JOB DESCRIPTION
Post Title:
Research Laboratory Manager
Section:
Leukocyte Biology
Institute:
National Heart and Lung Institute
Job Family and Level:
Technical Services, Level 3b
Salary Range:
£33,590 - £41,540 per annum
Accountable to:
Professor Clare Lloyd
Key Working Relationships:
Internal – Members of Professor Lloyd’s research
group, Leukocyte Biology administration, other
academic staff, service departments.
External – Research Collaborators
Duration:
Full-time and fixed-term for 2 years
Location:
South Kensington Campus
Summary of Research
Current projects led by Professor Lloyd are investigating lung epithelial interactions with
the immune system, and how these interactions are influenced by genetic and
environmental factors. We use murine models to determine how inhaled allergen affects
lung immune networks to delineate the mechanisms which determine whether allergen
exposure leads to acute resolving inflammation or chronic inflammation and remodelling.
We investigate the cells and molecules involved in the generation and resolution of house
dust mite induced allergic inflammation and how these parameters are affected by age,
viral infection or inhaled pollutants. We will determine the functional role of key asthma
susceptibility genes in the development of allergic inflammation and remodelling using
complex mutant models to dissect the regulatory and pro-fibrotic functions of key genes.
See http://www1.imperial.ac.uk/medicine/people/c.lloyd/
Summary of the Post
This post is based at Imperial College, South Kensington Campus and is specifically to
support the research undertaken by Professor Lloyd investigating mechanisms of
inflammation and remodelling in in vivo models of allergic airways disease.
You will be part of Professor Lloyd’s group within the Leukocyte Biology Section. The work
involves a variety of in vivo and in vitro techniques to investigate how the inhaled
environment affects lung homeostatic/regulatory networks. You will assist in the
coordination and management of projects within the group funded by research charities,
councils and industrial collaborators, and will advise and supervise research staff,
undergraduate and postgraduate students
Main Duties and Responsibilities
You will assist Professor Lloyd in the running of the research group. Key responsibilities
are to:
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Supervise and coordinate on-going research projects funded by grant bodies as
well as industrial collaborators. This will involve advising group members on the set
up, design and interpretation of experiments and to assist with data acquisition and
analysis, data management, interpretation of results and preparing data for
publications
Contribute to on-going projects as needed
Provide day-to-day coordination and running of the laboratory including supervisory
responsibilities for laboratory staff and students
Ensure that all work done in the laboratory complies with the applicable regulations
concerning biohazards, home office licences and human tissue use
Develop experimental models as necessary and write applications and reports for
submission to research sponsors
Ensure that all records and data are maintained as appropriate, to ensure
compliance and data integrity
Contribute to the dissemination of results to the group, collaborators, and to the
research community in general by participating in laboratory meetings, undertaking
data analysis and where necessary making presentations at internal and external
meetings
Contribute to the preparation of budgets for grant applications, grant reports and
scientific publications
Train new members of the lab in key techniques
Be willing to investigate and learn about novel technology
Carry out any other duties which may arise commensurate with the grade of the
post as directed by the Head of Section
To observe and comply with all College policies and regulations, including the key
policies and procedures on Confidentiality, Conflict of Interest, Data Protection,
Equal Opportunities, Financial Regulations, Health and Safety, Imperial
Expectations (for new leaders, managers and supervisors), Information Technology,
Private Engagements and Register of Interests, and Smoking.
To undertake specific safety responsibilities relevant to individual roles, as set out
on the College Website Health and Safety Structure and Responsibilities page
(http://www3.imperial.ac.uk/safety/policies/organisationandarrangements).
Job descriptions cannot be exhaustive and the post-holder may be required to
undertake other duties, which are broadly in line with the above key responsibilities.
Imperial College is committed to equality of opportunity and to eliminating
discrimination. All employees are expected to adhere to the principles set out in its
Equal Opportunities in Employment Policy, Promoting Race Equality Policy and all
other relevant guidance/practice frameworks.
IMPERIAL COLLEGE LONDON
PERSON SPECIFICATION
Imperial Expectations:
These are the 7 principles that Imperial leaders, managers and supervisors are expected
to follow:
1) Champion a positive approach to change and opportunity
2) Communicate regularly and effectively within, and across, teams
3) Consider the thoughts and expectations of others
4) Deliver positive outcomes
5) Encourage inclusive participation and eliminate discrimination
6) Support and develop staff to optimise talent
7) Work in a planned and managed way
Qualifications:
Essential
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Master’s degree in Biological Sciences, ideally with a high immunology content
Desirable
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PhD in Biological Sciences with a high immunology content, or equivalent industrial
or commercial experience
Experience and Knowledge:
Essential
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Substantial experience in laboratory research in inflammation biology and
immunology
Knowledge of research methods and statistical procedures
Evidence of experience in publishing peer-reviewed papers
Experience of research supervision of undergraduate/postgraduate students and
research staff
Home office licence and experience in biosciences research
Desirable
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Experience at post-doctoral level in laboratory research in inflammation biology and
immunology with proven publications
Experience of working with complex mutant in vivo models, including genotyping
and breeding, ideally of cre-lox expression systems
Experience with induction and analysis of allergic airways disease, or respiratory
infections
Measurement of lung function in vivo
Experience in immunocytochemistry, in situ hybridisation, confocal microscopy,
RNA and DNA preparation, flow cytometry, in vitro culture of T cells and pulmonary
cells, in vitro T cell polarisation and regulatory T cell assays
Experience in supervising laboratory staff, including training and regulatory
compliance
Skills and Abilities:
Essential
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Excellent laboratory skills in particular the ability to participate in and coordinate
multiple projects
Ability to relate effectively to other researchers and students in an academic
context
Ability to conduct a detailed review of recent literature
Ability to develop and apply new concepts
Ability to solve problems using innovative and flexible thinking
Ability to work autonomously and take responsibility
Ability to work proactively within an agreed programme
Ability to organise and prioritise own work with minimal supervision
Ability to work to tight deadlines
Ability to work as part of a team
Excellent organisational skills and attention to detail
Excellent interpersonal and supervisory skills
Excellent verbal communication skills and the ability to deal with a wide range of
people
Excellent written communication skills and the ability to write clearly and succinctly
for publication
Proven ability to prioritise, plan ahead and organise a high volume of work to meet
deadlines, both prescribed and self-imposed, and ensure that the laboratory runs in
an efficient and timely manner
Ability and willingness to adapt to changing timetables or work patterns as dictated
by changing circumstances
Ability to work under pressure while maintaining a high degree of accuracy
Excellent IT skills, PC and Mac, including the use of Microsoft Word, PowerPoint,
Excel spreadsheets and the Internet
Ability to use flow cytometry software for example, Summit, DIVA, and FlowJo
Desirable
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Proven presentation skills
Ability to administer financial resources
Other Requirements:
Essential
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An open, flexible and positive approach to working in a constantly changing
environment
Discipline and regard for confidentiality and security at all times
You should be prepared to work unsociable hours as work demands from time to
time