CURRICULUM VITAE
Name:
Date of Last Update:
Hospital:
Telephone:
Fax:
Robert M Hamilton
July. 10, 2013
Division of Cardiology
The Hospital for Sick Children
555 University Avenue
Toronto, ON
M5G 1X8
(416)813-7418
(416)813-7547
Personal Information:
EDUCATION some publications are listed in medline under Hamilton R
Degrees, Diplomas, Licensures and Certifications
1975 - 1978 B.Sc. (Chemistry), Dalhousie University
Halifax, Nova Scotia
1978 - 1982
Subject: Chemistry
M.D.(Medicine), Dalhousie University
Halifax, Nova Scotia
Subject: Medicine
1982 - 1986 Educational Registry, Provincial Medical Board of Nova Scotia
Nova Scotia yearly for 4 years
1982 - 1986 FRCP(C) Pediatrics 1983 Izaak, Dalhousie University and the Izaak
Walton Killam Hospital
Halifax, Nova Scotia
Subject: Pediatrics
1986 - 1987
1987 - 1988
Temporary Registry, College of Physicians and Surgeons
Alberta
Licensure : 1 year
Ontario : Educational Registry, College of Physicians and Surgeons
Ontario

May 1987 - Jun 1987
1988
1988 - 1989
1989 - Present
1993
1994
2003 - 2005
1986
1987
2010
Specialty Training
1983
Licensure : 1 year
Locum Tenens, College of Physicians and Surgeons
Alberta
Licensure : 2 months
FRCP(C), Royal College of Physicians and Surgeons of Ontario
Ottawa, Ontario
Subject: Pediatric Cardiology
Permit, Texas State Board of Medical Examiners
Texas
Licensure : 1 year
General License, College of Physicians and Surgeons of Ontario
Ontario
FAAP, American Academy of Pediatrics
USA
Fellow
FAAP, American Academy of Pediatrics. Sub-board in Pediatric
Cardiology
USA
Fellow
Subject: Pediatric Cardiology
M.Sc., University of Toronto
Toronto, Ontario
Supervisor(s): Tina Smith
Subject: (MHSc) Department of Health Policy, Management and
Evaluation
Izaak Walton Killam Children's Hospital
Halifax, Nova Scotia
Straight Internship
Izaak Walton Killam Children's Hospital
Halifax, Nova Scotia
Resident
Subject: Pediatrics
W.C.MacKenzie Health Sciences Centre
Edmonton, Alberta

1986
1986 - 1987
1987 - 1988
1988 - 1989
1988
1989
Fellowships
1985 - 1986
Other
2008
Pediatric Cardiology Fellowship
The Hospital for Sick Children
Toronto, Ontario
Pediatric Cardiology Fellowship
Texas Children's Hospital
Houston, Texas
Pediatric Cardiac Electrophysiology fellowship
Dalhousie University
Halifax, Nova Scotia
Clinical Fellowship
Supervisor(s): Douglas R, Finley J
Subject: Pediatric Cardiology
Izaak Walton Killam Children's Hospital
Halifax, Nova Scotia
Fellow
Subject: Pediatric Cardiology
University of Alberta
Edmonton, Alberta
Clinical fellow
Supervisor(s): Dr.Neil Duncan
Subject: Pediatric Cardiology
University of Toronto
Toronto, Ontario
Clinical Fellow
Supervisor(s): Freedom RM
Subject: Pediatric Cardiology
Baylor College of Medicine
Houston, Texas
Post-doctoral fellow
Supervisor(s): Garson A
Subject: Pediatric Cardiac Electrophysiology
Jackson Laboratories 2 week course on Mammalian Genetics
Subject: (An intensive 2 week course with lectures from 8 am to 9 pm daily for 11 working days; course hours equivalent to graduate coursework; designed for both clinicians and PhD students)

APPOINTMENTS
University Appointments
1989 - 1996 Assistant Professor of Pediatrics, University of Toronto, Toronto,
Ontario
1996 - 2004 Associate Professor of Pediatrics, University of Toronto, Toronto,
Ontario
2004 - Present
Jan 7, 2004
Hospital Appointments
1989 - 2011
Professor of Pediatrics, University of Toronto, Toronto, Ontario
Associated Graduate Faculty, University of Guelph, Guelph, Ontario
Director of Pacemaker Clinic : Pediatric Cardiologist and
Electrophysiologist, Division of Cardiology, Hospital for Sick
Children, Toronto, Ontario
1993 - Present Consultant Electrophysiologist, Toronto Congenital Cardiac Center for
Adults, Division for Cardiology, University Health Network, Toronto,
Ontario
1998 - 2012 Director of Electrophysiology, The Hospital for Sick Children,
Toronto, Ontario
1999 - 2010 Associate Scientist, Hospital for Sick Children Research Institute,
Toronto, Ontario
2010-Present Senior Associate Scientist, Hospital for Sick Children Research
Institute, Toronto, Ontario
1999 - Present Clinician Investigator, Department of Pediatrics, Hospital for Sick
Children Research Institute, Toronto, Ontario
1999 - Present Consultant to Neonatal Intensive Care Unit, Mount Sinai Hospital,
Toronto, Ontario
2000 - 2001 Acting Director, Division of Cardiology, The Hospital for Sick
Children, Toronto, Ontario
Oct 2002 - Oct 2007 Medical Director of TeleHealth, The Hospital for Sick Children,
Toronto, Ontario
2003 Active Staff, London Health Sciences Center, London, Ontario

Other Appointments
1999 - Present Cardiology consultant, Ministry of Transportation, Province of
Ontario, Toronto, Ontario
2011 – Present Consultant, Cardiac Genetics, Sistemas Genomicos SL, Valencia,
Spain
Cross Appointments
1999 - Present
1999 - Present
PUBLICATIONS
Mount Sinai Hospital, Pediatrics
Toronto General Hospital, Cardiology
PA-denotes Principal Author; SRI-Senior Responsible Investigator; CPA-Co-Principal
Author; C-Collaborator
Peer Reviewed - Journal Publications
Published (PubMed-recognized authorship)
1. Hamilton RM, Gillespie CT, Cook HW: Relationships between levels of essential fatty acids and zinc in plasma of cystic fibrosis patients. Lipids 1981: 16 (5): pp 374-376. PA
2. Hamilton RM, Crocker JF, Murphy DA: Uric acid metabolism in children who undergo cardiopulmonary bypass. Canadian Journal of Surgery 1982: 25 (2): pp 131-132. PA
3. Finley JP, Hamilton R, Gordon-MacKenzie M: Heart rate response to tilting in newborns in quiet and active sleep. Biology of the Neonate 1984: 45: pp 1-10. SRI
4. Hamilton RM, Penkoske PA, Byrne P, Duncan NF: Spontaneous aortic thrombosis in a neonate presenting as coarctation. Annals of Thoracic Surgery 1988: 45: pp 564-5. PA
5. Hamilton R, Bahoric B, Griffiths J, Freedom R, Williams W: Steroid-eluting epicardial leads in pediatrics: Improved epicardial thresholds in the first year. Pacing and Clinical
Electrophysiology 1991: 14 (11): pp 2066-2072. PA
6. Hosking MCK, Thomaidis C, Hamilton R, Burrows PE, Freedom RM, Benson L:
Clinical impact of balloon angioplasty for branch pulmonary artery stenosis. American
Journal of Cardiology 1992: 69 (17): pp 1467-1470. CPA
7. Newman D, Dorian P, Downar E, Harris L, Cameron D, Waxman M, Hamilton R, Gow

R, Hardy J: The utility of telemetry functions in the assessment of implanted antitachycardia device efficacy. American Journal of Cardiology 1992: 70: pp 616-621. C
8. Garson A, Dick M, Fournier A, Gillette PC, Hamilton R, Kugler JD, Van Hare G,
Vetter V, Vick GW: The long QT syndrome in children: an international study of 287 patients. Circulation 1993: 87: pp 1866-1872. C
9. Figa FH, Gow RM, Hamilton RM, Freedom RM: Clinical efficacy and safety of intravenous Amiodarone in infants and children. American Journal of Cardiology 1994: 74
(6): pp 573-577. C
10. Dodo H, Gow RM, Hamilton RM, Freedom RM: Chaotic atrial rhythm in children.
American Heart Journal 1995: 129: pp 990-995. C
11. Bauersfeld U, Gow R, Hamilton R, Izukawa T: Treatment of atrial ectopic tachycardia in infants under 6 months of age. American Heart Journal 1995: 129: pp 1145-1148. C
12. Berkovitch M, Matsui D, Fogelman R, Komar L, Hamilton R, Johnston D: Assessment of the terminal 40-millisecond QRS vector in children with a history of tricyclic antidepressant ingestion. Pediatric Emergency Care 1995: 11 (2): pp 75-77. C
13. Gelatt M, Hamilton RM, McCrindle BW, Gow RM, Williams WG, Freedom RM: Risk factors for atrial tachyarrhythmias after the Fontan operation. Journal of the American
College of Cardiology 1995: 24 (7): pp 1735-1741. SRI
14. Rao V, Williams WG, Hamilton RH, Williams G, Goldman BS, Gow RM: Trends in pediatric cardiac pacing. Canadian Journal of Cardiology 1995: 11: pp 993-999. SRI
15. Silverman ED, Buyon J, Laxer RM, Hamilton R, Bini P, Chu JL, Elkon K:
Autoantibody response to the Ro/La particle may predict outcome in neonatal lupus erythematosus. Clinical and Experimental Immunology 1995: 100 (3): pp 499-505. C
16. Davis AM, Gow RM, McCrindle BW, Hamilton RM: Clinical spectrum, therapeutic management and follow-up of ventricular tachycardia in infants and young children.
American Heart Journal 1996: 131 (1): pp 186-191. C
17. Press J, Uziel Y, Laxer RM, Luy L, Hamilton RM, Silverman ED: Long-term outcome of mothers of children with complete congenital heart block. American Journal of Medicine
1996: 100: pp 328-332. C
18. Hamilton RM, Dorian P, Gow RM, Williams WG: Five year experience with implantable defibrillators in children. American Journal of Cardiology 1996: 77 (7): pp 524-526. PA
19. Davis AM, McCrindle BW, Hamilton RM, Moore-Coleman PM, Gow RM: Normal values for the childhood signal-averaged ECG. Paediatric Pacing and Clinical
Electrophysiology 1996: 19: pp 793-801. CPA
20. Gladman G, Davis AM, Fogelman R, Hamilton RM, Gow RM: Torsade des pointes, acquired complete heart block and Inappropriately Long QT in childhood. Canadian Journal

of Cardiology 1996: 12 (7): pp 683-685. C
21. Gelatt MC, Hamilton RM, McCrindle BW, Connelly MB, Davis AM, Harris PIL, Gow
RM, Williams WG, Trusler GA: Arrhythmia and mortality following the mustard procedure: A thirty year single-center experience. Journal of the American College of
Cardiology 1997: 29 (1): pp 194-201. d.clarke@dal.ca
SRI
22. Casey FA, McCrindle BW, Hamilton RM, Gow RM: Neonatal atrial flutter: significant early morbidity and excellent long-term prognosis. American Heart Journal 1997: 133 (3): pp 302-306. C
23. Hamilton RM, Chiu C, Gow RM, Williams WG: A comparison of two stab-on unipolar epicardial pacing leads in children. Paediatric Pacing and Clinical Electrophysiology 1997:
20 (3 Pt1): pp 631-636. PA
24. Chiu CC, Gow RM, McCrindle BW, Newman A, Hamilton RM: Impact of programmed sensitivity safety factor on atrial sensing in children. Paediatric Pacing and Clinical
Electrophysiology 1997: 20 (9 Pt1): pp 2163-2170. SRI
25. Dele Davies H, King SM, Doyle J, Matlow A, Koren G, Hamilton R, Portwine C:
Randomized, blinded and controlled pilot study of rapid amphotericin B Infusions in children. Archives of Disease in Childhood 1997: 76: pp 165-166. C
26. Fogelman R, Gow RM, Casey F, Hamilton RM: Pseudoinfarction pattern in an infant.
Pediatric Cardiology 1997: 18 (4): pp 312-314. C
27. Figa FH, McCrindle BW, Bigras JL, Hamilton RM, Gow RM: Risk Factors for venous obstruction associated with transvenous pacing in children. Pediatric Pacing and Clinical
Electrophysiology 1997: 20 (8 Pt1): pp 1902-1909. C
28. Beland M, Guiffre M, Hamilton R: Standards for training in pediatric electrophysiology.
Canadian Cardiovascular Society. Canadian Journal of Cardiology 1998: 14 (7): pp 902-906.
CPA
29. Gow RM, Beland M, Guiffre M, Hamilton R: Standards of pediatric electrophysiology.
Canadian Journal of Cardiology 1998: 14 (8): pp 1007-1012. CPA
30. Hamilton RM, Lee-Poy M, Kruger K, Silverman ED: Investigative methods in congenital complete heart block. Journal of Electrocardiology 1998: 30 (S25): pp 69-74. PA
31. Smith GL, Law Y, Hamilton R, Benson L, West L, Coles J: Complication of ventricular demand pacing following orthotopic heart transplantation: unusual case of pacemaker syndrome in an infant. Journal of Heart and Lung Transplantation 1998: 12: pp 1267-1270.
C
32. Menon A, Silverman ED, Gow RM, Hamilton RM: Chronotropic competence of the sinus node in congenital complete heart block. American Journal of Cardiology 1998: 82 (9): pp
1119-1121. SRI

33. Yetman A, Hamilton RM, Benson L, McCrindle B: Long-term outcome and prognostic determinants in children with hypertrophic cardiomyopathy. Journal of the American
College of Cardiology 1998: 32 (7): pp 1943-1950. CPA
34. Dipchand AI, McCrindle BW, Gow RM, Freedom RM, Hamilton RM: Accuracy of surface electrocardiograms for differentiating children with hypertrophic cardiomyopathy from normal children. American Journal of Cardiology 1999: 83 (4): pp 628-630. SRI
35. Jaeggi E, Chui C, Hamilton R, Gilljam T, Gow R: Adenosine-induced atrial proarrhythmia children. Canadian Journal of Cardiology 1999: 15 (2): pp 169-172. CPA
36. Yetman A, Hamilton R, Benson L, McCrindle B: Long-term outcome and prognostic determinants in children with hypertrophic cardiomyopathy (Updated). Journal of the
American College of Cardiology 1999: 34: pp 949-950. CPA
37. Gillis AM, Hamilton RM, LeFeuvre CA: Unusual cases of sudden cardiac death due to ventricular tachyarrhythmias. Canadian Journal of Cardiology 2000: 16(Sup C ): pp 34C-
40C. CPA
38. Freedom RM, Hamilton R, Yoo SJ, Mikailian H, Benson L, McCrindle B, et al: The
Fontan procedure: Analysis of cohorts and late complications (In Process Citations).
Cardiology in the Young 2000: 10 (4): pp 307-331. CPA
39. Yetman AT, Lee KJ, Hamilton R, Morrow WR, McCrindle BW: Exercise capacity after repair of Tetralogy of Fallot in infancy. American Journal of Cardiology 2001: 87: pp 1021-
23. SRI
40. Chiu CC, McCrindle BW, Hamilton RM, Griffiths JE, Gow RM: Clinical use of permanent pacemaker for conversion of intraatrial reentry tachycardia in children. Paediatric
Pacing and Clinical Electrophysiology 2001: 24: pp 950-6. CPA
41. Azakie A, McCrindle BW, Van Arsdell G, Benson LN, Coles J, Hamilton R, Freedom
RM, Williams WG: Extracardiac conduit versus lateral tunnel cavopulmonary connections at a single institution: impact on outcomes. Journal of Thoracic and Cardiovascular Surgery
2001: 122: pp 1219-28. C
42. Jaeggi ET, Hamilton RM, Silverman ED, Zamora SA, Hornberger LK: Outcome of children with fetal, neonatal or childhood diagnosis of isolated congenital atrioventricular block. A single institution's experience of 30 years. Journal of the American College of
Cardiology 2002: 39: pp 130-7. CPA
43. Dillenburg RF, Hamilton RM: Is exercise testing useful in the identification of the congenital long QT syndrome. American Journal of Cardiology 2002: 89: pp 233-6. SRI
44. Sanatani S, Peirone A, Chiu C, Human DG, Gross GJ, Hamilton RM: Use of an implantable loop recorder in the evaluation of children with congenital heart disease.
American Heart Journal 2002: 143: pp 366-72. SRI
45. Nield LE, Silverman ED, Taylor GP, Smallhorn JF, Mullen JB, Silverman NH, Finley

JP, Law YM, Human DG, Seaward PGR, Hamilton RM, Hornberger LK: Maternal anti-Ro and anti-La antibody-associated endocardial fibroelastosis. Circulation 2002: 105: pp 843-8. C
46. Suto F, Cahill SA, Wilson GJ, Hamilton RM, Greenwald I, Gross GJ: A novel rabbit model of variably compensated complete heart block. Journal of Applied Physiology 2002:
92: pp 1199-204. C
47. Lin AE, Grossfeld PD, Hamilton RM, Smoot L, Gripp KW, Proud V, Weksberg R,
Wheeler P, Picker J, Irons M, Zackai E, Marino B, Scott Jr CI, Nicholson L: Further delineation of cardiac abnormalities in Costello syndrome. American Journal of Medical
Genetics 2002: 111: pp 115-129. C
48. Sanatani S, Hamilton RM, Gross GJ: Predictors of refractory tachycardia in infants with supraventricular tachycardia. Pediatric Cardiology 2002: 23: pp 508-12. CPA
49. Stephenson EA, Collins KK, Dubin AM, Epstein MR, Hamilton RM, Kertesz NJ,
Alexander ME, Cecchin F, Triedman JK,Walsh EP, Berul CI: Circadian and seasonal variation of malignant arrhythmias in a pediatric and congenital heart disease population.
Journal of Cardiovascular Electrophysiology 2002: 13: pp 1009-14. C
50. Zalzstein E, Hamilton R, Zucker N, Diamant S, Webb G: Aortic dissection in children and young adults: diagnosis, patients at risk, and outcomes. Cardiology in the Young 2003:
13: pp 341-4. SRI
51. Dubin AM, Berul CI, Bevilacqua LM, Collins KK, Etheridge SP,Fenrich AL, Friedman
RA, Hamilton RM, Schaffer MS, Shah M, Silka MJ, Van Hare GF, Kertesz NJ: The use of implantable cardioverter-defibrillators in pediatric patients awaiting heart transplantation.
Journal of Cardiac Failure 2003: 9: pp 375-9. C
52. Sanatani S, Chiu C, Nykanen D, Coles J, West L, Hamilton R: Evolution of heart rate control after transplantation: conduction versus autonomic innervation. Pediatric Cardiology
2003: 25: pp 113-118. SRI
53. Zalzstein E, Hamilton R, Zucker N, Levitas A, Gross GJ: Presentation, natural history, and outcome in children and adolescents with double orifice mitral valve. American Journal of Cardiology 2004: 93: pp 1067-9. SRI
54. Chiu CC, Vicente KJ, Buffo-Sequeira I, Hamilton RM, McCrindle BW: Usability assessment of pacemaker programmers. Paediatric Pacing and Clinical Electrophysiology
2004: 27: pp 1388-98. C
55. Simpson C, Dorian P, Gupta A, Hamilton R, Hart S, HoffmasterB, Klein G, Krahn A,
Kryworuk P,Mitchell LB, Poirier P, Ross H, Sami M, sheldon R, Stone J, Surkes J, brennan FJ: Assessment of the cardiac patient for fitness to drive: drive subgroup executive summary. Canadian Journal of Cardiology 2004: 20: pp 1314-20. C
56. Kirsh JA, Gross GJ, O'Connor S, Hamilton RM, Cryocath International Patient
Registry: Transcatheter cryoablation of tachyarrhythmias in children: Initial experience

from an international registry. Journal of the American College of Cardiology 2005: 45: pp
133-136. CPA
57. Walls J, Sanatani S, Hamilton R: Post-hoc diagnosis of congenital long QT syndrome in patients with tetralogy of Fallot. Paediatric Cardiology 2005: 26: pp 107-10. CPA
58. Hinek A, Teitell MA, Schoyer L, Allen W, Gripp KW, Hamilton R, Weksberg R,
Kluppel M, Lin AE: Myocardial storage of chondroitin sulfate-containing moieties in
Costello syndrome patients with severe hypertrophic cardiomyopathy. American Journal of
Medical Genetics 2005: 133: pp 1-12. C
59. Suzuki H, Silverman ED, Wu X, Borges C, Zhao S, Isacovics B, Hamilton RM: Effect of maternal autoantibodies on fetal cardiac conduction: an experimental murine model.
Pediatric Research 2005: 57: pp 557-62. SRI
60. Spence D, Hornberger L, Hamilton R, Silverman ED: Increased risk of complete congenital heart block in infants born to women with hypothyroidism and anti-Ro and/or anti-La antibodies. Journal of Rheumatology 2006: 33: pp 167-70. C
61. Bronzetti G, Chiu C, Stephenson EA, Gross GJ, Hamilton RM, Dongsheng G, Neilson
AL, Kirsh JA: Simultaneous wide and narrow QRS complex tachycardias in a child: what is the mechanism? Journal of Cardiovascular Electrophysiology 2006: 17: pp 560-2. C
62. Gross GJ, Chiu CC, Hamilton RM, Kirsh JA, Stephenson EA: Natural history of postoperative heart block in congenital heart disease: implications for pacing intervention.
Heart Rhythm 2006: 3: pp 601-4. SRI
63. Sanatani S, Wilson G, Smith CR, Hamilton RM, Williams WG, Adatia I: Sudden unexpected death in children with heart disease. Congenit Heart Dis 2006: 1: pp 89-97. C
64. Anand N, McCrindle BW, Chiu CC, Hamilton RM, Kirsh JA, Stephenson EA, Gross
GJ: Chronotropic incompetence in young patients with late postoperative atrial flutter: A case-control study. European Heart Journal 2006: 27: pp 2069-73. C
65. Horenstein MS, Idriss SF, Hamilton RM, Kanter RJ, Webster PA Jr, Karpawich PP:
Efficacy of signal-averaged electrocardiography in the young orthotopic heart transplant patient to detect allograft rejection. Pediatric Cardiology 2006: 27: pp 589-93. C
66. Nii M, Hamilton RM, Fenwick L, Kingdom JC, Roman KS, Jaeggi ET: Assessment of fetal atrioventricular time intervals by tissue Doppler and pulse Doppler echocardiography: normal values and correlation with fetal electrocardiography. Heart 2006: 92: pp 1831-1837.
CPA
67. Gao DS, Fang WY, Chiu-Man C, Kirsh J, Gross G, Hamilton RM: QT hysteresis in long-QT syndrome children with exercise testing. Chinese Medical Journal (England) 2007:
120: pp 179-82. C
68. Chiu CC, Hamilton RM, Gow RM, Kirsh JA, McCrindle BW: Evaluation of computerized interpretation of the paediatric electrocardiogram. Journal of

Electrocardiology 2007: 40: pp 139-43. CPA
69. Grosse-Wortmann L, Hamilton R, Yo S-J: Massive systemic-to-pulmonary collateral arteries in the setting of a cavopulmonary shunt and pulmonary venous stenosis. Cardiology in the Young 2007: 17: pp 548-550. CPA
70. Hamilton RM: Genetic testing for mutations or polymorphisms in sudden infant death syndrome: "an argument that cuts both ways". Heart Rhythm 2008: 5: pp 716-718. PA
71. Fidler LM, Wilson GJ, Liu F, Cui X, Scherer SW, Taylor GP, Hamilton RM: Abnormal connexin43 in arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 mutations. J Cell Mol Med 2009. 13(10): 4219-28. SRI
72. Chiu CC, Huh J, De Souza L, Alfaro-Ramirez A, Clegg R, Fenwick L, Hamilton RM,
Kirsh JA, Gross GJ, Gao D, Stephenson EA: A prospective pediatric clinical trial of digital music players: do they interfere with pacemakers? J Cardiovasc Electrophysiol 2009:
20: pp 44-9. C
73. Kanbur NO, Goldberg E, Pinhas L, Hamilton RM, Clegg R, Katzman DK.
Int J Eat Disord. 2009 Feb 2. [Epub ahead of print]: Second-degree atrioventricular block
(Mobitz Type I) in an adolescent with anorexia nervosa: Intrinsic or acquired conduction abnormality. Int J Eat Disorder 2009. C
74. Collins KK, Van Hare GF, Kertesz NJ, Law IH, Bar-Cohen Y, Dubin AM, Etheridge
SP, Berul CI, Avari JN, Tuzcu V, Sreeram N, Schaffer MS, Fournier A, Sanatani S,
Snyder CS, Smith RT Jr, Arabia L, Hamilton R, Chun T, Liberman L, Kakavand B,
Paul T, Tanel RE: Pediatric nonpost-operative junctional ectopic tachycardia medical management and interventional therapies.
J Am Coll Cardiol. 2009 Feb 24;53(8):690-7. Journal of the American College of
Cardiology 2009: 53: pp 690-7. C
75. Hamilton RM, Fidler L: Right ventricular cardiomyopathy in the young: an emerging challenge. Heart Rhythm 2009: 6: pp 571-5. PA
76. Villafane J, Young ML, Maury P, Wolpert C, Anttonen O, Hamilton R, Kannankeril
PJ, Fischbach PS.
Pediatr Cardiol. 2009 Apr 14. [Epub ahead of print]: Short QT
Syndrome in a Pediatric Patient. Pediatr Cardiol 2009. C
77. Lin AE, O'Brien B, Demmer LA, Almeda KK, Blanco CL, Glasow PF, Berul CI,
Hamilton R, Micheil Innes A, Lauzon JL, Sol-Church K, Gripp KW.
Prenat Diagn. 2009 Jul;29(7):682-90: Prenatal features of Costello syndrome: ultrasonographic findings and atrial tachycardia. Prenat Diagn 2009: 29: pp 682-90. C
78. Hamilton R: Arrhythmogenic Right Ventricular Cardiomyopathy. PACE 2009: 32: pp S44-
S51. PA
79. Hamilton RM, Azevedo ER: Published Online: Jul 6 2009 11:22AM: Sudden Cardiac
Death in Dilated Cardiomyopathies. PACE 2009: 32: pp S32-S40. PA

80. Zangwill, S, Hamilton R: Restrictive Cardiomyopathy. PACE 2009: 32: pp S41-S43. PA
81. Sequeira IB, Kirsh JA, Hamilton RM, Russell JL, Gross GJ.
Am J Cardiol. 2009 Aug
1;104(3):411-3. Epub 2009 Jun 6: Utility of exercise testing in children and teenagers with arrhythmogenic right ventricular cardiomyopathy. American Journal of Cardiology 2009:
104: pp 411-3. C
82. Al Dhahri KN, Potts JE, Chiu CC, Hamilton RM, Sanatani S: Are implantable loop recorders useful in detecting arrhythmias in children with unexplained syncope? Pacing Clin
Electrophysiol 2009: 32: pp 1422-7. C
83. Warren AE, Hamilton R, Belanger SA, Gray C, Gow RM, Sanatani S, Cote J-M, J
Lougheed J, LeBlanc J, Martin S, Miles B, Mitchell C, Gorman D, Weiss M, Schachar
R: Cardiac risk assessment before the use of stimulant medications in children and youth: A joint position statement by the Canadian Paediatric Society, the Canadian Cardiovascular
Society, and the Canadian Academy of Child and Adolescent Psychiatry. Canadian Journal of Cardiology 2009. CPA
84. Hamilton R; Gray C; Belanger S A; Warren A E; Gow R M; Sanatani S; C'f4t'e9 J-M;
Lougheed J; Leblanc J; Martin S; Miles B; Mitchell C; Gorman D A; Weiss M;
Schachar R: Cardiac risk assessment before the use of stimulant medications in children and youth: A joint position statement by the Canadian Paediatric Society, the Canadian
Cardiovascular Society and the Canadian Academy of Child and Adolescent Psychiatry.
Journal of the Canadian Academy of Child and Adolescent Psychiatry 2009: 18: pp 349-55.
SRI
85. Raymond W. Sy, Robert Hamilton, Andrew D. Krahn: Neonatal Heart Block and Long
QT Syndrome. Journal of cardiovascular electrophysiology, 2010. 21 (9): p. 1059-60 .
C
86. Saltzman AJ, Mancini-DiNardo D, Li C, Chung WK, Ho CY, Hurst S, Wynn J, Care
M, Hamilton RM, Seidman GW, Gorham J, McDonough B, Sparks E, Seidman JG,
Seidman CE, Rehm HL: Short communication: the cardiac myosin binding protein C
Arg502Trp mutation: a common cause of hypertrophic cardiomyopathy. Circulation
Research 2010: 106: pp 1549-52. C
87. Lampert R, Hayes DL, Annas GJ, Farley MA, Goldstein NE, Hamilton RM, Kay GN,
Kramer DB, Mueller PS, Padeletti L, Pozuelo L, Schoenfeld MH, Vardas PE, Wiegand
DL, Zellner R: HRS Expert Consensus Statement on the Management of Cardiovascular
Implantable Electronic Devices (CIEDs) in patients nearing end of life or requesting withdrawal of therapy. Heart Rhythm 2010: 7: pp 1008-26. C
88. Wang S, Zhu W, Hamilton RM, Kirsh JA, Stephenson EA, Gross GJ: Diagnosis-specific characteristics of ventricular tachycardia in children with structurally normal hearts.
Heart Rhythm. 2010 Dec;7(12):1725-31. C
89. Yoo SJ, Grosse-Wortmann L, Hamilton RM: Magnetic resonance imaging assessment

of arrhythmogenic right ventricular cardiomyopathy/dysplasia in children. Korean Circ
J. 2010 Aug;40(8):357-67. CPA
90. Bélanger S, Warren A, Hamilton R, Gray C, Gow R, Sanatani S, Côté JM, Frcpc JL,
Leblanc J, Martin S, Miles B, Mitchell C, Gorman D, Weiss M, Schachar R: Cardiac risk assessment before the use of stimulant medications in children and youth. Paediatr
Child Health. 2009 Nov;14(9):579-592. CPA
91. Krishnamurthy S, Adhisivam B, Hamilton RM, Baskin B, Biswal N, Kumar M:
Arrhythmogenic Dilated Cardiomyopathy Due to a Novel Mutation in the Desmoplakin
Gene.
Indian journal of pediatrics, 2011. 78 (7): p. 866-9. C
92. Jaeggi, E., et al., The importance of the level of maternal anti-Ro/SSA antibodies as a prognostic marker of the development of cardiac neonatal lupus erythematosus a prospective study of 186 antibody-exposed fetuses and infants.
Journal of the American
College of Cardiology, 2010. 55 (24): p. 2778-84. CPA
93. Ackerman, M.J., et al., HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm
Association (EHRA).
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2011. 13 (8): p.
1077-109. C
94. Ackerman, M.J., et al., HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm
Association (EHRA).
Heart rhythm : the official journal of the Heart Rhythm Society, 2011.
8 (8): p. 1308-39. C
95. Gollob, M.H., et al.
, Recommendations for the use of genetic testing in the clinical evaluation of inherited cardiac arrhythmias associated with sudden cardiac death:
Canadian Cardiovascular Society/Canadian Heart Rhythm Society joint position paper.
The
Canadian journal of cardiology, 2011. 27 (2): p. 232-45. C
96. Graham, J., et al., European guidelines on managing adverse effects of medication for
ADHD.
European child & adolescent psychiatry, 2011. 20 (1): p. 17-37. C
97. Hamilton, R.M., Tinker, tailor: foretelling the future in long QT syndrome.
Heart rhythm : the official journal of the Heart Rhythm Society, 2011. 8 (10): p. 1544-5. PA
98. Hamilton, R.M., Risk vs benefit for catheter ablation in the small child: when does the
Bough break?
The Canadian journal of cardiology, 2011. 27 (4): p. 523 e1-2. PA
99. Hamilton, R.M., et al., Cardiovascular considerations of attention deficit hyperactivity

disorder medications: a report of the European Network on Hyperactivity Disorders work group, European Attention Deficit Hyperactivity Disorder Guidelines Group on attention deficit hyperactivity disorder drug safety meeting - CORRIGENDUM.
Cardiology in the young, 2011: p. 1. PA
100. Kwong, W., et al., The effect of NavX on fluoroscopy times in pediatric catheter ablation.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2011. C
101. Lin, A.E., et al., Clinical, pathological, and molecular analyses of cardiovascular abnormalities in Costello syndrome: a Ras/MAPK pathway syndrome.
American journal of medical genetics. Part A, 2011. 155A (3): p. 486-507. C
102. Semsarian, C. and R.M. Hamilton, Key role of the molecular autopsy in sudden unexpected death.
Heart rhythm : the official journal of the Heart Rhythm Society, 2011.
SRI
103. Kwong, W., A. L. Neilson, et al. (2012). "The effect of NavX on fluoroscopy times in pediatric catheter ablation." Journal of interventional cardiac electrophysiology : an
C international journal of arrhythmias and pacing 33 (1): 123-126.
104 Hamilton, R. M., E. Rosenthal, et al. (2012). "Cardiovascular considerations of attention deficit hyperactivity disorder medications: a report of the European Network on
Hyperactivity Disorders work group, European Attention Deficit Hyperactivity Disorder
Guidelines Group on attention deficit hyperactivity disorder drug safety meeting."
Cardiology in the young 22 (1): 63-70. PA
105 Hamilton RM. One man's junk is another man's treasure: GWAS, ENCODE, and the search for control of the heart. Heart Rhythm. 2013 Mar;10(3):409-11.
106 Al-Ghamdi S, Al-Fayyadh MI, Hamilton RM. Potential New Indication for Ivabradine:
Treatment of a Patient with Congenital Junctional Ectopic Tachycardia. J Cardiovasc
Electrophysiol. 2012 Dec 24. doi: 10.1111/jce.12081. [Epub ahead of print]
107 Villafañe J, Atallah J, Gollob MH, Maury P, Wolpert C, Gebauer R, Watanabe H, Horie M,
Anttonen O, Kannankeril P, Faulknier B, Bleiz J, Makiyama T, Shimizu W, Hamilton RM,
Young ML. Long-term follow-up of a pediatric cohort with short QT syndrome. J Am Coll
Cardiol. 2013 Mar 19;61(11):1183-91
108 Walsh EP, Bar-Cohen Y, Batra AS, Dick M 2nd, Erickson C, Fish F, Hamilton RM, Kanter
RJ, Reed JH, Van Hare GF, Vetter VL, Webster G, Walsh EP, Bar-Cohen Y, Hamilton RM,
Reed JH, Van Hare GF. Recommendations for advanced fellowship training in clinical pediatric and congenital electrophysiology: a report from the training and credentialing committee of the pediatric and congenital electrophysiology society. Heart Rhythm. 2013
May;10(5):775-81
109 Laksman ZW, Hamilton RM, Chockalingam P, Ballantyne E, Stephenson EA, Gross GJ,
Gula LJ, Klein GJ, Wilde AA, Krahn AD. Mutation Location Effect on Severity of Phenotype
During Exercise Testing in Type 1 Long-QT Syndrome: Impact of Transmembrane and C-

Loop Location. J Cardiovasc Electrophysiol. 2013 Apr 29. doi: 10.1111/jce.12172. [Epub ahead of print]
110 Hamilton, R. M. Letter by Hamilton Regarding Article, "Prophylactic Radiofrequency
Ablation in Asymptomatic Patients With Wolff-Parkinson-White Is Not Yet a Good Strategy:
A Decision Analysis".[Letter] Circulation: Arrhythmia and Electrophysiology. 6(3):e38, June
2013.
111 Baskin B, Skinner J, Sanatani S, Terespolsky D, Krahn AD, Ray PN, Scherer SW, Hamilton
RM: TMEM43 mutations associated with arrhythmogenic right ventricular cardiomyopathy in non-newfoundland populations. Human Genetics June, 2013 (accepted)
112 Strandberg LS, Cui X, Rath A, Liu J, Silverman ED, Liu X, Siragam V, Ackerley C,
Su B, Yan J, Capecchi M, Biavati L, Accorroni A, Yuen W, Quattrone F, Lung K,
Jaeggi ET, Backx PH, Deber CM, Hamilton RM. Congenital heart block maternal sera autoantibodies target an extracellular epitope on the α1G T-type calcium channel in human fetal hearts. Submitted to PLOS One
Published (recognized as author, contributor or peer-reviewer, but not in Pubmed)
1.
Silka MJ, Kron J, Dunnigan A, Dick M for the Pediatric Electrophysiology Society
(Hamilton RM): Sudden cardiac death and the use of implantable cardiovertor-defibrillators in pediatric patients. Circulation 1993: 87: pp 800-807. C
2.
Kugler JD, Danford DA, Deal B et al (Hamilton RM): Radiofrequency catheter ablation for tachyarrhythmias in children and adolescents. New England Journal of Medicine 1994:
330 (21): pp 1481-1487. C
3.
Kugler JD, Danford DA, Houston K, Felix G. and the other particiating members
(Hamilton RM) of the Pediatric EP Society: Pediatric radiofrequency catheter ablation
(RFCA) Registry: Update of immediate results. American Journal of Cardiology 1997: 80: pp 1438-43. C
4.
Kugler JD, Danford DA, Houston KA, Felix G. and the other particiating members
(Hamilton RM) of the Pediatric EP Society: Pediatric radiofrequency catheter ablation
(RFCA) Registry: Update of immediate results. Journal of Cardiovascular Electrophysiology
2002: 13: pp 336-41. C
5.
Highlights of Heart Rhythm 2006, the Annual Scientific Sessions of the Heart Rhythm
Society: May 17 to 20, 2006, in Boston, Massachusetts Heart Rhythm (September 2006), 3
(9), pg. 1116-1125 Rhythm Society Scientific Program Committee Heart; B.D. Lindsay;
N.A.M. Estes; R. Cappato; M.D. Carlson; P.S. Chen; C. Chiu-Man; A.B. Curtis; J.D. Day;
A.E. Epstein; A.M. Ferrick; P.A. Friedman; M.H. Hamdan; R.M. Hamilton; S.H. Hohnloser;
R.J. Kanter; A. Natale; D.W. Reynolds; J.E. Saffitz; L.A. Saxon; W.K. Shen; W.G.
Stevenson; G.F. Tomaselli
6.
Estes NA rd, Page R, Boyden P, Cappato R, Chiu-Man C, Day J, Dimarco J, Ferrick A,
Hamdan M, Hamilton R, Hohnloser S, Jung W, Kanter R, Knight B, Lindsay B, Natale

A, Reynolds D, Rosenbaum D, Saxon L, Shen WK, Trayanova N, Wilkoff B: Highlights of Heart Rhythm 2007, The Annual Scientific Sessions of the Heart Rhythm Society: May 9-
12, 2007, Denver, CO. Heart Rhythm 2007: 4 (10): pp e1-e9. SRI
7.
Saul JP, Epstein AE, Silka MJ, Berul CI, Dick M, DiMarco JP, Friedman RA,
Rosenthal E, Stephenson EA, Hamilton RM - Peer Reviewer: HRS clinical competency statement on pathways for implantation of ICDs/CRDs in pediatric and congenital heart patients (peer reviewer). Heart Rhythm Journal 2008: 5: pp 926-33. C
8.
Carole A. Warnes, MD, FRCP, FACC, Co-Chair , Roberta G. Williams, MD, MACC,
FAHA, Co-Chair , Thomas M. Bashore, MD, FACC Sharon A. Hunt, MD, FACC,
FAHA , John S. Child, MD, FACC Mary Etta King, MD, FACC, FASE , Heidi M.
Connolly, MD, FACC Michael J. Landzberg, MD, FACC , Joseph A. Dearani, MD,
FACC Pamela D. Miner, RN, MN, NP , Pedro del Nido, MD, FACC Martha J. Radford,
MD, FACC , James W. Fasules, MD, FACC Edward P. Walsh, MD, FACC , Thomas P.
Graham, MD, FACC Gary D. Webb, Robert Hamilton, MD, FRCPC: ACC/AHA
Guidelines for the Management of Adults with Congenital Heart disease (peer reviewer).
Circulation 2008. C
Submitted
1.
Berivan Baskin
1,2
, Jon Skinner
3
, Shubhayan Sanatani
4
, Debbie Terespolsky
5
, Andrew Krahn
6
,
Peter N. Ray
1,7,11
, Stephen Scherer
7,11
and Robert M. Hamilton
,8,9,10,11
TMEM43 gene mutations associated with arrhythmogenic right ventricular cardiomyopathy in non-
Newfoundland populations submitted for publication in the: Journal of Medical Genetic
1.
2.
Kristopher T. Kang*, Susan P. Etheridge
†
, Michal J. Kantoch
‡
, Svjetlana Tisma-
Dupanovic
§ , David J. Bradleyǁ, Seshadri Balaji ¶
, Robert J. Hamilton#, Anoop K. Singh**,
Bryan C. Cannon
††
, Michael S. Schaffer
‡‡
, James E. Potts*, Shubhayan Sanatani* Current
Management of Ectopic Atrial Tachycardia in Children: A Multi-Center Experience .
Submitted to JACC
3. Linn S. Strandberg, Xuezhi Cui, Arianna Rath, Xiaoru Liu, Earl D. Silverman,
Vinayakumar Siragam, Cameron Ackerley, Brenda Bin Su, Jane Yuqing Yan , Marco
Capecchi, Luca Biavati, Alice Accorroni, William Yuen, Filippo Quattrone, Kalvin Lung,
Edgar T. Jaeggi, Charles M. Deber, Robert M. Hamilton. α
1G
T-type calcium channel is expressed 1 in human fetal hearts and has an extracellular epitope bound by autoantibodies from congenital heart block maternal sera. submitted to PLOS One
Non Peer Reviewed Publications
Hamilton, RM: Non-pharmacologic Therapy of Repolarization Syndromes. The Journal of
Turkish Arrhythmia, Pacing and Electrophysiology. PA
2. Robert Hamilton, Chair: FINAL REPORT: Expert Advisory Panel on Trasylol. Health
Canada Report (2010). SRI
3. Robert Hamilton: FINAL REPORT: Expert Advisory Panel on Caffeinated Beverages.

Health Canada Report (2011). C
Books/Chapters in Books/Proceedings
Published
1. Gow R, Hamilton R: Current approaches to the diagnosis and therapy of fetal tachycardia, and other fetal rhythm abnormalities. In: Current Opinion in Pediatrics (3) 1991: pp 838-
843. CPA
2. Hamilton RM, Gow RM: Disorders of Heart Rate and Rhythm. In: Neonatal Heart Disease
(Freedom RM, Benson LN, Smallhorn JF, eds). Springer-Verlag Ltd, London 1992: pp 777-
805. PA
3. Hamilton RM: Electrocardiographic Features of Atrial Flutter: Differences between
Congenital Heart Lesions. In: Electrocardiography '96: From the Cell to the Body Surface
World Scientific Publishing Co. Pte. Ltd, 1996. PA
4. Hamilton RM, Lee-Poy M, Silverman ED: The Langendorff Rabbit Model of Congenital
Heart Block: Enhancement using Neonatal Hearts. In: Proceedings of the Second World
Congress of Pediatric Cardiology Futura Publishing Co, Armonk, NY 1997: pp 714-717. PA
5. Hamilton RM: Arrhythmia and Mortality after the Mustard Procedure. In: 1998 Year Book of Cardiology 1998. PA
6. Hamilton RM: Molecular Cardiology of Heart Block. In: Molecular Genetics of Cardiac
Electrophysiology (Berul C, Towbin J, eds). Kluwer Academic Press, 2000. PA
7. Hamilton RM: Atrial Flutter. In: Emedecine Textbook of Pediatrics (Charles Berul, Mary
L. Windle, Alvin J. Chin, Gilbert Herzberg, Steven Neish, eds). eMedicine Journal, 2001.
PA
8. Hamilton RM: Congenital Third Degree Atrioventricular Block. In: Emedecine Textbook of Pediatrics (Charles Berul, Mary L. Windle, Alvin J. Chin, Gilbert Herzberg, Steven Neish, eds). eMedicine Journal, 2001. PA
9. Hamilton RM: Junctional Ectopic Tachycardia. In: Emedecine Textbook of Pediatrics
(Charles Berul, Mary L. Windle, Hugh D. Allen, Gilbert Herzberg, Stuart Berger, eds). eMedicine Journal, 2001. PA
10. Hamilton RM: Second Degree Atrioventricular Block. In: Emedecine Textbook of
Pediatrics (Charles Berul, Mary L. Windle, Alvin J. Chin, Gilbert Herzberg, Steven Neish, eds). 2001. PA
11. Hamilton RM, Dilenburg R: Atrioventricular Node Re-entry. In: Emedecine Textbook of
Pediatrics (Charles Berul, Mary L. Windle, Hugh D. Allen, Gilbert Herzberg, Stuart Berger, eds). eMedicine Journal, 2001. SRI

12. Hamilton RM, Sanatani S: Atrial Ectopic Tachycardia. In: Emedecine Textbook of
Pediatrics (Charles Berul, Mary L. Windle, Alvin J. Chin, Gilbert Herzberg, Steven Neish, eds). eMedicine Journal, 2001. SRI
13. Hamilton RM, Sanatani S: Wolff-Parkinson-White syndrome. In: Emedecine Textbook of
Pediatrics (Charles Berul, Mary L. Windle, Hugh D. Allen, Gilbert Herzberg, Stuart Berger, eds). 2001. PA
14. Fraser Golding, Robert Hamilton: Pediatric Cardiology. In: Atlas of Pediatrics (Ron
Laxer, ed). 2002. PA
15. Hamilton RM: Syncope. In: Emedecine Textbook of Pediatrics 2002. PA
16. Hamilton RM, Kirsh JA, Gross GJ: Supraventricular & Atrial Tachycardias. In: The
Natural and Modified History of Congenital Heart Disease (Freedom RM, ed). 2002. PA
17. Hamilton RM, Silverman AD, Kirsh JA, Gross GJ: Congenital Heart Block. In: The
Natural and Modified History of Congenital Heart Disease (Freedom RM, ed). 2002. PA
18. Kirsh JA, Dillenburg R, Hamilton RM: The Long QT Syndrome. In: The Natural and
Modified History of Congenital Heart Disease (Freedom RM, ed). 2002. PA
19. Earl D. Silverman,: Neonatal Lupus Erythematosus . In: textbook of Pediatric
Rheumatology Cassidy and Petty, 2004. C
20. Fraser Golding and Robert Hamilton: Pediatric cardiology. In: Atlas of Pediatrics
(Jeremy Friedman, Ronald M. Laxer, J. Ted Gerstle, Elizabeth L. Ford-Jones, eds). Current
Medicine, Philadelphia 2004. CPA
21. Hamilton RM: The Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy
(ARVC) in Children. In: Congenital Diseases in the Right Heart (Andrew Redington,
Robert Henry Anderson, Glen S. Van Arsdell, eds). Springer-Verlag, London 2009: pp 131-
8. PA
22. Hamilton, Robert M: Chapter 12
ECG Curiosities: The fetal ECG. In: Atlas of Advanced Electrogram Interpretation (Adrian
Baranchuk, ed). Remedica, London, U.K. 2010: pp 9-11. PA
General Publications and Reports
PA-denotes Principal Author; SRI-Senior Responsible Investigator; CPA-Co-Principal
Author; C-Collaborator
Invited Reviews

Published
1. Hamilton RM:
86. PA
Chest Pain in Children. Canadian Journal of Diagnosis 1991: 8 (10): pp 61-
2. Hamilton RM, Gow RM: Diagnosis and therapy of fetal tachycardia and other rhythm abnormalities. Current Opinion in Pediatrics 1992: 3: pp 838-842. PA
3. Hamilton RM, Gow RM:
PA
Arrhythmias in Children. Canadian Journal of Diagnosis 1992.
4. Hamilton RM: For the Life of a Child: Learning about Cardiac Emergencies in Pediatric
Patients. Perspectives in Cardiology 1994. PA
5. Hamilton RM: Emergency Management of cardiac problems in children. Perspectives in
Cardiology 1994. PA
6. Hamilton RM: Developmental Mechanisms of Heart Disease (Textbook Review). Critical
Care Medicine. PA
Abstracts
1. Hamilton, R. M: Relationships between Levels of Essential Fatty Acids and Zinc in Plasma of Cystic Fibrosis Patients. Canadian Pediatric Society Conference, Ottawa. 1981. PA
2. Finley, J. P.; Hamilton, R. M: Heart Rate Response to Tilting in Newborns in Quiet and
Active Sleep. Canadian Cardiovascular Society Conference, 1982. CPA
3. Hamilton, R. M: Uric Acid Metabolism in Children Who Undergo Cardiopulmonary
Bypass. Canadian Cardiovascular Society Conference, 1982. PA
4. Hamilton, R. M: Echocardiographic Biventricular Regional Wall Motion in Neonates with
Persistent Pulmonary Hypertension. Canadian Cardiovascular Society Conference, 1987.
PA
5. Hamilton, R. M: Pulmonary Artery Baloon Angioplasty: Clinical Followup. American
Heart Association, 1988. PA
6. Robert Hamilton: Clinical Implications of Epicardial Atrial Cryoablation: Action Potential and Histologic Effects. American Heart Association, 1989. PA
7. Paret, G., Taylor, R., Hamilton, R. M.,: Drug Therapy for Postoperative Junctional Ectopic
Tachycardia. Society for Pediatric Research, 1990. CPA
8. M. Hosking and R. Hamilton: Oral Sotalol in Children. North American Society of Pacing and Electrophysiology, 1990. SRI
9. Newman, D.;Hardy, J.;Thorne, S.; Downar, E.;Harris, L.; Hamilton, R: Single Centre

Experience with a Combination Antitachycardia Pacemaker and Defibrillator. American
College of Cardiology 40th Annual Scientific Session, 1991. C
10. Hamilton, R: Steroid-eluting Epicardial Leads in Pediatrics: Improved Epicardial
Thresholds in the First Year. IXth World Symposium on Cardiac Pacing and
Electrophysiology, 1991. PA
11. Pediatric Electrophysiology Society Radiofrequency Catheter Ablation Registry
(Hamilton RM): Pediatric Electrophysiology Society Radiofrequency Catheter Ablation
Registry, Radiofrequency catheter ablation in children and adolescents: early results in 189 patients from 13 centers. North American Society of Pacing and Electrophysiology, PACE
1992: 15 (4 Pt2): pp 589. C
12. Le Gras, M.; Hamilton, R: Atrial antitachycardia pacing in a pediatric population.
Canadian Cardiovascular Society, 1992. SRI
13. Bauersfeld, U.; Gow, R.; Hamilton, R: Treatment of Atrial Ectopic Tachycardia in Infants
Under 6 Months of Age. Canadian Cardiovascular Society, 1992. SRI
14. Figa F., Gow R., Hamilton R: The use of IV amiodarone for life threatening arrhythmias in children. World Congress of Pediatric Cardiology, Paris. 1993. CPA
15. Gelatt, M.; Hamilton, R. M: Arrhythmias following Fontan Connection. American College of Cardiology, Atlanta. 1994. SRI
16. Bauersfeld, U.; Hamilton, R: The incidence of arrhythmias following TAPVD repair.
(submitted). American College of Cardiology, 1994. SRI
17. Robert M. Hamilton: A New Epicardial Steroid Lead, Improved Performance in
Children.(submitted). American Heart Association, 1994. PA
18. Fogelman, R.; Komar, L.; Davis, A.; Hamilton, R. M: Assessment of the Terminal 40millisecond QRS Vector in Children with a History of Tricyclic Antidepressant Ingestion.
1994. SRI
19. A. M. Davis, R. M. Gow, B. W. McCrindle, R. M. Hamilton: Can the Signal Averaged
ECG Predict Cardiac Rejection in Children. (submitted). Canadian Cardiovascular Society,
1994. SRI
20. Robert M. Hamilton: Can the Signal Averaged ECG predict Cardiac Rejection in Children?
American Heart Association, 1994. PA
21. J. Press, Y. Uziel, R. Laxer, R. Hamilton: Long-term Outcome of Children with Complete
Congenital Heart Block (CHB). 1994. C
22. H. Dele Davies, Susan M.King, John Doyle, Ann Matlow, Gideon Koren, Robert
Hamilton: Randomized, Blinded Controlled Pilot Study of Rapid Amphoterecin B Infusions in Children. Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando,
Florida. 1994. C

23. Joshi P. Verjee Z. McGuigan M. Hamilton R: Toxicokinetics and Electrocardiographic
Changes in Propafenone Overdose in an Infant. Congress of the World Federation of
Clinical Toxicology centers and Poison Control Centers, Taipei. 1994. C
24. Figa F, Bigras J-L, Hamilton RM: Risk Factors for Venous Obstruction associated with
Transvenous Pacing in Children. American College of Cardiology, 1995. C
25. Gelatt MC, Hamilton RM: Factors Associated With Arrhythmias After Mustard Operation-
-30 YearExperience With 534 Patients. American College of Cardiology, 1995. SRI
26. R. Hamilton: A Comparison of Fixed Screw Leads in Children: Effect of Steroid Elusion and Microporous Platinized Electrode. (submitted). North American Society of Pacing and
Electrophysiology, 1995. PA
27. Hamilton RM: A New Epicardial Steroid Lead: Improved Performance in Children.
Canadian Cardiovascular Society, 1995. SRI
28. R. Fogelman, R. Hamilton: Heart Block after Surgical enlargement of Ventricular Septal
Defect: Effect of Underlying Anatomy and Direction of Enlargement. (submitted). North
American Society of Pacing and Electrophysiology, 1995. SRI
29. Hamilton RM: Radiofrequency Catheter Ablation in Children: High Success with
Experience. Canadian Cardiovascular Society, 1995. PA
30. Robert M. Hamilton: A New Epicardial Steroid Lead: Improved Performance in Children.
Canadian Cardiovascular Society, Toronto. 1995. SRI
31. Bauersfeld UK, Chiu C, Hamilton RM: Arrhythmias 5 to 15 Years after Repair of
Tetralogy of Fallot. Canadian Cardiovascular Society, 1995. C
32. Hamilton RM: Five Year Experience with Implantable Defibrillators in Children. Canadian
Cardiovascular Society, 1995. PA
33. Hamilton RM: Five Year Experience with Implantable Defibrillators in Children. Canadian
Cardiovascular Society, Toronto. 1995. PA
34. Hamilton RM: Heart Block after Surgical Enlargement of Ventricular Septal Defect: Effect of Underlying Anatomy and Direction of Enlargement. Canadian Cardiovascular Society,
1995. SRI
35. Rami Fogelman, Robert Hamilton: Heart block after surgical enlargement of ventricular septal defect: Effect of underlying anatomy and direction of enlargement. Canadian
Cardiovascular Society, 1995. SRI
36. Casey FA, McCrindle BW, Hamilton RM: Neonatal Atrial Flutter: Significant Early
Morbidity, Benign Long-Term Prognosis. American Heart Association, 1995. C
37. Robert M. Hamilton: Electrocardiographic Differences in Atrial Flutter Differences

between Congenital Heart Lesions. 23rd International Congress on Electrocardiography and
37th International Symposium on Vectorcardiography, Cleveland. 1996. PA
38. R. M. Hamilton: Atrial Flutter in Congenital Heart Disease: Differences between Lesions.
Canadian Cardiovascular Society Annual Meeting, 1996. PA
39. S. Lawrence, T. Dorner, L. Luy, F. Hiepe, R. Hamilton: Maternal Serology in the
Prediction of Complete Heart Block (CHB) in Neonatal Lupus Erythematosus (NLE).
American College of Rheumatology, 1996. C
40. R. M. Hamilton: Flutter in Congenital Heart Disease: Differences between Lesions.
American Heart Association Annual Meeting, 1996. PA
41. Michael Connelly, Louise Harris, Samuel Siu, Geoff Puley, David Harrison, Robert
Hamilton,: Adult Patients Following the Mustard Procedure: Atrial Arrhythmias and
Clinical Outcomes. (submitted). NASPE, 1996. C
42. Christine Chiu, Robert Gow, Brian McCrindle, Alice Newman, Robert Hamilton: Atrial sensing: Role of the programmed safety factor in children. North American Society of
Pacing and Electrophysiology 17thAnnual Scientific Sessions, 1996. SRI
43. A. Menon, K-Y. Chan, E. D.Silverman, R.M. Gow, R. M. Hamilton: Chronotropic
Competence of the Sinus Node in Patients with Congenital Atrioventricular Block.
American Pediatric Society, Society for Pediatric Research, 1997. SRI
44. M. Lee-Poy, R. M. Hamilton: Reproduction of the Features of Congenital Heart Block in
Isolated Rabbit Hearts exposed to Human Maternal Serum. World Congress of Pediatric
Cardiology, Hawaii. 1997. SRI
45. M. Lee-Poy, R. M. Hamilton: Reproduction of the Features of Congenital Heart Block
Secondary to Neonatal Lupus Erythematosusin the Isolated Rabbit Heart (submitted).
American Pediatric Society, Society for Pediatric Research, 1997. SRI
46. A. Yetman, R. Hamilton: Factors Associated with Outcome in Children with Hypertrophic
Cardiomyopathy. Canadian Cardiovascular Society, 1997. SRI
47. . I. Dipchand, B. W. McCrindle, R. M. Gow, R. M. Freedom, R. M. Hamilton: The
Surface ECG does not Accurately Differentiate Children with Hypertrophic Cardiomyopathy from Normals. Abstract to the Canadian Cardiovascular Society, 1997. SRI
48. A. Yetman, R. Hamilton: Factors Associated with Outcome in Children with Hypertrophic
Cardiomyopathy. American Heart Association, 1997. SRI
49. A. I. Dipchand, B. W. McCrindle, R. M. Gow, R. M. Freedom, R. M. Hamilton: The
Surface ECG does not Accurately Differentiate Children with Hypertrophic Cardiomyopathy from Normals. (submitted). American Heart Association, 1997. SRI
50. A. Menon, E. D.Silverman, R. M. Hamilton: Chronotropic Competence of the Sinus Node in Patients with Congenital Atrioventricular Block. North American Society of Pacing and

Electrophysiology, 1997. SRI
51. Chiu C.C, , Griffiths J, Gow R , Hamilton RM: Experience with a New Bipolar Iridium
Oxide Fixed Screw Lead in Children: Lower Thresholds and Smaller Diameters. North
American Society of Pacing and Electrophysiology, 1997. PA
52. M. Lee-Poy, R. M. Hamilton: Reproduction of the Features of Congenital Heart Block in
Isolated Rabbit Hearts exposed to Human Maternal Serum. North American Society of
Pacing and Electrophysiology, 1997. SRI
53. Hamilton RM: Six Year Follow-up of a Steroid-eluting Epicardial Lead Designed for
Pediatric Pacing. Association of European Pediatric Cardiology, Ireland. 1998. PA
54. Chiu C, Gow R, McCrindle B, Hamilton R: Manual pacing conversion of atrial flutter through the permanent pacemaker system in children (submitted). NASPE, 1998. CPA
55. Davis A, McCrindle B, Hamilton R: The signal-averaged electrocardiogram as a marker of cardiac allograft rejection in children (submitted). NASPE, 1998. SRI
56. R. M. Hamilton: Investigative methods in congenital complete heart block. Annual Fetal
Program, HSC, 1999. PA
57. Christine Chiu, BSC, Robert M. Hamilton, MD: Evolution of the QT interval in children with congenital complete heart block. North American Society of Pacing and
Electrophysiology, Toronto. 1999. PA
58. Christine Chiu, BSC, Robert M. Hamilton, MD: Evolution of the QT interval in children with congenital complete heart block. Society for Pediatric Research, San Fransisco. 1999.
PA
59. Michael F. Lee-Poy, BSc, Shufang Zhao, PhD, Earl D.Silverman, MD, Claudia Borgess,
MD, Bonnie Isacovics, BSc, Robert M. Hamilton, MD: Fetal and neonatal manifestations in a murine model of congenital heart block, including fetal echo assessment. North
American Society of Pacing and Electrophysiology, Toronto. 1999. SRI
60. Michael F. Lee-Poy, BSc, Shufang Zhao, PhD, Earl D.Silverman, MD, Claudia Borgess,
MD, Bonnie Isacovics, BSc, Robert M. Hamilton, MD: Fetal and neonatal manifestations in a murine model of congenital heart block, including fetal echo assessment. Society for
Pediatric Research, San Fransisco. 1999. SRI
61. Michael F. Lee-Poy, BSc, Shufang Zhao, PhD, Earl D.Silverman, MD, Claudia Borgess,
MD, Bonnie Isacovics, BSc, Robert M. Hamilton: Fetal and Neonatal Manifestations in a
Murine Model of Congenital Heart Block, Including Fetal Echocardiographic Assessment.
Society for Pediatric Research, 1999. SRI
62. Yetman AT, Lee K-J, Morrow RW, Gow RM, Hamilton RM, McCrindle BW: Factors associated with Exercise Capacity after Repair of Tetralogy of Fallot in the Current Era.
Canadian Cardiovascular Society, 1999. C

63. . E. Neild, J Smallhorn, G. Taylor, B Mullen, E. Silverman, N. Silverman, J. Finley, Y.
Law, D. Human, G. Seward, R. Hamilton, L. K. Hornberger: Primary Endocardial
Fibroelastosis (EFE) Associated with Maternal Anti-Ro and Anti-La Antibodies. Canadian
Cardiovascular Society, 1999. C
64. Yetman AT, Lee K-J, Morrow RW, Gow RM, Hamilton RM, McCrindle BW: Factors associated with Exercise Capacity after Repair of Tetralogy of Fallot in the Current Era.
American Heart Association, 1999. C
65. Neild LE , Smallhorn J, Taylor G, Mullen B, Silverman VE, Silverman N, Finley J,
Law Y, Human D, Seward G, Hamilton R, Hornberger LK: Primary Endocardial
Fibroelastosis Associated with Maternal Anti-Ro and Anti-La Antibodies. American Heart
Association, 1999. C
66. Sunita Vohra, Robert Hamilton, Sara Werb, Michael McGuigan: Pediatric Tricyclic
Antidepressant Overdose: Is There a Relationship betweeen ECG Changes and Seizure?
Canadian Pediatric Society, 2000. CPA
67. Sunita Vohra, Robert Hamilton, Sara Werb, Michael McGuigan: Pediatric Tricyclic
Antidepressant Overdose: Is There a Relationship betweeen ECG Changes and Seizure?
European Association of Poison Control Centres and Toxicology, 2000. CPA
68. Sunita Vohra, Robert Hamilton, Sara Werb, Michael McGuigan: Pediatric Tricyclic
Antidepressant Overdose: Is There a Relationship betweeen ECG Changes and Seizure?
Society for Pediatric Research, 2000. CPA
69. E Jaeggi, RM Hamilton, ED Silverman, LK Hornberger: Outcome of Children with
Fetal, Neonatal or Childhood Diagnosis of Isolated Complete Heart Block. A Single
Institutions Experience of 30 Years. American College of Cardiology, Journal of the
American College of Cardiology 35(2 suppl. A):518, March, 2000. CPA
71. Warren A, MacDonald C, Yoo S-J, Hamilton RM: Diagnostic Criteria for
Arrhythmogenic Right Ventricular Dysplasia in Children: Separating the Fat from the Lean.
North American Society of Pacing and Electrophysiology, 2000. SRI
72. Warren A, MacDonald C, Yoo S-J, Hamilton RM: Diagnostic Criteria for
Arrhythmogenic Right Ventricular Dysplasia in Children: Separating the Fat from the Lean.
Association of European Pediatric Cardiology, 2000. SRI
73. Dillenburg R, Hamilton RM: Is Exercise Testing a Useful Modality in the Identification of the Congenital Long QT Syndromes? North American Society of Pacing and
Electrophysiology, 2000. SRI
74. Hamilton RM, Russell J, Freedom R, Coates: Comparison of Cardiopulmonary Exercise
Performance Late following Fontan Correction by Differing Techniques. Canadian
Cardiovascular Society, Vancouver. 2000. PA
75. Dillenburg RF, Hamilton RM: QTc and JTc prolongation after radiofrequency ablation
(RFA) in children. North American Society of Pacing and Electrophysiology, Boston.

2001. SRI
76. Angela Lim, Paul Grossfeld, Robert M. Hamilton, Leslie Smoot, K Gripps V. Proud, R
Weksberg, P Wheeler, J. Picker, M. Irons, E. Zackai, C Scott Jr., L Nicholson: Further delineation of cardiac anomalies in Costello syndrome. David Smith Workshop, Lake
Arrowhead, CA. 2001. C
77. Angela Lim, Paul Grossfeld, Robert M. Hamilton, Leslie Smoot, K Gripps V. Proud, R
Weksberg, P Wheeler, J. Picker, M. Irons, E. Zackai, C Scott Jr., L Nicholson: Further delineation of cardiac anomalies in Costello syndrome. American Society of Human
Genetics, 2001. C
78. Buffo-Sequiera I, Hamilton RM, Kirsh JA, Russell JL, Gross GJ: Suppression of ventricular ectopy with exercise may be falsely reassuring in patients with arrhythmogenic right ventricular dysplasia (ARVD). Canadian Cardiovascular Congress, Toronto. Canadian
Journal of Cardiology 2003: 19A: pp 176A. CPA
79. Wald RM, Veldtman GR, Hamilton RM, McCrindle B, Kirsh JA, Benson LN: The
Pediatirc Expression of Isolated Ventricular Noncompaction: Clinical Characteristics,
Prognosis and Outcome. Canadian Cardiovascular Congress, Toronto. Canadian Journal of
Cardiology 2003: 19A: pp 156A. C
80. Buffo-Sequiera I, Gross GJ, Davis AM, Kirsh JA, Hamilton RM: Utility of ECG precordial S-wave duration in diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) in pediatric patients. Canadian Cardiovascular
Congress, Toronto. Canadian Journal of Cardiology 2003: 19A: pp 155A. SRI
81. Eli Zalzstein1, Gil Gross2, Nili Zucker1, Aviva Levitas1, Robert Hamilton2: Surgical
Closure of Secundum ASD during Infancy: Clinical Considerations, Dilemma, and
Outcome . Association of European Pediatric Cardiology, Munich. 2004. SRI
82. J Schneiderman-Walker, SG Thomas, AL Coates, RM Hamilton, G Smith, J Li, AN
Redington: Suitability of the Innocor Device for the Measurement of Cardiac Output at Rest and During Dynamic Exercise . North American Society for Pediatric Exercise
Medicine, 2004. C
83. Robert Hamilton, MD, Christine Chiu, BSc: 10-years experience with Capsure Epi'e4 bipolar epicardial pacing lead in children. Cardiostim, Nice. 2004. SRI
84. Christine Chiu, BSc, Robert Hamilton, MD: Usability Assessment of Pacemaker
Programmers. NASPE, San Francisco. 2004. C
85. Robert M. Hamilton1, 2, 5, 7, Hiroshi Suzuki1, 2, Wendy Tsang7, Sulochana
Shanmugathasan7, Xuejun Wu1, Lisa K. Hornberger1, 5, 7, Martin Petric3, 6, 7, and
Earl D. Silverman1, 4, 5, 7: CMV Infection in Cultured Fetal Myocytes Induces
Cytoplasmic and Cell Surface Expression of Ro Autoantigen: A Potential Second Hit in the Development of Congenital Complete Heart Block . Workshop on Neonatal Lupus and the Ro-SSA/La-SSB System during the Fourth International Conference on Sex Hormones, Pregnancy and the Rheumatic Diseases, Stresa, Italy. Lupus 2004: 13: pp

758. PA
86. Robert M. Hamilton, Hiroshi Suzuki, Xuejun Wu and Gil J. Gross: Developmentally-
Specific Effects of Ion Channel Blockers on Atrioventricular Conduction in Rabbit .
Workshop on Neonatal Lupus and the Ro-SSA/La-SSB System during the Fourth
International Conference on Sex Hormones, Pregnancy and the Rheumatic Diseases, Stresa, Italy. Lupus 2004: 13: pp
758. PA
87. Hamilton RM 1,2,5, Suzuki H 1, 2, Wu X1, Borges C3, Zhao S 1, Isacovics B1,3 and
Silverman ED1,3,4,5: Effect of maternal sutoantibodies on fetal cardiac conduction: An experimental murine model. Workshop on Neonatal Lupus and the Ro-SSA/La-SSB System during the Fourth International Conference on Sex Hormones, Pregnancy and the Rheumatic Diseases, Stresa, Italy. Lupus 2004: 13: pp
758. PA
88. Robert M. Hamilton1,2,4, Hiroshi Suzuki1, 2, Xuejun Wu1, Shufang Zhao1, Bonnie
Isacovics1,3, Michael Lee-Poy1 and Earl D. Silverman1,3,4: Quantification of atrioventricular block caused by autoantibodies in a neonatal rabbit Langendorff model.
Workshop on Neonatal Lupus and the Ro-SSA/La-SSB System during the Fourth
International Conference on Sex Hormones, Pregnancy and the Rheumatic Diseases, Stresa, Italy. Lupus 2004: 13: pp
758. PA
89. R. M. Hamilton: Viability of trans-abdominal fetal electrocardiography (ECG) using the fetal electrocardiography monitoring (FEMO) system. Workshop on Neonatal Lupus and the
Ro-SSA/La-SSB System during the Fourth International Conference on Sex Hormones, Pregnancy and the Rheumatic Diseases, Stresa. Lupus 2004: 13: pp 759.
PA
90. Kirsh JA, Collins KK, Cannon BC, Dubin AM, Fenrich AL, Friedman RA, Gross GJ,
Kertesz NJ, Stephenson EA, Van Hare GF, Hamilton RM: Catheter cryoablation of pediatric AVNRT: Are there predictors of success, failure and recurrence? Heart Rhythm
Society, New Orleans. Heart Rhythm 2005: 2: pp S46. CPA
91. Chiu-Man CC, Corey PN, Stephenson EA, Kirsh JA, Gross GJ, Bronzetti G, Hamilton
RM: Competing risks analysis: A new approach to model lead failures. Heart Rhythm
Society, New Orleans. Heart Rhythm 2005: 2: pp S6. SRI
92. Stephenson EA, Chiu-Man CC, Alexander ME, Cecchin F, Gross GJ, Hamilton RM,
Kirsh JA, Treidman JK, Walsh EP, Berul CI: Efficacy and complications of ICD therapy stratified by indication in the pediatric and congenital heart disease population. Heart
Rhythm Society, New Orleans. Heart Rhythm 2005: 2: pp S55. CPA
93. Chiu-Man CC, Hamilton RM, Gow RM, Kirsh JA, Corey PN, Etchells E, Stephenson
EA, Bronzetti G, Gross GJ, McCrindle BW: Evaluation of automated electrogram interpretation in children: Modelling influential factors. Heart Rhythm Society, New
Orleans. Heart Rhythm 2005: 2: pp S25. CPA

94. Bronzetti G, Chiu-Man CC, Kirsh JA, Stephenson EA, Gross GJ, Neilson AL,
Hamilton RM: Implantable cardioverter-defibrillator in young patients with ARVC/D- Are there differences in R wave sensing amplitude compared to patients with other diseases.
Heart Rhythm Society, New Orleans. Heart Rhythm 2005: 2: pp S89. SRI
95. Jaeggi E, Hamilton RM, Kingdom J, Roman KS, Nii M: Assessment of fetal atrioventricular time intervals by tissue doppler and pulse doppler echocardiography: normal values and correlation with fetal electrocardiography. 41st Annual Meeting of The
Association for European Paediatric Cardiology, May 24-27, 2006, Basel, Switzerland.
Cardiology in the Young 2006: 16 (suppl): pp 64. CPA
96. Kirsh JA, Chiu CC, Gross GJ, Stephenson EA, Hamilton RM: Improvement in acute outcomes of cryoablation of right septal substrates in children: role of the learning curve and evidence for a dose-response effect. 41st Annual Meeting of The Association for European
Paediatric Cardiology, May 24-27, 2006, Basel, Switzerland. Cardiology In The Young
2006: 16 (suppl): pp 2. C
97. Hamilton RM, Lee J, Gross GJ, Stephenson E, Kirsh JA, Benson L: Morphometric quantitation of Fat & Fibrosis in Endomyocardial Biopsies from Children with Clinical and suspected Arrhythmogenic Right Ventricular dysplasia/Cardiomyopathy. Heart Rhythm
Society, Boston. Heart Rhythm 2006: 3: pp S94. SRI
98. MacIntyre C, Warren A, Wilson G, Hamilton RM: Morphometric quantitation of fat & fibrosis in endomyocardial biopsies from children with clinical and suspected arrhythmogenic right ventricular dysplasia/cardiomyopathy. Heart Rhythm Society - 27th
Annual Scientific Sessions, Boston, Massachusetts, USA. Heart Rhythm 2006: 3: pp S45.
SRI
99. Neilson AL, Kirsh JA, Chiu CC, Stephenson EA, Gross GJ, Soucie L, Hamilton RM:
NavX reduces fluoroscopy times in paediatric catheter ablation. 41st Annual Meeting of The
Association for European Paediatric Cardiology, May 24-27, 2006, Basel, Switzerland.
Cardiology In the Young 2006: 16 (suppl): pp 2. C
100. Hamilton RM, Lee J, Gross GJ, Stephenson EA, Kirsh J: Progressive conduction disorders following placement of perimembranous ventricular septal defect occluder devices in infants and children. Heart Rhythm Society - 27th Annual Scientific Sessions, Boston,
Massachusetts,USA. Heart Rhythm 2006: 3: pp S94. PA
101. Cannon BC, Kirsh JA, Collins KK, Pappagiannis J, Chiu C, Dubin AM, Fenrich AL,
Hamilton RM, Kertesz NJ, Stephenson EA, Van Hare GF, Friedman RA: Safety and efficacy of cryoablation in accessory pathways in children: A multicentered study from the
Pediatric Electrophysiology Working Group on Cryoablation. Heart Rhythm Society - 27th
Annual Scientific Sessions, May 17-20, 2006, Boston, Massachusetts, USA. Heart Rhythm
2006: 3 (Suppl): pp S43. CPA
102. Natural history of postoperative heart block in congenital heart disease: Implications for pacing intervention Heart Rhythm (May 2006), 3 (5), pg. 601-604 G.J. Gross; C.C.
Chiu; R.M. Hamilton; J.A. Kirsh; E.A. Stephenson

103. Stothers S, Gross GJ, Kirsh JA, Stephenson EA, Hamilton RM: Cost and yield of clinical cardiovascular genetics within a cardiac arrhythmia clinic . Canadian
Cardiovascular Society 59th Annual Scientific Meeting, October 21-25, 2006, Vancouver,
B.C. The Canadian Journal of Cardiology 2006: 22 (Suppl): pp 153D. PA
104. MacIntyre CJ, Wilson GJ, Yoo S-J, Stothers SL, Hamilton RM: Sensitivity and specificity of clinical tests/criteria against ARVC task force diagnosis in children suspected to have ARVC.
Canadian Cardiovascular Society 59th Annual Scientific
Meeting October 21-25, 2006, Vancouver, B.C. Canadian Journal of Cardiology 2006: 22
(Suppl): pp 177D. SRI
105. Christine C. Chiu, MSc, Robert M. Gow, MD, Robert M. Hamilton, MD, Joel A. Kirsh,
MD, Gil J. Gross, MD, Laura De Souza, BSc and Elizabeth A. Stephenson, MD: Bipolar epicardial pacemaker oversensing problems in children . Heart Rhythm Society, Denver,
CO. Heart Rhythm 2007. C
106. Gao D, PhD, Chiu CC, MS, Gross GJ, MD, Hamilton RM, MD, Stephenson EA, MD and Kirsh JA, MD: Electrograms in successful cryoablation of AVNRT differ from those in radiofrequency ablation.
Heart Rhythm Society - 28th Annual Scientific Sessions of Heart Rhythm Society May 9-12, 2007, Denver, CO. Heart Rhythm 2007: 4 (suppl): pp
S142. C
107. Hamilton RM, Iori S, Buffo I: The utility of ECG criteria in pediatric ARVC. 42nd Annual
Meeting of The Association for European Paediatric Cardiology May 16-19, 2007, Warsaw,
Poland. Cardiology in the Young 2007: 17 (suppl): pp 15. PA
108. Hamilton RM, Iori S, Buffo I: The utility of ECG criteria in pediatric ARVC. 60th Annual
Meeting of the Canadian Cardiovascular Society, October 20-24, 2007, Quebec City, QC.
Canadian Journal of Cardiology 2007: 23 (suppl): pp 202C. PA
109. Hamilton RM , MD, Kirsh JA, MD, Gross GJ, MD, Basciano A, No Degree, de Souza L,
No Degree, Stephenson EA, MD: Utility of signal-averaged electrocardiography in paediatric ARVC. Heart Rhythm Society - 28th Annual Scientific Sessions of Heart Rhythm
Society May 9-12, 2007, Denver, CO. Heart Rhythm 2007: 4 (suppl): pp S44. PA
110. Hamilton RM, MD, Kirsh JA, MD, Gross GJ, MD, Basciano A, No Degree, de Souza L,
No Degree, Stephenson EA, MD: Utility of signal-averaged electrocardiography in paediatric ARVC. 42nd Annual Meeting of the Association for European Paediatric
Cardiology May 16-19, 2007, Warsaw, Poland. Cardiology in the Young 2007: 17 (Suppl): pp 6. PA
111. Chiu CC, Huh J, De Souza L, Alfar-Ramiez A, Clegg R, Fenwick L, Hamilton RM,
Kirsh JA, Gross GJ, Gao D, StephensonEA: A pediatric clinical trial of digital music players: Do they interfere with pacemakers? Heart Rhythm Society Annual Scientific
Sessions May 2008, San Francisco. Heart Rhythm. SRI
112. Villafane J, Fischbach P, Young ML, Maury P, Wolpert C, Hamilton RM, Antonnen O,
Kannankeril PJ: Mid-Term follow up of pediatric patients with short QT syndrome. Heart
Rhythm Society Annual Scientific Sessions May 2008, San Francisco, CA. Heart Rhythm.

SRI
113. Hamilton RM, Fenwick LM, Gross GJ: Sensitivity and specificity of QT-RR relationship on holter in LQT1, LQT2 versus Gene-negative patients being assessed for Long QT
Syndrome (LQTS). Heart Rhythm Society Annual Scientific Sessions May 2008, San
Francisco, CA. Heart Rhythm. PA
114. Hamilton RM,Fenwick LM, Gross GJ: Sensitivity and specificity of QT-RR relationship on holter in LQT1, LQT2 versus Gene-negative patients being assessed for Long QT
Syndrome (LQTS). Association for European Paediatric Cardiology May 2008, Venice,
Italy. Cardiology in the Young. PA
115. Hamilton RM, Huh J, De Souza L: Sinus bradycardia is a frequent presenting finding in arrhythmogenic right ventricular cardiomyopathy (ARVC). Heart Rhythm Society Annual
Scientific Sessions May 2008, San Francisco, CA. Heart Rhythm. PA
116. Gao D, Chiu-Man CC, Kirsh JA, Stephenson EA, Gross GJ, Hamilton RM: Usefulness of pre-excitation index (PI) to differentiate AVNRT, left, right septal accessory pathways in children. Heart Rhythm Society Annual Scientific Sessions May 2008, San Francisco,CA.
Heart Rhythm. SRI
117. Hamilton RM, Fidler LM, Scherer SW, Taylor GP , Wilson GJ: Abnormal cardiomyocyte connexin expression in arrhythmogenic right ventricular cardiomyopathy caused by heterozygous desmosomal protein mutations. Canadian Cardiovascular Congress
(Canadian Cardiovascular Society, Featured Research) 60th Annual Meeting of the Canadian
Cardiovascular Society October 20-24, 2007, Quebec City, Quebec. Canadian Journal of
Cardiology 2007: 23 (suppl): pp 226C. PA
118. Buffo I, MD, Iori S, Hamilton RM, MD,: The utility of ECG criteria in Pediatric ARVC.
Canadian Cardiovascular Congress - 60th Annual Meeting of the Canadian Cardiovascular
Society, Quebec City, Quebec. Canadian Journal of Cardiology 2007: 23 (suppl): pp 202C.
PA
119. Hamilton RM, MD, Kirsh JA, MD, Gross GJ, MD, Basciano A, No Degree,de Souza L,
No Degree, Stephenson EA MD: Utility of signal-averaged electrocardiography in paediatric ARVC. 60th Annual Meeting of the Canadian Cardiovascular Society (Canadian
Cardiovascular Congress) October 20-24, 2007, Quebec City, Quebec. Canadian Journal of
Cardiology 2007: 23 (suppl): pp 122C. PA
120. Angela E. Lin,1 Steven D. Colan,2 Mark E. Alexander,2 Robert Hamilton,3 Bronwyn
Kerr,4 Leslie Smoot,3 A. Micheil Innes,5 Jeanne Baffa,6 Katia Sol-Church,7 Elizabeth
Hopkins,8 Deborah Stabley,7 Karen W. Gripp8: CARDIAC ABNORMALITIES IN
COSTELLO SYNDROME: CLINICAL AND MOLECULAR ANALYSES. 2009. C
121. Wendy Tsang*, Earl Silverman, Rachel Cui, Brenda Bin Su*, Xuejun Wu and Robert
Hamilton: CMV Infection in Cultured Fetal Myocytes Induces Cell Surface Expression of
Ro Antigen: A Potential Second Hit in the Development of Congenital Complete Heart
Block. International Conference on Congenital Heart Block, Stockholm. Scandinavian
Journal of Immunology 2010: 72: pp 267. SRI

122. Yuqing (Jane) Yan1,2, Langming Xie2, Brenda B. Su1, Lily Liu1, Rachel Cui1, Robert
M. Hamilton1: DRUG TARGET SCREENING FOR CONGENITAL HEART BLOCK.
International Conference on Congenital Heart Block, Stockholm. Scandinavian Journal of
Immunology 2010: 72: pp 266. SRI
123. Brenda B. Su, Marco Capecchi*, Kalvin Lung, Jane Yuqing Yan, Lily Liu, Rachel Cui,
Edgar T Jaeggi, Earl D. Silverman and Robert M. Hamilton: GENE EXPRESSION IN
THE ATRIOVENTRICULAR JUNCTION FROM FETAL HEARTS. International
Conference on Congenital Heart Block, Stockholm. Scandinavian Journal of Immunology
2010: 72: pp 267. SRI
124. Xuezhi Cui, Xiaoru Liu, Bin Su, Xuejun Wu, Yuqing Yan, Earl Silverman, Edgar
Jaeggi & Robert Hamilton: Identification of autoantibody binding site on a1G T-type Ca channel in congenital heart block. International Conference on Congenital Heart Block,
Stockholm. Scandinavian Journal of Immunology 2010: 72: pp 265. SRI
125. Parveen Sharma1, 2, Nicolas Bousette1, 2, Melissa Noronha1, 2, Alex
Ignatchenko3,Vladimir Ignatchenko3 , Tetsuaki Miyake1, 2, Nicole Dubois4, Jie Liu2,
Robert Hamilton5, Peter H. Backx2, Gordon M. Keller4, Anthony O. Gramolini1, 2*, and Thomas Kislinger 4, 6*: Proteomic profiling of the mouse and human cardiomyocyte plasma membrane . American Heart Association, Chicago. Circulation
2010. C
126. Robert Hamilton, Maryam Farhan, Berivan Baskin, Peter Ray, Stephen Scherer: The
Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC): Evaluation of New Criteria in a Young Gene-tested Population . American Heart Association,
Chicago. Circulation 2010. C
127. Jaeggi E. (1), Laskin C. (2), Hamilton R.M. (1), Kingdom J. (2), Silverman E. (1) The
Importance of the Level of Maternal Anti-Ro/SSA Antibodies as a Prognostic Marker of the
Development of Cardiac Neonatal Lupus Erythematosus:
A Prospective Study of 186
Antibody-Exposed
Fetuses and Infants
. 44 th Annual Meeting of the AEPC, Innsbruck,
Austria. Cardiology in the Young 20(2):S39 2010.
128 Hamilton RM. (1), Su B.B. (1). Lung K. (1), Capecchi M. (2), Yan JY. (1), Cui R. (1), Liu L.
Gene Expression In Atrioventricular Junction From Fetal Hearts
 (1) 44 th Annual Meeting of the AEPC, Innsbruck, Austria. Cardiology in the Young 20(2):S55 2010.
129. Kristopher T. Kang, BA, Susan P. Etheridge, MD, Michal J. Kantoch, MD, Michael S.
Schaffer, MD, Bryan C. Cannon, MD, David J. Bradley, MD, Robert J. Hamilton, MD,
Svjetlana Tisma-Dupanovic, MD, James E. Potts, PhD and Shubhayan Sanatani,
130. Parveen Sharma
1
; Nicolas Bousette
1
; Alex Ignatchenko
2
; Nicole Dubois
3
; Melissa Noronha
1
;
Vladimir Ignatchenko 2 ; Tetsuaki Miyake 1 ; Jie Liu 1 ; Robert Hamilton 4 ; Peter H Backx 1 ;
Gordon M Keller
3
; Thomas Kislinger
5
; Anthony Gramolini Detailed Proteomic Analysis Of
Mouse And Human Cardiac Membrane Proteins Reveals Novel Cardiac Proteins

American Heart Association, . Circulation 2011. C
133. Farhan M., Hamilton R.M. Predictors of Adverse Events in Children with Arrhythmogenic
Right Ventricular Cardiomyopathy 45 th Annual Meeting of the AEPC, Granada, Spain.
Cardiology in the Young 21(1):S24 2011.
134. L. Grosse-Wortmann, S. Govindapillai, Y. Etoom, H. Moshonov, R. Hamilton, S.-J. Yoo
Magnetic resonance imaging in the diagnosis of childhood arrhythmogenic right ventricular cardiomyopathy Abstract to Jahrestagung der Deutschen Gesellschaft für Pädiatrische
Kardiologie Weimar, 1. bis 4. Oktober 2011 Clin Res Cardiol (2011) 100:817–861
135. Lars Grosse-Wortmann, Yousef Etoom, Sindu Govindapillai, Cedric Manhliot, Hadas
Moshonov, Brian McCrindle, Robert Hamilton, Shi-Joon Yoo. MRI in Childhood ARVC &
Proposed Modification of the Task Force Criteria for Children. Society for Cardiac Magnetic
Resonance Scientific Sessions Feb. 3-5, 2012.
136. Marie Chaix, Philippe Goyette, Azadeh Alikashani, Frédéric Latour, Laura Robb, Blandine
Mondesert, Lena Rivard, Sylvain Foisy, Martin Ladouceur, Robert M. Hamilton, Mario
Talajic & John D. Rioux. Whole-exome sequencing for identification of novel genes and variants underlying the risk of Lonq-QT syndrome. submitted to American Society for
Human Genetics.
137. Zachary Laksman, Robert M. Hamilton, Priya Chockalingam, Arthur A.M. Wilde, Emily
Ballantyne, Joel A. Kirsh, Elizabeth A. Stephenson, Gil J. Gross, George J. Klein, Andrew D.
Krahn. Does Mutation Location Affect Severity of Phenotype in Type 1 Long QT
Syndrome? Impact of Transmembrane and c-Loop location. submitted to American Heart
Association.
Chapters in Electronic Books
Medscape Reference (formerly e-medicine)
Cardiology
Article Title URL Page Views*
Wolff-Parkinson-White Syndrome http://emedicine.medscape.com/article/159222-overview
9,899 page views per month

Pediatrics: Cardiac Disease and Critical Care Medicine
Article Title URL Page Views*
Junctional Ectopic Tachycardia http://emedicine.medscape.com/article/898989-overview
736 page views per month
Pediatric Atrial Ectopic Tachycardia http://emedicine.medscape.com/article/898784-overview
525 page views per month
Pediatric Atrial Flutter http://emedicine.medscape.com/article/894226-overview
327 page views per month
Pediatric Congenital Atrioventricular Block http://emedicine.medscape.com/article/894703overview 465 page views per month
Pediatric Second-Degree Atrioventricular Block http://emedicine.medscape.com/article/890621overview 250 page views per month
Paper presentations
1) Hamilton RM. Analysis of the Non-Invasive Fetal ECG in Mothers with anti-Ro antibody
2) Hamilton RM, Mawson J. The implantable pace-maker-cardioverter-defibrillator: radiographic aspects in children
3) Hamilton RM, Chiu C, Gow RM. Catheter Ablation in Children: High Success with Experience
4) Hamilton RM, Chan KY, Silverman ED, McCrindle B. Relationships between Maternal
Immunologic Status, ECG Measurements and Need for Pacing in Children with Immune-Mediated
Congenital Heart Block
5) Hamilton RM, Gow RM. Ablation of a Mahaim fiber tachycardias in children
6) Hamilton RM. The Sicilian Gambit Approach to Arrhythmias: Developmental Implications
7) Davis A, Hamilton RM, Gow RM. Short Coupled Form of Torsade des Pointes in a child (case report)
8) Sananes R, Hamilton RM. Quality of life assessment of children requiring pacemakers
9) Le-Poy M, Hamilton RM, Silverman E: A rabbit model of immune-mediated congenital heart block
10) Hamilton RM, Reddy S: Is Chaotic Atrial Tachycardia Chaotic?
Publications in Journals
1) Hamilton RM, Chiu C, Griffiths J, Gow R: Pediatric application of a parallel wound, bipolar, active fixation lead with an iridium oxide-coated electrode. Reviewed by Pacing and Clinical
Electrophysiology, undergoing significant revision. PA
2) Bauersfeld U, Hamilton, R, Gow R. The incidence of arrhythmias following TAPVD repair. SRI

3) Hamilton RM, Teixeira OH, McCrindle BW, Gow RM, Chiu CC, Griffiths JE, Williams WG,
Rose M: A New Epicardial Steroid Lead: Improved Performance in Children. for submission to
PACE. PA
4) Hamilton RM, Chan KY, Silverman ED, Garson A. Pacing for Congenital Complete Heart Block in Children: A North American Experience. in prep. for the American Journal of Cardiology. PA
5) Hamilton RM, McCrindle BW, Chiu C, Gow RM: Radiofrequency ablation of Pediatric
Arrhythmias: Beneficial Effects of Monitoring Tip Temperature. for submission to Canadian Journal of Cardiology. PA
6) Liepa Z, Hamilton RM: Accessory pathways in the Hypoplastic Left Heart Syndrome. short report in prep. for the American Journal of Cardiology. CPA
7) Hamilton RM. Outcomes of the Fontan procedure: a Formal Review utilizing Meta-analysis
Technique. ACC Highlights
8) Hamilton RM: Outcomes of the Mustard Surgery: a Formal Review utilizing Meta-analysis
7.
8.
9.
Technique. ACC Highlights
9) Hamilton RM, Steeves J. Programming the aggressiveness of a rate drop response by assessment of heart rate variability parameters. Medtronic
5.
6.
2.
3.
PRESENTATIONS
Invited Visits to Other Hospitals/Universities/Etc.
1. Canadian Cardiac Electrophysiology Society, 1989. Cellular Electrophysiology and
Histology of Cryoablation in a Canine Model.
McMaster University. Pediatric Grand Rounds, 1990. Congenital Heart Block.
International Symposium on Syncope in Children, Genoa, Italy, 1990. Syncope in Children with Congenital Heart Disease.
4. Medtronic Pacemaker Implant and Follow-up Meeting, 1992. 1) Advances in Pediatric
Pacing Leads; 2) Epicardial Lead Systems; 3) Radiographic Assessment of Pacing Systems.
Medifacts Lecture, 1992. Cardiac Emergencies in Children.
Pediatric update, Orillia, Ontario, 1992. Management of Rhythm Disorders in Children.
Canadian Cardiac Electrophysiology Society, 1992. Steroid Eluting Epicardial Leads.
Society of Ontario Pacing Professionals, 1993. Radiofrequency Ablation in Children.
North American Society of Pacing and Electrophysiology. Meet the Experts Seminar, 1993.

Sudden death after repair of congenital heart disease.
10. Ontario Physicians Pacemaker Symposium, 1994. Advances in Pediatric Lead Technology.
11. Canadian Cardiovascular Society. Maintenance of Competency Exam Review, 1994. Wolff-
Parkinson-White syndrome in an infant.
12. Canadian Cardiovascular Society. Satellite Symposium, 1995. Device Therapy for the Long
QT Syndrome.
13. Canadian Council of Cardiovascular Nurses. Annual Meeting, 1995. Pediatric Pacing and
Defibrillators.
14. Canadian Cardiovascular Society. Fontan Workshop, 1995. Rhythm Disturbances following the Fontan Procedure.
15. Canadian Cardiovascular Society Meeting. Satellite Symposium "Sudden Arrhythmia Death
Syndromes", 1995. Session Moderator.
16. Pacing Update at Lake Louise, 1996. 1) Epicardial Steroid and Non-steroid Leads in
Children; 2) Defibrillators in Children; 3) Transvenous Leads and Vascular Obstruction in
Children.
17. Canadian Pacing Physicians Conference, Hawaii, 1996. 1) Management of Congenital
Complete Heart Block; 2) Sudden Death in Children: Implications for ICDs.
18. North American Society of Pacing and Electrophysiology. Meet the Experts Seminar, 1996.
Indications for Pacing in Children.
19. American College of Cardiology, Orlando, FL, 1996. Invited Chairman. Original
Contributions, Pediatric Electrophysiology.
20. Pacing Overview Seminar for NASPExAM Associated Professionals Candidates, 1996.
Medtronic of Canada.
21. International Society of Computers in Electrophysiology, Palm Coast, 1997. Fetal
Electrocardiography/Immune Mechanisms of Conduction System Disease.
22. North American Society of Electrophysiology, 1997. Invited Chairman. Treatment
Strategies for Atrial Flutter.
23. Pacing Overview Seminar for NASPExAM Associated Professionals Candidates, 1997.
Medtronic of Canada.
24. American College of Cardiology. Congenital Heart Disease in the Adult, 1998. Arrhythmias and their Treatment in Adults with CHD: Before and After Cardiac Surgery.
25. North American Society of Pacing and Electrophysiology. Core Curriculum: Molecular and
Genetic Basis for Arrhythmias in the Young Patient, 1998. Etiology and management of

Congenital Heart Block.
26. North American Society of Pacing and Electrophysiology, 1998. Session Chair.
27. North American Society of Pacing and Electrophysiology, May 12, 1999 - May 15, 1999.
The Long QT syndrome: Clinical Dilemmas.
28. The Canadian Sudden Arrhythmic Death Syndromes Society, Jul 1999. "Diagnostic
Dilemmas". Life Perspectives on Cardiac Arrhythmias.
29. North American Society of Electrophysiology, Jul 1999. Invited Chairman.
Pediatric/Congenital Electrophysiology.
30. Annual Coroners Conference, Jul 1999. Medico-Legal Implications of Implantable
Programmable Devices.
31. Society of Ontario Associated Professionals, Jul 1999. Pacing.
32. North American Society of Pacing and Electrophysiology, Jul 1999. Session Chair.
33. Canadian Concensus Conference on Sudden Death, Jul 1999. Unusual Causes of Sudden
Death.
34. Guidant Canada Seminar, Mont Tremblant, Mar 2000. Arrhythmogenic Right Ventricular
Dysplasia in Children.
35. Ontario Physicians Pacemaker Symposium, Jul 2000. Assessing Cardiovascular Risk/Fitness to Drive.
36. North American Society of Electrophysiology, Jul 2000. Invited Chairman.
Pediatric/Congenital Electrophysiology.
37. Israeli Pediatric Cardiology Society, Jan 2001. Invited Chairman.
38. Asian-Pacific Society of Electrophysiology, Jan 2001. Invited Chairman.
Pediatric/Congenital Electrophysiology.
39. North American Society of Electrophysiology, Jan 2001. Invited Chairman.
Pediatric/Congenital Electrophysiology.
40. World Congress of Pediatric Cardiology & Cardiac Surgery, Jan 2001. Invited Chairman.
Pediatric/Congenital Electrophysiology.
41. International Dead Sea Symposium at Tel Aviv, Tel Aviv, Israel, Mar 2002. Ablation of
Complex Pathways in Children with "Normal" Heart and Congenital Heart Disease.
42. International Dead Sea Symposium at Tel Aviv, Tel Aviv, Israel, Mar 2002. Pediatric
Aspects of Arrhythmogenic Right Ventricular Dysplasia.

43. 13th Great wall International Conference of Cardiology, Beijing, China, Sep 13, 2002 - Sep
17, 2002.
44. Ontario Pacemaker Physicians Symposium, Medtronic of Canada, Niagara-on-the-Lake,
Ontario, Oct 2002. Medical Fitness to Drive: Cardiac Assessment.
45. Twelfth World Congress on Cardiac Pacing and Electrophysiology, Hong Kong, China, Feb
19, 2003 - Feb 22, 2003. Prophylactic ICD: use and misuse.
46. Twelfth World Congress on Cardiac Pacing and Electrophysiology, Hong Kong, China, Feb
19, 2003 - Feb 22, 2003. Transvenous pacing in young children.
47. North American Society of Pacing and Electrophysiology, Washington, May 14, 2003 - May
17, 2003. Controversies in Pediatric/Adult Congenital Heart Disease: EP Studies in
Asymptomatic Post-Op CHD Patients with Non-Sustained VT Should be Used to Select
Patients for ICD Implant .
48. North American Society of Pacing and Electrophysiology, Washington, May 14, 2003 - May
17, 2003. Multicenter cryoablation experience in pediatric patients .
49. Association of European Pediatric Cardiology (short oral and poster presentation),
Amsterdam, May 28, 2003 - May 31, 2003. Double Orifice Mitral Valve (DOMV) - Clinical
Presentation, Natural History and Outcome in Children and Adolosence.
50. (short oral and poster) presentation , Amsterdam, May 28, 2003 - May 31, 2003.
Multicenter cryoablation experience in pediatric patients .
51. e-medicine e-le@rning, Naples, Italy, Jun 5, 2003 - Jun 8, 2003. First International
Conference of Telemedicine & Teleteaching.
52. PEDIRHYTHM (Pediatric Arrhythmia Symposium), Ankara, Turkey, Jul 31, 2003 - Aug 2,
2003. FEATURED SYMPOSIUM: LONG QT SYNDROME AND OTHER
REPOLARISATION DISORDERS: Non-Pharmacologic Therapy. Hamilton RM, Canada.
53. PEDIRHYTHM (Pediatric Arrhythmia Symposium), Ankara, Turkey, Jul 31, 2003 - Aug 2,
2003. Meet the Experts Session:Pacing Indications and Pacing Modes (Chair).
54. PEDIRHYTHM (Pediatric Arrhythmia Symposium), Ankara, Turkey, Jul 31, 2003 - Aug 2,
2003. Pediatric Pacing: How to deal with complications.
55. PEDIRHYTHM (Pediatric Arrhythmia Symposium), Ankara, Turkey, Jul 31, 2003 - Aug 2,
2003. Workshop: Electrical Therapy (Chair) .
56. Paediatric Pacing and Arrhythmia Workshop, Bristol, UK, Oct 2003. Cryoablation.
57. American Heart Association, Orlando, Nov 9, 2003 - Nov 12, 2003. Increased Risk of
Congenital Block in Infants of Mothers with Hypothyroidism and Anti-Ro and/or Anti-La
Antibodies.

58. Workshop on Neonatal Lupus and the Ro-SSA/La-SSB System during the Fourth
International Conference on Sex Hormones, Pregnancy and the Rheumatic Diseases, Stresa Italy, Sep 22, 2004. Basic
Science Studies in Congenital Heart Block.
59. Heart Rhythm Society, New Orleans, LA, May 5, 2005. Debate: All patients with TOF undergoing conduit change should have leads for potential biventricular pacing.
60. Heart Rhythm society Annual Scientific Sessions, Boston, MA, May 17, 2006 - May 20,
2006. Congenital Heart Block: From Bench to Bedside (Joint Session: Heart Rhythm
Society and the Pediatric EP Society) [Chair].
61. Heart Rhythm Foundation, Denver, CO, May 17, 2006 - May 20, 2006. Invited Speaker,
Pediatric Summit.
62. Heart Rhythm Foundation Annual Scientific Sessions, Boston, MA, May 17, 2006 - May 20,
2006. New Technologies in Fetal Arrhythmia Diagnosis: Electrocardiography.
63. 4th Annual International Arrhythmia Winter School, The Westin Trillium House Blue
Mountain, Collingwood, ON, Feb 9, 2007 - Feb 22, 2007. Electrophysiology for
Electrophysiologists:"How I Re-Do SVTs.
64. Sudden Cardiac Arrest in the Young (Pediatric EP Society and Heart Rhythm Foundation:
Pre-Heart Rhythm Society Symposium), Denver, CO, May 8, 2007. DCM, ARVC, and
Restrictive CM.
65. Heart Rhythm Society Annual Scientific Sessions, Denver, CO, May 9, 2007 - May 12, 2007.
Diagnosis in Children (Arrhythmogenic Right Ventricular Dysplasia in Children Session) .
66. Association of European Pediatric Cardiology, Warsaw, Poland, May 16, 2007 - May 19,
2007. Evolving ICD concepts and therapies in pediatric patients from shockbox to ICD-CRT.
67. Canadian Cardiovascular Congress (Canadian Cardiovascular Society Workshop, Organizer and Co-chair), Quebec City, Oct 28, 2007. Towards Consensus on the Diagnosis &
Management of Arrhythmogenic Right Ventricular
Cardiomyopathy.
68. Canadian Cardiovascular Congress (Canadian Cardiovascular Society Workshop, Organizer and Co-chair), Quebec City, Oct 30, 2007. CARDIOVASCULAR SCREENING OF
CANADIAN ATHLETES FOR PREVENTION OF SUDDEN
DEATH.
69. Heart Rhythm Society 29th Annual Scientific Sessions May 14-17, 2008, San Francisco, CA,
May 14, 2008 - May 17, 2008. Mid-Term follow up of pediatric patients with short QT syndrome (abstract submission).
70. Heart Rhythm Society, Denver, CO, May 14, 2010. HRS Expert Consensus on Management of Cardiac Devices at Patients' End of Life: Special Population - Pediatrics.

71. Heart Rhythm Society, Denver, CO, May 14, 2010. New Technologies in Pediatric EP
(Chair).
72. International Workshop
Clinical & Molecular Aspects of Congenital Heart Block, Stockholm, Sweden, Sep 17, 2010
- Sep 19, 2010. CMV Infection in Cultured Fetal Myocytes Induces Cell Surface Expression of Ro Antigen: A Potential Second Hit in the Development of Congenital Complete Heart
Block
Wendy Tsang*, Earl Silverman, Rachel Cui, Brenda Bin Su*, Xuejun Wu and Robert
Hamilton.
73. International Workshop
Clinical & Molecular Aspects of Congenital Heart Block, Stockholm, Sweden, Sep 17, 2010
- Sep 19, 2010. DRUG TARGET SCREENING FOR CONGENITAL HEART BLOCK
Yuqing (Jane) Yan1,2, Langming Xie2, Brenda B. Su1, Lily Liu1, Rachel Cui1, Robert M.
Hamilton1.
74. International Workshop
Clinical & Molecular Aspects of Congenital Heart Block, Stockholm, Sweden, Sep 17, 2010
- Sep 19, 2010. GENE EXPRESSION IN THE ATRIOVENTRICULAR JUNCTION
FROM FETAL HEARTS
Brenda B. Su, Marco Capecchi*, Kalvin Lung, Jane Yuqing Yan, Lily Liu, Rachel Cui,
Edgar T Jaeggi, Earl D. Silverman and Robert M. Hamilton.
75. International Workshop
Clinical & Molecular Aspects of Congenital Heart Block, Stockholm, Sweden, Sep 17, 2010
- Sep 19, 2010. Identification of autoantibody binding site on a1G T-type Ca channel in congenital heart block
Xuezhi Cui, Xiaoru Liu, Bin Su, Xuejun Wu, Yuqing Yan, Earl Silverman, Edgar Jaeggi &
Robert Hamilton.
76. International Workshop
Clinical & Molecular Aspects of Congenital Heart Block, Stockholm, Sweden, Sep 17, 2010
- Sep 19, 2010. Screenig for Novel Autoantibodies in Congenital Heart Block.
77. American Heart Association, Chicago, IL, Nov 13, 2010 - Nov 17, 2010. Arrhythmogenic
Right Ventricular Cardiomyopathy.
78. American Heart Association, Chicago, IL, Nov 13, 2010 - Nov 17, 2010. The Diagnosis of
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC): Evaluation of New
Criteria in a Young Gene-tested Population
Author Block: Robert M Hamilton, Maryam Farhan, Berivan Baskin, Peter N Ray, Stephen
W Scherer.
79.
Genetics and Arrhythmias in Children: Utility of Genetic Testing for ARVC/D, Thursday, May
5, 2011, 11:10 AM
Heart Rhythm Society, San Francisco, California
80.
Update on Congenital Complete Heart Block (Chair), Friday, May 6, 2011, 10:30 AM
Heart

Rhythm Society, San Francisco, California
81. Predictors of Adverse Events in Children with Arrhythmogenic Right Ventricular
Cardiomyopathy. Hamilton R. M., Farhan M.
Association of European Pediatric
Cardiology, Granada, Spain
82. Canadian Cardiovascular Congress, Vancouver, B.C. CCC 2011 Pediatric education session:
ARVC genetics: what exactly does variant of unknown significance mean?
83.
Update on Congenital Complete Heart Block (Chair), Friday, May 6, 2011, 10:30 AM
Heart
Rhythm Society, San Francisco, California
84. Second Cardiff International Symposium on Cardiovascular Genetics: Phenotype-Genotype
Correlations in Cardiac Channelopathies, November, 2011
85. Invited Panelist,
SUDDEN CARDIAC DEATH AND THE REST OF THE FAMILY
Heart Rhythm Annual Scientific Sessions, Boston, MA, May 8 th
, 2012
86. Perinatal Management of Arrhythmias: Diagnosis, Antenatal and Postnatal Intervention,
Chair & Commentator. Heart Rhythm Annual Scientific Sessions, Boston, MA, May 10,
2012
87. What Do I Tell Family Members About Their Risk? In Core Curriculum
Common Clinical Questions in Genetic Testing. Heart Rhythm Annual Scientific Sessions,
Boston, MA. Thu, May 10, 2012
88. Univentricular Heart Symposium, Riyadh, Sept. 24-26, 2012: Do arrhythmias contribute to
Stage 1-Stage 2 morbidity or mortality?
89. Univentricular Heart Symposium, Riyadh, Sept. 24-26, 2012: Management of late arrhythmias.
90. Keynote Presenter: Research and Scientific Program of the Canadian Academy of Child and
Adolescent Psychiatry (CACAP) 2012 Annual Conference, Sept 30 to Oct 2, Montreal
91 Syncope in an Athlete. Canadian Pediatric Society, London, Ontario, June, 2012. (1.5 hour
Workshop)
Peer Reviewed Papers Read at Scientific Meetings
1. Hamilton RM, Gillespie CT, Cook HW: Relationships between Levels of Essential Fatty
Acids and Zinc in Plasma of Cystic Fibrosis Patients. Canadian Pediatric Society
Conference, 1981.
2. Finley JP, Hamilton RM, Gordon-MacKenzie M: Heart Rate Response to Tilting in
Newborns in Quiet and Active Sleep. Canadian Pediatric Society Conference, 1982.
3. Hamilton RM, Crocker JF, Murphy DA: Uric Acid Metabolism in Children Who Undergo

Cardiopulmonary Bypass. Canadian Cardiovascular Society Conference, 1982.
4. Hamilton RM, Robertson MA, Jugdutt BI, Joffre MR, Duncan NF: Serial
Echocardiographic Biventricular Regional Wall Motion in Neonates with Persistent
Pulmonary Hypertension. Canadian Cardiovascular Society Conference, 1987.
5. Hamilton RM, Moak J, Kearney D, Garson A: Clinical Implications of Epicardial Atrial
Cryoablation: Action Potential and Histologic Effects. American Heart Association Meeting,
1988.
6. Hamilton RM, Benson L, Freedom RM: Pulmonary Artery Baloon Angioplasty: Clinical
Followup. American Heart Association Meeting, 1988.
7. Paret G, Taylor R, Hamilton RM, Edmonds J, Barker G: Drug Therapy for Postoperative
Junctional Ectopic Tachycardia. Society for Pediatric Research, 1990.
8. Hosking M, Hamilton R: Oral Sotalol in Children. North American Society of Pacing and
Electrophysiology, 1990.
9. Hamilton RM, Bahoric B, Griffiths J, Freedom R, Williams W: Steroid-eluting
Epicardial Leads in Pediatrics: Improved Epicardial Thresholds in the First Year. IXth
World Symposium on Cardiac Pacing and Electrophysiology, May 28, 1991.
10. Newman D, Hardy J, Thorne S, Downar E, Harris L, Hamilton R, Gow R, Dorian P:
Single Centre Experience with a Combination Antitachycardia Pacemaker and Defibrillator.
American College of Cardiology. 40th Annual Scientific Session, 1991.
11. Le Gras M, Hamilton R: Atrial antitachycardia pacing in a pediatric population. Canadian
Cardivascular Society, 1992.
12. Hamilton RM, Griffiths J, Gow RM: Implantable Defibrillators in Pediatric Hypertrophic
Cardiomyopathy: Early Experience. Canadian Cardivascular Society, 1992.
13. Bauersfeld U, Gow R, Hamilton R, Izukawa T: Treatment of Atrial Ectopic Tachycardia in Infants Under 6 Months of Age. Canadian Cardiovascular Society, 1992.
14. Figa F, Gow R, Hamilton R, Freedom R: The use of IV amiodarone for life threatening arrhythmias in children. World Congress of Pediatric Cardiology, Paris, France, 1993.
15. Gelatt M, Hamilton RM, McCrindle B, Gow R, Williams WG, Freedom RM:
Arrhythmias following Fontan Connection. American College of Cardiology, Atlanta, GA,
1994.
16. Hamilton RM, Benson L, Gow RM, Davis A, Moore-Coleman P, Freedom RM: Can the
Signal Averaged ECG Predict Cardiac Rejection in Children. Canadian Cardiovascular
Society, 1994.
17. Hamilton RM, Benson L, Gow RM, Davis A, Moore-Coleman P, Freedom RM: Can the
Signal Averaged ECG predict Cardiac Rejection in Children? American Heart Association,

1994.
18. Hamilton RM, Teixeira OH, McCrindle BW, Gow RM, Chiu CC, Griffiths JE,
Williams WG, Rose M: Can the Signal Averaged ECG predict Cardiac Rejection in
Children? American Heart Association, 1994.
19. Davis AM, Gow RM, McCrindle BW, Hamilton RM, Freedom RM: The Clinical
Spectrum and Follow-up of ventricular tachycardia in infants and young children with structurally normal hearts. Canadian Cardiovascular Society, 1994.
20. Bauersfeld U, Hamilton R, Gow R: The incidence of arrhythmias following TAPVD repair.
American College of Cardiology, 1994.
21. Davies HD, King SM, Doyle J, Matlow A, Koren G, Hamilton R, Portwine C:
Randomized, Blinded Controlled Pilot Study of Rapid Amphoterecin B Infusions in
Children. Interscience Conference on Antimicrobial Agents and Chemotherapy, Orlando,
Florida, Oct 1994.
22. Joshi P, Verjee Z, McGuigan M, Hamilton R: Toxicokinetics and Electrocardiographic
Changes in Propafenone Overdose in an Infant. Congress of the World Federation of
Clinical Toxicology centers and Poison Control Centers, Taipei, Nov 8, 1994.
23. Gelatt MC, Hamilton RM, McCrindle BW, Connelly MB, Davis AM, Harris PIL, Gow
RM, Williams WG, Trusler GA: Factors Associated With Arrhythmias After Mustard
Operation - 30 Year Experience With 534 Patients. American College of Cardiology, Mar
20, 1995.
24. Figa F, Bigras JL, Hamilton RM, McCrindle BW, Gow RM: Risk Factors for Venous
Obstruction associated with Transvenous Pacing in Children. American College of
Cardiology, Mar 20, 1995.
25. Hamilton R, Chiu C, Griffiths J, Williams W, Gow R, Mans D, Lach L: A Comparison of Fixed Screw Leads in Children: Effect of Steroid Elusion and Microporous Platinized
Electrode. North American Society of Pacing and Electrophysiology. Annual Meeting, 1995.
26. Hamilton RM, Teixeira OH, Gow RM, Chiu CC, Griffiths JE, Williams WG: A New
Epicardial Steroid Lead: Improved Performance in Children. Canadian Cardiovascular
Society, Toronto, Ontario, 1995.
27. Bauersfeld UK, Chiu C, Hamilton RM, Williams WG, Gow RM: Arrhythmias 5 to 15
Years after Repair of Tetralogy of Fallot. Canadian Cardiovascular Society, Toronto,
Ontario, 1995.
28. Hamilton RM, Dorian P, Gow RM, Williams WG: Five Year Experience with Implantable
Defibrillators in Children. Canadian Cardiovascular Society, Toronto, Ontario, 1995.
29. Fogelman R, Hamilton R, Williams W, Gow R, Freedom R: Heart Block after Surgical enlargement of Ventricular Septal Defect: Effect of Underlying Anatomy and Direction of
Enlargement. North American Society of Pacing and Electrophysiology. Annual Meeting,

1995.
30. Hamilton RM, Fogelman R, Williams WG, Gow RM, Freedom RM: Heart Block after
Surgical Enlargement of Ventricular Septal Defect: Effect of Underlying Anatomy and
Direction of Enlargement. Canadian Cardiovascular Society, Toronto, Ontario, 1995.
31. Casey FA, McCrindle BW, Hamilton RM, Gow RM: Neonatal Atrial Flutter: Significant
Early Morbidity, Benign Long-Term Prognosis. American Heart Association, 1995.
32. Hamilton RM, Chiu CC, Gow RM: Radiofrequency Catheter Ablation in Children: High
Success with Experience. Canadian Cardiovascular Society, Toronto, Ontario, 1995.
33. Connelly M, Harris L, Siu S, Puley G, Harrison D, Hamilton R, McLaughlin P, Webb
G, Williams WG: Adult Patients Following the Mustard Procedure: Atrial Arrhythmias and
Clinical Outcomes. NASPE, 1996.
34. Hamilton RM, McCrindle BW, Gow RM: Atrial flutter in congenital heart disease: differences between lesions. Canadian Cardiovascular Society. Annual Meeting, 1996.
35. Hamilton RM, McCrindle BW, Gow RM: Atrial flutter in congenital heart disease: differences between lesions. American Heart Association. Annual Meeting, 1996.
36. Chiu C, Gow R, McCrindle B, Newman A, Hamilton R: Atrial sensing: Role of the programmed safety factor in children. North American Society of Pacing and
Electrophysiology. 17thAnnual Scientific Sessions, 1996.
37. Hamilton RM: Electrocardiographic Differences in Atrial Flutter Differences between
Congenital Heart Lesions. 23rd International Congress on Electrocardiography, Cleveland,
OH, 1996.
38. Hamilton RM: Electrocardiographic Differences in Atrial Flutter Differences between
Congenital Heart Lesions. 37th International Symposium on Vectorcardiography, Cleveland,
OH, 1996.
39. Lawrence S, Dorner T, Luy L, Hiepe F, Hamilton R, Laxer R, Silverman E: Maternal serology in the prediction of Complete Heartblock (CHB) in Neonatal Lupus Erythematosus
(NLE). American College of Rheumatology, Oct 18, 1996.
40. Menon A, Chan KY, Silverman ED, Gow RM, Hamilton RM: Chronotropic Competence of the Sinus Node in Patients with Congenital Atrioventricular Block. American Pediatric
Society, Society for Pediatric Research meeting, 1997.
41. Menon A, Silverman ED, Hamilton RM: Chronotropic Competence of the Sinus Node in
Patients with Congenital Atrioventricular Block. North American Society of Pacing and
Electrophysiology, 1997.
42. Chiu C, Griffiths J, Gow R, Hamilton R: Experience with a New Bipolar Iridium Oxide
Fixed Screw Lead in Children: Lower Thresholds and Smaller Diameters. North American
Society of Pacing and Electrophysiology, 1997.

43. Yetman A, Hamilton R, Benson L, McCrindle BW: Factors Associated with Outcome in
Children with Hypertrophic Cardiomyopathy. Canadian Cardiovascular Society, 1997.
44. Yetman A, Hamilton R, Benson L, McCrindle BW: Factors Associated with Outcome in
Children with Hypertrophic Cardiomyopathy. American Heart Association, 1997.
45. Lee-Poy M, Hamilton RM, Silverman ED: Reproduction of the Features of Congenital
Heart Block in Isolated Rabbit Hearts exposed to Human Maternal Serum. North American
Society of Pacing and Electrophysiology, 1997.
46. Lee-Poy M, Hamilton RM, Silverman ED: Reproduction of the Features of Congenital
Heart Block in Isolated Rabbit Hearts exposed to Human Maternal Serum. World Congress of Pediatric Cardiology, 1997.
47. Lee-Poy M, Hamilton RM, Silverman ED: Reproduction of the Features of Congenital
Heart Block Secondary to Neonatal Lupus Erythematosus in the Isolated Rabbit Heart.
American Pediatric Society, Society for Pediatric Research meeting, 1997.
48. Dipchand AI, McCrindle BW, Gow RM, Freedom RM, Hamilton RM: The Surface ECG does not Accurately Differentiate Children with Hypertrophic Cardiomyopathy from
Normals. Canadian Cardiovascular Society, 1997.
49. Dipchand AI, McCrindle BW, Gow RM, Freedom RM, Hamilton RM: The Surface ECG does not Accurately Differentiate Children with Hypertrophic Cardiomyopathy from
Normals. American Heart Association, 1997.
50. Chiu C, Gow R, McCrindle B, Hamilton R, Griffiths J: Manual pacing conversion of atrial flutter through the permanent pacemaker system in children. North American Society of Pacing and Electrophysiology, 1998.
51. Hamilton RM, Chiu C, Gow RM, Freedom RM: Six Year Follow-up of a Steroid-eluting
Epicardial Lead Designed for Pediatric Pacing. Association of European Pediatric
Cardiologists, Ireland, 1998.
52. Davis A, McCrindle B, Hamilton R, Benson L, Gow R: The signal-averaged electrocardiogram as a marker of cardiac allograft rejection in children. North American
Society of Pacing and Electrophysiology, 1998.
53. Chiu C, Hamilton RM: Evolution of the QT interval in children with congenital complete heart block. Society for Pediatric Research, San Fransisco, CA, May 1999.
54. Lee-Poy MF, Zhao S, Silverman ED, Borgess C, Isacovics B, Hamilton RM: Fetal and neonatal manifestations in a murine model of congenital heart block, including fetal echo assessment. Society for Pediatric Research, San Fransisco, CA, May 1999.
55. Chiu C, Hamilton RM: Evolution of the QT interval in children with congenital complete heart block. North American Society of Pacing and Electrophysiology, Toronto, Ontario,
May 1, 1999.

56. Lee-Poy MF, Zhao S, Silverman ED, Borgess C, Isacovics B, Hamilton RM: Fetal and neonatal manifestations in a murine model of congenital heart block, including fetal echo assessment. North American Society of Pacing and Electrophysiology, Toronto, Ontario,
May 1, 1999.
57. Yetman AT, Lee KJ, Morrow RW, Gow RM, Hamilton RM, McCrindle BW: Factors associated with Exercise Capacity after Repair of Tetralogy of Fallot in the Current Era.
Canadian Cardiovascular Society, Jul 1999.
58. Yetman AT, Lee KJ, Morrow RW, Gow RM, Hamilton RM, McCrindle BW: Factors associated with Exercise Capacity after Repair of Tetralogy of Fallot in the Current Era.
American Heart Association, Jul 1999.
59. Hamilton RM: Fetal and Neonatal Manifestations in a Murine Model of Congenital Heart
Block, Including Fetal Echocardiographic Assessment. Society for Pediatric Research, Jul
1999.
60. Neild LE, Smallhorn J, Taylor G, Mullen B, Silverman E, Silverman N, Finley J, Law
Y, Human D, Seward G, Hamilton R, Hornberger LK: Primary Endocardial
Fibroelastosis Associated with Maternal Anti-Ro and Anti-La Antibodies. American Heart
Association, Jul 1999.
61. Neild LE, Smallhorn J, Taylor G, Mullen B, Silverman E, Silverman N, Finley J, Law
Y, Human D, Seward G, Hamilton R, Hornberger LK: Primary Endocardial
Fibroelastosis Associated with Maternal Anti-Ro and Anti-La Antibodies. Canadian
Cardiovascular Society, Jul 1999.
62. Warren A, MacDonald C, Yoo SJ, Hamilton RM: Diagnostic Criteria for Arrhythmogenic
Right Ventricular Dysplasia in Children: Separating the Fat from the Lean. North American
Society of Pacing and Electrophysiology, Washington, DC, Jul 2000.
63. Warren A, MacDonald C, Yoo SJ, Hamilton RM: Diagnostic Criteria for Arrhythmogenic
Right Ventricular Dysplasia in Children: Separating the Fat from the Lean. Association of
European Pediatric Cardiologists, Strasbourg, France, Jul 2000.
64. Dillenburg R, Hamilton RM: Is Exercise Testing a Useful Modality in the Identification of the Congenital Long QT Syndromes? North American Society of Pacing and
Electrophysiology, Washington, DC, Jul 2000.
65. Vohra S, Hamilton RM, Werb S, McGuigan M: Pediatric Tricyclic Antidepressant
Overdose: Is There a Relationship betweeen ECG Changes and Seizure? Canadian Pediatric
Society, Jul 2000.
66. Vohra S, Hamilton RM, Werb S, McGuigan M: Pediatric Tricyclic Antidepressant
Overdose: Is There a Relationship betweeen ECG Changes and Seizure? European
Association of Poison Control Centres and Toxicology, Jul 2000.
67. Vohra S, Hamilton RM, Werb S, McGuigan M: Pediatric Tricyclic Antidepressant

4.
5.
Overdose: Is There a Relationship betweeen ECG Changes and Seizure? Society for Pediatric
Research, Jul 2000.
68. Frank Cecchin, Charles I. Berul, Naomi Kertesz, Robert M. Hamilton, Anne M. Dubin,
Christopher B. Stefanelli,, James C. Perry, Larry A Rhodes, Andrew D. Blaufox,
Thomas Paul, Ruchir Sehra, Maully J Shah: Risks and Benefits of Implantable
Cardiovertor-Defibrillators for Prevention of Sudden Death in Young Patients with
Hypertrophic Cardiomyopathy. ?NASPE, May 14, 2003.
69. Vohra, Hamilton: Maternal Thyroid and Congenital heart Disease. Canadian Pediatric
Society, Aug 2003.
70. Vohra, Hamilton: Maternal Thyroid and Congenital heart Disease. Society for Pediatric
Research, Aug 2003.
71. Dawn Spence, Lisa Hornberger, Robert Hamilton and Earl D. Silverman: The increased risk of Congenital Heart Block (CHB) in infants born to women with hypothyroidism and anti-Ro &/or anti-La antibodies. American College of Rheumatology, Oct 23, 2003.
Other Lectures or Papers Given
1. The Hospital for Sick Children. Department of Critical Care, Toronto, Ontario, 1989.
Temporary Cardiac Pacing in the ICU.
2. The Hospital for Sick Children. Department of Critical Care, Toronto, Ontario, 1990.
Temporary Cardiac Pacing in the ICU.
3. The Hospital for Sick Children. Pediatric Update and Advanced Life Support Course,
Toronto, Ontario, 1991. Cardiology Emergencies.
Telemedicine, Toronto, Ontario, 1991. Chest Pain in Children.
The Hospital for Sick Children. Department of Pediatrics. Resident Lectures, Toronto,
Ontario, 1991. Diagnosis and management of Supraventricular Tachycardia.
6. The Hospital for Sick Children. Pediatric Update and Advanced Life Support Course,
Toronto, Ontario, 1992. Cardiology Emergencies.
7. The Hospital for Sick Children. Pediatric Grand Rounds, Toronto, Ontario, 1992. New
Modalities in Arrhythmia Management.
8. The Hospital for Sick Children. Department of Anesthesia, Toronto, Ontario, 1992.
Pacemakers: Preoperative Evaluation, Indications for Preoperative Pacing and Intraoperative
Management.
9. The Hospital for Sick Children. Emergency Medicine Journal Club, Toronto, Ontario, 1993.
Emergency Management of Patients with Implantable Defibrillators.

10. The Hospital for Sick Children. Pediatric Residents Lecture Series, Toronto, Ontario, 1994.
Supraventricular Tachycardia.
11. The Hospital for Sick Children. Pediatric Residents Lecture Series, Toronto, Ontario, 1995.
Supraventricular Tachycardia.
12. The Hospital for Sick Children. GI Rounds, Toronto, Ontario, 1996. Cisapride and QT prolongation.
13. The Hospital for Sick Children. Cardiovascular Surgery Rounds, Toronto, Ontario, 1996.
Pacing and Electrophysiology for Surgeons.
14. The Hospital for Sick Children. Cardiology Program Education Day, Toronto, Ontario, 1996.
Pediatric Arrhythmias.
15. St. Michaels Hospital. Electrophysiology Rounds, Toronto, Ontario, 1997. Atrial Flutter following Congenital Heart Disease.
16. The Hospital for Sick Children. Department of Pediatric Laboratory Medicine Rounds,
Toronto, Ontario, 1998. A Hundred Years of Congenital Heart Block: Have We Learned
Anything.
17. Hospital for Sick Children. Pediatric Update, Toronto, Ontario, 1998. Quick Hits: Cardiac
Causes of Syncope in Children.
18. The Hospital for Sick Children. Children's Heart Association (CHASE), Toronto, Ontario,
Jul 1999. Pacemakers in Children.
19. The Hospital for Sick Children. Neonatal Cardiology, Toronto, Ontario, Jul 2000.
Congenital Heart Block, Failure and Cyanosis.
20. The Hospital for Sick Children. CV Surgery Rounds, Toronto, Ontario, Jul 2000. Outcome and Arrhythmias in Tetralogy of Fallot.
21. The Hospital for Sick Children. Pediatric Update, Toronto, Ontario, Jul 2000. Quick Hits:
Cardiac Syncope in Children: When is a Faint not just a Faint.
22. Citywide EP Rounds, St. Michael's Hospital, Toronto, Ontario, Apr 25, 2003. LQT in families, ICD in LQT.
23. Hospital for Sick Children, Toronto, Ontario, May 2003. Paediatric Update: Telehealth.
24. SADS Canada, Toronto, Ont., Oct 3, 2003 - Oct 4, 2003. Canadian Sudden Arrhythmia
Death Syndromes Symposium.
25. First Annual Toronto Symposium: Contemporary Questions in Congenital Heart Disease,
Toronto, Ont., May 29, 2005 - May 31, 2005. How should we investigate the child who faints in school assembly?

26. First Sick Kids Conference on Arrhythmias (Hospital for Sick Children Foundation and
SADS Canada), Toronto, Ontario, Jun 17, 2006. The Diagnosis of Arrhythmogenic Right
Ventricular Dysplasia.
27. Toronto Symposium: The Right Heart, Toronto, Ontario, Jun 18, 2006 - Jun 20, 2006.
ARVD: How do we diagnose it?
28. The Hospital For Sick Children, 2007 Paediatric Update, Toronto, ON, Apr 23, 2007 - Apr
28, 2007. Understanding paediatric arrhythmias. (1) Contemporary therapy of common arrhythmias: Who to treat - How to treat - What to send (2) Sudden cardiac arrest in the young - screening, diagnosis and prevention.
29. New Developments in Prenatal Diagnosis and Medical Genetics , Toronto, Ontario, May
16, 2007. The Genetics of Cardiac Arrythmias .
30. Second Annual Sick Kids Conference on Arrhythmias (Hospital for Sick Children
Foundation and SADS Canada), Toronto, ON, Jun 15, 2007 - Jun 16, 2007. Hypertrophic
Cardiomyopathy (HCM): 1) ARVC in the young: Diagnosis and identification of risk factors
2) Research and clinical genetic testing availability in Canada.
31. Pediatric Update, Toronto, Ontario, Apr 15, 2010. Hereditary Arrhythmias.
32. Pediatric Update, Toronto, Ontario, Apr 15, 2010. Pediatric Arrhythmias (Workshop
Organizer/Chair).
Poster Presentations, Scientific Exhibits and Movie Presentations
1. Jaeggi E, Hamilton RM, Kingdom J, Roman KS, Nii M: Assessment of fetal atrioventricular time intervals by tissue doppler and pulse doppler echocardiography: normal values and correlation with fetal electrocardiography. (Poster presentation) Association for
European Paediatric Cardiology, 41st Annual Meeting of The Association for European
Paediatric Cardiology, Basel, Switzerland, May 24, 2006 - May 27, 2006.
2. Chiu CC, MSc, Gow RM, MD, Hamilton RM, MD, Kirsh JA, MD, Gross GJ, MD, De
Souza L, BSc and Stephenson EA, MD: Bipolar epicardial pacemaker oversensing problems in children. (Poster presentation) Heart Rhythm Society, 28th Annual Scientific
Sessions of Heart Rhythm Society May 9-12, 2007, Denver, CO, May 9, 2007 - May 12,
2007.
3.
Gao D, Gross GJ, Hamilton RM, Stephenson EA, Kirsh JA: Electrograms in successful cryoablation of AVNRT differ from those in radiofrequency ablation. (Poster presentation)
Heart Rhythm Society Annual Meeting 2007, Denver, CO, May 9, 2007 - May 12, 2007.
I : Innovative Research Programmer Development
Basic

1993-1996 : In collaboration with Dr.Earl Silverman of the Division of Rheumatology, and with
Main operating grant support, I developed a programme for the immunologic, echocardiographic, electrocardiographic and outcomes assessment of the fetus or neonate affected by maternal aut immune disease.
1995-2000 : I developed a reproductible animal model (Langendroff rabbit) of congenital heart block to provide for detailed assessment of the antibody and antigen responsible for this disease.
1997-2000 : I have developed of an in vivo autoantigen-immunized mouse model of congenital complete heart block, and adapted an Embryonic Cardiac Doppler technique for assessment of rhythm in this model. A March, 1997 MDC operating grant application was highly rated (3.9-4.0).
The requested pilot data was achieved through a Pediatric Consultants grant and a reapplication was submitted (March 1, 1998) and resulted in a successfully funded 3-Yr MRC award which began in
November of 1998.
1997-2000
II : Innovative Research Development Programme Development
Applied
1999-2000 : I have investigated technologies for non-invasive fetal ECG acquisition using customized hardware and software. I am evaluating and adapting a device designed by MEDCO to determine it's utility in fetal heart disease and rhythm disorders. This project is the basis for all funded patient-based research seed grant (2 years, beginning April, 1999), and pilot data obtained has formed the basis for a multi-centered Heart and Stroke Foundation operating grant application.
This application recently missed external funding by one slot, and will be appropriately revised to obtain funding in the September, 2000 competition.
1992-2000 : I initiated the application of signal-averaged electrocardiography to children, including the development and publication of clinical normal values for 5 to 15 year olds. This technique saw multiple cardiac electrical depolarization signals (QRS), allowing for the assessment of late sign indicative of cardiac conduction delays. These "late potentials" are markers for areas of disease myocardium, such as in cardiac transplant rejection, right ventricular dysplasia, and other cardiac conditions predisposed to arrhythmias. These applications have been summarized in the
Australian MD thesis of Dr.Andrew Davis. The sensitivity and specificity of late potentials in the diagnosis of pediatric arrhythmogenic right ventricular dysplasia is now being assessed.
1999-2000 : Just as the ventricular QRS signal can be averaged for the detection of late potential atrial P-wave signal-averaged ECGs can be assessed. We have therefore begun to assess whether
P-wave signal-averaged measurements can differentiate patients with or without atrial for episodes following complex atrial repairs of congenital heart disease.
1999-2000 : The assessment of measures of heart rate variability (HRV) have become important for understanding the relative autonomic influences on the heart, and in predicting outcomes such as sudden cardiac death. We are evaluating the application of clinical HRV software to the assessment of HRV measurements in children. In particular, we are investigating two particular groups where automatic abnormalities are identified or suspected:the pediatric patient post-transplant, and the

pediatric patient undergoing tilt table testing.
1999-2000 Applied Research : See also Impedance Cardiogarphy, Antitachycardia Pacing
III : Innovative Research Programme Development
Clinical
1999-2000 : In collaboration with Dr.Allan Coates, we have combined the cardiac and pulmonary exercise laboratories into a single cardioplumonary exercise unit and are expanding the capabilities and scope of the lab to support bot clinical care and clinical investigation. We have developed the ability to assess pulmonary variables, anaerobic threshold and peak VO2 and step state cardiac output, and are developing the ability to measure beat to beat indices of cardiac outputs and diastolic function using impedance cardiography.
I have developed three protocols for the assessment of all these factors in subgroups pf fontan patients (one co-developed with Dr.V.Arsdell), and have been funded to complete these studies.
1999-2000 : In collaboration with Drs.Bob Campbell and Gerry Serwer and with the support of
Medtronic International, a new antitachycardia pacemaker, the AT500
Media Work
1) Children's Miracle Telethon: ICDs in children. 1995
2) Discovery Channel: "Separate Lives" (The Jamal Conjoined Twins). 1996
(Gemini Award-Winning Documentary)
3) Fifth Estate: The Long QT Syndrome. 1997
4) CBC Market Place: Long QT syndrome. Sept. 23, 1997
RESEARCH AND INVESTIGATION
Senior Investigator's Name Appears in Bold
Research Funding:
Histology and whole cell currents in a canine model of atrial cryoablation. Hamilton RM, Mary
Hamra, Jeffrey Moak: Abercrombie Foundation of the Texas Children's Hospital ($15,490 1988 -
1989)
Auto-antibodies in neonatal lupus erythematosus. Silverman E, Hamilton R (Co-PI): Medical
Research Council ($356,385 1993 - 1996)
Murine Model of Congenital Heart Block: Effects of Prednisolone Therapy on Fetal Wastage and
Rhythm. Hamilton R: Pediatric Consultants ($4,000 1997)
Investigation of congenital heart block using animal models. Hamilton RM, Silverman ED,

Hornberger LK: Canadian Institutes of Health Research ($202,759 1998 - 2001)
Animal models of immune-mediated conduction system disease. Hamilton R, R Silverman (coinvestigator): Medical Research Council of Canada, now the Canadian Institutes of Health Research
($72,331 2001 - 2002)
Maternal Autoantibodies in Pregnancy and Congenital Atrioventricular Heart Block. Hornberger
L, Hamilton R (Co-PI): March of Dimes Foundation ($97,216 1998)
Fetal electrocardiography, patient-based research. Hamilton RM: The Hospital for Sick Children
($23,000 1999 - 2001)
Evaluation of indirect fetal ECG in fetal cardiac diagnosis. Hamilton R (PI), Hornberger LK: Seed
Grant, The Hospital for Sick Children ( $ ($35,605 2001-2004)
Can Cardiopulmonary Exercise Testing with Impedence Cardiography Identify Optimal
Interventions in Children with Congenital Heart Disease? Coates A, Hamilton RM: The Hospital for
Sick Children ($35,605 2001 - 2003)
Patient-based research committee: A case-control study to examine relationship between maternal hypothyroid/thyroid replacement therapy and congenital heart disease, pilot study. Hamilton RM ,
Vohra S : (Approved by committee, funded by Cardiology Divisional Research Funds) ($24,000
2000 - 2002)
Patient-based research committee: Supraventricular tachycardia in infants. Gross G, Hamilton RM:
(Approved by committee, funded by Cardiology Divisional Research Funds) ($5,000 2000 - 2002)
Anticoagulation Post-Fontan/ Closure of ASD's - The Paediatric Heart Disease Clinical Research
Network. McCrindle BW (PI), Williams WG, Benson L, Smallhorn J, Yoo SJ, Hamilton R, Massicotte
P, West L, Rabinovitch M, Bohn D, Holtby H: The National Institutes of Health ($2,199,976 2001 -
2006)
Fetal Electrocardiography, Heart and Stroke Foundation of Ontario, Operating Grant #NA-4852,
Robert Hamilton (PI), $137,449, July 1, 2001 to June 30, 2004
Maternal Autoantibodies in Pregnancy and Congenital Atrioventricular Heart Block.
Hornberger L,
Hamilton R (Co-PI): Operating Grant 6FY00-252, March of Dimes Foundation ($97,216 2001 -
2004)
Cardiac Genetics. Robert M. Hamilton, Peter Ray, Stephen Scherer: Sir Jules Thorn Charitable
Trust ($99,000 2002 - 2004)
Molecular Expression and Physiology in Developing Atrioventricular Nodal Cells, Canadian
Institutes of Health Research (CIHR), Operating Grant: Cardiovascular A, Robert Hamilton , PI,
$370,500, 10/2006 to 09/2009
Intercalated Disc Protein Expression in Arrhythmogenic Right ventricular Cardiomyopathy, Heart and Stroke Foundation of Canada (HSFC), Operating Grant NA6379, Robert Hamilton , PI,

$144,800, 07/2008 to 06/2010
Pregnancies at risk of immune mediated fetal heart disease: Role of serial fetal monitoring and early treatment in preventing complete atrioventricular block. Jaeggi E (PI), Hamilton R,
Hornberger L, Laskin C, Ryan G, Silverman E, Smallhorn J: The Hospital for Sick Children Research
Institute Seed Grant ($31,538 2003-2005)
Molecular mechanism of congenital heart block. Hamilton RM (PI), Silverman ED, Gross GJ:
Canadian Institutes of Health Research ($25,000 2005-2006)
Hypertrophic Cardiomyopathy Parent/Patient Education Meeting, Sickkids Foundation, $5000, Jan
31, 2007
Cardiac gene bank. Mital S (PI), Hamilton R, Coles J: Labatt Heart Centre Fund ($100,000 2008-
2010)
Molecular expression and epitopes in congenital heart block. Hamilton R (PI), Jaeggi E, Silverman
ED: ICRH Mandate Bridge Funding ($100,000, 07/2010 to 06/2011 )
Exome sequencing to identify the gene underlying Alveolar Capillary Dysplasia, a rare cause of pulmonary hypertension lethal to infants, Rare Diseases Foundation, 2012. $3500.
Exome sequencing to identify a new gene underlying Arrhythmogenic Right Ventricular
Cardiomyopathy (ARVC), Rare Diseases Foundation, 2012. $3500.
Exome sequencing to identify the gene underlying Congenital Junctional Ectopic Tachycardia (CJET),
Rare Diseases Foundation, 2012. $3500.
Identification of genes predisposing to idiopathic Ventricular Fibrillation, Rare Diseases Foundation,
2013. $3500.
Identification of genes predisposing to Familial Arrhythmia Syndrome, Rare Diseases Foundation,
2013. $3500.
Exome-sequencing for identification of rare genetic variants and novel genes contributing to
Brugada Syndrome, Rare Disease Foundation and the BC Children’s Hospital Foundation (BCCNF),
July 10, 2013 $3,500.
Identification of genes predisposing to Sudden Cardiac Death with Gene-elusive conduction system disease, Rare Disease Foundation and the BC Children’s Hospital Foundation (BCCNF), July 10, 2013
$3,500.
Identification of genes predisposing to Sudden Cardiac Death, Rare Disease Foundation and the BC
Children’s Hospital Foundation (BCCNF), July 10, 2013 $3,500.

CIHR Emerging Team in ARVC Research, Canadian Institutes of Health Research (CIHR),
Emerging Team Grant, Robert Hamilton , PI, $2,499,925, 12/2009 to 11/2014
Congenital Heart Block Research Network, Institute of Infection and Immunity, June 1. 2012 to May
31, 2015, CIHR Ref # NC4-122933 $311172
Cardiac Antibodies as a Mechanism for Right ventricular Hypertrophy in Epidermolysis Bullosa,
Sajic , Dusan; Pope, Elena; Lara-Corrales, Irene; Hamilton, Robert (coinvestigator) Canadian
Dermatology Foundation, $5,000
CLINICAL/CLINICAL RESEARCH TRAINEES
Location of EP trainees and publications arising from EP fellows during their fellowship training
Fellow Authors Title
Dr. Urs Baursfeld
(Zurich, Switzerland)
Dr. Andrew Davis
Melbourne, Australia
Bauersfeld U, Gow
RM, Hamilton RM,
Izukawa T.
Gladman G, Davis
AM, Fogelman R,
Hamilton RM, Gow
RM.
Davis AM, McCrindle
BW, Hamilton RM,
Moore-Coleman P
Davis AM, Gow RM,
McCrindle BW,
Hamilton RM.
Treatment of atrial ectopic tachycardia in infants < 6 months old.
Torsade de pointes, acquired complete heart block and inappropriately long
QT in childhood.
Normal values for the childhood signalaveraged ECG.
Clinical spectrum, therapeutic management, and follow-up of ventricular tachycardia in infants and young children.
Journal Year
Am
Heart J.
1995
Can J
Cardiol
Pacing
Clin
Electro physiol.
Am
Heart J
1996
1996
1996
Dr. Rami Fogelman
Petta Tikva, Israel
Berkovitch M, Matsui
D, Fogelman R, Komar
L, Hamilton R,
Johnson D.
Fogelman R, Gow RM,
Casey F, Hamilton RM.
. 1997 Jul-
Assessment of the terminal 40millisecond QRS vector in children with a history of tricyclic antidepressant ingestion.
Pseudoinfarction pattern in an infant.
Pediatr
Emerg
Care
Pediatr
Cardiol
1995
1997

Dr. Felicia Figa
Fort Belvoir, VA
(U.S. Army)
Dr. Edgar Jaeggi
Fetal Cardiology,
Sickkids, Toronto
Dr. Anji Yetman
Salt Lake City, Utah
Dr. Anil Menon
Brampton, Ontario
Aug;18(4):312-4.
Figa FH, McCrindle
BW, Bigras JL,
Hamilton RM, Gow
RM.
Figa F, Chiu C, Gow
RM.
Figa FH, Gow RM,
Hamilton RM,
Freedom RM.
Jaeggi E
Hamilton R
Gow R .
, Chiu C
,
,
Gilljam T ,
Risk factors for venous obstruction in children with transvenous pacing leads.
Unusual electrophysiological findings in atrioventricular node reentrant tachycardia.
Clinical efficacy and safety of intravenous
Amiodarone in infants and children.
Adenosine-induced atrial proarrhythmia in children.
Yetman AT, Hamilton
RM, Benson LN,
McCrindle BW.
Yetman AT, McCrindle
BW, MacDonald C,
Freedom RM, Gow R.
N Engl J Med. 1998
Menon A , Silverman
ED , Gow RM ,
Hamilton RM .
Long-term outcome and prognostic determinants in children with hypertrophic cardiomyopathy.
Myocardial bridging in children with hypertrophic cardiomyopathy--a risk factor for sudden death.
Chronotropic competence of the
(Non-EP publications) sinus node in congenital complete heart block.
Can J
Cardiol
J Am
Coll
Cardiol.
N Engl J
Med
Am J
Cardiol
Pacing
Clin
Electro physiol
Pacing
Clin
Electro physiol
Am J
Cardiol
1997
1997
1994
1999
1998
1998
1998
Dr. Pim Soongswang
Bangkok, Thailand
Dr. Thomas Gilljam
Gothenburg, Sweden
Jaeggi ET, Gilljam T,
Bauersfeld U, Chiu C,
Gow R.
Electrocardiographic differentiation of typical
Am J
Cardiol.
2003

Dr. Rejane Dillenburg
Hamilton, Ontario
Dr. Shu Sanatani
Vancouver, B. C.
Jaeggi E, Chiu C,
Hamilton R, Gilljam T,
Gow R.
Dillenburg RF,
Hamilton RM.
Sanatani S, Chiu C,
Nykanen D, Coles J,
West L, Hamilton R.
Sanatani S, Hamilton
RM, Gross GJ.
Sanatani S, Peirone A,
Chiu C, Human DG,
Gross GJ, Hamilton
RM. atrioventricular node reentrant tachycardia from atrioventricular reciprocating tachycardia mediated by concealed accessory pathway in children.
Adenosine-induced atrial proarrhythmia in children.
Is exercise testing useful in identifying congenital long QT syndrome?
Evolution of heart rate control after transplantation: conduction versus autonomic innervation.
Predictors of refractory tachycardia in infants with supraventricular tachycardia.
Use of an implantable loop recorder in the evaluation of children with congenital heart disease.
Can J
Cardiol.
1999
Am J
Cardiol.
2002
Pediatr
Cardiol.
Pediatr
Cardiol.
Am
Heart J
2004
2002
2002
Svetlana Tisma-
Dupanovic
Kansas City, U.S.A.
Maria Ilina
U.K.
2008-9
Ilina MV, Kepron CA,
Taylor GP, Perrin DG,
Kantor PF, Somers
GR.
Undiagnosed heart disease leading to sudden unexpected death in childhood: a retrospective study.
Pediatri cs.
2011
Sep;12
8(3):e5
13-20.
Epub
2011

Dr. Orhan Uzun
Cardiff, Wales
Dr. Ilan Buffo
Winnipeg, Manitoba
Dr. Armando Alfaro
San Jose, Costa Rica
2011
Aug 8
(completed a publication from B.C. adult EP program)
Sequeira IB, Kirsh JA,
Hamilton RM, Russell
JL, Gross GJ.
Chiu CC
Souza L
RM
GJ ,
,
,
,
Fenwick L
Gao D
Huh J
Ramirez A
,
,
,
,
Alfaro-
De
Clegg R ,
Hamilton
Kirsh JA , Gross
Stephenson EA .
Utility of exercise testing in children and teenagers with arrhythmogenic right ventricular cardiomyopathy.
A prospective pediatric clinical trial of digital music players: do they interfere with pacemakers?
Am J
Cardiol.
2009
J
Cardiov asc
Electro physiol.
2009
Robin Clegg
Calgary, Alberta
Anders Nygren
Goteborg, Sweden
Dr. Khalid Dagriri
Riyadh, Saudi Arabia
(6 month fellowship)
Saleh Al-Ghamdi, M.D.,
Majid I. Al-Fayyadh,
M.D., Robert M.
Hamilton, M.D.,
M.H.Sc.
Potential new indication for ivabradine: treatment of a patient with congenital junctional ectopic tachycardia
Dr. Hans Odland
Oslo, Norway
DR. Neil Seller
Capetown, South Afr.
Dr. Christian Turner
Sydney, Australia
Dr. Dominic Hares
Leeds, U.K.
Dr. Jeffrey Vinocur
USA
Dr. Jason Wildschut
Australia
Dr. John Jacob,
India
Dr. Khyati Pandya,
USA
Sharmila Udupa
Hiroshi Asaki
(8 Ped. Card. publications)
(in progress)
(in progress)
(in progress)
(in progress)
(in progress)
2009
2010
2010
2011
2012
2012
2013
2013
2013-
14
2013-
2014

Santoch Dhillon
RESEARCH TRAINEES
Hiroshi Suzuki, research fellow, autoimmune congenital heart block, 2002-2004
Masaki Nii (co-supervised), research fellow, fetal electrocardiography, 2004-2006
Regan Williams (co-supervised), Graduate Student, Ablate and Pace model of heart failure in
Doberman Pinschers, DVM, Ont. Vet C., UGuelph, 2008-2010
Vanessa French (co-supervised), Arrhythmogenic Right Ventricular Cardiomyopathy, MSc,
Memorial University of Newfoundland
Jeremy Orr(co-supervised), Graduate Student, Arrhythmogenic Right Ventricular, 2010-2012
Cardiomyopathy in Boxer Dogs , DVM, Ont. Vet C., UGuelph
Jane Schneiderman-Walker (cosupervised), Exercise Physiology in Children, PhD, University of
Toronto, 2005-2012
Linn Strandberg, Autoimmune Congenital Heart Block, post-doctoral fellow, 2011-2012
Yuqing (Jane)Yuan, ARVC and Autoimmune Congenital Heart Block, post-doctoral fellow
Tamara T. Koopmann Cardiovascular Genetics, post-doctoral fellow, 2012-2014
SELECTED SUMMER STUDENTS PERSUING ELECTROPHYSIOLOGY
Ciorsti MacIntyre
RESEARCH OBSERVERS
Kit-Yee Chan
Hasri Samion
Luc
Sarupim Soongswang
Paweena
HONOURS AND AWARDS RECEIVED
Ciba-Geigy Medical Research Scholarship. 1979
Dalhousie Medical Research Scholarship. 1980
Canadian Diabetic Association Clinical Fellowship. 1984

Dalhousie Board of Governors Clinical Fellowship. 1985
Hospital for Sick Children Foundation Duncan L. Gordon Fellowship. 1988
William Osler Library of the History of Medicine Award. 2004
Featured Research, Canadian Cardiovascular Congress: Abnormal Cardiomyocyte Connexin
Expression in Arrhythmogenic Right Ventricular Cardiomyopathy caused by Heterozygous
Desmosomal Protein Mutations. 2007 (to trainee, Lee Fidler)
Lupus Fndn. Of America Finzi Fellowship. 2011 (to trainee William Yuen)
Carter Heart Rhythm Fellowship, $150,000, 2012-2014 (to trainee Tamara T. Koopmann)
1st prize at Medical Students Research Day, U. of Toronto, 2013 (to trainee Michael Fridman)
COMMITTEE INVOLVEMENT
Department of Paediatrics Committees
- Clinical Advisory Committee, Member
1998 - 2003
Hospital Committees
- Clinical Advisory Committee, Department of Pediatrics, The Hospital for Sick Children, Toronto,
Ontario, Member
1999-2004
- Resuscitation Committee, The Hospital for Sick Children, Toronto, Ontario, Member
1999
- Patient Monitoring Task Force, The Hospital for Sick Children, Toronto, Ontario, Member
2000
- Task Force: Duty of Care, The Hospital for Sick Children, Toronto, Ontario, Member
2000
- Medical Staff Association, The Hospital For Sick Children, Toronto, ON, Review Committee -
Division of Nephrology
Feb 2007
Research Institute
1999 Clinical Research Secretariat, Member

Medical/Scientific Organizations-Committees/Affiliations
2010-13 Canadian Institutes of Health Research: Doctoral Research Awards
Committee (~22 submissions reviewed each year)
2011-2012 Canadian Institutes of Health Research: Masters Award Review
Committee (~10 submissions reviewed)
Canadian Heart Rhythm Society
2006 - 2010 Consensus Committee on Genetic Testing, Member & Subcommittee
Chair
Health Canada
2007 - 2009 Expert Advisory Committee on the Vigilance of Health Products,
Member
2008 - 2009 Expert Advisory Panel on Trasylol, Chair
2011
1993 - 1997
Expert Advisory Panel on Caffeinated Drinks, Member
Health Care Computerization Committee
Member
Heart Rhythm Society
2005 - 2007 Program Committee, Member. Responsible for Pediatric Track of the
Annual Scientific Sessions
2007 – 2011
2011 – present
Scientific and Clinical Documents Committee, Member
Heart Rhythm Journal Editorial Board
2013 – present
1994 - 1995
Content Experts Committee Co-Chair, International Board of Heart
Rhythm Examiners
Metropolitan Toronto District Health Council Hospital Restructuring Committee
Diagnostic and Therapeutic Services Task Force, Member

Ministry of Transport
2001 - present Cardiac Review Committee, Member
North American Society of Pacing and Electrophysiology
1999 Fellowship Committee, Member
Pediatric Electrophysiology Society
Feb 1, 2007 - Present Selection Committee, Wil Webster award in Pediatric
Electrophysiology, member
Other
1994
1994
Cardiology Web-site Administrator
Competency Program in Pediatric Cardiology, Setting/administering exam
1995 - 1998
1997 - 2005
1997 - present
1999
Cardiology Database Committee, Member
Duncan L. Gordon Fellowship Selection Committee, Member
Medical Student Research Day, Judge
CCS Consensus Panel on the Prevention of Sudden Cardiac Death,
Member
2010 – present Canadian Journal of Cardiology Editorial Board
SADS Canada (Sudden Arrhythmic Death Syndrome Foundation)
1995 - Present Board of Directors, Member and Scientific Advisor
Heart Rhythm Society
Abstract Reviewer
Review and score 103 pediatric and adult congenital abstracts for Heart Rhythm Society Annual
Scientific Sessions
Heart Rhythm Journal

Editorial Board 2011 - present
Telemedicine
Canadian Society of Teleheath
Scientific Abstract Reviewer
MEDICAL/SCIENTIFIC ORGANIZATIONS-MEMBERSHIPS
- 1986-present Fellow of the Royal College of Physicians of Canada
- 1987-1989 Canadian Cardiovascular Society (Associate Membership)
- 1988-1989 Houston Electrophysiology Society (Member)
- 1988-1991 American College of Cardiology (Affiliate Membership)
- 1989-present Canadian Cardiac Electrophysiology Society/Canadian Heart Rhythm Society
(Member)
- 1989-present Pediatric Electrophysiology Society (Member)
- 1990-present North American Society of Pacing and Electrophysiology (Member)
- 1991-present American Heart Association Council on Cardiovascular Disease in the Young
(Member)
- 1995-present Cardiac Electrophysiology Society (Member)
- 1996-present International Society of Computerized Electrocardiography
- 1996-present International Society of Electrocardiography
- 1996-present Society for Pediatric Research
- 2000- present Pediatric Academic Society
- 2000-present Canadian Cardiovascular Society
- 2003-present American Telemedicine Association
- 2003-present Canadian Society for TeleHealth
- Health Canada - 2007-2009 Expert Advisory Committee on the Vigilance of Health Products
- Heart Rhythm Society - 2005-2007 Program Committee, Member. Responsible for Pediatric

Track of the Annual Scientific Sessions
- Heart Rhythm Society - 2007-2011: Scientific and Clinical Documents Committee Member
- Pediatric and Congenital Electrophysiology Society: 2009-present: Education Subcommittee member
2010-present: Multicenter Pediatric and
­Adult Congenital EP Quality Initiative
(MAP-IT) committee member
Other
Medical Student Research Day, Judge
Canadian Journal of Cardiology Editorial Board
1997 – present:
2010 – present:
Other Activities
Ad-hoc Reviewer
1) NASPE
2) Journal of Rheumatology
3) European Journal of Cardiology
4) American Journal of Cardiology
5) CRITICAL CARE MEDICINE
6) The Hospital for Sick Children Research Institute
7) The Hospital for Sick Children Foundation
8) Heart and Stroke Foundation
9) Pediatric Research
10) Clinical Science
11) Canadian Journal of Cardiology
12) Pediatric Cardiology
13) Toronto Hospital Committee for Research on Human Subjects
14) Circulation
15) Heart Rhythm Journal

CREATIVE PROFESSIONAL ACTIVITY
3D Mapping: Enhancing safety in Pediatric Catheter Ablation
The surgical repair of congenital heart disease frequently results in the late complication of complex forms of atrial flutter. These complex atrial arrhythmias usually differ from "typical" atrial flutter seen in adults, but are frequently treatable by catheter ablation techniques. Because of their complexity, it is desirable to have a three-dimensional technique to display the anatomical substrate of the atrial endocardium and its sequence of activation.
The ideal system is inexpensive to use, easily applicable to a wide varity of cases, and allows for the use of any ablation technology (hot-tip or cold-tip). I run the only Canadian center dedicated to 3D mapping and ablation in pediatric arrhythmias, and have evaluated, acquired and developed a successful experience using multiple mapping systems including those based on magnetic positioning (CARTO), inverse solution mapping (ESI) and impedance-based catheter positioning
(Localisa and NAVX). By working with the latter technology, I have been able to reduce the number of lesions delivered (increasing safety) and accurately deliver insurance lesions (incresing efficacy).
Our use of this technology allows for the use of our crocatheter technology in ablation of these complex pediatric arrhythmias, which is a novel application. At the same time, we are comparing the anatomical accuracy of each of these techniques.
Antitachycardia Pacing in Children
Antitachycardia Pacing in Children
Cardiac Genetic Clinic, DNA Bank and Gene Sequencing Program
I developed a Cardiac Genetics Clinic and DNA banking program for both research and clinical care in 1998 with collaborators Peter Ray and Steve Scherer . Families with high-risk heritable heart conditions are seen and assessed as a unit. Proband DNA is banked and up to 2004 was sent to research colleagues either within or outside HSC depending on the suspected condition. For large family cohorts with undiagnosed familial conditions, candidate genes have been sequenced locally through collaboraton with Dr. Steve Scherer (PRKAG2, HCN4, PKP2, DSG2, DSP). Beginning in
2004 with the advent of North American clinical testing sites for many heritable arrhythmia conditions, we initiated a streamlined urgent process for assessing high risk conditions (Long QT
Syndrome, Hypertrophic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy) through American CLIA-approved laboratories (Genaissance, Harvard Partners Laboratory, Johns
Hopkins respectively) under Ontario Ministry of Health approvals. For non-CLIA approved genes
(DSG2, DSP), research sequencing is performed at the Hospital for Sick Children and a CLIA approval process was initiated through a CETT application in collaboration with Peter Ray.
Over 270 patients have undergone DNA banking, with over 100 positive results. Families are undergoing sequential case expansion to identify genetically positive and confirmed negative family members, with appropriate gene-specific counselling and intervention.
Arrhythmogenic Right Ventricular Cardiomyopathy: Clinical and Research programs
1995-2008: As a pediatric electrophysiologist, high-risk hereditary heart rhythm disorders have been a challenging group of patients to diagnose and treat. I recognized early the potential for

prevention of Sudden Cardiac Arrest or Death (SCA/SCD) through the assessment of patients presenting with warning symptoms (exercise syncope) or a family history of SCA or SCD. With the first report of the genes underlying one of these syndromes (LQT, Keating & Curran, 1994) I initiated a DNA banking program for these conditions. When clinical testing became available in
2003, I arranged genetic testing for all these patients, resulting in SickKids being the site for 70% of provincial diagnoses. Subsequently, genetic testing for hypertrophic cardiomyopathy (HCM) became available and I organized a patient conference on HCM including the option of genetic testing. Clinical genetic testing for Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) remained limited or unavailable, so I translated our research testing program to SickKids Clinical
Molecular Diagnostics laboratory under a 5 year NIH project called Clinical Education and Test
Translation (CETT) resulting in our lab being listed on genetests.org.
SickKids clinical laboratory continues to perform ARVC gene testing on most Ontario patients, and on New Zealand patients. I succeeded in 2009 in obtaining a $2.5M 5-year grant leading 4 SickKids labs and 3 other UofT labs in gene discovery, functional studies, pathology, protein interactions and drug descovery related to ARVC. This year, I am submitting 2 Genome Canada grants (1 as PI, 1 as co-PI) related to gene discovery in SCA/SCD conditions. I also collaborate with and International
Genome Consortia for gene discovery in LQT and Brugada syndromes. I was a member of 2 panels providing guidelines for Cardiac Genetic testing (Canada, US & Europe, 2011), organized a Toronto cardiac genetics symposium and was invited to speak at the 3 rd Cardiff cardiac genetics symposium.
The development of clinical genetic testing for Arrhythmogenic Right Ventricular Cardiomyopathy has improved the diagnosis of this life-threatening condition, and gene-testing frequently avoids the need for invasive cardiac catheterization and endomyocardial biopsy for the condition, along with the attendant risk of complication. Genetic testing, where positive, allows for cascade screening of family members to identify those requiring further monitoring of their disease and those who can be discharged from follow-up. I have seen and assessed 400+ individuals in cardiac genetics clinic at SickKids for ARVC, and the clinical molecular genetics laboratory has performed ARVC gene testing for an additional 400+ individuals outside of SickKids.
The rapid adoption of genetic testing for other high-risk cardiac conditions (LQT SQT CPVT and
Brugada syndromes and HCM) has similarly aided diagnosis and allowed for cascade genetic testing. The development of Cdn., U.S. and European guidelines for the use of cardiac genetic testing has guided other practitioners in the diagnosis and cascade screening of their patients/families.
Gene discovery work which we are leading for ARVC and contributing to for LQT/Brugada syndromes will allow for identification of remaining genes underlying these conditions, resulting in further success in diagnosis and cascade screening. For some conditions, the specific gene mutation and/or genetic modifiers also contribute to risk, such that a specific risk 'prescription' can be provided to individuals with these conditions.
The developing AV node and its diseases (Congenital Heat Block; CHB and Congenital
Junctional Ectopic Tachycardia; CJET)
1990's to 2008: Congenital heart block (CHB) has always been a strong passion of mine in translational research and clinical care, as it should be a preventable condition. However, little is understood about the specific antibody and its protein/cellular target in the fetal heart. Dr.
Silverman and I identified (some) antibody CHB predictors in neonatal lupus in 1995, and outcomes of mothers in 1996. In 2002, Dr. Jaeggi and I sowed that CHB outcome also related to age at diagnosis (fetus, newborn or child), and in 2006 we showed that we could monitor AV nodal conduction in the fetus (echo and fetal ECG. In 1998 I published an isolated rabbit heart model of
CHB, and in 2005 I published an autoimmunized mouse model including assessment of fetal rhythm. I was a coapplicant on CHB grants with Dr. Silverman in the 1990's and PI on a CIHR grant ifunded in 2005.

2009-2012: I received CIHR grant funding to investigate the AV node target of CHB from 2006-
2010, a 4.2 score on a 2011 app., and have applied to March of Dimes in late 2011 and CIHR in
2012. For the International CHB Symposium in 2010, we published and presented 4 basic science abstracts from my lab, and I gave and invited presentation on the molecular genetics of the AV node. We have now identified the protein target of CHB in the AV node, and if antibodies to a specific area of this protein are found in maternal sera, the fetus is highly likely to get CHB. Thus we have found a marker to specifically identify pregnancies at risk for CHB, and have applied for a patent for this biomarker. We have a publication in submission, and through CIHR and/or internal funding optimize this biomarker with the plan of conducting clinical trials of (steroid) therapy targetted to these high-risk pregnancies in the near future. Idnetification of the fetal target will also guide development of specific therapies for CHB.
We are also performing molecular studies of other AV nodal diseases (Cong. and Postop. Junctional
Tach.)
Identification of a biomarker for CHB will allow current therapies to be targeted only to pregnancies that will be affected by a CHB outcome, rather than treating 100 primry pregnancies to autoimmune mothers to prevent 1 CHB, or treating six subsequent pregnancies to a CHB child to prevent one further CHB. Using our biomarker approach, therapy can begin prior to fetal pathology, providing a higher chance of effective prevention with current steroid therapies. Since we have identified the fetal protein target of maternal antibodies resulting in CHB, we eanticipate that we can make better disease models, which should lead to more specific preventive therapies avoiding
CHB. Our understanding of the molecular biology of the developing AV node, along with whole exome genetic studies, is providing an understanding of congenital JET (a rare but serious hereditary disorder) and postoperative JET, which s the most serious and frequent postoperative arrhythmia in congenital heart surgery.
Guidelines for Cardiovascular Considerations of ADHD Medications
Identification of 'signals' consisting of sudden deaths in young individuals on ADHD medication in the previous decade prompted the FDA to require 'Black Box' warnings and Health Canada to require similar warnings, as well as temporarily suspending one ADHD medication in Canada.
Further evaluation determined that (recognizing the problem of under-reporting in adverse event reporting systems) ADHD drug associated deaths were occurring at below the spontaneous sudden death risk of young individuals, and the 'signal' likely only reflected the very widespread use of these medications. Through this period, ADHD prescribers sought guidance as to how to respond to these warnings, and how to evaluate patients for these purported risks.
Beginning in 2009, I co-led the Canadian guidelines response to these issues, resulting in simultaneous guidelines statements in the Canadian Journal of Adolescent and Child Psychiatry,
Canadian Journal of Cardiology and Pediatric and Child Health in 2009. I also led the European
Network on Hyperkinetic Disorders (Eunethydis) and was lead author on their European Gudelines published in Cardiology in the Young in 2011. I am now the invited Keynote Speaker for the
Research and Scientific Program of the Canadian Academy of Child and Adolescent Psychiatry
(CACAP) 2012 Annual Conference, Sept 30 to Oct 2, Montreal.
FDA and Health Canada warnings for ADHD medication resulted in a large burden on healthcare through the excessive use of cardiovascular testing (ECGs) and cardiac referrals where they would not have otherwise been indicated. Although such warnings may have been in keeping with the application of the 'Precautionary Principle' to the very limited data initially available at the time, subsequent large administrative database studies have demonstrated that there is no measurable increase in Sudden Cardiac Death (SCD) risk in the standard patient treated with ADHD medications. A small subgroup of cardiac patients are at intrinsically increased risk of SCD, although this is likely not modified by ADHD medication. Cardiac patients also have a higher prevalence of
ADHD. Thus, ADHD practitioners and prescribers needed a document to guide their practice with

respect to these cardiavascular considerations in ADHD individuals. I led (Europe) and co-led
(Canada)
It is estimated from administrative databases that patient exposure-years to ADHD medications number in the millions worldwide. Thus, Canadian and European guidelines will have a major impact on guiding appropriate evaluation of these patients.
For further studies, I am a member of the European Union Framework Programme 7 Project
ADDUCE (Attention Deficit Hyperactivity Drugs Use Chronic Effects)
Chronic Lead Study
Chronic Lead Study
Cryoablation: Safer Catheter Rx for Arrhythmias in Children
Although we have performed over 1000 catheter ablation procedures in children without any major complication, the broader experience across all centers which perform these procedures for pediatric arrhythmias indicates that atrioventricular (AV) block occurs in 2% of cases. This results in the devastating need for lifelong pacing in these patients. In addition, electrophysiologists may not attempt curative ablation therapy in some patients if they perceive the risk of block is high, and patients often turn down the opportunity of curative ablation therapy when they hear about this possible risk.
A Canadian company, Cryocath Technologies, recently developed a "cold-tip" catheter technology which is capable of cooling the adjacent heart at two levels: a reversible -30 degree lesion or a permanent -70 degree lesion. This allows assessment of the potential effect of a delivered lesion before committing to permanent injury, and should reduce the risk of AV block. I undertook with this company to apply and evaluate this potentially safer technology for catheter ablation of heart rhythm disorders in children. I led our group in obtaining this technology, as well as leading a multicentered pediatric registry.
The program which I created here currently has the largest pediatric experience in catheter cryoablation in the world. We have presented this experience to the North American Society of
Pacing and Electrophysiology (the major international organization for clinical and research cardiac electrophysiologists), the Association of European Pediatric Cardiology and the Charleston
Symposium on International Pediatric Electrophysiology. A manuscript describing the results of our multicentered registry is almost completed.
As a result of this experience and exposure, my program has become a teaching and resource site for this technique in pediatric ablation, with American and international pediatric electrophysiologists coming to visit and observe cases in our clinical laboratory, and frequent calls and correspondence for mentoring in this technique. An example is attached.
Defibrillators in Children
Defibrillators in Children
Fetal Electrocardiography
I have developed and evaluated non-invasive fetal electrocardiography as a clinical tool for the diagnosis of fetal heart rhythm disorders. The device we use is capable of providing within 10 minutes a fetal electrocardiogram acquired from simple electrodes on the mothers abdomen. I have identified the success rate of this technique in relation to the gestation of the fetus, and have

developed normal values for the fetal PR interval, QRS interval and QT interval in relation to gestational age. I am comparing the values measured with this technique with those measured by both fetal echocardiography and fetal magnetocardiography. The accuracy, reproducibility and utility of fetal electrocardiography in fetal cardiology has been the subject of a current Heart and
Stroke Foundation grant for which I am the Principle Investigator.
Real-Time Asymptomatic Event Monitoring
The intermittent and infrequent nature of arrhythmias in children and adults makes documentation difficult. Current options include 24-hour ambulatory monitoring for asymptomatic events, and longer-term external or implantable recorders for symptomatic events. The prognosis of certain relatively common cardiomyopathies appears to be related to the presence or absence of even infrequent asymptomatic ventricular arrhythmias, but these are difficult to document with current recorders. Indeed, the identification af non-sustained asymptomatic events may alter therapy by supporting the application of primary preventive therapies such as an implantable defibrillator.
The advent of small, sophisticated "palm"-based computing devices should allow for real-time analysis and documentation of asymptomatic arrhythmias over a long period of recording. I am working with a local inventor, Kieth Labelle, of New Products, New Technologies Inc. to refine and assess the accuracy and utility of a real-time asymptomatic event recorder in identifying cardiac arrhythmias.
PRACTICE INTERESTS AND AREAS OF SUBSPECIALIZATION
Pediatrics
Pediatric Cardiology
Pediatric Cardiac Electrophysiology
Genetics of High-risk Hereditary Heart Conditions
SIGNIFICANT FUNDRAISING ACTIVITIES
D'Antonio Fundraising Dinner, 1993, ~$20,000
Fundraising: Bestbuy annual dinner and golf fundraiser, 1992-present ~$30,000/year $665K total
Fundraising: Atrens-Councel Insurance Annual Golf fundraiser, Glen Abbey Golf Course, 1994present, ~$120,000/year $1.5M total
Fundraising: Appliance Canada/Caitlin Morris Memorial Golf Tournament, ~1998-present,
~$30K/yr
Fundraising: "Life for Kids" Gala, 2003-2007, ~$70,000/year
Fundraising: "Queen of Hearts" Health Fair, 2007

Fundraising: Pizzi Family Heart to Heart Gala, 2012, TBD
Media Work
1) Children's Miracle Telethon: ICDs in children. 1995
2) Discovery Channel: "Separate Lives" (The Jamal Conjoined Twins). 1996
(Gemini Award-Winning Documentary)
3) Fifth Estate: The Long QT Syndrome. 1997
4) CBC Market Place: Long QT syndrome. Sept. 23, 1997
5) Herbie Fund 2011: Part 4 - CityNews, 2011