Posters –
Devices and Imaging
NAME OF THE PROJECT
NAME OF THE MAIN CONTACT
ORGANISATION NAME
Technology
Customers / Target market
APIOS
Catherine PICART
LMGP – Grenoble INP
We have developed a biopolymer based film including growth factors enabling
osteo-induction and bone regrowth, especially in cases of severe bone defaults. Our
technology :
- enables strong and fast bone growth with low BMP doses (cost-effective)
- can be potentially applied to any type of implants (ceramics/polymers/metals of any
shape/geometry/surface texture)
- enables precise control of BMP doses
- reduces patient pain and the need of revision surgery
- can be used with implantable biomaterials already used by surgeons.
- clinicians working on bone repair (orthopedics, spine, maxilla-facial, dentistry)
- veterinarian (repair of severe bone fractures/sefects in animals)
- industrial company in the field of orthopedic/maxilla-facial/dental implants with
products made in polymers, metals or ceramics
- industrial company in the field of pharmaceutics (growth factors production, bone
morphogenetic family of proteins
Industry and competitors
- thin surface coatings made of ceramics (hydroxyapaptite/tricalcium phosphates)
(already commercial products but difficulty in precisely controlling the thickness of
the coating and adhesion to the implant surface)
- surface coatings made of biopolymers (other groups working in the USA, in
Netherlands) – direct competition (at the research /pre-clinical trials stage)
The technology has been maturing for seven years in the lab and has been validated
by several pre-clinical studies in small animals (mice, rats). Industrial partners are
now essential to bring this technology to market.
Financing need / Commercial
opportunity
We are looking for contacts & partners in different application domains of our
technology :
- Orthopaedic/maxilla-facial / dental implants & implant manufacturers
- Compatible with additive manufacturing processes
For veterinary/ human health applications / personalized medicine
IP – Patent situation
Future steps / Milestones
WO2005052035 - Methods for preparing crosslinked polyelectrolyte multilayer films
WO2010081884 - Process for preparing a surface coated by crosslinked
polyelectrolyte multilayer films as a biomimetic reservoir for proteins
- pre-clinical trials in large animals to repair a critical size bone defect
- refine market search in order to define clear priorities
- broaden the technology to a large variety of growth factors (currently proved for
BMP-2 and BMP-7, two growth factors that are approved by regulatory agencies
for bone repair)
- precisely establish the different steps toward a clinical trial in humans
TEDX presentation by Catherine Picart (in French)
Further reading
https://www.youtube.com/watch?v=gk7X5gbcz_w&index=4&list=PL5UBgub1
YWk3_ntSmubjbqZE6IS7Q7XbB
Website : http://lmgp.grenoble-inp.fr
Contact person
Frederique
SOUQ,
Innovation
Frederique.souq@linksium.fr
1/2
Project
Manager,
LINKSIUM,