Upper Secondary Workshop 2015 Case Module Template Title: Should I Get That Ragdoll? Idea for the case or the case draft Jane loves cats, so she was delighted when her parents finally agreed to buy her a 2 year old Ragdoll. Jane enthusiastically named her Ragdoll Minny. A few months after Minny joined her household, Jane noticed that Minny appeared extremely lethargic, had abdominal swelling, and seemed to be dragging her hind legs along. Alarmed, Jane brings Minny to the vet. She was informed by the vet that Minny has hypertrophic cardiomyopathy – a type of blood disease where the heart muscle thickens. Apparently, this disease is common in the Ragdoll breed. Jane felt shocked as she had never heard of such a thing before. Resources: Include the main simulation or tool used and one additional resource - - Journal Paper: Patterns of molecular genetic variation among cat breeds http://www.sciencedirect.com/science/article/pii/S0888754307002078 virtual pedigree analysis lab at http://virtuallabs.stanford.edu/life/pedigree.swf Two possible investigations that involve students in inquiry (Copy of handout if possible.) Heart structure and function - Find out consequences of thickened heart left ventricular muscle (not able to relax properly), and how it relates to the symptoms of this disease. Inheritance - What are the traits in pet breeding that are desirable to humans? NIE 2014 LS-24 - - - Inbreeding is one of the ways of breeding pets, in order to preserve the gene pool of the desired traits. The word inbreeding typically has a negative connotation to it, but is inbreeding always a bad thing? Use Punnett Squares to show your reasoning. This can also be demonstrated at the virtual pedigree analysis lab at http://virtuallabs.stanford.edu/life/pedigree.swf Are recessive genes are always “bad”? Extend into discussion on ethics of pet breeding. What makes an ethical animal breeder? Two possible student products - Pedigree chart Increasing public awareness on buying pedigree breeds One example rubric Themes/major concepts of Upper Secondary Science Syllabus 2013 addressed Theme Major idea - Artificial selection Inheritance - Evolution (history, development of ragdoll breed) Genes and alleles – dominant and recessive - Structure and function of the heart Transport in Humans Authors and school affiliations Valerie Lim Suat Fong – NUS High School NIE 2014 LS-24 Koh Hsing Dee – Hai Sing Catholic School Tay Wee Beng – CPDD, MOE NIE 2014 LS-24