12.6)
17422 (23.1)
13889 (18.4)
4713 (6.3)
6392 (8.5)
5108 (6.8)
4108 (5.5)
9848 (13.1)
1531 (35.4)
3528 (37)
6468 (37.1)
5108 (36.8)
1707 (36.2)
2143 (33.5)
2170 (42.5)
1166 (28.4)
3404 (34.6)
2791 (64.6)
6001 (63)
10954 (62.9)
8781 (63.2)
3006 (63.8)
4249 (66.5)
2938 (57.5)
2942 (71.6)
6444 (65.4)
p<0.0001
31247 (85.8)
5187 (14.2)
p<0.0001
8071 (10.7)
2977 (36.9)
5094 (63.1)
p<0.0001
147691 (87.3)
21498 (12.7)
38821 (51.5)
14073 (36.3)
24748 (63.7)
75477 (86.6)
22648 (86.4)
11690 (13.4)
3565 (13.6)
21485 (28.5)
6954 (9.2)
7921 (36.9)
2254 (32.4)
13564 (63.1)
4700 (67.6)
21116 (85.9)
69015 (86.3)
186932 (87.2)
3465 (14.1)
10953 (13.7)
27522 (12.8)
p<0.0001
5798 (7.7)
18926 (25.1)
50607 (67.2)
2225 (38.4)
7010 (37)
17990 (35.5)
3573 (61.6)
11916 (63)
32617 (64.5)
p<0.0001
--
58138 (77.2)
17193 (22.8)
21171 (36.4)
6054 (35.2)
36967 (63.6)
11139 (64.8)
p< 0.0001
---
--272058 (86.7)
5005 (95.2)
41687 (13.3)
253 (4.8)
p<0.0001
73666 (97.8)
1665 (2.2)
26390 (35.8)
835 (50.2)
47276 (64.2)
830 (49.8)
p<0.0001
3369 (88.1)
14432 (97.2)
12568 (94.2)
246694 (86)
454 (11.9)
423 (2.8)
775 (5.8)
40288 (14)
p<0.0001
860 (1.1)
590 (0.8)
1215 (1.6)
72666 (96.5)
378 (44)
337 (57.1)
560 (46.1)
25950 (35.7)
482 (56)
253 (42.9)
655 (53.9)
46716 (64.3)
p<0.0001
Boost given
No
45202 (14.2)
40484 (89.6)
4718 (10.4) p<0.0001
27025 (35.9)
10487 (38.8)
16538 (61.2) p<0.0001
Yes
272717 (85.5)
235637 (86.4)
37080 (13.6)
47934 (63.6)
16577 (34.6)
31357 (65.4)
Unknown
1084 (0.3)
942 (86.9)
142 (13.1)
372 (0.5)
161 (43.3)
211 (56.7)
Abbreviations: NH, non-Hispanic, NCI=National Cancer Institute, No.=number
†Clinical stage used if pathologic stage was missing
‡Area-level median household income quartiles from the 2000 US Census data
* p-values calculated using chi-square tests
¥ Among breast-conserving surgery patients, <1% of patients were reported as having radiation to the chest wall so breast and chest wall groups combined.
Among mastectomy-treated patients, 31% of patients were reported as having radiation to the breast; breast and chest wall combined. Approximately 25% of patients with mastectomy
who had breast radiation were reported to have reconstruction