Degree and Diploma Programs by Graduate Unit 2014-15 SGS Calendar Molecular Genetics Faculty Affiliation Medicine Degree Programs Offered Genetic Counselling—MSc Molecular Genetics—MSc, PhD Collaborative Programs The following collaborative programs are available to students in participating degree programs as listed below: 1. Developmental Biology Molecular Genetics, MSc, PhD 2. Genome Biology and Bioinformatics Molecular Genetics, PhD Overview The Department of Molecular Genetics is administered from the Medical Sciences Building and has nearly 100 faculty members whose labs are located within the Medical Science Building, the Best Institute, the Donnelly Centre for Cellular and Biomolecular Research, the FitzGerald Building, the Hospital for Sick Children, Mount Sinai Hospital, the Ontario Institute for Cancer Research, and Princess Margaret Hospital. The Master of Science program in Genetic Counselling is a full-time professional degree program that prepares students with the academic and clinical skills to provide genetic counselling. Graduates may work as part of a health care team to gather relevant medical and family histories, to guide further investigations, and to communicate probable or established diagnoses, mode of inheritance, natural history, risk of recurrence, and associated options. This program has been accredited by the American Board of Genetic Counseling. The Master of Science and Doctor of Philosophy programs in Molecular Genetics offer research training in a broad range of genetic systems from bacteria and viruses to humans. Research projects include DNA repair, recombination and segregation, transcription, RNA splicing and catalysis, regulation of gene expression, signal transduction, interactions of host cells with bacteria and viruses, developmental genetics of simple organisms (worms and fruit flies) as well as complex organisms (mice), molecular neurobiology, molecular immunology, cancer biology and virology, structural biology, and human genetics and gene therapy. For detailed information on these programs, visit the department's website. 2014-2015 School of Graduate Studies Calendar www.sgs.utoronto.ca/calendar Contact and Address Web: www.moleculargenetics.utoronto.ca Email: graduate.coordinator@utoronto.ca Telephone: (416) 978-8359 Fax: (416) 978-6885 Department of Molecular Genetics University of Toronto Medical Sciences Building Room 4398, 1 King's College Circle Toronto, Ontario M5S 1A8 Canada Degree Programs Genetic Counselling Master of Science Minimum Admission Requirements Applicants are admitted under the General Regulations of the School of Graduate Studies. Applicants must also satisfy the Department of Molecular Genetics' additional admission requirements stated below. An appropriate bachelor's degree from a recognized university with standing equivalent to a University of Toronto B+, both cumulatively and in the final year. Prerequisite courses in biology, molecular biology/genetics, biochemistry, embryology/developmental biology, statistics, and psychology. The development of strong interpersonal skills as evidenced by extracurricular activity is sought in both the application and interview processes. Conditional acceptance may be granted to outstanding applicants lacking the above prerequisite courses; in such instances, the courses deemed necessary must be completed with a B+ standing prior to admission. Program Requirements Students must complete the 14 required courses listed below (6.5 full-course equivalents [FCEs] and laboratory and clinical practicum) with a minimum B standing. Lectures, meetings, and rounds must be attended at a minimum of 85% of scheduled occurrences. There is no thesis requirement, but an independent research project consisting of a limited clinical research study, an extensive literature review from a novel viewpoint, or a new case presentation involving clinical, cytogenetic, and molecular workup will be completed and presented both orally and in written format suitable for publication. Molecular Genetics 1 Degree and Diploma Programs by Graduate Unit Students spend a minimum of 21 months over a twoyear period in full-time attendance. Students are required to organize an intervening summer rotation in a geographic location of their choice. Program Length 6 sessions full-time (typical registration sequence: F/W/S/F/W/S) Time Limit 3 years full-time Required Courses chemistry, computer science, engineering, etc.) are also strongly encouraged to apply. Program Requirements Successful completion of MMG 1010H, MMG 1012H0 (or equivalent), and MMG 1015Y0 (seminar course). A thesis on a research project. Defence of the thesis at an oral examination. Students are required to spend 12 months in full-time attendance. Program Length MSC 2010Y Advanced Concepts in Human Genetic Disease 6 sessions full-time (typical registration sequence: F/W/S/F/W/S) MMG 1120Y+ Clinical Rotations I MMG 1122Y Issues in Genetic Counselling I 3 years 0 Course that may continue over a program. The course is graded when completed. MMG 1124Y Principles of Effective Counselling Doctor of Philosophy MMG 1126Y Clinical Issues in Pregnancy and Child Development Minimum Admission Requirements MMG 1128Y Risk Calculation and Research Methodology MMG 1130Y Tutorial in Molecular Genetics MMG 1132H Laboratory Skills MMG 1220Y Clinical Rotations II MMG 1222Y Issues in Genetic Counselling II MMG 1224Y Advanced Principles of Effective Counselling MMG 1226Y Concepts in Clinical Genetics MMG 1228Y Independent Research Project of the School of Graduate Studies. Applicants must also satisfy the Department of Molecular Genetics' additional admission requirements stated below. Admission via one of three routes: 1. admission into the PhD program with a completed MSc degree or equivalent from the University of Toronto or another recognized university 2. reclassification to the PhD program during the first or second year in the MSc program 3. under exceptional circumstances, outstanding students with a BSc degree, an MD degree, or equivalent, may be accepted directly into the PhD program Attainment of minimum admission standards does not guarantee acceptance into the PhD program. MMG 1230H Cancer Genetic Counselling Extended course. For academic reasons, coursework is extended into session following academic session in which course is offered. + Molecular Genetics Master of Science Minimum Admission Requirements Applicants are admitted under the General Regulations of the School of Graduate Studies. Applicants must also satisfy the Department of Molecular Genetics' additional admission requirements stated below. Normally, a BSc or MD degree or equivalent with excellent academic credentials in molecular biology, genetics, microbiology, and/or biochemistry. Applicants trained in other quantitative sciences (math, physics, 2014-2015 School of Graduate Studies Calendar www.sgs.utoronto.ca/calendar Time Limit Applicants are admitted under the General Regulations Program Requirements Successful completion of MMG 1010H, MMG 1012H0 (or equivalent), and MMG 1015Y0 (seminar course), MMG 1016H0 (or equivalent), and MMG 1017H0. A thesis on a research project. Students entering the doctoral program from a master's program, either through transfer or admission, are required to spend a minimum of two sessions in full-time attendance. Students entering the doctoral program from a bachelor's program are required to spend a minimum of three sessions in full-time attendance. Successful completion of a Qualification Examination in the second year of the program. The Qualifying Exam consists of the submission of a written proposal and an oral examination. If a student is unsuccessful at the first attempt at the Qualifying Exam, there are three possible outcomes: Molecular Genetics 2 Degree and Diploma Programs by Graduate Unit o the student may retake the oral exam within four to eight weeks without revision of the written proposal; o the student may submit a revised written proposal and retake the oral exam within four to eight weeks; o or the student may withdraw from the program. Program Length 4 years full-time; 5 years direct-entry; 5 years transferfrom-master's Time Limit 6 years full-time; 7 years direct-entry; 7 years transferfrom-master's Course List JBB 1425H Biophysical Methods JBB 2025H Protein Crystallography JDB 1024Y Topics in Developmental Biology JDB 1025H Developmental Biology JDB 1026Y Student Seminars in Developmental Biology MMG 1010H Molecular Genetics Colloquium MMG 1012H0 Topics in Molecular Genetics I (formerly MMG 1012Y0) MMG 1015Y0 Seminar MMG 1016H0 Topics in Molecular Genetics II (formerly MMG 1014Y0) MMG 1017H0 Topics in Molecular Genetics III MMG 1420H Regulation of Gene Expression MMG 1425H Signal Transduction and Cell Cycle Regulation MMG 1451H Genetic Analysis of Development: Yeast and Worms Course that may continue over a program. The course is graded when completed. 0 2014-2015 School of Graduate Studies Calendar www.sgs.utoronto.ca/calendar Molecular Genetics 3