Table 1: Basic characteristics of patients undergoing surgical and non-surgical treatments (lifestyle and pharmacotherapy) for weight loss. Data are also provided for each of the 3 surgical sub-groups. Surgical group & sub-groups RYGB VSG BAND All surgical patients Non-surgical group Number Gender (male/female) Age (years) 72 12/60 46.7 ± 10.1 6 2/4 45.3 ± 10.5 12 3/9 46.6 ± 10.2 90 17/73 46.5 ± 10.1 36 14/22 54.1 ± 13.3* Pre-operative body weight (kg) 134.4 ± 20.6 122.3 ± 41.2 129.7 ± 24.2 133.0 ± 22.8 118.5 ± 23.0* Pre-operative BMI (kg/m2) 49.0 ± 7.0 42.7 ± 8.3 48.7 ± 9.0 48.5 ± 7.5 40.7 ± 7.5* Percentage weight loss at 1 year (%) 29.7 ± 8.0 20.7 ± 6.0 12.4 ± 5.6 26.8 ± 9.7 Descriptive data are shown as mean ± SD. The surgical and non-surgical groups were compared with unpaired t-tests or Mann Whitney U test depending on normality distribution. BAND: adjustable gastric banding, RYGB: Roux-en-Y gastric bypass, VSG: vertical sleeve gastrectomy, BMI: body mass index. (*) p<0.05 compared to all surgical patients 1 Table 2: Pre-operative psychological characteristics of patients undergoing surgical and non-surgical treatments (lifestyle and pharmacotherapy) for weight loss. Data are also provided for each of the 3 surgical sub-groups. Psychological parameters Comparisons between the surgical and non-surgical groups Comparisons between the surgical sub-groups Non-surgical Surgical P RYGB VSG BAND Overall ANOVA P value Impulsivity HADS Anxiety 61.3 ± 10.6 9.5 ± 3.6 60.3 ± 11.0 10.3 ± 4.3 0.65 0.49 59.9 ±10.7 10.2 ± 3.9 64.8 ± 13.8 7.0 ± 5.3 63.8 ± 14.6 16.5 ± 2.1 0.40 0.04 BAND>VSG, <0.05 0.06 (0.62) 0.07 (0.70) HADS Depression 8.7 ±3.5 8.9 ± 4.3 0.86 8.8 ± 4.1 5.7 ± 3.8 15.5 ± 0.7 0.03 BAND>VSG, <0.05 0.16 (0.36) BAS-Fun Seeking BAS-Reward Responsivity 10.3 ± 2.3 15.7 ± 3.2 10.4 ± 2.2 16.9 ± 2.0 0.89 0.03 9.8 ± 2.1 9.9 ± 2.3 10.8 ± 2.1 10.8 ± 3.9 8.3 ± 2.4 10.7 ± 2.2 0.05 0.47 0.05 (0.11) -0.19 (0.13) BAS-Drive Barratt Impulsivity Scale 9.9 ± 2.6 20.8 ± 4.8 10.0 ± 1.9 22.7 ± 3.1 0.82 0.02 16.6 ± 2.2 22.3 ± 3.2 17.8 ± 1.7 24.5 ± 2.3 17.1 ± 2.2 22.9 ± 2.5 0.35 0.23 -0.18 (0.13) -0.12 (0.32) Post hoc pair-wise comparison, P value Correlation coefficient r (P value of correlation) Descriptive data are shown as mean ± SD. The surgical and non-surgical groups were compared with unpaired t-tests or Mann Whitney U test depending on normality distribution. The surgical sub-groups were compared with one-way ANOVA or one-way ANOVA on ranks depending on normality distribution. Pair-wise post hoc ANOVA comparisons were performed using the Tukey multiple comparison correction testing. Predictors of percentage weight loss were determined using linear regression. BAND: adjustable gastric banding, BAS: behavioural activation scale, HADS: hospital depression and anxiety score, RYGB: Roux-en-Y gastric bypass, VSG: vertical sleeve gastrectomy. 2 Table 3: Pre-operative eating behaviour of patients undergoing surgical and non-surgical treatments (lifestyle and pharmacotherapy) for weight loss. Data are also provided for each of the 3 surgical sub-groups. Eating behaviour Parameters TFEQ Cognitive Restraint TFEQ Disinhibition TFEQ Hunger EDEQ Restraint EDEQ Eating EDEQ Shape concerns EDEQ Weight concerns EDEQ Global Comparisons between the surgical and non-surgical groups Comparisons between the surgical sub-groups Non-surgical Surgical P RYGB VSG BAND 7.7 ± 5.1 7.9 ± 3.6 7.4 ± 4.4 1.8 ± 1.7 1.7 ± 1.6 4.3 ± 1.1 3.6 ± 1.3 2.8 ± 1.2 7.5 ± 4.6 8.9 ± 4.0 7.8 ± 4.2 1.9 ± 1.5 2.2 ± 1.7 4.2 ± 1.4 3.8 ± 1.2 2.9 ± 1.3 0.87 0.33 0.73 0.77 0.19 0.62 0.66 0.74 8.1 ± 5.1 8.8 ± 4.2 7.7 ± 4.6 1.8 ± 1.3 2.2 ± 1.8 4.2 ± 1.4 3.8 ± 1.3 2.9 ± 1.2 9.0 ± 8.5 8.0 ± 4.2 9.5 ± 2.1 2.3 ± 1.8 3.1 ± 0.7 4.9 ± 0.5 4.5 ± 0.9 3.7 ± 0.7 12.0 ± 2.0 6.7 ± 3.8 6.7 ± 3.1 2.7 ± 2.1 2.2 ± 1.8 4.5 ± 1.5 4.2 ± 1.0 2.8 ± 1.8 Overall ANOVA P value 0.44 0.68 0.79 0.17 0.50 0.46 0.26 0.37 Correlation coefficient r (P value of correlation) Post hoc pair-wise comparison, P value -0.60 (<0.005) 0.56 (<0.005) 0.12 (0.47) -0.16 (0.18) -0.16 (0.19) 0.05 (0.71) -0.13 (0.28) -0.04 (0.77) Descriptive data are shown as mean ± SD. The surgical and non-surgical groups were compared with unpaired t-tests or Mann Whitney U test depending on normality distribution. The surgical sub-groups were compared with one-way ANOVA or one-way ANOVA on ranks depending on normality distribution. Pair-wise post ANOVA comparisons were performed using the Tukey multiple comparison correction testing. Predictors of percentage weight loss were determined using linear regression. BAND: adjustable gastric banding, EDEQ: Eating Disorders Examination Questionnaire, RYGB: Roux-en-Y gastric bypass, TFEQ: three factor eating questionnaire, VSG: vertical sleeve gastrectomy. 3 Table 4: Pre-operative quality of life of patients undergoing surgical and non-surgical treatments (lifestyle and pharmacotherapy) for weight loss. Data are also provided for each of the 3 surgical sub-groups. Quality of life Parameters Comparisons between the surgical and nonsurgical groups Non-surgical Surgical P Comparisons between the surgical sub-groups RYGB VSG BAND Overall ANOVA P value SF-36 physical function SF-36 limitation to physical health SF-36 limitation to emotional problems SF-36 energy SF-36 emotional well being SF-36 social function SF-36 pain SF-36 general health IWQOL physical function IWQOL self esteem IWQOL sexual life IWQOL public distress 41.3 ± 28.1 31.0 ± 37.0 57.9 ± 43.3 44.3 ± 19.3 61.5 ± 16.0 54.2 ± 28.3 40.0 ± 19.3 38.6 ± 17.6 39.1 ± 11.0 25.9 ± 6.9 14.6 ± 5.4 15.9 ± 6.2 35.0 ± 23.7 42.1 ± 37.8 47.2 ± 47.4 33.6 ± 21.2 52.9 ± 21.8 44.7 ± 28.6 46.7 ± 26.9 29.7 ± 18.0 40.9 ± 9.1 29.1 ± 6.5 15.5 ± 4.5 19.2 ± 5.0 0.37 0.28 0.40 0.06 0.12 0.23 0.32 0.08 0.50 0.08 0.52 0.03 38.8 ± 24.3 42.1 ± 38.6 48.4 ± 47.0 31.5 ± 18.2 54.7 ± 20.0 43.1 ± 29.6 44.7 ± 27.5 30.6 ± 18.0 41.2 ± 9.3 28.7 ± 6.6 15.2 ± 4.4 19.1 ± 5.0 16.7 ± 17.6 25.0 ± 25.0 33.3 ± 57.7 10.0 ± 0.0 61.3 ± 26.6 33.3 ± 26.0 29.2 ± 11.6 28.3 ± 10.4 53.5 ± 0.7 33.5 ± 0.7 20.0 ± 0.0 23.0 ± 1.41 20.0 ± 14.1 0.0 ± 0.0 50.0 ± 70.7 58.3 ± 27.5 24.0 ± 28.3 18.8 ± 8.8 18.8 ± 26.5 25.0 ± 28.3 40.70 ± 6.5 33.7 ± 2.3 17.0 ± 4.4 22.7 ± 2.5 0.20 0.25 0.88 0.02 0.88 0.46 0.29 0.90 0.18 0.28 0.27 0.30 IWQOL work problems IWQOL total 11.1 ± 4.4 100.0 ± 34.4 11.3 ± 4.5 115.9 ± 20.9 0.85 0.03 11.1 ± 4.3 115.0 ± 21.5 17.5 ± 2.1 148.0 ± 3.5 18.3 ± 2.9 132.0 ± 1.5 0.01 0.06 Post hoc pair-wise comparison, P value BAND>VSG, <0.05 BAND>RYGB, <0.05 Correlation coefficient r, (P value of correlation) 0.04 (0.84) -0.10 (0.57) -0.09 (0.60) -0.45 (0.01) 0.05 (0.79) 0.001 (0.1) 0.17 (0.32) 0.03 (0.85) 0.19 (0.28) -0.10 (0.58) -0.20 (0.23) -0.21 (0.22) -0.12 (0.50) -0.07 (0.69) Descriptive data are shown as mean ± SD. The surgical and non-surgical groups were compared with unpaired t-tests or Mann Whitney U test depending on normality distribution. The surgical sub-groups were compared with one-way ANOVA or one-way ANOVA on ranks depending on normality distribution. Pair-wise post ANOVA comparisons were performed using the Tukey multiple comparison correction testing. Predictors of percentage weight loss were determined using linear regression. BAND: adjustable gastric banding, IWQOL: impact of weight on quality of life, RYGB: Roux-en-Y gastric bypass, SF: short form, VSG: vertical sleeve gastrectomy. 4