Catatonia in Outpatients: Analysis of a Single Clinical Practice. Robert Arnold Johnson, MD SUPPLEMENTAL DIGITAL CONTENT Means of diagnosis in this study. Diagnoses for each patient in this outpatient practice of general psychiatry during a period extending from the inception of the practice (September 2007) to December 2013 were reviewed by means of a record-by-record survey. These surveys were retrospective: neither diagnosis nor treatment was conceived according to an interventional or experimental design. The patients in the practice are subject to the psychiatric evaluation and care of a single provider, the author, who alone creates the record of clinical encounters. All diagnoses are based on informally structured clinical interviews, but extended, in all of the cases reported herein, to multiple encounters over months or, more commonly, years. Diagnoses conform to criteria specified in DSM-5; one instance of catatonia is an exception (see Table). For purposes of this study, the Bush-Francis Catatonia Rating Scale (BFCRS) is employed as a supplemental tool for diagnosing catatonia (6). Answers for each of its 23 items are not specifically sought in these clinical encounters, so the score entered in each case accounts for items answered within the record, and assigns a score of 0 to the others: the score here is a minimum value, therefore. In the case of ASD in adult patients not previously diagnosed, the clinical interview in itself may leave doubt, especially with regard to the certain presence or absence of typical childhood symptoms and signs (Criterion C, DSM-5); the modifier “likely” is assigned to the diagnosis in such instances. The Practice and Its Community This outpatient practice of general adult psychiatry is located in Walla Walla, the largest city in a semi-rural region of approximately 55,000 in southwestern Washington State. Walla Walla is known for wine-making (more than 100 wineries), (sweet) onionfarming, dry-land wheat farming, higher education (two colleges and one community college), and Washington State Penitentiary, Its population is 22% Hispanic, 2.7% African-American, 1.4% Native American, and 1.3% Asian. This information about the community in which the practice is embedded is taken largely from the 2010 census. The author is the only psychiatrist in general practice in the immediate region. Two general hospitals are located in the city; there is no inpatient psychiatric unit. The closest provider for electroconvulsive therapy (ECT) is removed by 130 miles. No one living independently is taken into the practice who is deemed incapable of keeping scheduled appointments and being free of intoxication while in-session, incapable of maintaining basic hygiene, and incapable of restraining an impulse to physically assault. No new patient actively psychotic is accepted unless a supportive family member or staff-member of a care-facility is available and willing to accompany him or her to the session. If a patient lacks capability—physically, mentally, or financially—for coming to a session and resides in a sufficiently safe and supportive home or facility, the author is able to attend him or her there, given enough notice for scheduling. Eighty percent of the patients are insured, either privately (70%) or via Medicare (10%). Of those who pay themselves, 79% are extended a means-based reduction in fee; a very few are wholly unable to pay. The practice does not bill Medicaid in Washington or in the nearby state of Oregon. The practice does not include children; only four of the patients have been less than 18 years of age. Of patient-contact hours, a majority (75%) involve psychotherapy, at least in part—solely psychotherapy in 25% of these; in the remainder, clinical attention is confined principally to medication management and evaluation. Case Report1 A 55-year-old man, the youngest of 5 siblings, was brought for ongoing psychiatric care. His mother, age 95, stated that all developmental milestones were late, thus he was considered intellectually impaired early in childhood, even though savant skills (calendric; memory for strings of numbers) were recognized also. Reciprocal social interaction was always impaired; self-presentation was immature and ritualistic. Bullying by peers began in 1st grade. He was placed in special education by 7th grade; school ended in 10th grade. A recurrently disruptive feature of childhood, persisting since, was that of assaultive explosion: battery occasioned three inpatient psychiatric hospitalizations through the years and a rare overnight confinement to the local jail. He lived at home until age 27, then in a series of residential facilities, from which he traveled by foot or local bus to day-treatment or a work-center. Never was he capable of independent living. Never did he fall in love. His mother in her later years believed that autism was the best diagnosis for her son; I was the first mental-health provider to agree. The most common diagnosis in his records was schizoaffective disorder, despite absence of hallucinations or delusions (confirmed by a nurse who had seen him for years) and absence of the disordered moods typical of that diagnosis. The assaultive explosions were very brief; they did not mark an epoch of disturbed mood. The social and communicative 1 The patient described here, despite the author’s masking or withholding the most obviously identifying features, is yet recognizable by a few within the small city in which the practice is located. Informed consent for publication of the case has been provided by his two living siblings. (Although the patient himself also has provided consent, he lacks capacity for doing so, in the author’s opinion.) impairments of autism seem to have been confused with the negative features of a schizophrenic illness. Echolalic repetition had been common. Sometimes answering a doorbell he would be overtaken by inexplicable mutism. Lorazepam had been prescribed and continued, but nowhere in the record was a diagnosis of catatonia stated explicitly. I, too, failed to consider it at first. He is a very large man, and on presentation was clean, casually attired, cooperative, and pleasant. Eye-contact was inconsistently engaged, and he spoke with an odd, fixed prosody. One instance of echolalia was noted. Affect was euthymic but restricted in range. Neither hallucinatory nor delusional experience was in evidence. Orientation was normal, with the exception that he had trouble naming the country without a prompt. He could spell “world” rapidly, forward and back. Judgment was fair, insight poor. He knew no proverbs; he recognized biblical passages, but could offer no interpretations. No hyperactivity, immobility, posturing, staring, mutism, ambitendency, or oppositional behaviors were present then. The score on the Folstein mini-mental-status exam was 21 of 30. IQ, estimated by the verbally based Ammons Quick Test, was 78. Medications had not changed in over a decade: thioridazine, haloperidol, procyclidine, diphenhydramine, sertraline, lorazepam (2 mg three times daily), and fludrocortisone. ECG showed QTc of 0.47 s. Complete blood count and the results of a metabolic screen were normal. The rationale for the prescription of two antipsychotic agents appears to have been a trial-anderror conclusion that both were needed to prevent enactment of the impulse to assault. Thioridazine was tapered and discontinued as aripiprazole was added. He became more cheerful and conversational; his mother was so impressed that she hired a tutor. Clonazepam was substituted for lorazepam, with a plan for slowly tapering off benzodiazepine altogether; procyclidine and diphenhydramine were discontinued. Three months later, when the dose of clonazepam was half the initial amount, his caretaker complained that the patient seemed confused and uncoordinated. Spontaneous speech was diminished but he answered questions reasonably. Performances on the Folstein test and clock-drawing were unchanged. Confabulation, however, was newly present. Neurological examination showed nothing remarkable otherwise. CT-scan of the head was normal, as were the results of repeated laboratory testing, including TSH and vitamin B12 serum levels. Over the next 18 weeks clonazepam and aripiprazole were tapered off, the latter on the speculation that this unexplained change in functioning might represent a delayed cognitive effect of the drug. No sustained improvement occurred. In fact, spontaneous speech declined further. He began episodically to urinate into his trousers, sometimes standing in view of others as if on show, and similar behavior was true of defecation; sometimes he would play with his feces (copromania) before the watchful gaze of others. Yet he remained fully oriented and alert, with no hallucinations or delusions. At that time he began holding the left upper extremity in an odd, anglepoise posture: I made the diagnosis of catatonia. Lorazepam three times daily was prescribed, and the dose gradually advanced. Distinct improvement occurred quickly and was pronounced within a month. Occasional spells over the next 3 years of the following have provoked further adjustment in the dose of lorazepam and the re-introduction of aripiprazole: public masturbation; assaultive explosions (verbal or physical); bedwetting; abrupt, bizarre food-stuffing (to the point of near-asphyxiation, requiring a visit to an emergency room); one instance of sitting down on a highway; echopraxia; echolalia; staring; an exaggerated manneristic smile; a temporary but dramatic “shuffle” in gait; and pronounced mutism. Once, when asked why he had suddenly blurted out, “I wish I was dead or could kill somebody!” he answered, “I’m not going to talk like that anymore; yet I don’t know that I can stop; maybe I do it for attention.” In the past year he is free of all such catatonic features, apart from rare posturing of the left upper extremity. He exercises at the YMCA twice weekly, attends church each Sunday, and goes out to lunch with one of his caretakers weekly. Medications are lorazepam three times daily (total of 10 mg), aripiprazole 30 mg daily, sertraline 100 mg daily, and haloperidol 10 mg at bedtime.