CURRICULUM VITAE - Medical University of South Carolina
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CURRICULUM VITAE Date of Document: 11/11 Howard J. Jacob, Ph.D. Director, Human and Molecular Genetics Center Warren P. Knowles Chair in Genetics Professor, Departments of Physiology and Pediatrics Office Address: Medical College of Wisconsin Human & Molecular Genetics Center 8701 Watertown Plank Road, HRC 5th Floor, Rm. #H5160 Milwaukee, WI 53226 Phone: 414/456-4887 Fax: 414/456-6516 Email: jacob@mcw.edu Place of Birth: Topeka, Kansas Citizenship: U.S.A. Major Research Interests: 1. 2. 3. 4. 5. Board of Trustees: Quantitative genetics Genetic dissection of complex disease Disease interaction/target organ damage Integrative physiology NextGen Sequencing and clinical applications 2009 – Present Alverno College 1997 1997 2006 2011 Founder and Chairman of the Board PhysioGenix, Inc. Chief Executive Officer PhysioGenix, Inc Founder and Board Member, PhysioGenix, Inc. Founder and Board member, Primary Genetics Business Activities: Patent Issued: – – – – 2006 2004 2009 Present Rat Model of Diabetic Nephropathy. 650053 - 91657 Education: 1979 - 1983 1984 - 1989 B.S. (Biology) Iowa State University Ames, IA Ph.D. (Pharmacology) University of Iowa Iowa City, IA 1 Postdoctoral Training and Fellowship Appointments: 1989 – 1991 Postdoctoral Fellow 1989 – 1992 Postdoctoral Fellow 1991 – 1992 Hypertension Training Program Harvard Medical School Cambridge, MA Whitehead Institute for Biomedical Research Massachusetts Institute of Technology Boston, MA Postdoctoral Fellow Cardiology Stanford University Stanford, CA Faculty Appointments (Including Secondary Appointments): 1992 - 1996 Assistant Professor 1996 – 1997 Associate Professor 1996 – 2006 1997 – 2001 1999 - Present 1999 - Present Department of Medicine Harvard Medical School Cambridge, MA Department of Physiology Medical College of Wisconsin Milwaukee, WI Associate Professor Department of Pediatrics Children’s Hospital of Wisconsin Milwaukee, WI Associate Professor with Tenure Department of Physiology Medical College of Wisconsin Milwaukee, WI Director Human and Molecular Genetics Center Medical College of Wisconsin Milwaukee, WI Warren P. Knowles Chair of Genetics Medical College of Wisconsin Milwaukee, WI 2001 - Present Professor with Tenure 2006 – Present Professor Department of Physiology Medical College of Wisconsin Milwaukee, WI Department of Pediatrics Children’s Hospital of Wisconsin Milwaukee, WI 2 Administrative Appointments: 1993 – 1994 Organizer 1999 - Present Director 2004 – 2009 2009 – Present Cardiovascular Research Center Seminar Series Massachusetts General Hospital Boston, MA Human and Molecular Genetics Center Medical College of Wisconsin Milwaukee, WI Associate Section Chief of Genetics Children’s Hospital of Wisconsin Milwaukee, WI Vice Chair of Research Department of Research Children’s Hospital & Health System Milwaukee, WI Educational Administrative Positions: 1998 – 2000 Co-Director 1998 – 2004 Director Positional Cloning Course Cold Spring Harbor Laboratory Cold Spring Harbor, NY Physiological Genetics Course Department of Physiology Medical College of Wisconsin Milwaukee, WI Hospital and Clinic Administrative Appointments: 1992 – 1996 Assistant Geneticist Department of Medicine Massachusetts General Hospital Boston, MA Awards and Honors: 1991 1991 1998 1999 1999 2007 2009 Merck, Sharpe and Dohme Travel Award for Outstanding Cardiovascular Research Sokol Post Doctoral Fellowship Award, Whitehead Institute for Biomedical Research Elected Fellow in the Council for High Blood Pressure American Physiological Society, Bowditch Award and Lecturer (Young Investigator Award) Warren P. Knowles Chair of Genetics A. Ross McIntyre Award, University of Nebraska Golden Medal, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava. 3 2011 2011 Milwaukee Regional Research Forum’s T. Michael Bolger Award. Milwaukee WI. Memberships and Professional Scientific Societies: American Association for the Advancement of Science American Physiological Society American Society of Human Genetics American Society of Nephrology Genetics Society of America International Mammalian Genome Society International Society of Nephrology Editorial Boards: 1995 1996 1997 1997 1999 - 1997 – 2004 - 1997 – 2004 – 2005 American Journal of Physiology Genome Research American Heart Association Council for High Blood Pressure Mammalian Genome Physiological Genomics Local/Appointed Leadership and Committee Positions: 1986 – 1987 1999 1999 2000 2000 2000 2000 2000 2000 2001 2001 2001 2001 2002 2003 – Present – Present – Present – Present – 2007 – 2006 2004 – 2008 2006 2006 2006 2008 2009 – – – – – 2008 2008 2008 Present Present Student Representative Faculty Search Committee Department of Pharmacology University of Iowa Iowa City, IA Executive Faculty Committee Human Research Review Committee Animal Research Center Faculty Advisory Committee Arrayer Executive Faculty Committee Barrier Facility Advisory Committee Cancer Center Advisory Committee Medical Scientist Training Program Committee Strategic Issues Group Committee Cancer Center Director Search Committee Educational Retreat Committee Research Strategy Advisory Committee Stem Cell Research Committee BiCore Advisory Committee Physiological Genomics Publications Committee Associate Editor Children’s Research Institute Scientific Advisory and Policy Committee Executive Steering Committee Biomedical Research Advisory Committee Strategic Planning Committee Dean’s Advisory Committee Pediatric Executive Committee 4 2011 – 2014 2011 – Present 2011 – Present Dean’s Appointee to the Faculty Career Development Committee MCW Centers Work Group MCW Search Committee for the Director of Cardiovascular Center and Divisional Chief of Cardiology. National and Regional Elected/Appointed Leadership and Committee Positions: 1990 Hypertension Task Force Basic Science Rapporteur 1993 Session Chair National Heart, Lung and Blood Institute Bethesda, MD Gene Polymorphism in Hypertension American Heart Association Council for High Blood Pressure Dallas, TX 1994 Breakfast Workshop Moderator 1995 – 2005 Advisory Board 1995 - 1995 1995 1996 1996 1996 – 1997 1996 – 2000 1996 – 1998 1996 – 1997 1996 International Society of Hypertension Melbourne, Australia Mammalian Genotyping Center National Heart, Lung and Blood Institute Bethesda, MD Ad Hoc Grant Reviewer Canadian Medical Council Montreal, Canada Ad Hoc Grant Reviewer National Institute of Alcohol Addiction and Abuse Bethesda, MD Session Chair Molecular Biology of Hypertension International Society of Hypertension Glasgow, Scotland Breakfast Workshop Speaker International Society of Hypertension Glasgow, Scotland Chairman, Dean’s Committee for the Genetics Initiative Medical College of Wisconsin Milwaukee, WI Program Committee International Society of Hypertension 2000 American Society of Hypertension New York, NY Faculty Search Committee Department of Pediatrics Medical College of Wisconsin Milwaukee, WI Co-Organizer Banbury Conference Cold Spring Harbor Laboratory Cold Spring Harbor, NY Meeting Organizer 5 1997 1997 – 1998 1997 1997 1997 – 1998 1998 1998 1998 1998 Genomics to Physiology and Beyond Cold Spring Harbor Laboratory Cold Spring Harbor, NY Coordinator Breakfast Workshop Ninth International Symposium on SHR and Cardiovascular Genetics Montreal, Canada Executive Committee Digestive Disease Center Medical College of Wisconsin Milwaukee, WI Special Emphasis Panel Genetic Susceptibility to Target Organ Damage in High Blood Pressure National Heart, Lung and Blood Institute Bethesda, MD Co-Organizer Program on Selected Advances in Cell and Molecular Biology, Foundation for Advanced Education in the Sciences National Institutes of Health Bethesda, MD Planning Group International Rat Genetics Meeting Hannover, Germany Angiotensin Consultant Merck Scottsdale, AZ Session Chair In Focus Program/FASEB American Physiological Society San Francisco, CA Session Chair Genome Mapping, Sequencing and Biology Cold Spring Harbor Laboratory Cold Spring Harbor, NY Office of Director Mouse Genome Priorities Setting Meeting National Human Genome Research Institute Bethesda, MD 1998 Office of Director 1998 Special Review Group 1998 Human Genome Planning Meeting National Human Genome Research Institute Bethesda, MD National Human Genome Research Institute Bethesda, MD Co-Chairman Workshop on Strategies for Identification of Nephropathy Susceptibility Genes National Institute of Diabetes, Digestive and Kidney 6 1998 1998 1998 1998 1998 1998 1998 – 2005 1999 1999 – 2000 1999 – 2000 2000 – 2004 2001 2001 – 2004 Diseases Bethesda, MD Planning Group Program for the 12th International Workshop on Alloantigenic Systems in the Rat Halifax, Nova Scotia Special Emphasis Panel Genetic Basis of Variability in the Progression and Outcome of Heart, Lung, and Blood Diseases National Heart, Lung and Blood Institute Bethesda, MD Co-Chairman Rat Model Repository Meeting National Heart, Lung and Blood Institute National Human Genome Research Institute Bethesda, MD Planning Group Model Organisms Databases Workshop National Heart, Lung and Blood Institute Bethesda, MD Special Emphasis Panel Polycystic Kidney Disease National Institute of Diabetes, Digestive and Kidney Diseases Bethesda, MD Ad Hoc Reviewer National Human Genome Research Institute Bethesda, MD Organizer Physiological Genomics and Rat Models Cold Spring Harbor Laboratory Cold Spring Harbor, NY Basic Science Writing Committee National Institute of Digestive Disorders and Kidney Diseases Bethesda, MD Planning Committee Animal Resource Center Medical College of Wisconsin Milwaukee, WI Chair ISH 2000 Genetics Satellite Symposium Chicago, IL Chair PGA Coordinating Committee Program for Genomic Applications National Heart, Lung and Blood Institute Bethesda, MD Rat Resource and Research Center Advisory Committee University of Missouri Columbia, MO Advisor US Genome Sequencing Program 7 2002 2002 2002 2002 2003 2003 2003 2004 – Present 2005 2005 – 2008 2006 2005 2006 – 2011 National Human Genome Research Institute Bethesda, MD Review Committee Genemill 2002 University of Liege Brussels, Belgium Participant National Human Genome Research Institute The Future of Genomics Meeting Airlie, VA Advisor National Institute of Diabetes, Digestive and Kidney Diseases Division of Diabetes, Endocrinology and Metabolic Diseases Bethesda, MD. Expert Scientific Panel Member National Human Genome Research Institute SAP/PI Meeting Bethesda, MD Participant National Institute of Health, National Human Genome Research Institute Human Genome Database Workshop Bethesda, MD Review Committee Ad Hoc Member Mammalian Genetics Study Section, Bethesda, MD Speaker/Participant National Institute of Health National Heart, Lung and Blood Institute Biomedical Information Science and Technology Initiative Bethesda, MD Scientific Advisory Board Vialactia Biosciences Auckland, New Zealand Ad hoc Committee Member Center for Scientific Review Genetics of Health & Disease Study Section National Institutes of Health Bethesda, MD Committee Member Mammalian Gene Collection External Steering Committee National Human Genome Research Institute Bethesda, MD Committee Member National Heart, Lung & Blood Institute – Strategic Planning Committee Referee & Committee Member International Evaluation of Research Groups Max Delbruck Center for Molecular Medicine Berlin-Buch, Germany Committee Member 8 2006 -- 2011 2008 - 2011 Genetics of Health & Disease Study Section National Institutes of Health Bethesda, MD Committee Member - External Scientific Panel National Institute of General Medical Sciences National Institutes of Health Pharmacogenetics Network Bethesda, MD Committee Member – The TMJ Association Scientific Advisory Board The TMJ Association Milwaukee WI Other Professional Positions and Major Visiting Appointments: 1981 - 1983 Summer Technician 1984 - 1984 Technician 1984 - 1989 1992 - 1996 1996 - 1998 1996 – 1998 Abbott Laboratories Abbott Park, IL Abbott Laboratories Abbott Park, IL Research Assistant University of Iowa Iowa City, IA Visiting Scientist Whitehead Institute for Biomedical Research Massachusetts Institute of Technology Boston, MA Visiting Scientist Massachusetts General Hospital Boston, MA Visiting Scientist Harvard Medical School Cambridge, MA Self Report of Teaching: 1983 Tutor 1986 – 1988 Tutor/Lecturer 1988 - 1989 1989 Biology Iowa State University Ames, IA Drugs, Their Nature, Action and Use University of Iowa Iowa City, IA Tutor Medical Pharmacology University of Iowa Iowa City, IA Supervisor 9 1990 - 1992 1993 1993 Undergraduate student Harvard Medical School Cambridge, MA Supervisor Undergraduate Research Opportunities Program - Biology Massachusetts Institute of Technology Cambridge, MA Lecturer Graduate Course in Molecular Endocrinology Karolinska Institute Stockholm, Sweden Instructor Genetics Course for Medical Students Harvard Medical School Cambridge, MA 1994 - 1996 Sponsor/Mentor 1994 Lecturer 1994 – 1996 1993 - 1995 1995 1996 1996 1996 - 1998 1998 - 2000 Pro-Tech high school students Massachusetts General Hospital Boston, MA ABI Linkage Workshop National Institutes of Health Bethesda, MD Course Mentor Department of Genetics Harvard Medical School Cambridge, MA Thesis Advisor For Anna Pettersson Karolinska Institute Stockholm, Sweden Medicine Honors Thesis Committee Member Harvard Medical School Cambridge, MA Ph.D. Thesis Committee Member For David Stec Medical College of Wisconsin Milwaukee, WI Thesis Opponent For Matt Sunvald Department of Human Genetics University of Uppsala Uppsala, Sweden Thesis Committee Member For Christina Kendziorski Department of Mathematics Marquette University Milwaukee, WI Co-Director Positional Cloning Course Cold Spring Harbor Laboratory Cold Spring Harbor, NY 10 1998 – Present Instructor 1998 – 2004 Lecturer 2001 – 2008 Physiological Genetics Medical College of Wisconsin Milwaukee, WI Genetic Approaches to Heart, Lung and Blood Diseases National Heart, Lung and Blood Institute Bar Harbor, ME Lecturer Microbiology Techniques Course Milwaukee, WI Lecturer 2002 The Jackson Laboratory 43rd Annual Short Course Bar Harbor, ME Visiting Professor 2004 Curriculum of the Post-Graduate Master of Science & Ph.D. Scientific Studies, Basic & Clinical Medical Sciences Clinical Physiology/Physiological Genomics University of Split School of Medicine Split, Croatia Lecturer 2010 The Future of Genomic Medicine IV “Bringing genomic sequence into the clinic: just another lab value?” Scripps Translational Science Institute, San Diego CA. Trainees: Visiting Scientists: 1995 – 1998 1998 – 2000 1999 – 2000 2008 Masahide Shiozawa, M.D., Ph.D. Yasuhiro Kita, Ph.D. Diana Maas, M.D. Hairong Wang, Ph.D. 1992 1992 1992 1993 1993 1993 1996 1996 1996 1996 1998 1999 2000 2001 Pei-wen Chiang, Ph.D. Maria R. Trolliet, Ph.D. Jason S. Simon, Ph.D. Sarah Weksler-Zangen, Ph.D. Ela Knapik, M.D. George Koike, M.D., Ph.D. Monika Stoll, Ph.D. Ulrich Broeckel, M.D. Anne Kwitek-Black, Ph.D. Jian Jiang, Ph.D. Simon Twigger, Ph.D. Pierre Dumas, Ph.D. Michael Jensen-Seaman, Ph.D. Thomas E. Feroah, Ph.D. Post Doctoral Fellows: – – – – – – – – – – – – – – 1993 1995 1995 1996 1996 1996 1999 2000 1997 1997 2000 2001 2004 2001 11 2001 2001 2002 2002 2002 2004 2006 2006 2006 2006 2009 2009 2010 2010 – – – – – – – – – – – – – – 2002 2004 2004 2004 2005 2007 2009 2007 2008 2008 2009 Present Present Present Vicky Grumman, D.V.M. Carol Moreno-Quinn, M.D., Ph.D. Andrea Baessler, M.D. Marcus Fischer, M.D. Marijo Bilusic, M.D. Leah Solberg, Ph.D. Aron Geurts, Ph.D. Nancy Schlick, Ph.D. Artur Rangel-Filho, M.D., Ph.D. Tatjana Adamovic, Ph.D. Vidya Rao, Ph.D. Sheng Yang, Ph.D. Mike Flister, Ph.D. Caitlin O’Meara, Ph.D. Research Fellows: 1997 – 1999 Vishwanatha Nadig, M.D. Research Scientists: 2008 – Present 2008 – 2010 Hiang Xu, Ph.D. Elizabeth Worthey, Ph.D. 1993 1994 1995 1996 1997 2000 2000 2001 2001 2001 2002 2007 2007 2008 2009 2010 2010 – 1995 – 1995 – 1996 – 2001 – 1998 – 2006 – 2006 – 2002 – 2002 – 2002 – 2006 -- Present – Present – Present – Present – Present – Present Anna Pettersson, Ph.D. Michael McLaughlin, M.D. Brendan Innes (visiting for 9 months) Marcelo Nobrega, M.D., Ph.D. Vishwanatha Nadig, M.D. Artur Rangel-Filho, M.D., Ph.D. Nancy Schlick, Ph.D. Marcus Corat Patricia Corat Danilo Carlos Michelle Lutz, M.D., Ph.D. Caitlin O’Meara Allison Sarkis Sheila Reagles Sasha Zheng (MSTP) Bryce Schuler (MSTP) Nan Cher (Florence) Yeo 1995 2004 2004 2008 – 1995 (Summer) (Summer) (Summer) Michael G. McLaughlin Matthew Weston Barbara Meinecke Deepak Rai Graduate Students: Medical Students: 12 2010 - present 2010 – 2011 Brennan Decker Ameen Salahudeen Undergraduates: 1990 1990 1996 1996 1997 1998 1998 1998 1999 2000 2000 2001 2001 2002 2002 2003 2003 2003 2004 2005 2005 2006 2006 2006 2007 2007 2008 2009 (Summer) Jerome McDonald – 1992 Ruth Bunker (Summer) Tamara Taylor – 1997 Atta Behfar-Rad – 1998 Obinna Menome (Summer) Sahera Dirajlal (Summer) Delisa Atkins (Summer) Carla Fluentes (Summer) Karen L. Stark – 2001 Beth Konicek (Summer) Stacy Johnson (Summer) Mark Biagtan (Summer) Lisa Bosnjak (Summer) Ryan Gore (Summer) Lisa Bosnjak (Summer) Christopher Janowak (Summer) Elizabeth Oberg (Summer) Sarah Roach (Summer) Jozef Lazar, Jr. (Summer) Jozef Lazar, Jr. (Summer) Sarah Kahn (Summer) Marielle Discipulo (Summer) Michael Soule (Summer) Jozef Lazar, Jr. (Summer) Erin Mathewson (Summer) Jozef Lazar, Jr. (Summer/Fall) Ivana Micanovic (Summer) Barthalomew Sillah 1994 1995 1996 1996 1997 1997 1999 1999 1999 2001 2001 2001 2001 2002 2002 – 1995 (Summer) (Summer) (Summer) (Summer) (Summer) (Summer) – 2001 – 2000 – 2002 (Summer) (Summer) – 2003 – 2003 (Summer) High School Students: Cory Futrell Luc Pierre Mathew Stein Nathan Pedretti Joshua Cohen Rami Peltz Jeremiah P. Holzbauer Nasuh Malas James Wu Jennifer Holland Michelle Lombard Jacob Frautschi Wassim Malas Jozef Lazar, Jr. Andrew Zaeske 13 2002 2003 2003 2004 2004 2005 (Summer) (Summer) – 2005 (Summer) – 2005 – 2007 Joseph Johnny Joseph Haines Nour Malas Christopher Gore Rachel Theisen Max Machotka Awards Earned by Members of the Jacob Lab: 1995 1995 1996 Merck, Sharpe & Dohme Travel Award for Outstanding Cardiovascular Research Jason Simon Trainee Investigator Award for Excellence in Scientific Research George Koike Young Investigator Travel Grant (International Society of Hypertension Meeting) George Koike Previous Support for Former Lab Members: Medical Research Council of Sweden The Stanley J. Sarnoff Endowment of Cardiovascular Science, Inc. Anna Pettersson Michael G. McLaughlin Florida American Heart Association Maria R. Trolliet, Ph.D. American Heart Association Sarah W. Zangen, Ph.D. NIH, NRSA Jason S. Simon, Ph.D. Deutsche Forschungsgemeinschaft (DFG), Germany Ulrich Broeckel, M.D. Deutsche Forschungsgemeinschaft (DFG), Germany Monika Stoll, Ph.D. NIH, NRSA Michael J. Jensen-Seaman, Ph.D. Deutsche Forschungsgemeinschaft (DFG), Germany Andrea Baessler, M.D. Deutsche Forschungsgemeinschaft (DFG), Germany Marcus Fischer, M.D. American Physiological Society Fellowship Grant Aron Geurts, Ph.D. Research Grants, Contracts, Awards & Projects: Completed: 1992 - 1996 1993 - 1996 Bristol-Myers Squibb Genetics of Hypertension and Renal Failure in FH-Rats PI Bristol-Myers Squibb Human Polygenic Disorders 14 1993 - 1997 1994 - 1996 1994 - 1996 1995 - 2005 1996 - 1999 1996 - 2000 1996 - 2006 1997 - 1998 1997 - 2003 1997 - 2005 1997 - 2002 1998 - 2001 1999 – 2000 2000 - 2004 2000 - 2005 2000 - 2005 PI National Institutes of Health Genetic Dissection of Diabetes in Man and the BB Rat PI National Institutes of Health Construction of a Genetic Linkage Map of Zebrafish PI (Grant PI transferred to Dr. Mark Fishman, 1996-1999) National Institute of Health Genetic Basis of Stroke in SHRSP Subcontract National Institute of Health Genetic Determinants of High Blood Pressure: Rat Mapping Center PI National Institute of Health Genetic Map and Large Insert Library for the Rat Genome Co-PI National Institute of Health Fawn Hooded Rat: Model for ESRD PI National Institute of Health Rat Genetic Mapping Center, SCOR: Molecular Genetics of Hypertension PI National Heart Lung and Blood Institute Genotyping Service Genetics of Obesity (>1,000,000 genotypes) Co-PI National Heart Lung and Blood Institute Genotyping Service Genetics of Myocardial Infarction (>1,000,000 genotypes) Co-PI National Heart, Lung and Blood Institute Genetic Control of BB rat Autoimmunity Subcontract, Co-PI National Institute of Health Construction of Unigen Style Rat Map Using Rat RH’s PI National Institute of Health Genetic Dissection of Ventilatory Traits PI, Subcontract Genome Research Institute Consomic Animals for Rapid Generation of Single Gene Models of Complex Disease PI National Institute of Health Genetic Basis of Myocardial Infarction in Humans Co-PI National Heart, Lung and Blood Institute Genetic Determinates: Rat Mapping Center PI National Institute of Health 15 2001 - 2005 2004 – 2007 2006 – 2007 2006 – 2007 2006 – 2008 2006 – 2008 2000 - 2009 2005 - 2009 2007 – 2009 2008 - 2009 2008 - 2009 2008 - 2009 HyperGEN: Genetics of Left Ventricular Hypertrophy, NHLBI Subcontract, Co-PI National Institute of Health Physiological Genomics of Hypertensive Renal Disease PI United States-Israel Bi-National Science Foundation (BSF) Study of Differential Gene Expression in the Kidneys of the Sabra Rat PI Dillon Trust Family Based Genetic Analysis of Genes Related to End Stage Renal Disease PI Medical College of Wisconsin; Children’s Research Institute IMI: Children’s Research Institute – Genetics Initiative PI Medical College of Wisconsin/Children’s Research Institute Development of an Animal Model of ARPKD for Therapy Testing PI Medical College of Wisconsin; Advancing a Healthier Wisconsin MCW Genetic Analysis Initiative for Individualized Medicine PI National Institute of Health Program for Genomic Applications (PGA) PI Total Costs: $25,549,623 National Institutes of Health PGA Supplement (Knockout Rats for Physiological Genomics) PI Total Costs: $347,625 American Physiological Society Validation of Rab38 as a Genetic Component of End-Stage Renal Disease in the Fawn Hooded Hypertensive Rat Sponsor – Post Doctoral Fellowship Total Costs: $81,000 Medical College of Wisconsin; Biotechnology and Bioengineering Center Development of Genomic Sequencing in Clinical Practice PI Total Costs: $100,000 Dept. of Health & Human Services, Health Resources & Service Administration (HSRA) Genomic Sequencer PI Total Costs: $492,188 Sigma Aldrich Genome Modification in the Rat Using Zinc Finger Nucleases PI Total Costs: $98,727 16 2007 - 2011 2005 – 2010 2008 - 2011 2008 - 2011 National Institutes of Health 5R01HL069321-08. Physiological Genomics of Hypertensive Renal Disease PI National Institute of Health Genetic control of BB Rat Autoimmunity Collaborator (as needed) Advancing a Healthier Wisconsin Systems Biology Program in Cardiovascular Disease PI Total Costs: $745,676 National Institutes of Health 5R21RR025187-02.Transposon Mutagenesis for Modeling Complex Human Disease in Rats PI Total Costs: $416,625 Current: 2005 - 2014 2006 – 2016 2007 - 2012 2009 – 2012 2009 - 2012 2009 – 2013 2010 – 2015 National Institute of Health 5R01HL064541-11. Rat Genome Database PI Total Costs: $43,241,585 National Institute of Health 5P01HL082798-06A1. Genetic & Physiological Basis of SaltInduced Hypertension PI (Genomics Core) Total Costs: $11,412,625 National Institutes of Health IP50DK079306-02. Integrative Biology of Childhood Kidney Disease PI (Genomics Core) Total Costs: $557,461 National Institutes of Health 1RC2HL101681-02. Mechanistic characterization of genes for hypertension and renal disease PI Total cost: $5,308,060 European Union Centre of Translational Medicine Collaborator Total Costs: ($1,000,000 Euros to Slovakia) Fellows visit to MCW covered. National Institutes of Health 1R01HL089930-01A2. Genetic and Cellular Resistance/Sensitivity to Myocardial Ischemia Total Costs: $2,407,413 Basis of European Union Euratrans. FP7 Large Scale Collaborative Project Euratrans European Commission (Funding Agency) Co-PI Total cost: $467,825 17 2010 – 2015 National Institutes of Health 5UL1RR031973-02 Clinical and Translational Science Award (Bioinformatics Component) Co-PI Total cost: $14,757,837 Pending 2011 – 2016 2012-2017 2012-2017 2012-2017 National Institutes of Health 1RO1HL111234 Mechanistic characterization of genes for pulmonary function Co-I Total cost: $1,912,500 National Institues of Health 2R01HL069321-09 Identification of Genes & Gene Networks for Renal Disease PI Total cost: $1,444,392 National Institues of Health 1R01HL114713-01 Defining the genetic structure of hypertension through multiple strain sequencing PI Total cost: $2,436,487 National Institues of Health 1R24HL114474-01 Resources for translating GWAS genes to mechanism and function PI Total cost: $9,064,195 Submitted/Not Funded: 2009 – 2015 2009 – 2010 2009 – 2011 2009 – 2011 National Institutes of Health Genetics of Obstructive Anatomic Malformation in Congenital Heart Disease PI Total cost: $5,000,000 Wellcome Trust Wisconsin Genomics Initiative Co-PI Total cost: $6,000,000 (no money to MCW) National Institutes of Health Generating a resource of germline-competent stem cells from widely used rat strains PI Total cost: $999,445 National Institutes of Health 18 GWAS for TMJD and Associated Chronic Pain Phenotypes Co-PI 2009 – 2011 2009 – 2010 2009 – 2011 2010 – 2015 2011 – 2015 Total cost: $3,517,000 National Institutes of Health Next Steps in Gene Discovery: The Wisconsin Genomics Initiative Co-PI Total cost: $18,012,000 National Institutes of Health Supplement for Physiological Genomics of Hypertensive renal disease PI Total cost: $224,233 United States – Israel Bidirectional Science Foundation Genomics of Rare Diseases in Children Co-PI Total cost: $36,719 National Institutes of Health (T32) Translational genetics of diabetes, obesity and the metabolic syndrome (TG-DOMS) PI Total cost: $801,344 National Institutes of Health 1UO1HG006506 Advancing Genomic Sequence to a Clinical Laboratory Assay. PI Total cost: $8,894,685 Invited Lectures/Workshops/Presentations/Site Visits: 1992 1992 1993 1993 1993 1993 1993 1993 1993 1993 1993 1994 1994 1994 1994 University of Alabama, Vascular Biology and Hypertension Research Retreat, Birmingham, AL. Johns Hopkins Hospital, Division of Neuroanesthesia, Baltimore, MD. Columbia University, New York, NY. Albany Medical College, Department of Pharmacology and Toxicology, Albany, NY. Mount Sinai, Department of Pediatric Cardiology and Human Genetics, Milwaukee, WI. Centre de Recherche Hotel-Dieu de Montreal, Canada. Medical College of Wisconsin, Department of Physiology, Milwaukee, WI. Rhône-Poulenc Rorer, Department of Cardiovascular Pharmacology, Paris, France. Massachusetts General Hospital, Department of Cardiology, Boston, MA. Henry Ford Hospital, Hypertension and Vascular Research Division, Detroit, MI. Research Genetics, Huntsville, AL. Massachusetts General Hospital, Research Finance, Boston, MA. University of Regensburg, Department of Medicine, Medizinische Klink II, Munich, Germany. Millennium Pharmaceuticals, Cambridge, MA. Baxter, Renal Division, North Chicago, IL. 19 1994 1994 1995 1995 1995 1995 1995 1995 1996 1996 1996 1996 1996 1996 1996 1996 1996 1997 1997 1997 1997 1997 1997 1997 1997 1997 1997 1997 1997 1997 1998 1998 1998 1998 1998 1998 1998 1998 1998 1999 1999 1999 National Heart Institute, São Paulo, Brazil. University of São Paulo, Department of Physiology, Sao Paulo, Brazil. Bowman Gray Medical School, Nephrology Department, Wake Forest, North Carolina. Emory University School of Medicine, Renal Unit, Atlanta, GA. Inter-American Society of Hypertension, Montreal, Canada. American Society of Nephrology, San Diego, CA. University of Montreal, Montreal, Canada. Centre de Recherche Hotel-Dieu de Montreal, Montreal, Canada. Baylor College of Medicine, Division of Endocrinology, Houston, TX. Ciba Pharmaceuticals, Basel, Switzerland. Massachusetts General Hospital, Reproductive Endocrine, Boston, MA. INSERM Unit 47, Paris, France. Sequana Therapeutics, San Diego, CA. Research Genetics, Huntsville, AL. Synthelabo Recherche, Department de Recherche Cardiovasculaire, Paris, France. National Public Health Institute, Department of Human Genetics, Helsinki, Finland. University of Uppsala, Department of Medical Genetics, Uppsala, Sweden. Incyte Pharmaceuticals, Palo Alto, CA. Marquette University, Biomedical Engineering Department, Milwaukee, WI. The Congress of Molecular Medicine, International Congress Center, Berlin, Germany. American Society of Hypertension, Twelfth Scientific Meeting, San Francisco, CA. Genetics of Diabetes Satellite Meeting, Ystad, Sweden. Genome Therapeutics, Boston, MA. Gemini Research, Cambridge, UK. Thirty-Second Annual MCW/Marquette Medical Alumni Association Clinical Conference, Palm Springs, CA. Marshfield Clinic, Marshfield, WI. Parke-Davis Pharmaceutical Research, Ann Arbor, MI. American Society of Nephrology, San Antonio, TX. Banyu Institute, Tsukuba, Japan. Roche/Jackson Laboratory, Palo Alto, CA. Cambridge Healthtech, Functional Genomics, San Diego, CA. Gordon Conference, Angiotensin II, San Marino del Mar, CA. Pfizer Canada, Consultants Meeting, West Palm Beach, FL. Incyte Pharmaceuticals, Palo Alto, CA. Seventeenth Scientific Meeting of the International Society of Hypertension, Amsterdam, The Netherlands. Parke-Davis Pharmaceutical Research, Ann Arbor, MI. Parke-Davis Molecular Genetics Laboratories, Alameda, CA. Fifty-Eighth Annual American Diabetes Association, Chicago, IL. Merck Research Laboratories, West Point, PA. Cardiovascular Genetics, Cambridge Healthtech, Orlando, FL. Rat Model Priority Meeting, Washington, DC. University of Virginia School of Medicine, Cardiovascular Research Center Seminar Series, Charlottesville, VA. 20 1999 1999 1999 1999 1999 1999 1999 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 2000 2001 2001 2001 2001 2001 2001 2001 2001 FASEB, “Genetic Mechanisms Determining the Role of the Kidney in the Pathogenesis of Hypertension,” Washington, DC. Joslin Diabetes Center, Boston, MA. Mouse Genome Database Project, Bar Harbor, ME. International Society of Hypertension in Blacks, Toronto, Ontario. Eleventh International Genome Sequencing and Analysis Conference, Miami Beach, FL. University of Rochester, Rochester, NY. CuraGen Corporation, New Haven, CT. Second International Cardiovascular Genomics, Miami, FL. Incyte Pharmaceuticals, Palo Alto, CA. Cold Spring Harbor Laboratory, Genome Sequencing and Biology Meeting, Cold Spring Harbor, NY. Experimental Biology 2000, San Diego, CA. National Heart, Lung and Blood Institute Committee Management Service Center, Bethesda, MD. University of California Los Angeles Medical Center, ACCESS Seminar, Los Angeles, CA. The 13th International Workshop on Genetic Systems in the Rat, Goteborg, Sweden. Merck Research Laboratory, Philadelphia, PA. TOPS International Meeting, San Antonio, TX. The Jackson Laboratory, “Mouse Initiatives II – Modeling of the Human Genome and Disease,” Bar Harbor, ME. DOE Human Genome Program Meeting, “Which Organism To Sequence,” San Francisco, CA. Twenty-Seventh International Conference on Animal Genetics, Minneapolis, MN Excellence in Human Genetics Lecture Series, “In Search of Hypertension Genes Using Rats and Humans,” Dallas, TX. American Society of Nephrology, Toronto, Canada. Genetics of Hypertension, “Approaches, Paradigms, Impact,” Porto Cervo, Sardinia, Italy. Fourteenth International Mouse Genome Conference, Tokyo, Japan. Approaches to Integrative Physiology, Worcestershire, London. Fifty-Fourth Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research, Washington, DC. Rat Functional Genomics Meeting, Washington, DC. Association of Anatomy, Cell Biology, Neurobiology Chairpersons Annual Meeting, Los Cabos, Mexico. Medical College of Wisconsin, Bioethics Center, “The Brave New Genetic World,” Milwaukee, WI. FASEB Conference, “Physiological Genomics: Gene Profiling, Regulation and Analysis,” Orlando, FL. University of Cincinnati, Children’s Hospital Medical Center, “Functional Genomics: From Rat to Man,” Cincinnati, OH. Milwaukee Biotechnology Interest Group, “After the Genomic Project: Real Biotech Possibilities,” Milwaukee, WI. Charles River Laboratories, “Selection of Microsatellites for Characterizing and Monitoring Outbred Stocks of Rats,” Wilmington, MA. Medical College of Wisconsin, Summer Program for Undergraduate Research (SPUR), “From Sequence to Biology,” Milwaukee, WI. 21 2001 2001 2001 2001 2001 2001 2001 2001 2001 2001 2001 2001 2002 2002 2002 2002 2002 2002 2002 2002 2002 2002 2002 2002 2002 American Thoracic Society, “C7-Genetic Dissection of Respiratory Traits,” San Francisco, CA. Medical College of Wisconsin, Plastic Surgery Research Council, “Sequence Based Biology: A Clinical Interest?” Milwaukee, WI. University of Wisconsin-Madison, Midwest Physiological Society, “Physiological Genomics: Strategies for Understanding Gene Function,” Madison, WI. Children’s Hospital of Wisconsin, Pediatric Grand Rounds, “Sequence Based Biology - Medicine for the 21st Century,” Milwaukee, WI. Waukesha Memorial Hospital, Oncology Review Board, “Using Genomics to Go from Benchside to Bedside,” Waukesha, WI. Michigan State University, GE Molecular Imaging Workshop, “Sequence Based Biology: Microarray to Bedside,” East Lansing, MI. Merck Research Laboratories, “Comparative Genomics for Renal Disease Targets,” West Point, PA. IV International Symposium – Vasoactive Peptides, “Adopting Genomic Tools for Physiological Studies,” Bel Horizonte, Minas Gerais, Brazil. American Heart Association 55th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research, “Comparative Genomics: A Tool for Gene Discovery,” Chicago, IL. Medical College of Wisconsin, Center for the Study of Bioethics, Midwest Ethics Committee Network, “Over View of Genetics,” Milwaukee, WI. Medical College of Wisconsin, Young Presidents Organization, “Beyond 2001: How Genetics Will Change Your Life,” Milwaukee, WI. Columbia Hospital, Medical Grand Rounds, “Molecular Genetics and Application to Clinical Medicine,” Milwaukee, WI. University of Regensburg, “Identifying Genes for Coronary Artery Disease,” Munich, Germany. Cleveland Clinic Foundation, “Functional Genomics and Applications to Cardiovascular Disease,” Cleveland, OH. University of Chicago, “Comparative Genomics for SNPs, Chips and Disease Genes,” Chicago, IL. American Physiological Society, “Physiological Genomics: From Rat to Human,” San Francisco, CA. Transcriptome 2002: From Functional Genomics to Systems Biology, “System Biology, from Genome to Physiology,” Seattle, Washington. St. Mary’s Hospital, Grand Rounds, “Molecular Genetics and Application to Clinical Medicine,” Milwaukee, WI. National Human Genome Research Institute, National Institute of Health, “Application of Functional Genomics to Cardiovascular Disease,” Bethesda, MD. Medical College of Wisconsin, North Central Chapter of the Health Physics Society, Milwaukee, WI. University of Texas, Physiology at the UTHSC, “Physiological Genomics in Sequencing World,” San Antonio, TX. University of Michigan, “Systems Biology: Rat to Man,” Ann Arbor, MI. Medical College of Wisconsin, Bioinformatics Research Center Seminar Series, “Linking Physiology, genomics and disease,” Milwaukee, WI. Baylor College of Medicine, “Rat Genome Sequence and Physiological Genomics,” Houston, TX. University of Wisconsin-Madison, Wisconsin Technology Council, “Systems Biology and Drug Discovery,” Madison, WI. 22 2002 2002 2002 2002 2002 2002 2002 2002 2002 2002 2003 2003 2003 2003 2003 2003 2003 2003 2003 2003 2003 2003 2003 2003 2003 American Thoracic Society, “Systems Biology and Functional Genomics for Heart, Lung and Blood Disorder,” Atlanta, GA. Endocrine Society, “Systems Biology Approaches to the Genetics of Hypertension and Insulin Resistance,” San Francisco, CA. Eighth International Sleep and Breathing Symposium, “Genetic Models of Cardiovascular Disease in Rats,” Reykjavik, Iceland. Fidelity Foundation Enabling Technologies for Alzheimer’s Disease Research II, Bar Harbor, ME. University of Tennessee, “Hypertension Research Using Systems Biology,” Memphis, TN. Cambridge Healthtech Institute, Genomic Animal Models, “Genetic Models for ADME, Disease Characterization and Efficacy Testing,” Boston, MA. XVI Congreso LatinoAmericano De Patologia Clinica, “Pharmacogenomics Plenary Session,” Acapulco, Mexico. Brigham and Women’s Hospital Molecular Medicine Seminar Series, “System Biology for Understanding End Organ Disease,” Cambridge, MA. Abbott Laboratories, “Systems Biology for Understanding End Organ Disease,” Abbott Park, IL. Charles River Laboratories, “Novel Rat Models for Drug Discovery,” Strasbourg, France. Louisiana State University, “Pharmacology in a Sequence Based World,” New Orleans, LA. University of Minnesota, “Genetics and Genomics of Complex Disease,” Duluth, MN. Harvard Medical School/Framingham Heart Study, National Heart, Lung and Blood Institute, “High throughput rat physiology,” Cambridge, MA. Federation of American Societies for Experimental Biology, “Rat Models of HLBS,” San Diego, CA. Association of University of Anesthesiologists, “Genetics, Genomics and Clinical Medicine,” Milwaukee, WI. Center for Research on Environmental Disease Symposium, “Genetic Models for Drug Discovery and Toxicology,” Austin, TX. Woodlands Academy of the Sacred Heart, “Human Genetics: An Oracle to Your Future Health?” Lake Forest, IL. American Thoracic Society, “Genetic Mapping of Lung Phenotypes in Rats with Substituted chromosomes,” Seattle, WA. University of Wisconsin-Madison, Wisconsin Symposium III, “System Analysis in the Rat,” Madison, WI. Universitat Regensburg, Klinik und Poliklink fur Innere Medizin II, "Sequence, Systems Biology and Progress Towards Unraveling Cardiovascular Disease," Regensburg, Germany. Society of Toxicology, “Rat Genetic Models for Disease; Efficacy Testing and ADMET,” Savannah, GA. International Diabetes Federation, “Animal Models and Diabetes Complications,” Lille, France. Duke Clinical Research Institute, Genetics of Cardiovascular Disease Symposium, “Animal Models and Comparative Genomics,” Arlington, VA. The Jackson Laboratory, “Applying Microarrays to Complex Disease Studies,” Bar Harbor, ME. National Institute of Health, National Heart, Lung and Blood Institute, “Program for Genomic Applications,” Bethesda, MD. 23 2003 2003 2003 2003 2003 2004 2004 2004 2004 2004 2004 2004 2004 2004 2004 2004 2004 2004 2004 2005 2005 2005 The American Physiological Society, “The Genetic Basis of End Stage Renal Disease,” Augusta, GA. The American Society of Human Genetics, “Animal Models of Human Complex Disease,” Los Angeles, CA. American Heart Association, “Physiologic Genomics of Hypertensive Renal Failure,” Orlando, FL. American Society of Nephrology, “Renal Failure,” San Diego, CA. American Society of Human Genetics, “Animal Models of Human Complex Disease,” Los Angeles, CA. Specialized Center of Research, Hypertension Program Grantees’, “Update on Program of Genomic Applications,” Bethesda, MD. International Society of Hypertension 20th Scientific Meeting, “Gene Hunting Using the Physiological Toolset: Practical Demonstrations,” Sao Paulo, Brazil University of Washington, School of Medicine, “Application of Comparative Genomics to Common Complex Disease,” Seattle, Washington. American Physiological Society, Experimental Biology 2004, “Rat Cardiovascular Functional Genomics,” Washington, D.C. Medical Research Council Workshop on Integrative Physiology, “Program in Genomic Applications, A Model for Collaborative Research,” London, UK. Cambridge Healthtech Institute, Beyond Genome 2004, “Using genetics and genomics in the rat to build better models for efficacy, toxicology and disease characterization,” San Francisco, CA. Wisconsin Section, American College of Obstetricians & Gynecologists & Wisconsin Society of Obstetrics and Gynecology, “Clinical Applications of the Human Genome,” Wisconsin Dells, WI. National Institute of Health, National Heart, Lung and Blood Institute, Program in Genomic Application and Rat Genome Database update/hands on computer training and tutorial, Washington, D.C. The Institute for Genomic Research, 16th International Genome Sequencing and Analysis Conference, “Reducing Failures in Clinical Trials by Increasing the Predictive Power of Animal Models,” Washington, D.C. The Jackson Laboratory, Genetic Approaches to Complex Heart, Lung and Blood Diseases, “From QTL to Gene,” Bar Harbor, ME. National Institute of Health, Long Term Maintenance of Genome Sequence Assemblies: Human & Other Genomes meeting, Herndon, Virginia. Columbia St. Mary’s Hospital, Medical Grand Rounds, “Individualized Medicine Will We Be Ready?” Milwaukee, WI. University of California – San Francisco Biomedical Sciences Seminar Series, “Chromosome Substitution Strains: Linking Complex Diseases to Systems Biology,” San Francisco, CA. Cambridge Healthtech Institute’s 2nd Annual Predictive Toxicology, “Pharmacogenetic Models for Predictive Toxicology, San Francisco, CA. University Medical Centre Nijmegen/Nijmegen Centre for Molecular Life Sciences, “Chromosome Substitution Strains & Building Models for Human Disease,” The Netherlands. National Institute of Health, National Institute of Environmental Health Sciences, “Building Better Rat Models for Safety and Efficacy Testing, Triangle Research Park, NC. Cambridge Healthtech Institute, Molecular Medicine Tri-Conference, “Rapid Target Identification Using Rat Genomics Sequencing,” San Francisco, CA. 24 2005 2005 2005 2005 2005 2005 2005 2005 2006 2006 2006 2006 2006 2006 2006 2006 2006 2007 2007 2007 2007 2008 Federal Drug Administration, 11th Annual Science Forum, “Building Better Animal Models for Safety and Efficacy Test – is it Possible?” Washington, D.C. The Jackson Laboratory, Predictive Models for Drug Safety Assessment, “Building Better Animal Models for Safety and Efficacy Test – is it Possible?” Bar Harbor, ME. Universitat Regensburg, Genetics in Atherosclerosis and Cardiovascular Disease Symposium, “Chromosome Substitution and Factors Influencing Cardiovascular Disease, Regensburg, Germany. National Institute of Health, National Institute of Environmental Health Sciences, ICEM 2005 Satellite Meeting: Toxicogenomics, “The Rat Genome Database and Rat Model Systems for Pharmacological and Toxicological Research,” Kauai, HI. Toho University School of Medicine, “Building Better Animal Models for Human Disease,” Tokyo, Japan. Iowa State University, “Individualized Medicine, Fact or Fiction?” Ames, Iowa University College Utrecht, “Mining Rat Data in a Functional Genomics World, Utrecht, The Netherlands. American Society of Nephrology, Renal Week 2005, “Phenome Informatics: The Rat Example,” Philadelphia, PA. Goteborg University, “Rat Models in Biomedical Research,” Goteborg, Sweden National Institutes of Health, National Center for Research Resources, “Rat Models and Resources,” Bethesda, MD. The Institute for Genomic Biology, “Individualized Medicine, Fact or Fiction?” Urbana, IL. Cambridge Healthtech Institute, World Pharmaceutical Congress, “The Rat Remains a Major Model System within the Pharmaceutical Industry,” Philadelphia, PA. National Institutes of Health, National Institutes of Health, Department of Health and Human Services, NIH Roadmap, “Building Better Animal Models Using Population Genetics & Comparative Genomics”, Bethesda, MD. The TMJ Association, Fourth Scientific Meeting, “Genetics as a Glue for Translational Research,” Bethesda, MD. Twentieth International Mouse Genome Conference, “Rat Genome Database Disease Portals: A Platform for Genetic and Genomic Research,” Charleston, SC. Cold Spring Harbor Laboratory, Pharmacogenomics, “Building Better Models for Toxicity & Efficacy Testing, Cold Spring Harbor, NY. The Australian Health & Medical Research Congress, Rat Genomes & Models, “Searching for Renal Failure Genes Using the Rat Genomic Toolbox: What Else Do We Need?” Melbourne, Australia. Hinxton Hall, Ltd., Wellcome Trust Genome Campus, “Rat Genome Database Potential Contributions to the Genome Assembly,” Cambridge, England. University of Nebraska, Ross McIntyre Lecture, “Using Tissue Engineering and Genomics to Understand Myocardial Infarction,” Omaha, NE. The Jackson Laboratory, Discovery Strategies Conference, “Using Rat Models to Understand T2D Pathophysiology,” Bar Harbor, ME. Cold Spring Harbor Laboratory, Rat Genomics & Models, “Tacrine Toxicity Detected in a Rat Test Population,” Cold Spring Harbor, NY. The Association for Research in Otolaryngology, “Translational Research within an Academic Medical Center in an Era of the Clinical and Translational Science Awards,” Phoenix, AZ. 25 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2009 2009 2009 2009 2009 2009 2009 2009 2009 2009 2009 2009 2009 2010 MRC Clinical Sciences Centre European Rat Tools for Functional Genomics 2nd Annual Meeting, “Linking Clinical Cardiovascular Studies to Program for Genomic Applications,” Glasgow, UK. International Symposium on Animal Functional Genomics, “The Complex Nature of QTLS: How Many Genes are Under the Peak?” Edinburgh, UK. Hypertension 2008, Chair Genetics/Genomics, Berlin, Germany. Thirteenth International SHR Symposium, “Changing Roles of Genetics and Genomics,” Prague, Czech Republic. Slovenskej Akademie Vied, “Understanding Common Disease Through Molecular Genetics: An Example Using Kidney Failure,” Bratislava, Slovak Republic. Comenius University, “Genetic Tools for Dissection of Common, Complex Disease: Bench-side to Bedside,” Martin, Slovak Republic. National Institute of Health, National Heart, Lung, and Blood Institute, Genotype-Phenotype Working Group in Sickle Cell Disease, “An Introduction to Computational Models and Systems Biology,” Bethesda, MMD. National Institute of Health, The Fifth DCVD Visiting Professor Lecture Series Seminar, “Systems Biology to Understand GWAS Results,” Bethesda, MD. Sigma-Aldrich, “The Role of Transgenic Rats in a Genome Wide Association Studies (GWAS) World”. Broad Institute of Harvard & MIT, “After the GWAS is Done, New Roles of Animal Models?”. Iowa State University CIAG Pfizer Genomics Scholar Forum, “Integration of Medicine and Genomics: The Impact of High Throughput Sequencing”. Cold Spring Harbor, Hinxton UK. “Identification of Rf-1”. University of Kansas Medical Center Research Seminar Series in Cancer & Developmental Biology, “Using Chromosome Substitution Strains and Site Directed Mutagenesis Knockouts in Rats to Study Cancer”. Case Western Reserve University School of Medicine, Department of Genetics Research Seminar “Role of Animal Models in a GWAS World”. EuraTools, Barcelona, Spain. University of Wisconsin, Madison, Genomic Seminar Series, “From Genome Wide Association Studies (GWAS) to Understanding Common Disease”. Monash University, Melbourne, Australia, “The Role of Animal Models in a Genome Wide Association Study (GWAS) World”. Vanderbilt University, Nashville, Integrative Genomics Seminar Series, “Genome Wide Association Studies and Animal Models for Understanding Cardiovascular Disease”. Egyptian Society of Endocrinology, “Tissue Engineering: Inducible Pluripotent Stem Cells and its Impact on Clinical Medicine in the Future”. AstraZeneca, Philadelphia, “Building Better Animal Models for Pre Clinical Drug Testing”. Marshfield Clinic, Eau Claire, “WGI, Today and Tomorrow”. Marshfield Clinic, Wausau,”‘WGI, Today and Tomorrow”. University of Wisconsin, Madison, B6/BTBR F2 project retreat. 2nd Next Generation Sequencing Hinxton Retreat, UK. Experimental Biology 2009 New Orleans, “The Rat Genome Contribution to understanding the Pathogenesis of Hypertension”. 11th Annual Meeting of Dr. Victor Dzau Research Conference, Tokyo “Translating Genome Wide Association Studies in Mechanisms”. 26 2010 2010 2010 2010 2010 2010 2010 2011 2011 2011 2011 2011 2011 2011 2011 2011 2011 2011 2011 2011 2011 2011 Plant & Animal Genome XVIII, San Diego, “3rd Generation Sequencing and Gene KO Coming to Herds and Flocks Near You”. Grant Writing Workshop, Medical College of Wisconsin, “A successful career built on many, many triaged grants”. Jackson Laboratory, Bar Harbor, Animal Models for Human Stem Cell Therapy. “The Rat – it’s not just for Physiology any more”. Genomics of Common Diseases 2010, Baylor College of Medicine, Houston TX. “From GWAS to function for hypertension and renal disease using sensitizied strains, transgenic rescue and gene KO”. American Heart Association HBPR 2010, Washington DC. “Genetics of Experimental Models of Hypertension”. American Society of Nephrology. Denver CO. “Using Gene Knock-outs and Transposon based transgenics in sensitized rat strains to study genes nominated by human GWAS for renal disease”. The 18th International Workshop on Genetic Systems in the Rat, Kyoto Japan. “Mechanisms related to hypertension associated renal disease”. Hammersmith Lecture, Imperial College, London. “GWAS to mechanism of disease: role for gene knock out in sensitive strains”. Charge Consortium meeting, Boston MA. “From GWAS to function for cardiovascular disease using sensitized strains, transgenic rescue and gene KO”. The Future of Genomic Medicine IV, Scripps Institute of Oceanography, San Diego. “Bringing genomic sequence into the clinic: just another lab value?” Research in Progress Series, Medical College of Wisconsin. “Translational medicine in an academic medical center: do I really want to do this?” Otitis Media Symposium 2011, New Orleans LA. ‘Chinchilla to Human and Personalized Medicine”. Milwaukee Downtown Rotary. “The promise of personalized medicine: one in a billion”. Partners HealthCare System, Brigham and Women’s Hospital, Boston MA. “Bringing Genome Sequencing into the clinic: “just” another lab value?” Science Café, Community Engagement Key Function of CTSI, Milwaukee WI. “One in a billion – a story of personalized genomic medicine.” The Translational Sciences Department at Abbott Laboratories, Translational Sciences Seminar Series. “Building better models of human diseases from Genome Wide Association Studies in human to rat models”. Singularity University, San Francisco CA, 2011 Graduate Summer Program Biotechnology and Bioinformatics track. “Saving lives with DNA”. Jackson Laboratory. Invited Lecturer at Genomic & Proteomic Approaches to Complex Heart, Lung, Blood and Sleep Discorders. Bar Harbor, Maine “Rat”. CAS International Symposium on Animal Models of Diseases, Beijing, China. “Building Better Models of Human Disease Using ZFNs”. American Association for Laboratory Animal Science National Meeting, San Diego Ca. “Using ZFN to Generate Knock-Out Rats”. Monash Medical Center, Institute of Medical Research (MIMR), Melbourne Australia “Using gene editing and GWAS data to build models of human disease”. Monash University, Australian Regenerative Medicine Institute, Melbourne, Australia. ”Whole Genome Sequencing Just another Lab Test: The Milwaukee Experience”. 27 2011 2011 2011 2011 Second Stem Cell and Bone Marrow Transplant Symposium, Bucaramanga, Columbia. “Assessing cases for bone marrow transplant using whole gene sequencing”. University of Sao Paulo Medical School, Sao Paulo, Brazil. “Sequencing for clinical Diagnosis”, “GWAS to Function”. University of Wisconsin, Whitewater, Department of Biological Sciences Colloquium course. “Whole genome sequencing for clinical diagnosis.” 7th Annual Personalized Medicine Conference, Harvard Medical School, Boston Ma. Case study “Gene Sequencing: Staking a Position in an Expanding Industry. Symposia: 1992 1992 1992 1993 1996 1994 1994 1994 1995 1995 1995 1995 1996 1996 1996 1996 1996 1996 1997 1997 1997 1997 1997 Fourth Robert C. Tarazi Symposium, “Molecular Genetics of Hypertension,” Cleveland Clinic Foundation, Cleveland, OH Canadian Animal Production Network Biozootech Workshop, Halifax, Nova Scotia, Canada The Tissue Renin-Angiotensin Systems, “From Molecular Biology to Clinical Disease,” Stanford University, Stanford, CA “Cellular and Molecular Biology of the Cardiovascular System,” Julian Claveria, Spain Sixth European Meeting on Hypertension, “Satellite Symposium on Molecular Biology of Hypertension for Clinicians,” Milan, Italy International Society of Hypertension Meeting, “Genes and Genetics Satellite,” Sydney, Australia Ethnic Differences in Hypertension, “Diet, Genetics and Social Factors,” Columbia University, New York, NY University of Florida, “International Symposium on Cellular and Molecular Aspects of Angiotensin Receptors,” Gainesville, FL European Hypertension Genetics Symposium, Max Delbruck Center, Berlin Symposium on Quantitative Genetics, Bar Harbor, ME Quantitative Genetics Symposium, Regensberg, Germany HUGO, Comparative Mapping Symposium, Brisbane, Australia American Academy of Allergy Asthma and Immunology, New Orleans, LA Genetics Symposium, International Society of Hypertension, Glasgow, UK Molecular Genetics of Complex Cardiovascular and Metabolic Disease, Stanford University, Stanford, CA Allerton II, “Genetic Analysis of Economically Important Traits of Livestock,” University of Illinois, Chicago, IL Fourth Symposium by the ESSM, “Genes and Cardiovascular Disease: Damage or Salvage?” Brescia, Italy Ninth International Vascular Biology Meeting, Seattle, WA American Physiological Society Experimental Biology 97, “Genomics to Physiology: How Do We Get There,” New Orleans, LA Nature Genetics Conference, “Functional Genomics: From Genes to Drugs,” Washington, DC Ninth International Symposium, “SHR and Cardio-Vascular Genetics,” Montreal, Canada Satellite Symposium, “Predictive Preventive Medicine for Hypertensive Cardiovascular Diseases (CVD),” Kyoto, Japan The 2nd Shizuoka Forum on Health and Longevity Program, Shizuoka, Japan 28 1997 1997 1998 1998 1998 1998 1999 1999 1999 1999 1999 1999 2000 2000 2001 2001 2001 2002 2002 2002 2003 2003 2004 2005 2007 2007 2008 2009 Fifteenth Ernst Klenk Conference, Cologne, Germany Free University, Berlin, Germany QTL Mapping in Animal Models Workshop, Center for Environmental Genetics, University of Cincinnati Experimental Biology 98 In Focus Program, San Francisco, CA Seventeenth ISH Meeting, “Interaction of Genetic and Environmental Factors in the Etiology of Hypertension,” Prague, Czech Republic The Jackson Laboratory First Annual Meeting, “Rodent Models in Modern Risk Assessment,” Bar Harbor, ME Japan/US, National Academy of Science Merck Research Laboratories, Metabolic Diabetes Complications, West Point, PA Howard Hughes Medical Institute/University of Wisconsin Medical School, University of Wisconsin Comprehensive Cancer Center, “Genetics, Genomics and Molecules,” Madison, WI Cold Spring Harbor Laboratory, Genome Mapping and Sequencing, “Genetics of Complex Traits,” Cold Spring Harbor, NY The Jackson Laboratory/Hoffmann-La Roche, “Advanced Approaches to Complex Diseases,” Roche Nutley, NY Keystone Symposium, “Molecular Biology of the Cardiovascular System (A3),” Snowbird, CO The Future of Molecular Medicine, Berlin, Germany International Society of Hypertension “End Stage Renal Disease With and Without Hypertension,” Chicago, IL Tenth International Symposium, Rat Genetics, Genomics and Model Systems for Human Disease, “NHLBI’s program in Genomic Application,” Berlin, Germany Wisconsin Symposium on the Analysis of Human Biology, Genes, Genomes and Molecules, “Functional Genomics, from Rat to Man,” University of WisconsinMadison, Madison, WI American Heart Association, Scientific Sessions 2001, “Genetic Interactions in Multigene Disorders,” Anaheim, CA Division of Intramural Research of the National Human Genome Research Institute, Bethesda, MD American Society of Human Genetics, Moderate 52nd Annual Meeting, Baltimore, MD The American Society of Nephrology 35th Annual Meeting and Scientific Exposition, Symposium Moderator, Philadelphia, PA Wisconsin Symposium III, University of Wisconsin-Madison, Madison, WI Cold Spring Harbor Laboratory, Rat Genomics & Models, Cold Spring Harbor, NY Society of Toxicology 43rd Annual Meeting, Baltimore, MD National Institute of Environmental Health Sciences, National Toxicology Program 2005, Research Triangle Park, NC National Heart, Lung and Blood Institute Systems Medicine Workshop, Bethesda, MD Clinical Research Forum, Analysis, Advocacy, Action, Washington, DC Laird Center for Medical Research dedication ‘Building the Future of Medicine’. Genetics panel discussion. University of Wisconsin, Madison Genomics Seminar Series. “From Genome Wide Association Studies (GWAS) to understanding common disease. 29 2009 Experimental Biology 2009 New Orleans, ‘The Rat Genome Contribution to understanding the Pathogenesis of Hypertension. Bibliography: Original Reports 1. Alper RH, Jacob HJ, Brody MJ. Regulation of arterial pressure labiality following sinoaortic deafferentation in rats. Am J Physiol. 1987 Aug;253(2 Part 2):H466-74. PMID: 3618819 2. Alper RH, Jacob HJ, Brody MJ. Central and peripheral mechanisms of arterial pressure labiality following baroreceptor denervation. Canadian J Physiol Pharmacol. 1987 Aug;65(8):1615-18. PMID: 3121155. 3. Jacob HJ, Barres CP, Machado BH, Brody MJ. Studies on neural and humeral contributions to arterial pressure labiality. Am J Med Sci. 1988 Apr;295(4):341-5. PMID: 3284353. 4. Lewis SJ, Barres C, Jacob HJ, Ohta H, Brody MJ. Cardiovascular effects on the N-methyl-D aspartate receptor antagonist MK in conscious rats. Hypertension. 1989 Jun:13(6 Pt 2):75965. PMID: 2544522. 5. Jacob HJ, Alper RH, Brody MJ. Lability of arterial pressure after baroreceptor denervation is not pressure dependant. Hypertension. 1989 Nov;14(5):501-10. 2807511. 6. Jacob HJ, Lewis SJ, Alper RJ, Grosskreutz CL, Brody MJ. Role of peripheral mechanisms in arterial pressure labiality after sinoaortic deafferentation. Am J Physiol. 1991 Feb;260(2 Pt 2):R359-67. PMID: 1996723. 7. Sigmund CD, Jones CA, Jacob HJ, Ingelfinger J, Kim U, Gamble D, Dzau VJ, Gross KW. Pathophysiology of vascular smooth muscle Renin expression in Renin promoter-T-antigen transgenic mice. Am J Physiol. 1991 Feb;260(2 Part 2):F249-57. PMID: 1996675. 8. Jacob HJ, Alper RH, Grosskreutz CL, Lewis SJ, Brody MJ. Vascular tone influences arterial pressure liability after sionoaortic deafferent. Am J Physiol. 1991 Feb;260(2 Pt 2):359-67. PMID: 1996723. 9. Jacob HJ, Sigmund CD, Shockley TR, Gross KW, Dzau VJ. Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia. Hypertension. 1991 Jun;17(6 Pt 2):1167-72. PMID: 2045162. 10. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao Y, Ganten D, Dzau VJ, Lander ES. Genetic mapping of a gene causing hypertension in the spontaneously hypertensive rat. Cell. 1991 Oct 4;67(1):213-24. PMID: 1655275. 11. Dzau VJ, Jacob HJ, Lindpaintner K, Ganten D, Lander ES. Genetic mapping in hypertension. J Vasc Surg. 1992 May;15(5):930. PMID: 1578573. 12. Barres C, Lewis SJ, Jacob HJ, Brody MJ. Arterial pressure labiality and renal sympathetic nerve activity are dissociated in SAD rats. Am J Physiol. 1992 Sep;263(3 Pt 2):R639-46. PMID: 1415652. 13. Schunkert H, Ingelfinger JR, Jacob HJ, Jackson B, Dzau VJ. Reciprocal regulation of renal Renin and angiotensinogen gene expression by angiotensin II. Am J Physiol. 1992 Nov;263(5 Pt 1):E863-9. PMID: 1443118. 14. Kimura S, Mullins JJ, Bunnemann B, Metzger R, Hilgenfeldt U, Zimmermann F, Jacob HJ, Fuxe K, Ganten D, Kaling M. High blood pressure in transgenic mice carrying the rat angiotensinogen gene. EMBO J. 1992 Mar;11(3):821-7. PMID: 1547785. 15. Jacob HJ, Pettersson A, Wilson D, Mao Y, Lernmark Å, Lander ES. Genetic dissection of autoimmune type I diabetes in the BB rat. Nature Genetics. 1992 Sep;2(1):56-60. PMID: 1303251. 16. Schunkert H, Ingelfinger JR, Hirsch AT, Pinto Y, Jacob H, Dzau VJ. Feedback regulation of angiotensin of converting enzyme activity and mRNA levels by angiotensin II. Circ Res. 1993 Feb;72(2):312-8. PMID: 8380358. 30 17. Rakugi H, Jacob HJ, Krieger JE, Ingelfinger JR, Pratt RE. Vascular injury induces angiotensinogen gene expression in the media and neointima. Circulation. 1993 Jan;87(1):283-90. PMID: 8419017. 18. Koike G, Krieger JE, Jacob HJ, Masashi M, Pratt RE, Dzau VJ. Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme. Biochem Biophys Res Commun. 1994 Jan 14;198(1):380-6. PMID: 8292044. 19. Hsu LC, Kennan WS, Shepel L, Jacob HJ, Szpirer C, Lander ES, Gould MN. Genetic identification of Mcs-1, a rat mammary carcinoma suppressor gene. Cancer Res. 1994 May 15;54(10):2765-70. PMID: 8168109. 20. Koike G, Horiuchi M, Yamada T, Szpirer C, Jacob HJ, Dzau VJ. Human type 2 angiotensin II receptors gene cloned, mapped to the X chromosome and its mRNA is expressed in the human lung. Biochem Biophys Res Commun. 1994 Sep 30;203(3):1842-50. PMID: 7945336. 21. Jacob HJ, Brown D, Bunker R, Daly MJ, Dzau VJ, Goodman A, Koike G, Kren V, Kurtz T, Lernmark Å, Levan G, Mao Y, Pettersson A, Pravenec M, Simon JS, Szpirer C, Szpirer J, Trolliet MR, Winer E, Lander ES. A genetic linkage map of the laboratory rat, Rattus norvegicus. Nature Genetics. 1995 Jan;9(1):63-69. PMID: 7704027. 22. Truett GE, Jacob HJ, Miller J, Drouin G, Bahary N, Smoller JW, Lander ES, Leibel RL. Genetic map of rat chromosome 5 including the fatty (fa) locus. Mamm Genome. 1995 Jan;6(1):2530. PMID: 7719022. 23. Tay A, Simon JS, Squire J, Jacob HJ, Skorecki K. Cytosolic phospholipase A2 gene in human and rat: chromosomal localization and polymorphic markers. Genomics. 1995 Mar 1;26(1):138-141. PMID: 7782073. 24. Bloch KD, Wolfram JR, Roberts JD, Zapol DG, Lepore JJ, Filippov G, Thomas JE, Brown D, Jacob HJ, and Bloch DB. Three members of the nitric oxide synthase II gene family colocalize to human chromosome 17. Genomics. 1995 Jun 10;27(3):526-30. PMID: 7558036. 25. Pettersson A, Wilson D, Daniels T, Tobin S, Jacob HJ, Lander ES, Lernmark Å. Thyroiditis in the BB rat is associated with lymphopenia but occurs independently of diabetes. J. Autoimmunity. 1995 Aug;8(4):493-505. PMID: 7492346. 26. Pettersson A, Winer ES, Weksler-Zangen S, Lernmark Å, Jacob HJ. Predictability of heterozygosity scores and polymorphism information content values for rat genetic markers. Mamm Genome. 1995 Aug;6(8):512-520. PMID: 8589519. 27. Osten M, Den Bieman M, Jacob HJ, Szpirer J, Szpirer C, Bender K, Van Zutphen BFM. Use of simple sequence length polymorphisms for genetic characterization of rat inbred strains. Mamm Genome. 1995 Sep;6(9):595-601. PMID: 8535065. 28. Schork NJ, Krieger JK, Trolliet M, Franchini KG, Koike G, Krieger EM, Lander ES, Dzau VJ, Jacob HJ. A biometrical genome search in rats reveals the multigenic basis of blood pressure variation. Genome Research. 1995 Sep;5(2):164-172. PMID: 9132270. 29. Koike G, Jacob HJ, Krieger JE, Szpirer C, Hoehe MR, Horiuchi M, Dzau VJ. Investigation of the phenylethanolamine N-methyltransferase gene as a candidate gene for hypertension. Hypertension. 1995 Oct;26(4):595-601. PMID: 7558218. 30. Jacob HJ, Ramanathan A, Pan SG, Brody MJ, Myers GA. Spectral analysis of arterial pressure labiality in rats with sinoaortic deafferentation. American Journal of Physiology. 1995 Dec;269 (6 Pt 2):R1481-8. PMID: 8594953. 31. Koike G, Winer ES, Horiuchi M, Brown DM, Szpirer C, Dzau VJ, Jacob HJ. Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene. Hypertension. 1995 Dec;26(6 Pt 1):998-1002. PMID: 7490161. 32. Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ. Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat. Nature Genetics. 1996 Jan;12(1):44-51. PMID: 8528250. 31 33. Galli J, Li LS, Glaser A, Ostenson C, Jiao H, Fakhrai-Rad H, Jacob HJ, Lander ES, Luthman H. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nature Genetics. 1996 Jan;12(1):31-7. PMID: 8528247. 34. St. Lezin EM, Pravenec M, Wong AL, Liu W, Wang N, Lu S, Jacob HJ, Roman RJ, Stec DE, Wang JM, Reid IA, Kurtz TW. Effects of Renin gene transfer on blood pressure and renin gene expression in a congenic strain of Dahl salt-resistant rats. J Clin Invest. 1996 Jan 15;97(2):522-27. PMID: 8567976. 35. Lee JS, Adrie C, Jacob HJ, Roberts JD, Zapol WM, Bloch KD. Chronic inhalation of nitric oxide inhibits neointimal formation after balloon-induced arterial injury. Circ Res. 1996 Feb;78(2):337-42. PMID: 8575078. 36. Jacob HJ. A landmark for orphan genomes? Nat Genet. 1996 May;13(1):14-5. PMID: 8673094. 37. Simon JS, Deshmukh G, Couch FJ, Merajver SD, Weber BL, Van Vooren P, Tissil F, Szpirer J, Szpirer C, Alper SL, Jacob HJ, Brosius FC III. Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2 and Ae3. Mamm Genome. 1996 May;7(5):380-2. PMID: 8661729. 38. Stec DE, Trolliet MR, Krieger JE, Jacob HJ, Roman RJ. Renal cytochrome P4504A activity and salt sensitivity in spontaneously hypertensive rats. Hypertension. 1996 Jun;27(6):132936. PMID: 8641744. 39. Chung H, Roberts CT, Greenberg S, Rebeck GW, Christie R, Wallace R, Jacob HJ, Hyman BT. Lack of association of trinucleotide repeat polymorphisms in the very low density lipoprotein receptor gene with Alzheimer’s disease. Ann Neurol. 1996 June;39(6):800-3. PMID: 8651653. 40. Satler CA, Walsh E, Vesely M, Plummer MH, Ginsburg GS, Jacob HJ. Novel mis-sense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome. Am J Medl Genet. 1996 Oct 2;65(1):27-35. PMID: 8914737. 41. Koike G, Van Vooren P, Shiozawa M, Galli J, Li LS, Glaser A, Balasubramanyam A, Brown LJ, Luthman H, Szpirer C, MacDonald JM, Jacob HJ. Genetic mapping and chromosome localization of the rat mitochondrial 3-phosphate dehydorogenase gene, a candidate for noninsulin-dependant diabetes mellitus. Genomics. 1996 Nov 15;38(1):96-9. PMID: 8954787. 42. Otsen M, den Bieman M, Kuiper MTR, Pravenec M, Kren V, Kurtz TW, Jacob HJ, Lankhorst A. Van Zutphen BFM. Use of AFLP markers for gene mapping and QTL detection in the rat. Genomics. 1996 Nov 1;37(3):289-94. PMID: 8938440. 43. Knapik EW, Goodman A, Atkinson OS, Roberts CT, Shiozawa M, Sim CU, Weksler-Zangen S, Trolliet MR, Futrell C, Innes BA, Koike G, McLaughlin MG, Pierre L, Simon JS, Vilallonga E, Roy M, Chiang P-W, Fishman MC, Driever W, Jacob HJ. A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphisms. Development. 1996 Dec;123:451-60. PMID: 9007262. 44. Schork NJ, Nath SP, Lindpainter K, Jacob HJ. Extensions to quantitative trait locus mapping in experimental organisms. Hypertension. 1996 Dec;28(6):1104-11. PMID: 8952606. 45. Larsson M, Tissir F, Walter L, Gunther E, Jacob HJ, Klinga-Levan K, Levan G. Mapping of the rat ribosomal protein S18 gene (Rps 18) to chromosome 20p12. Mamm Genome. 1996 Jan;7(1):90. PMID: 8903742. 46. Jiang J, Stec DE, Drummond H, Simon JS, Koike G, Jacob HJ, Roman RJ. Transfer of a saltresistant renin allele raises blood pressure in Dahl salt-sensitive rats. Hypertension. 1997 Feb;29(2):619-27. PMID: 9040448. 47. Stelzner T, Hofmann TA, Brown DM, Deng AY, Jacob HJ. Genetic determinants of pulmonary hypertension in fawn-hooded rats. Chest. 1997 Jun;111(6 Suppl):96S. PMID: 9184548. 48. Szpirer C, Szpirer J, Vanvooren P, Riviere M, Maget B, Svoboda M, Shiozawa M, Simon JS, Jacob HJ, Koike G. Localization of the rat genes encoding glucagon, glucagon receptor, and 32 insulin receptor, candidates for diabetes mellitus susceptibility loci. Mamm Genome. 1997 Aug;8(8):586-8. PMID: 9250867. 49. Zhang, QY, Dene H, Deng AY, Jacob HJ, Rapp JP. Interval mapping and congenic strains for a blood pressure QTL on rat chromosome 13. Mamm Genome. 1997 Sep;8(9):636-41. PMID: 9250867. 50. Van Dokkum, RPE, Jacob HJ, Provoost AP. Difference in susceptibility to develop renal damage in normotensive fawn-hooded (FHL) and August Copenhagen Irish (ACI) rats after N(omega)-n arginine methyl ester induced hypertension. Am J Hypertens. 1997 Oct;10(10 Pt 1):1109-16. PMID: 9370381 51. Schunkert H, Broeckel U, Kromer EP, Elsner D, Jacob HJ, Riegger GA. A large pedigree with vavuloseptal defects. Am J Cardiol. 1997 Oct 1;80(7):968-70. PMID: 9382022. 52. Harris EL, Grigor MR, Innes BA, Harrap SB, Koike G, Jacob HJ. Strain-specific deletions in exon 10 of rat K-kininogen and T1-kininogen genes allow mapping of both genes to rat chromosome 11. Mamm Genome. 1997 Oct;8(10):791-2. PMID: 9321484. 53. Koike G, Miano J.M, Vanvooren P, Shiozawa M, Szpirer C, Jacob HJ. Mapping of the rat SM22 gene to Chromosome 8q24: a candidate for high blood pressure and cardiac hypertrophy. Mamm Genome. 1998 Jan;9(1):76-7. PMID: 9434951 54. Innes BA, McLaughlin M, Kapuscinski MK, Jacob HJ, Harrap SB. Independent genetic susceptibility to cardiac hypertrophy in inherited hypertension. Hypertension. 1998 Mar;31(3):741-6. PMID: 9495256. 55. Jiang J, Jacob HJ. EbEST: An automated tool using expressed sequence tags to delineate gene structure. Genome Res. 1998 Mar;8(3):268-75. 56. Brown DM, Van Dokkum RP, Korte MR, McLaughlin MG, Shiozawa M, Jacob HJ, Provoost AP. Genetic control of susceptibility for renal damage in hypertensive fawn-hooded rats. Ren Fail. 1998 Mar;20(2):407-11. PMID: 9574469. 57. Bieg S, Koike G, Klaff L, Pettersson A, MacMurray AJ, Jacob HJ, Lander ES, Lernmark Å. Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat. Mamm Genome. 1998 Apr;9(4):324-6. PMID: 9530633. 58. Broeckel U, Shiozawa M, Kissebah AH, Provoost AH, Jacob HJ. Susceptibility genes for endorgan damage. New strategies to understand diabetic and hypertensive nephropathy. Nephrol Dial Transplant. 1998 Apr;13(4):840-2. PMID: 9568834. 59. Knapik EW, Goodman A, Ekker M, Chevrette M, Delgado J, Neuhauss S, Shimoda N, Driever W Fishman MC, Jacob HJ. A microsatellite genetic linkage map for zebrafish (Danio rerio). Nat Genet. 1998 Apr;18(4):338-43. PMID: 9537415. 60. Van Dokkum RP, Jacob HJ, Provoost AP. Genetic differences define severity of renal damage after L-NAME-induced hypertension in rats. J Am Soc Nephrol. 1998 Mar;9(3):363-71. PMID: 9513898. 61. Brown DM, Matise TC, Koike G, Zangen S, Simon JS, McLaughlin MG, Winer ES, Chakravarti A, Lander ES, Jacob HJ. An integrated genetic linkage map of the laboratory rat. Mamm Genome. 1998 Jul;9(7):521-30. PMID: 9657848. 62. Szpirer C, Szpirer J, Van Vooren P, Tissir F, Simon JS, Koike G, Jacob HJ, Lander ES, Helou K, Klinga-Levan K, Levan G. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Mamm Genome. 1998 Sep;9(9):721-34. PMID: 9716657. 63. Moralejo DH, Wei S, Wei K, Weksler-Zangen S, Koike G, Jacob HJ, Hirashima T, Kawano K, Sugiura K, Sasaki Y, Ogino T, Yamada T, Matsumoto K. Identification of quantitative trait loci for non-insulin-dependent diabetes mellitus that interact with body weight in the Otsuka Long-Evans Tokushima Fatty rat. Proc Assoc Am Physicians. 1998 Nov-Dec;110(6):545-58. PMID: 9824537. 33 64. Van Dokkum RPE, Alonso-Galicia M, Provoost AP, Jacob HJ, Roman RJ. Impaired autoregulation of renal blood flow in the fawn-hooded rat. Am J Physiol. 1999 Jan;276(1 Pt 2):R189-96. PMID: 9887194. 65. Koike G, Chiche JD, Shiozawa M, Simon JS, Szpirer J, Jacob HJ, Szpirer C, Bloch KD. Localization of rat genes in the nitric oxide signaling pathway: candidates for the pathogenesis of complex diseases. Mamm Genome. 1999 Jan;10(1):71-3. PMID: 9892738. 66. Wei S, Wei K, Moralejo DH, Ogino T, Koike G, Jacob HJ, Sugiura K, Sasaki Y, Yamada T, Matsumoto K. Mapping and characterization of quantitative trait loci for non-insulindependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima Fatty Rat. Mamm Genome. 1999 Mar;10(3):249-58. PMID: 10051320. 67. Van Dokkum RP, Sun CW, Provoost AP, Jacob HJ, Roman RJ. Altered renal hemodynamics and impaired myogenic responses in the fawn-hooded rat. Am J Physiol. 1999 Mar;276(3 Pt 2):R855-63. PMID: 10070148. 68. Szpirer C, Szpirer J, VanVooren P, Tissir F, Kela J, Lallemand F, Hoebee B, Simon JS, Koike G, Jacob HJ, Lander ES, Helou K, Klinga-Levan K, Levan G. Gene-based anchoring of the rat genetic linkage and cytogenetic maps. Transplant Proc. 1999 May;31(3):1541-3. PMID: 10330994. 69. Steen RG, Kwitek-Black A, Glenn C, Gullings-Handley J, Van Etten Van W, Atkinson OS, Appel D, Twigger S, Muir M, Mull T, Granados M, Kissebah M, Russo K, Crane R, Popp M, Peden M, Matise T, Brown DM, Lu J, Kingsmore S, Tonellato PJ, Rozen S, Slonim D, Young P, Knoblauch M, Provoost A, Ganten D, Coleman S, Rothberg J, Lander ES, Jacob HJ. A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. Genome Res. 1999 Jun;9(6):AP1-8. PMID: 10400928. 70. Jacob HJ. Physiological genetics: application to hypertension research. Clin Exp Pharmacol Physiol. 1999 Jul;26(7):530-5. PMID: 10405781. 71. Glickman M, Malek RL, Kwitek-Black A, Jacob HJ, Lee NH. Molecular cloning, tissuespecific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein-coupled receptor, nrg-1. Mol Cell Neurosci. 1999 Aug;14(2):141-52. PMID: 10532805. 72. Jacob HJ. Functional genomics and rat models. Genome Res. 1999 Nov;9(11):1013-6. PMID: 10405781. 73. Fakhrai-Rad H, Jiao H, Li L, Glaser A, Koike George, Jacob HJ, Luthman H, Galli J. A rat genetic linkage map including 67 new microsatellite markers. Mamm Genome. 1999 Nov;10(11):1102-5. PMID: 10556432. 74. Shimoda N, Knapik EW, Ziniti J, Sim C, Yamada E, Kaplan S, Jackson D, Sauvage F, Jacob HJ, Fishman MC. Zebrafish genetic map with 2000 microsatellite markers. Genomics. 1999 Jun 15;58(3):219-32. PMID: 10373319. 75. Klaff LS, Koike G, Jiang J, Wong Y, Bieg S, Pettersson A, Lander E, Jacob HJ, Lernmark Å. BB Rat Diabetes susceptibility and body weight regulation genes colocalize on chromosome 2. Mamm Genome. 1999 Sep;10(9):883-7. PMID: 10441739. 76. Nobrega MA, Shiozawa M, Koike G, Jacob HJ, Miano JM. Gene structure and chromosomal mapping of the rat smooth muscle calponin gene. Mamm Genome. 2000 Feb;11(2):115-9. PMID: 10656925. 77. Jones GT, Harris EL, Jacob HJ, van Rij AM. Spontaneous elastic tissue lesions in the rat abdominal aorta, a genetically determined phenotype. J Vasc Res. 2000 Mar-Apr;37(2):7381. PMID: 10754392. 78. Baker JE, Konorev EA, Gross GJ, Chilian WM, Jacob HJ. Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection? Am J Physiol Heart Circ Physiol. 2000 Apr;278(4):H1395-400. PMID: 10749737. 34 79. Cowley AW, Stoll M, Greene AS, Kaldunski ML, Roman RJ, Tonellato, PJ, Schork NJ, Jacob HJ. Genetically defined risk of salt sensitivity in an intercross Brown Norway and Dahl S rats. Physiol Genomics. 2000 Apr 27;2(3):107-15. PMID: 11015589 80. Stoll M, Kwitek-Black AE, Cowley AW, Harris EL, Harrap SB, Krieger JE, Printz MP, Provoost AP, Sassard J, Jacob HJ. New target regions for human hypertension via comparative genomics. Genome Res. 2000 Apr;10(4):473-82. PMID: 10779487 PMCID: PMC310887. 81. Schork NJ, Chakravarti A, Thiel B, Fornage M, Jacob HJ, Cai R, Rotimi CN, Cooper RS, Weder AB. Lack of association between a biallelic polymorphism in the adducin gene and blood pressure in whites and African Americans. Am J Hypertens. 2000 June;13(6 Pt 1):693-8. PMID: 10912755. 82. Van Dokkum RPE, Jacob HJ, Provoost AP. Blood pressure and the susceptibility to renal damage after unilateral nephrectomy and L-NAME-induced hypertension in rats. Nephrol Dial Transplant. 2000 Sep;15(9):1337-43. PMID: 15976509. 83. Shiozawa M, Provoost AP, Van Dokkum RPE, Majewski R, Jacob HJ. Evidence of genegene interactions in the genetic susceptibility to renal impairment following unilateral nephrectomy. J. Am. Soc. Nephrol. 2000 Nov;11(11):2068-78. PMID:11053483. 84. Gosele C, Hong L, Kreitler T, Rossmann M, Hieke B, Grob U, Kramer M, Himmelbauer H, Bihoreau M, Kwitek-Black AE, Twigger S, Tonellato PJ, Jacob HJ, Schalkwyk LC, Lindpaintner K, Ganten D, Lehrach H, Knoblauch M. High-throughput scanning of the rat genome using interspersed repetitive sequence-PCR markers. Genomics. 2000 Nov 1;69(3):287-94. PMID: 11056046. 85. Ou H, Haendeler J, Aebly MR, Kelley LA, Koike G, Kwitek-Black AE, Jacob HJ, Berk BC, Miano JM. Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells. Circ Res. 2000 Nov 10;87(10):881-7. PMID: 11073883. 86. Zhu X, McKenzie CA, Forrester T, Nickerson DA, Broeckel U, Schunkert H, Doering A, Jacob HJ, Cooper RS, Rieder MJ. Localization of a small genomic region associated with elevated ACE. Am J Hum Genet. 2000 Nov;67(5):1144-53. PMID: 11001581 PMCID: PMC1288557. 87. Kissebah AH, Sonnenberg GE, Myklebust J, Goldstein M, Broman K, James RG, Marks JA, Krakower GR, Jacob HJ, Weber J, Martin L, Blangero J. Comuzzie AG. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of metabolic syndrome. Proc Natl Acad Sci USA. 2000 Dec 19;97(26):14478-83. PMID: 11121050 PMCID: PMC18944. 88. Schork NJ, Fallin D, Thiel B, Xu X, Broeckel U, Jacob HJ, Cohen D. The future of genetic case-control studies. Adv Genet. 2001;42:191-212. PMID: 11037322. 89. Nadeau JH, Balling R, Barsh G, Beier D, Brown SD, Bucan M, Camper S, Carlson G, Copeland N, Eppig J, Fletcher C, Frankel WN, Ganter D, Goldowitz D, Goodnow C, Guenet JL, Hicks G, de Angelis MH, Jackson I, Jacob HJ, Jenkins N, Johnson D, Justice M, Kay S, Kinglsey D, Lehrach H, Magnuson T, Meisler M, Poustka A, Rinchik EM, Rossant J, russell LB, Schimenti J, Shioroishi T, Skarnes WC, Soriano P, Stanford W, Takahashi JS, Wurst W, Zimmer A. Sequence interpretation. Functional annotation of mouse genome sequencing. Science. 2001 Feb 16;291(5507):1251-5. PMID: 11233449. 90. Kwitek-Black AE, Jacob HJ. The use of designer rats in the genetic dissection of hypertension. Curr Hypertens Rep. 2001 Feb;3(1):12-8. PMID: 11177702. 91. Cowley AW, Roman RJ, Kaldunski ML, Dumas P, Dickhout JG, Greene AS, Jacob HJ. Brown Norway chromosome 13 confers protection from high salt to consomic Dahl S rat. Hypertension. 2001 Feb;37(2 Pt 2):456-61. PMID: 11230318. 92. Sheetz TE, Raymond MR, Nishimura DY, McClain A, Roberts C, Birkette C, Gardiner J, Zhang J, Butters N, Sun C, Kwitek-Black A, Jacob HJ, Casavant TL, Soares MB, Sheffield VC. Generation of a high-density rat EST map. Genome Res. 2001 Mar;11(3):497-502. PMID: 11230173 PMCID: PMC311028. 93. Stoll M, Jacob HJ. Genetic rat models of hypertension: relationship to human hypertension. Curr Hypertens Rep. 2001 Apr;3(2):157-64. PMID: 11276399. 35 94. Tseng J, Kwitek-Black AE, Erbe CB, Popper P, Jacob HJ, Wackym PA. Radiation hybrid mapping of 11 alpha and beta nicotinic acetylcholine receptor genes in Rattus nrovegicus. Brain Res Mol Brain Res. 2001 Jul 13;91(1-2):169-73. PMID: 11457506. 95. Harris EL, Stoll M, Jones GT, Granados MA, Porteous WK, van Rij AM, Jacob HJ. Identification of two susceptibility loci for vascular fragility in the Brown Norway rat. Physiol Genomics. 2001 Aug 28;6(3):183-9. PMID: 11526202. 96. Comuzzie AG, Funahaski T, Sonnenberg G, Martin LJ, Jacob HJ, Black AE, Maas D, Takahashi M, Kihara S, Tanaka S, Matsuzawa Y, Blangero J, Cohen D, Kissebah A. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J Clin Endocrinol Metab. 2001 Sep;86(9):4321-5. PMID: 11549668. 97. Weksler-Zangen S, Yagil C, Zangen DH, Ornoy A, Jacob HJ, Yagil Y. The newly inbred Cohen diabetic rat: a non-obese normolipidemic genetic model of diet-induced type 2 diabetes expressing gender differences. Diabetes. 2001 Nov;50(11)2521-9. PMID: 11679430. PMID: 11679430. 98. Kwitek-Black AE, Tonellato PJ, Soares MB, Chen D, Scheetz TE, Gullings-Handley J, Casavant TL, Twigger S, Cheng YS, Stoll M, Sheffield VC, Jacob HJ. Automated construction of high-density comparative maps between rat, human and mouse. Genome Res. 2001 Nov;11(11):1395-43. PMID: 11691858 PMCID: PMC311144. 99. Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ. A genomic-systems biology map for cardiovascular function. Science. 2001 Nov 23;294(5547):1723-6. PMID 11721057. 100. Roman, RJ, Cowley AW Jr, Greene A, Kwitek AE, Tonellato PJ, Jacob HJ. Consomic rats for the identification of genes and pathways underlying cardiovascular disease. Cold Spring Harbor Symposia on Quantitative Biology. 2002 67:309-15. PMID: 12858554. 101. Twigger S, Lu J, Shimoyama M, Chen D, Pasko D, Long H, Ginster J, Chen C, Nigam R, Kwitek A, Eppig J, Maltais L, Maglott D, Schuler G, Jacob HJ and Tonellato P. Rat Genome Database (RGD): Mapping disease onto the genome. Nucleic Acids Res. 2002 Jan 1;30(1):125-8. PMID: 11752273. PMCID: PMC99132. 102. Kita Y, Shiozawa J, Jin W, Majewski RR, Besharse JC, Greene AS, Jacob HJ Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies. Pharmacogenetics. 2002 Jan;12(1):55-65. PMID: 11773865. 103. Jacob HJ and Kwitek A. Rat genetics: Attaching physiology and pharmacology to the genome. Nature Reviews Genetics. 2002 Jan;3(1):33-42. PMID: 11823789. 104. The FBPP Investigators. Multi-Center Genetic Study of Hypertension. Hypertension. 2002 Jan;39(1):3-9. PMID: 11799070. 105. Broeckel U, Hengstenberg C, Mayer B, Holmer S., Martin L, Comuzzie A, Blangero J, Nurnberg P, Reis A, Riegger G, Jacob HJ and Schunkert H. A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat Genet. 2002 Feb;30(2):210-14. PMID: 11818963. 106. Yoon JW, Kita Y, Frank D, Majewski RR, Konicek BA, Nobrega MA, Jacob HJ, Walterhouse D, Iannacconne P. Gene expression profiling leads to identification of GLI1 binding elements in target genes and a role for multiple downstream pathways in GLI1 induced cell transformation. J Biol Chem. 2002 Feb 15;277(7):5548-55. PMID: 11719506. 107. Provoost AP, Shiozawa J, Van Dokkum RP, Jacob HJ. Transfer of the Rf-1 region from FHH onto the ACI background increases susceptibility to renal impairment. Physiologic Genomics. 2002 Feb;8(2):123-29. PMID: 11875190. 108. Liang M, Yuan B, Rute E, Greene AS, Zou AP, Soares P, McQuestion GD, Slocum GR, Jacob HJ, Cowley AW JR. Renal medullary genes in salt-sensitive hypertension: a chromosomal substitution and cDNA microarray study. Physiological Genomics. 2002 Feb;8(2):139-49. PMID: 11875192. 36 109. Kendziorski CM, Cowley AW Jr, Greene AS, Salgado HC, Jacob HJ and Tonellato PJ. Mapping Baroreceptor Function to Genome: A Mathematical Modeling Approach. Genetics. 2002 Apr;160(4):1687-95. PMID: 11973321 PMCID: PMC1462065. 110. MacMurray AJ, Moralejo DH, Kwitek AE, Rutledge EA, Van Yserloo B, Gohlke P, Speros SJ, Snyder B, Schaefer J, Bieg S, Jiang J, Ettinger RA, Fuller J, Daniels TL, Pettersson A, Orlebeke K, Birren B, Jacob HJ, Lander ES, Lerhmark A. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Research. 2002 Jul;12(7):1029-39. PMID: 12097339 PMCID: PMC186618. 111. Kotchen, TA, Broeckel U., Grim CE, Hamet P, Jacob HJ, Kaldunski ML, Kotchen JM, Schork NJ, Tonellato PJ and Cowley AW Jr. Identification of Hypertension-Related QTLs in African American Sib pairs. Hypertension. 2002 Nov;40(5):634-39. PMID: 12411455. 112. Tseng J, Erbe CB, Kwitek AE, Jacob HJ, Propper P, Wackym PA. Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus. Hearing Research. 2002 Dec;174(1-2):86-92. PMID: 12433399. 113. Ueno T, Tremblay J, Kunes J, Zicha J, Dobesova Z, Pausova Z, Deng AY, Sun Y, Jacob HJ, Hamet P. Gender-specific genetic determinants of blood pressure and organ weight: pharmacogenetic approach. Physiol Res. 2003; 52(6):689-700. PMID: 14640890. 114. Hessner, MJ, Wang X, Khan S, Meyer L, Schlicht M, Tackes J, Datta MW, Jacob HJ, Ghosh S. Use of a three-color cDNA microarray platform to measure and control supportbound probe for improved data quality and reproducibility. Nucleic Acids Res. 2003 Jun 1;31(11):e60. PMID: 12771224 PMCID: PMC156737. 115. Ueno T, Tremblay J, Kunes J, Zicha J, Dobesova Z, Pausova Z, Deng AV, Sun YL, Jacob HJ, Hamet P. Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems. J Mol Med. 2003 Jan;81(1):51-60. PMID: 12545249. 116. Datta YV, Wu FC, Dumas PC, Rangel-Filho A, Datta MW, Ning G, Cooley BC, Majewski RR, Provoost AP, Jacob HJ. Genetic mapping and characterization of the bleeding disorder in the fawn-hooded hypertensive rat. Thromb Haemost. 2003 Jun;89(6):1031-42. PMID: 12783116. 117. Moreno C, Dummas P, Kaldusnki ML, Tonellato PJ, Greene AS, Roman RJ, Cheng Q, Wang Z, Jacob HJ, Cowley AW Jr. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiol Genomics. 2003 Nov 11;15(3):243-57. PMID: 14532335. 118. Moralejo DH, Park HA, Speros SJ, MacMurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A. Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. J Autoimmun. 2003 Dec;21(4):315-324. PMID 14624755. 119. Cioffi JA, Erbe CB, Raphael R, Kwitek AE, Tiwari UK, Jacob HJ, Popper P, Wackym PA. Expression of G-protein alpha subunit genes in the vestibular periphery of Rattus novegicus and their chromosomal mapping. Acta Otolaryngol. 2003 Dec;123(9):1027-1034. PMID: 14710903. 120. Vitt, U., Gietzen, D., Stevens, K., Wingrove, J., Becha, S., Bulloch, S., Burrill, J., Chawla, N., Chien, J., Crawford, M., Ison, C., Kearney, L., Kwong, M., Park, J., Policky, J., weiler, M., White, R., Xu, Y., Daniels, S., Jacob, H.J., Jensen-Seaman, M. I., Lazar, J., Stuve, L., Schmidt, J. Identification of candidate genes by EST alignments, synteny and expression and verification of Ensembl genes on rat chromosome 1q43-54. Genome Research 4: 640650, 2004. PMID: 15060005 PMCID: PMC383308. 121. Cowley AW Jr., Roman RJ, Jacob, HJ. Application of chromosomal substitution techniques in gene-function discovery. J Physiol. 2004 Jan 1;554(Pt 1):46-55. PMID: 14678490 PMCID: PMC1664739. 37 122. Mattson DL, Kunert MP, Kaldunski ML, Greene AS, Roman RJ, Jacob HJ, Cowley AW Jr. Influence of diet and genetics on hypertension and renal disease in Dahl salt-sensitive rats. Physiol Genomics. 2004 Jan 15;16(2):194-203. PMID: 14600213. 123. Ueno T, Tremblay J,Kunes J, Zicha J, Dobesova Z, Pausova Z, Deng, AY, Syn YL, Jacob HJ, Hamet P. Rat model of familial combined hyperlipidemia as a result of comparative mapping. Physiol Genomics. 2004 Mar 12;17(1):38-47. PMID 14709677. 124. Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, DuganRocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Alba M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hubner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, Lopez-Otin C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F; Rat Genome Sequencing Project Consortium. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature. 2004 Apr 1;428(6982):493-521. PMID: 15057822. 125. Nobrega MA, Fleming S, Roman RJ, Shiozawa M, Schlick N, Lazar J, Jacob HJ. Initial characterization of a rat model of diabetic nephropathy. Diabetes. 2004 Mar;53(3):735742. PMID: 14988259. 126. Jensen-Seaman MI, Furey TS, Payseur BA, Lu Y, Roskin KM, Chen CF, Thomas MA, Haussler D, Jacob, HJ. Comparative recombination rates in the rat, mouse and human genomes. Genome Res. 2004 Apr;14(4):528-538. PMID: 15059993 PMCID: PMC383296. 127. Twigger SN, Nie J, Ruotti V, Yj J, Chen D, Li D, Mathis J, Narayanasamy V, Gopinath GR, Pasko D, Shimoyama M, De La Cruz N, Bromberg S, Kwitek AE, Jacob HJ, Tonellato PJ. Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data. Genome Res. 2004 Apr;14(4)651-660. PMID: 15060006 PMCID: PMC383309. 128. Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ. High-density rat radiation hybrid maps containing over 24,000 38 129. 130. 131. 132. 133. 134. 135. 136. 137. SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Genome Res. 2004 Apr;14(4)750-757. PMID: 15060019 PMCID: PMC383322. Cowley AW Jr, Liang M, Roman RJ, Greene AS, Jacob HJ. Consomic rat model systems for physiological genomics. Acta Physiol Scand. 2004 Aug;181(4):585-92. PMID: 15283774. Michalkiewicz M, Michalkiewicz T, Ettinger RA, Rutledge EA, Fuller JM, Moralejo DH, Van Yserloo B, Macmurray AJ, Kwitek AE, Jacob HJ, Lander ES, Lernmark A. Transgenic rescue demonstrates involvement of the Ian5 gene in cell development in the rat. Physiol Genomics. 2004 Oct 4;19(2):228-32. PMID: 15328390. Bilusic M. Bataillard A, Tschannen MR, Gao L, Barretto NE, Vincent M, Wang T, Jacob HJ, Sassard J, Kwitek AE. Mapping the genetic determinants of hypertension, metabolic disease and related phenotypes in the lyon hypertensive rat. Hypertension. 2004 Nov;44(5):695701. PMID:15452030. Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beav WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NI, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammer-Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O’Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen-Palmer AA, Pan HJ, Peltonen-Palotie L, Pierce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyl LC, Seltzer Z, Shimomura K, Shou S, Sillanpaa MJ, Siracusa LD, Snoec HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshir T, Yi N, Zhang D, Zhang M, Zou F; Complex Trait Consortium. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 2004 Nov;36(11):1133-7. PMID: 15514660. Baessler A, Hasinoff MJ, Fischer M, Reinhard W, Sonnenberg GE, Olivier M, Erdmann J, Schunkert H, Doering A, Jacob HJ, Comuzzie AG, Kissebah AH, Kwitek AE. Genetic linkage and association of the growth hormone secretagogue receptor (Ghrelin receptor) gene in human obesity. Diabetes. 2005 Jan;54(1):259-67. PMID: 15616037 PMCID: PMC2793077. De La Cruz N, Bromberg S, Pasko D, Shimoyama M, Twigger S, Chen J, Chen CF, Fan C, Foote C, Gopinath GR, Harris G, Hughes A, Ji Y, Jin W, Li D, Mathis J, Nenasheva N, Nie J, Nigam R, Petri V, Reilly D, Wang W, Wu W, Zuniga-Meyer A, Zhao L, Kwitek A, Tonellato P, Jacob HJ. The Rat Genome Database (RGD): developments towards a phenomenal database. Nucleic Acids Res. 2005 Jan 1:33 Database Issue:D485-91. PMID: 15608243 PMCID: PMC540004. Fischer M, Broeckel U, Holmer S, Baessler A, Hengstenberg C, Mayer B, Erdmann J, Klein G, Riegger G, Jacob HJ, Schunkert H. Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction. Circulation. 2005 Feb 22;111(7):85562. PMID: 15710764. Rangel-Filho A, Sharma M, Datta YH, Moreno C, Roman RJ, Iwamoto Y, Provoost AP, Lazar J, Jacob HJ. RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. JASN 2005 Apr;16(4):85260. Epub 2005 Mar 9. PMID: 15758045. Shi Y, Hutchins W, Ogawa H, Chang CC, Pritchard KA Jr, Zhang C, Khampang P, Lazar J. Jacob HJ, Rafiee P, Baker JE. Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. J Mol Cell Cardiol. 2005 Apr;38(4):625-635. PMID: 15808839. 39 138. Mattson DL, Kunert MP, Roman RJ, Jacob HJ, Cowley AW Jr. Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat. Am J Physiol Renal Physiol. 2005 May;288(5):F1015-22. PMID: 15644486. 139. Shimoyama M, Petri V, Pasko D, Bromberg S, Wu W, Chen J, Nenasheva N, Kwitek A, Twigger S, Jacob HJ. Using multiple ontologies to integrate complex biological data. Comp Funct Genomics. 2005;6(7-8):373-8.PMID: 18629202 PMCID: PMC2447497. 140. Di Nicolantonio R, Kostka V, Kwitek A, Jacob HJ, Thomas WG, Harrap SB. Fine mapping of Lvm1 : a quantitative trait locus controlling heart size independently of blood pressure. Pulm Pharmacol Ther. 2006;19(1):70-3. Epub 2005 Apr 25. PMID: 162862. 141. Dwinell MR, Forster HV, Petersen J, Rider A, Kunert MP, Cowley AW Jr, Jacob HJ. Genetic determinants on rat chromosome 6 modulate variation the hypercapnic ventilatory response using consomic strains. J Appl Physiol. 2005 May;98(5):1630-8. PMID: 15661838. 142. Van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP. Renal Damage Susceptibility and Autoregulation in Rf-1 and Rf-5 Congenic Rats. Nephron Exp Nephrol. 2005 Jun 20;101(2):e59-366. PMID: 15976509. 143. Twigger SN, Pasko D, Nie J, Shimoyama M, Bromberg S, Campbell D, Chen J. Dela Cruz N, Fan C, Foote C, Harris G, Hickmann B, Ji Y, Jin W, Li D, Mathis J, Nenasheva N, Nigam, R, Petri V, Reilly D, Ruotti V, Schauberger E, Seiler K, Slyper R, Smith J, Wang W, Wu W, Zhao L, Zuniga-Meyer A, Tonellato PJ, Kwitek AE, Jacob HJ. Tools and strategies for Physiological Genomics – The Rat Genome Database. Physiol Genomics. 2005 Oct 17;23(2):246-56. Epub 2005 Aug 16. PMID: 16106031. 144. Lopez B, Ryan RP, Moreno C, Sarkis A, Lazar J, Provoost AP, Jacob HJ, Roman RJ. Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in Fawn Hooded-Hypertensive rats. Am J Physiol Renal Physiol. 2005 Nov 22. PMID: 16303858. 145. Van Dijk SJ, Spechat PA, Lutz MM, Lazar J, Jacob HJ, Provoost AP. Interaction between Rf1 and Rf-4 quantitative trait loci increases susceptibility to renal damage in double congenic rats. Kidney Int. 2005 Dec;68(6):2462-72. PMID: 16316323. 146. Lazar J, Moreno C, Jacob HJ, Kwitek AE. Impact of genomics on research in the rat. Genome Res. 2005 Dec;15(12):1717-28. PMID: 16339370. 147. Malek RL, Wang HY, Kwitek AE, Greene AS, Bhagabati N, Borchardt G, Cahill L, Currier T, Frank B, Fu X, Hassinoff M, Howe E, Letwin N, Luu TV, Saeed A, Sajadi H, Salzberg SL, Sultana R, Thiagarajan M, Tsai J, Veratti K, White J, Quackenbush J, Jacob HJ, Lee NH. Physiogenomic resources for rat models of heart, lung and blood disorders. Nat Genet. 2006 Feb;38(2):234. PMID: 16415889. 148. Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard Jr KA, Roman RJ, Tonellato PJ, Cowley Jr AW. BN Phenome: Detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. Physiol Genomics. 2006 Apr 13;25(2):303-13. PMID: 16478827. 149. Van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP. Synergistic QTL interactions between Rf-1 and Rf-3 increase renal damage susceptibility in double congenic rats. Kidney Int. 2006 Apr;69(8):1369-76. PMID: 16541022. 150. Roman RJ, Hoagland KM, Lopez B, Kwitek AE, Garrett MR, Rapp JP, Lazar J, Jacob HJ, Sarkis A. Characterization of blood pressure and renal function in chromosome 5 cogenic strains of Dahl S rats. Am J Physiol Renal Physiol. 2006 Jun 290(6):F1463-71. PMID: 16396943. 151. Levan G, Jacob HJ. Nomenclature of the rat Cyp genes and the problems of gene nomenclature in general [Nelson, D.R. (2005), Gene nomenclature by default, or BLASTing to Babel, Hum. Genomics Vol. 2, pp. 196-201]. Hum Genomics. 2006 Jun;2(6):343; author reply 343-4. PMID: 16848971. 152. Kunert MP, Drenjancevic-Peric I, Dwinell MR, Lombar JH, Cowley Jr AW, Greene AS, Kwitek AE, Jacob HJ. Consomic strategies to localize genomic regions related to vascular 40 153. 154. 155. 156. 157. 158. 159. 160. 161. 162. 163. 164. 165. 166. 167. reactivity in the Dahl salt sensitive rat. Physiol Genomics. Aug 16;26(3):218-25. Epub 2006 Jun 13. PMID: 16772359. van Dijk SJ, Specht PA, Lazar J, Jacob HJ, Provoost AP. Absence of an interaction between the Rf-1 and Rf-5 QTLs influencing susceptibility to renal damage in rats. Nephron Exp Nephrol. 2006 Jul 12;104(3):e96-e102. PMID: 16837819. Ali I, Rafiee P, Hogan WJ, Jacob HJ, Komorowski RA, Haasler GB, Shaker R. Dickkopf homologs in squamous mucosa of esophagitis patients are overexpressed compared with Barrett’s patients and healthy controls. Am J Gastroenterol. 2006 Jul;101(7):1437-48. PMID: 16863544. Schlick NE, Jensen-Seaman MI, Orlebeke K, Kwitek AE, Jacob HJ, Lazar J. Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strain. Am J Physiol Cell Physiol. Dec;291(6):C1183-92. Epub 2006 Jul 19. PMID: 16855218. Meurer JR, Lustig JV, Jacob HJ. Genetic aspects of etiology and treatment of asthma. Pediatr Clin North Am. 2006 Aug;53(4):715-725. PMID: 16873001. Wang X, Jia S, Meyer L, Xiang B, Chen LY, Jiang N, Moreno C, Jacob HJ, Ghosh S, Hessner MJ. Comprehensive quality control utilizing the prehybridization third-dye image leads to accurate gene expression measurements by cDNA microarrays. BMC Bioinformatics. 2006 Aug 14;7(1):378. PMID: 16907976. Twigger SN, Shimoyama M, Bromber S, Kwitek AE, Jacob HJ. The Rat Genome Database, update 2007 – Easing the path from disease to data and back again. Nucleic Acids Res. 2007 Jan;35(Database issue):D658-62. PMID: 17151068 PMCID: PMC1761441. Nye SH, Wittenburg AL, Evans DL, O’connor JA, Roman RJ, Jacob HJ. Rat survival to anthrax lethal toxin is likely controlled by a single gene. Pharmacogenomics J. 2007 Apr 17 [Epub ahead of print]. PMID: 19242337. Michalkiewicz M, Michalkiewicz T, Geurts AM, Roman RJ, Slocum GR, Singer O, Weinrauch D, Greene AS, Kaldunski ML, Verma IM, Jacob HJ, Cowley Jr AW. Efficient transgenic rat production by a lentiviral vector. Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H881-94. PMID: 17322424. Broeckel U, Hengstenberg C, Mayer B, Maresso K, Gaudet D, Seda O, Tremblay J, Homer S. Erdmann J, Glockner C, Harrison M, Martin LJ, Willias JT, Schmitz G, Riegger GA, Jacob HJ, Hamet P, Schunkert H. A locus on chromosome 10 influences C-reactive protein levels in two independent populations. Hum Genet. 2007 Aug;122(1):95-102. PMID: 17530289. Moreno C, Kaldunski ML, Wang T, Roman RJ, Greene AS, Lazar J, Jacob HJ, Cowley AW Jr. Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat. Physiol Genomics. 2007 Oct 22;31(2):228-35. PMID: 17566075. Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Cowley Jr AW, Jacob HJ. Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats. Am J Physiol Renal Physiol. 2007 Dec;293(6):F1905-14. PMID: 17898042. Petersen MC, Lazar J, Jacob HJ, Wakatsuki T. Tissue engineering: A new frontier in physiological genomics. Physiol Genomics. 2007 Dec 19;32(1):28-32. PMID: 17956999. Moreno C, Lazar J. Jacob HJ, Kwitek AE. Comparative genomics for detecting human disease genes. Adv Genet. 2008;60:655-97. PMID: 18358336. Gilbert S, Kwitek AE, Hubner N, Tschannen M, Jacob HJ, Sassard J, Bataillard AP. The effects of chromosome 17 on features of the metabolic syndrome in the Lyon Hypertensive (LH) rat. Phsyiol Genomics. 2008 Apr 22 ;33(2):212-7. PMID: 18285521. Twigger SN, Pruitt KD, Fernandez-Suarez XM, Karolchik D, Worley KC, Maglott DR, Brown G, Weinstock G, Gibbs RA, Kent J, Birney E, Jacob HJ. What everybody should know about the Rat Genome and its online resources. Nat Genet. 2008 May;40(5):523-7. PMID: 18443589 PMCID: PMC1761441. 41 168. Aitman TJ, Critser JK, Cuppen E, Dominiczak A, Fernandez-Suarez XM, Flint J, Gauguier D, Geurts A, Gould M, Harris PC, Holmdah R, Hubner N, Izsvak Z, Jacob HJ, Kuramoto T, Kwitek AE, Marrone A, Mashimo T, Moreno C, Mullins J, Mullins L, Olsson T, Pravenec M, Riley L, Saar K, Serikawa T, Shull JD, Szpirer C, Twigger SN, Voigt B, Worley K. Progress and prospects in rat genetics: a community view. Nat Genet. 2008 May;40(5):516-22. PMID: 18443588. 169. Guryev V, Saar K, Adamovic T, Verheul M, van Heesch SA, Cook S, Pravenec M, Aitman T, Jacob HJ, Shull JD. Distribution and functional impact of DNA copy number variation in the rat. Nat. Genet. 2008 May;40(5):538-45. PMID: 18443591. 170. Liang M, Lee NH, Wang H, Greene AS, Kwitek AE, Kaldunski ML, Luu TV, Frank BC, Bugenhagen S, Jacob HJ, Cowley AW Jr. Molecular networks in Dahl salt-sensitive hypertension based on transcriptome analysis of a panel of consomic rats. Physiol Genomics. 2008 Jun 12;34(1):54-64. PMID: 18430809. 171. Mattson DL, Dwinell MR, Greene AS, Kwitek AE, Roman RJ, Jacob HJ, Cowley AW Jr. Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease.Am J Physiol Renal Physiol. 2008 Sep;295(3):F837-42. Epub 2008 Jul 23. PMID: 18653478 PMCID: PMC2536867. 172. Wang T, Jacob HJ, Ghosh S, Wang X, Zeng ZB. A joint association test for multiple SNPs in genetic case-control studies. Genet Epidemiol. 2009 Feb;33(2):151-63. 2008 Sep 3. [Epub ahead of print]. PMID: 18770519 PMCID: PMC2719721. 173. Bilusić M, Moreno C, Barreto NE, Tschannen MR, Harris EL, Porteous WK, Thompson CM, Grigor MR, Weder A, Boerwinkle E, Hunt SC, Curb JD, Jacob HJ, Kwitek AE. Genetically Hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension. Croat Med J. 2008 Oct;49(5):586-99. PMID: 18925692 PMCID: PMC2582351. 174. Williams JM, Sarkis A, Hoagland KM, Fredrich K, Ryan RP, Moreno C, Lopez B, Lazar J, Fenoy FJ, Sharma M, Garrett MR, Jacob HJ, Roman RJ. Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. Am J Physiol Renal Physiol. 2008 Dec;295(6):F1764-77. Epub 2008 Oct 8.. PMID: 18842817 PMCID: PMC2604826. 175. Adamovic T, McAllister D, Rowe JJ, Wang T, Jacob HJ, Sugg SL. Genetic mapping of mammary tumor traits to rat chromosome 10 using a novel panel of consomic rats. Cancer Genet Cytogenet. 2008 Oct;186(1):41-8. PMID: 18786441. 176. Dwinell MR, Worthey EA, Shimoyama M, Bakir-Gungor B, Depons J, Laulederkind S, Lowry T, Nigram R, Petri V, Smith J, Stoddard A, Twigger SN, Jacob HJ; and the RGD Team. The Rat Genome Database 2009: variation, ontologies and pathways. Nucleic Acids Res. 2009 Jan;37(Database issue):D744-9. Epub 2008 Nov 7.. PMID: 18996890 PMCID: PMC2686558. 177. Aneas I, Rodrigues MV, Pauletti BA, Silva GJ, Carmona R, Cardoso L, Kwitek AE, Jacob HJ, Soler JM, Krieger JE. Congenic strains provide evidence that four mapped loci in chromosones 2,4, and 16 influence hyptersenion in the SHR. Physiol Genomics. 2009 Mar 3;37(1):52-7. Epub 2009 Jan 6. PMID: 19126752. 178. Iannaccone PM, Jacob HJ. Rats! Dis Model Mech. 2009 May-Jun;2(5-6):206-10. PMID: 19407324 PMCID: PMC2675817. 179. Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, Jenkins SS, Wood A, Cui X, Meng X, Vincent A, Lam S, Michalkiewicz M, Schilling R, Foeckler J, Kalloway S, Weiler H, Ménoret S, Anegon I, Davis GD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jacob HJ, Buelow R. Knockout rats via embryo microinjection of zinc-finger nucleases. Science. 2009 Jul 24;325(5939):433.PMID: 19628861 PMCID: PMC2831805. 180. Shimoyama M, Hayman GT, Laulederkind SJ, Nigam R, Lowry TF, Petri V, Smith JR, Wang SJ, Munzenmaier DH, Dwinell MR, Twigger SN, Jacob HJ; RGD Team. The rat genome database curators: who, what, where, why. PLoS Comput Biol. 2009 Nov;5(11):e1000582. Epub 2009 Nov 26. PMID: 19956751 PMCID: PMC2775909. 42 181. Beetz N, Harrison MD, Brede M, Zong X, Urbanski MJ, Sietmann A, Kaufling J, Barrot M, Seeliger MW, Vieira-Coelho MA, Hamet P, Gaudet D, Seda O, Tremblay J, Kotchen TA, Kaldunski M, Nüsing R, Szabo B, Jacob HJ, Cowley AW Jr, Biel M, Stoll M, Lohse MJ, Broeckel U, Hein L. Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice. J Clin Invest. 2009 Dec;119(12):3597-3612.PMID: 19959875 PMCID: PMC2786789.. 182. Lu L, Li P, Yang C, Kurth T, Misale M, Skelton MM, Moreno C, Roman RJ, Greene AS, Jacob HJ, Lazar J, Liang M, Cowley Jr AW. Dynamic convergence and divergence of renal genomic and biological pathways in protection from Dahl salt-sensitive hypertension. Physiol Genomics. [Epub ahead of print]PMID: 20009007. PMCID: PMC2841498. 183. Adamovic Tatjana, McAllister Donna , Guryev Victor , Wang Xujing, Wendt Andrae Jaime, Cuppen Edwin, Jacob HJ, and Sugg Sonia L. Microalterations of inherently unstable genomic regions in rat mammary carcinomas as revealed by long oligonucleotide array Comparative Genomic Hybridization. Cancer Research. 2009 Jun 15;69(12):5159-67. Epub 2009 Jun 9. PMID: 19509235. 184. Nobrega Marcelo A., Solberg Woods Leah C, Fleming Stewart, and Jacob HJ. Distinct genetic regulation of the progression of diabetes and renal disease in the Goto-Kakizaki (GK) rat. Physiological Genomics. 2009 Sep 9;39(1):38-46. Epub 2009 Jul 7. PMID: 19584172. 185. MGC Project Team, Temple G, Gerhard DS, Rasooly R, Feingold EA, Good PJ, Robinson C, Mandich A, Derge JG, Lewis J, Shoaf D, Collins FS, Jang W, Wagner L, Shenmen CM, Misquitta L, Schaefer CF, Buetow KH, Bonner TI, Yankie L, Ward M, Phan L, Astashyn A, Brown G, Farrell C, Hart J, Landrum M, Maidak BL, Murphy M, Murphy T, Rajput B, Riddick L, Webb D, Weber J, Wu W, Pruitt KD, Maglott D, Siepel A, Brejova B, Diekhans M, Harte R, Baertsch R, Kent J, Haussler D, Brent M, Langton L, Comstock CL, Stevens M, Wei C, van Baren MJ, Salehi-Ashtiani K, Murray RR, Ghamsari L, Mello E, Lin C, Pennacchio C, Schreiber K, Shapiro N, Marsh A, Pardes E, Moore T, Lebeau A, Muratet M, Simmons B, Kloske D, Sieja S, Hudson J, Sethupathy P, Brownstein M, Bhat N, Lazar J, Jacob HJ, Gruber CE, Smith MR, McPherson J, Garcia AM, Gunaratne PH, Wu J, Muzny D, Gibbs RA, Young AC, Bouffard GG, Blakesley RW, Mullikin J, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Hirst M, Zeng T, Tse K, Moksa M, Deng M, Ma K, Mah D, Pang J, Taylor G, Chuah E, Deng A, Fichter K, Go A, Lee S, Wang J, Griffith M, Morin R, Moore RA, Mayo M, Munro S, Wagner S, Jones SJ, Holt RA, Marra MA, Lu S, Yang S, Hartigan J, Graf M, Wagner R, Letovksy S, Pulido JC, Robison K, Esposito D, Hartley J, Wall VE, Hopkins RF, Ohara O, Wiemann S. The completion of the Mammalian Gene Collection (MGC). Genome Res. 2009 Dec;19(12):2324-33. PMID: 19767417. 186. Geurts AM, Cost GJ, Rémy S, Cui X, Tesson L, Usal C, Ménoret S, Jacob HJ, Anegon I, Buelow R. Generation of gene-specific mutated rats using zinc-finger nucleases. Methods Mol Biol. 2010;597:211-25.PMID: 20013236. 187. Jacob, HJ. The Rat: A Model Used in Biomedical Research. Humana Press, Inc. Rat Genomics: gene identification, functional genomics and model applications. Ignacio Anegon (Ed). Methods Mol Biol. 2010;597:1-11. PMID: 20013222. 188. Worthey, EA., Stoddard, A.J., Jacob, HJ., Sequencing of the rat genome and data bases. Humana Press, Inc. Rat Genomics: gene identification, functional genomics and model applications. Ignacio Anegon (Ed). Methods Mol Biol. 2010;597:33-53.PMID: 20013224. 189. Carlson DF, Geurts AM, Park CW, Rangel-Filho A, O’Grady SM, Jacob HJ, Steer CJ, Largaespada DA, Fahrenkrug SC: Efficient mammalian germline transgenesis by enhanced Sleeping Beauty transposition. Transgenic Research. Mar 30, 2010. [Epub ahead of print].PMID: 20352328. 190. Yang Yi, Dahly-Vernon Annette J, Blomme Eric AG, Lai-Zhang Jie, Kempf Dale J, Marsh Kennan C, Harrington Yvette A, Nye Steven H, Evans Darin L, Roman Richard J, Jacob, HJ, Waring Jeffrey F. Liver transcriptomic changes associated with ritonavir-induced 43 191. 192. 193. 194. 195. 196. 197. 198. 199. 200. 201. 202. 203. 204. hyperlipidemia in sensitive and resistant strains of rats. Vet J. 2010 Jul: 185(1):75-82. Epub 2010 May 23. PMID: 20547082. Shao H, Sinasac DS, Burrage LC, Hodges CA, Supelak PJ, Palmert MR, Moreno C, Cowley AW Jr, Jacob HJ, Nadeau JH. Analyzing complex traits with congenic strains. Mamm Genome June 2010. PMID: 2052400. Jacob HJ, Lazar J, Dwinell MR, Moreno C, Geurts AM. Gene targeting in the rat: advances and opportunities. Trends Genet 2010 September 23. PMID 20869786. PMCID: PMC2991520. Adamovic T, McAllister D, Wang T, Adamovic D, Rowe JJ, Moreno C, Lazar J, Jacob HJ, Sugg SL. Identification of novel carcinogen-mediated mammary tumor susceptibility loci in the rat using the chromosome substitution technique. Genes Chromosomes Cancer. 2010. Nov; 49(11):1035-45. PMID: 20737482. O'Meara CC, Lazar J, Hoffman M, Moreno C, Jacob HJ. Refined Mapping of the Renal Failure Rf-3 Quantitative Trait Locus. J Am Soc Nephrol. 2010 Dec 2. PMID: 21127141. PMCID: PMC3060445. Worthey EA, Mayer AN, Syverson GD, Helbling D, Bonacci BB, Decker B, Serpe JM, Dasu T, Tschannen MR, Veith RL, Basehore MJ, Broeckel U, Tomita-Mitchell A, Casper JT, Margolis DA, Bick DP, Hessner MJ, Routes JM, Verbsky JW, Jacob HJ, Dimmock DP. Making a definitive diagnosis: Successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. Genet Med. 2010 Dec 17. [Epub ahead of print]. PMID: 21173700. Mayer, A.N., Dimmock, D.P., Arca, M.J., Bick, D.P., Verbsky, J.W., Worthey, E.A., Jacob, HJ, Margolis, D.A. A timely arrival for genomic medicine, Dec. 10, 2010. Gen Med, In Press. [Epub ahead of print]. PMID: 21169843. Shimoyama, M, Smith J.R., Hayman T, Laulederkind S, Lowry T, Nigam R, Petri V, Wang S-J, Dwinell M, Jacob HJ and RGD Team, RGD: A comparative Genomics Platform, Human Genomics, Jan1; 5(2), pg 124-129, 2011. PMID: 21296746. Moreno C, Williams J, Lu Li, Liang M, Lazar J, Jacob HJ, Cowley Jr. A and Roman RJ. Narrowing a region on rat chromosome 13 that protects against hypertension in Dahl SS13BN congenic strains. Am J Physiol Heart Circ Physiol 2011 Jan 28 (Epub ahead of print). PMID: 21257920. Moreno C, Hoffman M, Stodola TJ, Didier DN, Lazar J, Geurts AM, North PE, Jacob HJ, Green AS. Creation and characterization of a Renin knockout rat. Hypertension 2011 Mar; 57(3):614-9. Epub 2011 Jan 17. PMID: 21242461 Williams, JM, Burke, M, Lazar J, Jacob HJ, Roman RJ: Temporal characterization of the development of renal injury in FHH rats and FHH.1BN congenic strains. Am J. Physiol Renal Physiol 2011 (Epub ahead of print). PMID: 21048028. He C, Weeks DE, Buyske S, Abecasis GR, Stewart WC, Matise TC; The Enhanced Map Consortium. Enhanced genetic maps from family-based disease studies: populationspecific comparisons. BMC Med Genet. 2011 Jan 19;12(1):15. PMID: 21247494 [PubMed as supplied by publisher PMID: 21247494 PMCID: PMC3037840. Laulederkind SJ, Shimoyama M, Hayman GT, Lowry TF, Nigam R, Petri V, Smith JR, Wang SJ, de Pons J, Kowalski G, Liu W, Rood W, Munzenmaier DH, Dwinell MR, Twigger SN, Jacob HJ; RGD team. The Rat Genome Database curation tool suite; a set of optimized software tools enabling efficient acquisition, organization, and presentation of biological data. Database (Oxford). 2011 Feb 14; 2011. PMID: 21321022 PMCID: PMC3041158. Petri, V, Shimoyama M, Hayman GT, Smith JR. Tutaj M, de Pons J, Dwinell MR, Munzenmaier DH, Twigger SN, Jacob HJ; RGD Team. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8; 2011. PMID: 21478484 PMCID: PMC3072770. Stodola TJ, Monteiro de Resende M, Sarkis AB, Didier DN, Jacob HJ, Huebner H, Hummel O, Saar K, Moreno C, Greene AS. Characterization of the genomic structure and function 44 of regions influencing renin and angiogenesis in the SS rat. Physiol. Genomics April 26, 2011; published ahead of print April 26, 2011. PMID: 21521778. Submitted and/or In Press: 1. Laulederkind SJF, Shimoyama M, Hayman GT, Lowry TF, Nigam R, Petri V, Smith JR, Wang SJ, DePons J, Kowalski G, Liu W, Rood W, Munzenmaier DH, Dwinell MR, Twigger SN, Jacob HJ and RGD Team. The Rat Genome Database curation tool suite: a set of optimized software tools enabling efficient acquisition, organization, and presentation of biological data, Database, Vol 2011 (IN PRESS). Proceedings of Meetings: 1. 2. 3. Pan S, Meyers G, Jacob HJ, Lewis S, Brody MJ. Non-stationary fluctuations of arterial pressure in sino-aotic deafferented rats. Proceedings of the 10th annual meeting for IEEE EMBS. New Orleans, 1988:135-6. Van Zutphen LFM, Otsen M, den Bieman M, van Lith HA, Jacob HJ, Bender. The value of microsatellites for the characterization and genetic monitoring of rat inbred strains. Proceedings of the 5th FELASA Symposium. Brighton, UK 1993 Jun;179-182. Roman RJ, Cowley, Jr. AW, Greene A, Kwitek AE, Tonellato PJ, Jacob HJ. The Cardiovascular System, Consomic rats for the identification of genes and pathways underlying cardiovascular disease. Cold Spring Harbor Symposium on Quantitative Biology, Cold Spring Harbor Press, 2003. Books & Chapters: 1. Jacob HJ, Krieger JE, Dzau VJ, Lander ES. Genetic Dissection of Hypertension in Experimental Animal Models. Mockrin S (Ed): Molecular Genetics and Gene Therapy of Cardiovascular Diseases. 1995. 2. Pettersson A, Jacob HJ, Lernmark Å. Lessons from the Animal Models: The BB Rat. Jerry P. Palmer (Ed): Prediction, Prevention and Genetic Counseling in IDDM. 1996. 3. Koike G, Jacob HJ. Genetic Analysis of Hypertension. Textbook of Molecular Medicine. Jameson J.L. (Eds.): Humana Press. 1997. 4. Kwitek-Black AE, Jacob HJ. Gene-Environment Interactions in Hypertension Primer: The Essentials of High Blood Pressure. Izzo and Black (Sr. Eds): American Heart Association. 1999. 5. Kyengar SK, Weder AB, Koike G, Jokelainen P, Jacob HJ, Schork NJ. The Developmental Evolution of Hypertensions: Evidence, Genetic Models, and Mechanisms. McCarthy DA, Blizard RL, Chevalier (Eds): Elsevier Science B.V., Handbook of Hypertension Vol 19. 1999. 6. Stoll M, Jacob HJ. Improved Strategies for the Mapping of Quantitative Trait Loci in the Rat Model. A.F. Dominiczak, J.M.C. Connell, F. Soubrier (Eds): Molecular Genetics of Hypertension. 1999. 7. Schork, NJ, Fallin D, Thiel B, Xu X, Broeckel U, Jacob HJ, Cohen D. The Future of Genetic Case/Control Studies. D.C. Rao and M.A. Province (Ed): Advances in Genetics/Academic Press. 2001. 8. Moreno, Jacob HJ. Integrating Biology with Rat Genomic Tools. M. Suckow (Ed): The Laboratory Rat/Academic Press. 2004. 9. C Moreno, K Kennedy, JW Andrae, Jacob HJ. Genome Wide Scanning with SSLPs in the Rat. J. Fennell and A.H. Baker (Eds): Humana Press, Molecular Methods in Hypertension. 2004. 10. C. Moreno, Jacob HJ, A.W. Cowley Jr. Attaching Physiology to the Genome. A.F. Dominiczak (Ed). Elsevier Science B.V. Vol 24, 2007. Handbook of Hypertension. 45 Abstracts: 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. Alper RH, Jacob HJ, and Brody MJ. Humeral regulation of arterial pressure labiality in rats. Fed Proc. 1985;44(4). Jacob HJ, Alper RH, and Brody MJ. Peripheral mechanisms regulating arterial pressure labiality in rats. Fed Proc. 1986;45(4). Jacob HJ, Machado BH, and Brody MJ. Endogenous vasoconstrictor and adrenergic mechanisms contribute to arterial pressure labiality in rats with sinoaortic deafferentation. Fed Proc. 1987;46(4). Jacob HJ, and Brody MJ. The direct vascular action of vasoconstrictor contribute to arterial pressure labiality (APL) in sinoaortic deafferented (SAD) rats. FASEB J. 1988;2(5):A1280. Pan XG, Jacob HJ, Meyers GA, and Brody MJ. Power spectrum estimation as a tool to investigate biological feedback mechanisms. Iowa Academy of Science. 1988. Pan XG, Meyers GA, Jacob HJ, and Brody MJ. Non-stationary fluctuations of blood pressure in sinoaortic deafferented rats. IEEE EMBS. 1988. Lewis SJ, Barres C, Jacob HJ, and Brody MJ. Cardiovascular effects of an N-methyl-D-aspirate (NMDA) receptor antagonist, MK-801 in conscious rats. Council for High Blood Pressure. 1988. Jacob HJ, Lewis SG, and Brody MJ. Does cardiac output (CO) contribute to arterial pressure labiality (APL) in sinoaortic deafferented rats? FASEB J. 1989;3(3):A851. Lewis SJ, Ohta H, Jacob HJ, and Brody MJ. Mechanisms of cardiovascular responses produced in conscious rats by kainic acid (KA) and N-methyl-D-aspirate (NMDA). FASEB J. 1989;3(3):A1146. Meyers GA, Pan S, Jacob HJ, Lewis SG, and Brody MJ. Spectral analysis demonstrates a low frequency peak involved in baroreflex regulation of arterial pressure. FASEB J. 1989;3(3):A857. Sigmund CD, Jones CA, Jacob HJ, Kim U, Dzau VJ, Gamble D, and Gross KW. Analysis of renal renin expression in renin promoter T-antigen transgenic mice. Council for High Blood Pressure, Hypertension. 1990;16(3):P344. Jacob HJ, Sigmund CD, Jones CA, Boyounes B, McDonald J, Gross KW, and Dzau VJ. Renin and blood pressure responses of Renin promoter-SV40 T-antigen transgenic mice (TAG+) to low sodium diet. Council for High Blood Pressure, Hypertension. 1990;16(3):P345. Jacob HJ, Lander ES, and Dzau VJ. Progress towards a genetic map of the hypertensive rat. Council for High Blood Pressure, Hypertension. 1991. Jacob HJ, Dzau VJ, and Lander ES. Construction of a genetic map in the spontaneously hypertensive rat. SHR Meeting, 1991. Hypertension. 1992. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao Y, Ganten D, Dzau VJ, and Lander ES. Genetic mapping of a gene causing hypertension in the spontaneously hypertensive rat. International Society of Hypertension. 1992. Jacob HJ, Lincoln SE, Lindpaintner K, Ganten D, and Dzau VJ. Mapping quantitative trait loci (QTL) in the hypertensive rat. Council for High Blood Pressure, Hypertension. 1992. St. Lezin E, Wong A, Wang J-M, Pravenec M, Stec D, Jacob HJ, Roman R, Kurtz TW. Transfer of the Dahl S Renin gene into the Dahl R stain does not promote NaCl-Sensitivity and may actually cause a decrease in blood. Hypertension. 1993. Jacob HJ, Brown DM, Mao Y-P, Bunker RK, Lincoln SE, Kurtz TW, St. Lezin EM, Pravenec M, Dzau VJ, Szpirer C, and Lander ES. Progress on Rat Genetic Linkage Map. Cold Spring Harbor Laboratory, Genome Mapping and Sequencing Meeting. 1993. Koike G, Jacob HJ, Krieger JE, Hoehe MR, Szpirer C, Pratt RE, Dzau VJ. Is the phenylethanolamine N-methyltransferase gene in the stroke prone spontaneously hypertensive rat Bp1. Clin. Res. 1993;41:167A 46 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. Krieger JE, Koike G, Franchini KG, Trolliet MR, Zangen SW, Krieger EM, Lander ES, Dzau VJ, and Jacob HJ. Genetic dissection of hypertension in the spontaneously hypertension rat (SHR). J. Hypertension. 1994;12(suppl. 3):S66. Brown DM, Provoost AP, Daly MJ, Lander ES, and Jacob HJ: Identification of a gene responsible for renal failure in a rat model of hypertension. J. Hypertension. 1994;12(suppl. 3):S69. Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, Kurtz T, Levan G, Mao YP, Pettersson A, Pravenec M, Simon JS, St. Lezin E, Szpirer C, Szpirer J, Trolliet MR, Winer ES, Lander ES. A genetic linkage map of the laboratory rat. The IVth Workshop of the Nordic Genome, Helsinki. 1994. Kreutz R, Hubner N, Jacob HJ, Ganten D, Lindpaintner K. Evidence that the hypertensionassociated locus of rat chromosome 10, BP-SP1, is not identical with the angiotensinconverting enzyme gene locus. Hypertension. 1994;24:373. Trolliet MR, Krieger JE, Schork NJ, Koike G, Jacob HJ. Systolic blood pressure (SBP) after salt loading is caused by 4 to 6 quanative trait loci (QTLs) acting in an additive fashion. Hypertension. 1994;24:387. Provoost AP, Brown DM, Daly MJ Lander ES, Jacob HJ. Genetic markers responsible for renal failure and hypertension in the fawn-hooded (FHH) rat. Pediatric Nephrology. 1994;8:C43. Koike G, Horiuchi M, Yamada T, Szpirer C, Jacob HJ, and Dzau VJ. Human type 2 angiotensin in receptor gene: Cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. J. Invest. Med. 1995;43:241A. Provoost AP, Brown DM, Daly MJ, Lander ES, Jacob HJ. Identification of Rf-1, a gene responsible for renal failure in the fawn-hooded (FHH) rat. Kidney International. 1995;47:702. Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, Koike G, Kren V, Kurtz T, Lernmark Å, Levan G, Mao Y, Pettersson A, Pravenec M, Simon JS, Szpirer C, Szpirer J, Trolliet MR, Winer ES, Lander ES. A genetic linkage map of the laboratory rat. Genome Mapping and Sequencing, Cold Spring Harbor Laboratory. 1995 May;10-14:202. Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ. Separate genes are responsible for proteinuria and hypertension in fawn-hooded (FHH) rats. International Society of Nephrology, Madrid. 1995;98. Simon JS, Roman RJ, Cowley AW, Greene A, Jacob HJ. Rat alpha-2 adrenergic receptor class III is linked to systolic blood pressure after salt load in genetic hypertension. Council for High Blood Pressure Research. Hypertension. 1995;26(3),537. Trolliet MR, Krieger JE, Koike JE, Simon JS, Krieger EM, Dzau VJ, Jacob HJ. Gender and grandparental strain influences the genetic basis of blood pressure. Council for High Blood Pressure Research. Hypertension 1995;26(3),537. Koike G, Horiuchi M, Winer ES, Brown DM, Dzau VJ, Jacob HJ. Cloning, characterization, and genetic mapping of the rat type 2 angiotensin II receptor gene. American Heart Association, Circulation. 1995;92(8)suppl:1340. McLaughlin MG, Printz MP, Jacob HJ. Genetic dissection of cardiovascular startle response and hypertension in the spontaneously hypertensive Rat. American Heart Association, Circulation. 1995;92(8)suppl:2643. Satler CA, Vesely MR, Walsh E, Wong JCL, Ginsburg GS, Jacob HJ. Mapping a gene for hereditary long QT syndrome to chromosome 7q35-36. American Heart Association, Circulation. 1995;92(8)suppl:2073. Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ. Genetic identification of Rf-1, a gene responsible for renal failure in the fawn-hooded rat. J American Society of Nephrology. 1994;5:618. 47 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. Satler CA, Plummer MH, Fan M, Zurakowski D, Walsh E, Jacob HJ, Ginsburg GS. Clinical severity increases in successive generations of familial LQT syndrome. American Heart Association, Circulation. 1995;92(8)suppl:2473. Wong JCL, Vesely MR, Fan M, Zurakowski D, Ginsburg GS, Walsh E, Jacob HJ, Satler CA: Genetic confirmation of a clinical diagnostic scoring system for autosomal dominant long QT syndrome (LQTS). American Heart Association, Circulation. 1995;92(8)suppl:1105. Lee JS, Adrie C, Jacob HJ, Roberts JD, Zapol WM, Bloch KD. Chronic inhalation of nitric oxide inhibits neointima formation after balloon arterial injury in rats. American Heart Association, Circulation. 1995;92(8)suppl:3394. Knapik EW, Goodman A, Neuhauss SCF, Chiang PW, Fishman MC, Driever W, Jacob HJ. A genetic linkage map for the zebrafish (Danio rerio) consisting of simple sequence repeats. Cold Spring Harbor Laboratory, Zebrafish Development and Genetics. 1996 Apr;24-28. Knapik EW, Goodman A, Atkinson OS, Roberts CT, Shiozawa M, Sim CU, Weksler-Zangen S, Trolliet MR, Futrell C, Innes BA, Koike G, McLaughlin MG, Pierre L, Simon JS, Vilallonga E, Roy M, Chiang PW, Fishman MC, Driever W, Jacob HJ. A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphism. Cold Spring Harbor Laboratory, Zebrafish Development and Genetics. 1996 Apr;24-28. Neuhauss SCF, Solnica-Krezel L, Schier AF, Zwartkruis F, Stemple DL, Malicki J, Abdelilah S, Stanier DYR, Mountcastle-Shah, Knapik E, Jacob HJ, Driever W. Mutations affecting craniofacial development in zebrafish. Cold Spring Harbor Laboratory, Zebrafish Development and Genetics. 1996 Apr;24-28. Knapik EW, Goodman A, Atkinson OS, Roberts CT, Shiozawa M, Sim CU, Weksler-Zangen S, Trolliet MR, Rutrell C, Innes BA, Koike G, McLaughlin MG, Pierre L, Simon JS, Vilallonga E, Roy M, Chiang PW, Fishman MC, Driever W, Jacob HJ. A genetic linkage map with simple sequence length polymorphisms and a reference cross for zebrafish (Danio rerio). Heidelberg, Human Genome Meeting. 1996 Mar;22-24. Knapik EW, Goodman A, Atkinson OS, Roberts CT, Shiozawa M, Sim CU, Weksler-Zangen S, Trolliet MR, Rutrell C, Innes BA, Koike G, McLaughlin MG, Pierre L, Simon JS, Vilallonga E, Roy M, Chiang PW, Fishman MC, Driever W, Jacob HJ. A genetic linkage map with simple sequence length polymorphisms and a reference cross for zebrafish (Danio rerio). Cold Spring Harbor Laboratory, Genome Mapping and Sequencing. 1996 May;8-12. Jacob Lab, Cowley Lab, Dzau Lab, Grigor Lab, Fanestil Lab, Harrap Lab, Harris Lab, Krieger E.M. Lab, Lander Lab, Printz Lab, Provoost Lab, Roman Lab, Sassard Lab, Schork Lab, Vincent Lab. Results from an international collaboration to map the genes responsible for high blood pressure in the rat. Sixteenth Scientific Meeting of the International Society of Hypertension. 1996 Jun;23-27 Glasgow:2B.5. Koike G, Horiuchi, Winer ES, Krieger JE, Dzau VJ, Jacob HJ. Investigation of candidate genes for genetic hypertension in rat. Sixteenth Scientific Meeting of the International Society of Hypertension. 1996 Jun;23-27 Glasgow:36.C. Harris EL, Koike G, Thompson CM, Porteous WK, Jacob HJ, Grigor MR. Mapping quantitative trait lici (QTL) on chromosome 2 in the New Zealand genetically hypertensive (GH) rat. Sixteenth Scientific Meeting of the International Society of Hypertension. 1996 Jun;23-27 Glasgow:P12. Innes BA, McLaughlin MG, Kapuscinski MK, Jacob HJ, Harrap SB. Molecular genetic analysis of hypertension and ventricular mass in an experimental model of hypertension. Sixteenth Scientific Meeting of the International Society of Hypertension. 1996 Jun;23-27 Glasgow:P48. Koike G, Harris EL, Shiozawa M, McLaughlin MG, Jacob HJ, Grigor MR. Independent genetic contributions to cardiac hypertrophy and hypertension in the New Zealand genetically hypertensive rat. Sixteenth Scientific Meeting of the International Society of Hypertension. 1996 Jun;23-27 Glasgow:P65. 48 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. Koike G, Pettersson A, Daly MJ, Szpirer C, Lander ES, Lernmark Å, Fuks A, Jacob HJ. Genetic identification of novel locus Iddm3 that modifies susceptibility to insulin dependent diabetes mellitus (IDDM) in the BB rat, an animal model for human IDDM. The American Journal of Human Genetics. 1996;59:1285. Thiel B, St. Jean P, Jacob HJ, Schork NJ. Genome-wide allele sharing and gene mapping studies for complex quantitative trait loci. The American Journal of Human Genetics. 1996;59:1373. Jacob Lab, Cowley Lab, Dzau Lab, Grigor Lab, Fanestil Lab, Harrap Lab, Harris Lab, Krieger EM, Krieger JE, Lander Lab, Printz Lab, Provoost Lab, Roman Lab, Sassard Lab, Schork Lab, Vincent Lab. Results from an international collaboration to map the genes responsible for high blood pressure in the rat. American Journal of Human Genetics. 1996;59:309. Stelzner TJ, Hofmann TA, Jacob HJ, Deng AY. Genes of the endothelia family do not cosegregate with pulmonary hypertension in fawn hooded rats (FHR). International Conference, New Orleans. 1996 May;5-11. Stelzner TJ, Hofmann TA, Brown DM, Jacob HJ. Mapping of a quantitative trait locus for pulmonary hypertension on rat chromosome 1. International Conference, New Orleans. 1996 May;5-11. Broeckel U, Kromer EP, Elssner D, Hengstenberg C, Riegger GAJ, Jacob HJ, Schunkert H. Autosomal-dominant inheritance pattern in a family with Ebsteins-anomaly and further congenital malformations of the heart. Z. Kardiol, 86 Suppl. 2, S367:1997. Jacob HJ, Shiozawa M, Broeckel U, Brown DM, Naff B, Majewski R, Gauthier S, Kissebah A, Provoost AP. Genetics of ESRD: Of Rat and Man? The American Society of Hypertension. 1997. Koike G, Jacob HJ, Cowley AW, Dzau VJ, Fanestil D, Grigor MR, Harrap SB, Harris EL, Krieger EM, Lander ES, Printz MP, Provoost A, Roman RJ, Samani NJ, Sassard J, Schork NJ, Vincent M. et al. The comprehensive total genome scan to map genes responsible for high blood pressure in the rat. Experimental Biology. 1997. Freedman BI, Yu H, Sale M, Rich SS, Spray BJ, Roh BH, Jacob HJ, Bowden DW. Evaluation of the renal failure-1 (Rf-1) gene and chromosome 10 markers for linkage to end stage renal disease, (ESRD). American Society of Nephrology, San Antonio. 1997 Nov. Lange AR, Gebremedhin D, Jacob HJ, Koike G, Szpirer C, Aebly MR, Harder DR. cDNA cloning and functional expression of Maxi-K channel subunits from rat cerebral vascular smooth muscle. The International Society of Cerebral Blood Flow and Metabolism. Journal of Cerebral Blood Flow and Metabolism. 1997;17:suppl 1. Broeckel U, Jiang J, Tonellato P, Feroah T, Jacob HJ, Miano JM. Assessing the spatial relationship between functional units of genes as a tool for defining genes from genomic sequence with bioinformatics and bioassays. Genome Mapping and Sequencing Meeting, May 14-18, 1997, Cold Spring Harbor, New York. Jiang J, Jacob HJ. EbEST: Using transcript sequences to divine gene elements and assess gene expression. American Society of Human Genetics, Baltimore, MD. The American Journal of Human Genetics. 1997 Sep;61;4. Stoll M, Kwitek-Black AE, Koike G, Shiozawa M, Jacob HJ. Comparative mapping of quantitative trait loci for complex diseases. American Society of Human Genetics, Baltimore, MD. The American Journal of Human Genetics. 1997 Sep;61;4. Kwitek-Black AE, Stoll M, Jiang J, Shiozawa M, Koike G, Jacob HJ. A novel “virtual comparative mapping strategy. American Society of Human Genetics, Baltimore, MD. The American Journal of Human Genetics. 1997 Sep;61;4. Iyengar S, Schork NJ, Jokelainen, P, Koike G, Jacob HJ, Weder AB. The function of growth in the regulation of blood pressure: Model organisms as a paradigm for human disease. American Society of Human Genetics, Baltimore, MD. The American Journal of Human Genetics. 1997 Sep;61;4. 49 64. 65. 66. 67. 68. 69. 70. 71. 72. 73. 74. 75. 76. 77. 78. 79. 80. Broeckel U, Tonellato P, Gauthier SA, Kissebah AH, LePain N, Jacob HJ. Screening dialysis patients for familial clustering of end-stage renal disease to determine genetic forms. J Am Soc Nephrol, 8, 387 A, 1997. Jacob HJ, Shiozawa M, Broeckel U, Brown DM, Neff B, Majewski RR, Gauthier S, Kissebah A, Provoost AP. Genetics of ERSD: Of rat and man? American Journal of Hypertension, 10(4), part 2, 216A, 1997. Jacob HJ, Majewski RR, Gauthier S, Broeckel U, Kissebah A, Provoost AP. Genetic susceptibility to end-stage renal disease. Nephrology, 3(Suppl. 1), S43, 1997. Broeckel U, Tonellato P, Kissebah AH, Provoost AP, Linzmeier D, LePain N, Lazarus JM, Jacob HJ. An epidemiological analysis to determine familial clustering of end-stage renal disease. Nephrology, Dialysis, Transplantation, 13 (6), 1998. Jacob HJ, Peiffer MM, Atkinson OS, Granados MA, Roman RJ, Cowley Jr. AW. Genome cassette system for determining genes and their function in hypertension. International Society of Hypertension, Amsterdam. 1998 Jun;7-11. Kwitek-Black AE, Glenn CC, Matise, T, Colman SD, Mull T, Tonellato P, Kingsmore SF, Jacob HJ. Comparativem in Silico. Genome Mapping, Sequencing & Biology, Cold Spring Harbor, NY. 1998 May;13-17. Jacob HJ, Runte M, Peiffer MM, Mull T, Granados M, Roman RJ, Cowley AC. Consomic rats for determining genes and their function. Genome Mapping, Sequencing & Biology, Cold Spring Harbor, NY. 1998 May 13-17. Kendziorski CM, Cowley AW, Green AS, Jacob HJ, Tonellato P. Physiologically informative quantitative trait loci. Genome Mapping, Sequencing & Biology, Cold Spring Harbor, NY. 1998 May13-17. Steen R, Russo K, Appel D, Slonim D, VanEtten W, Atkinson S, Jacob HJ, Lander E. Towards a high-density genetic map of the rat. Genome Mapping, Sequencing & Biology, Cold Spring Harbor, NY. 1998 May 13-17. Tonellato PJ, Lu J, Xu Y, Chuan Y, Chen D, Wang Z, Jacob HJ. Gene feature prediction and sequence mining. Genome Mapping, Sequencing & Biology, Cold Spring Harbor, NY. 1998 May 13-17. Van Dokkum RPE, Provoost AP, Sun CW, Jacob HJ, Roman RJ. Impaired renal vascular responses in the fawn-hooded hypertensive (FHH) rat. Journal of the American Society of Nephrology. 1998 Oct 25-28. Shiozawa M, Provoost AP, Majewski RR, Van Dokkum RPE, Jacob HJ. Interacting genes determine susceptibility to proteinuria after uninephrectomy in rats journal of The American Society of Nephrology. 1998 Oct 25-28. Nobrega MA, Roman RJ, Jacob HJ. Susceptibility For Renal Disease In the GK rat, a model for non-insulin-dependent diabetes mellitus (NIDDM). Journal of the America Society of Nephrology. 1998 Oct 25-28. Jacob HJ, Runte M, Peiffer MM, Mull TJ, Granados MA, Roman RJ. Consomics Rats: A platform for Physiological Genetics. Physiological Research. 1998; 5:39P. Cowley AW, Roman RJ, Greene A, Tonellato P, Jacob HJ. Chromosomal pattern of quantitative trait loci in the brown Norway and Dahl S intercross. Physiological Research. 1998;5:36P. Cowley AW, Jacob HJ, Roman RJ, Greene AS, Kaldunski M, Stoll M, Tonellato PJ. Genetic and phenotypic differences of Dahl S/MCW and Brown Norway/MCW inbred rats. The FASEB Journal. 1999;13(4):A380. Cowley AW, Roman RJ, Greene AS, Jacob HJ, Kaldunski ML. Renal phenotypic and gender differences between Dahl S/MCW and Brown Norway/MCW rats. The FASEB Journal. 1999;13 (4):A380. 50 81. 82. 83. 84. 85. 86. 87. 88. 89. 90. 91. 92. 93. 94. 95. 96. Kita Y, McQuestion GD, Eick DH, Jacob HJ, Tonellato PJ, Cowley AW, Greene AS. Massively parallel analysis of gene expression using cDNA microarrays. The FASEB Journal. 1999;13(4):A381. Kwitek-Black AE, Tonellato PJ, Zhu H, Chen D, Mull T, Stoll M, Jacob HJ. An integrated mammalian genome platform for physiological genomics. The FASEB Journal. 1999;13(4):A379. Nobrega MA, Roman RJ, Fogo AB, Jacob HJ. Genetic mapping of diabetes-associated renal disease phenotypes in the GK rat, a model of spontaneous non-insulin dependent diabetes mellitus (NIDDM). The FASEB Journal. 1999;13(4):A380. Runte ML, Johnson NL, Granados MA, Roman RJ, Cowley AW, Jacob HJ. Consomic rats for determining genes and their function. The FASEB Journal. 1999;13(4):A379. Koike G, Grigor MR, Harris EL, Jacob HJ, Sassard J, et al. Implication for genetic studies of human complex diseases from results obtained in genetic in Rats. The FASEB Journal. 1999;13(4):A380. Kwitek-Black AE, Chen D, Zhu CH, Mull T, Handley J, Stoll M, Twigger S, Tonellato PJ, Jacob HJ. Rat/human comparative maps based upon >25,000 unigene clusters. Genome Sequencing and Biology, Cold Spring Harbor, NY. 1999 May;19-23. Stoll M, Cowley AW, Greene AS, Kaldunski ML, Roman RJ, Tonellato PJ, Wang Z, Jacob HJ. Dissecting the Genetics of Hypertension Using Likely Determinant Phenotypes and Pharmacogenetics. Genome Sequencing and Biology, Cold Spring Harbor, NY. 1999 May;1923. Broeckel U, Shiozawa M, Fallin D, Wick GS, Cooper RS, Rotimi CN, Nobrega M, Provoost AP, Schork NJ, Jacob HJ. Comparative mapping and linkage disequilibrium of the rat RF-1 region identifies a haplotype associated with hypertensive end-stage renal disease in humans. Genome Sequencing and Biology, Cold Spring Harbor, NY. 1999 May;19-23. Wang Z, Stoll M, Wang Y, Chen D, Lu J, Jacob HJ, Tonellato PJ. QTL annotator. Genome Sequencing and Biology, Cold Spring Harbor, NY. 1999 May;19-23. Steen R, Kwitek-Black, Anne, Van Etten W, Appel D, Muir M, Twigger S, Mull T, GullingsHandley, Glenn C, Popp M, Knight J, Matise T, Brown D, Lu J, Kingsmore S, Tonellato P, Colman S, Jacob HJ, Lander E. A high-density integrated radiation hybrid/genetic linkage map of the laboratory rat. . Genome Sequencing and Biology, Cold Spring Harbor, NY. 1999 May;19-23. Broeckel U, Shiozawa M, Wick GS, Cooper RS, Provoost AP, Schork NJ, Jacob HJ. The human homologous region of rat RF-1 is associated with end-stage renal disease. European Renal Association Annual Meeting 1999. Stoll M, Cowley AW, Harrap SB, Harris EL, Krieger JE, Kwitek-Black A, Printz MP, Provoost A, Sassard J, Jacob HJ. Comparative genomics yields targets for human hypertension. FiftyThird Fall Conference of the HBPR Council 1999. Baker JE, Konorev EA, Gross GJ, Chilian WM, Jacob HJ. Resistance to myocardial ischemia in five rat strains: Evidence for a genetic basis for cardioprotection. Seventy-Second Scientific Sessions, American Heart Association 1999. Nobrega MA, Roman RJ, Jacob, HJ. Genetics of progressive renal disease in the GK rat: A model for spontaneous non-insulin dependant diabetes mellitus (NIDDM). ASN 32nd Annual Meeting; American Society of Nephrology. 1999:10. Shiozawa M, Brown D, Naff B, Van Dokkum R, Provoost AP, Jacob HJ. Genetic and physical mapping of Rf-1 gene region on rat Chromosome 1. ASN 32nd Annual Meeting; American Society of Nephrology. 1999:10. Broeckel U, Shiozawa M, Fallin D, Wick GS, Cooper RS, Nobrega M, Provoost AP, Schork NJ, Jacob HJ. Using comparative mapping of the rat Rf-1 region identifies a haplotype which is associated with human hypertensive end-stage renal disease. ASN 32nd Annual Meeting; American Society of Nephrology. 1999:10. 51 97. 98. 99. 100. 101. 102. 103. 104. 105. 106. 107. 108. 109. 110. 111. 112. 113. Kwitek-Black AE, Steen R, Shiozawa M, Handley J, Twigger S, Lander ES, Tonellato PJ, Jacob HJ. Building a backbone map for the rat genome. Physiological Genomics and Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–12. Cowley Jr. AW, Schork NJ, Greene AS, Roman RJ, Theil B, Stoll M, Tonellato PJ, Jacob HJ. Physiological genomics and cardiovascular profiling in the rat. Physiological Genomics and Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–12. Provoost AP, Shiozawa M, Broeckel U, Filho AR, Brown D, Nobrega MA, Jacob HJ. Genetic Mapping Of RF-1 Gene On The Fawn-Hooded Hypertensive Rat. Physiological Genomics and Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–12. Baker JE, Konorev EA, Gross GJ, Chilian WM, Jacob HJ. Resistance to myocardial ischemia in five rat strains: Is there a genetic component of cardioprotection? Physiological Genomics and Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–12. Jacob HJ, Runte ML, Johnson NL, Dye T, Roman RJ, Cowley, Jr. AW. Consomic rats for rapidly determining genes and their function. Physiological Genomics and Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–12. Scheel S, Thomas M, Vater A, Schatz P, Grob U, Vicentini M, Jacob, HJ, Ganten D, Knoblauch M. Establishment of a high resolution mapping cross for the rat genome. Physiological Genomics and Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–12. Twigger S, Gullings-Handley J, Kwitek-Black A, Tonellato P, Jacob HJ. ACP haplotyper and genome scanner – novel web tools for rat genomics. Physiological Genomics and Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–12. Wang Z, Stoll M, Xie X, Wang Y, Chen D, Lu J, Jacob HJ, Tonellato P. Web based quantitative trait analysis. Physiological Genomics and Rat Models, Cold Spring Harbor, NY. 1999 Dec;9– 12. Tonellato P, Twigger S, Lu J, Wang Z, Jacob HJ. The rat genome database. Physiological Genomics and Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–12. Nobrega M, Roman RJ, Jacob HJ. Genetics of progressive renal disease in the GK rat: A model for spontaneous non-insulin dependent diabetes mellitus (NIDDM). Physiological Genomics and Rat Models, Cold Spring Harbor, NY. 1999 Dec;9–12. Nobrega MA, Roman RJ, Jacob HJ. Genetics of progressive renal disease and dislipidemia in the spontaneously diabetic GK rat. Experimental Biology. 2000. Hodges M, Forster HV, Cowley Jr. AW, Jacob, HJ, Schmidt R, Provoost AP. Differences in ventilatory response to hypoxia and hypercapnia among three inbred strains of adult rats. Experimental Biology. 2000. Papanek PE, Hodges M, Forster HV, Jacob HJ, Cowley Jr. AW. Differences in ventilatory responses to graded exercise among inbred strains of adult rats. Experimental Biology. 2000. Karau K, Johnson R, Molthen R, Provoost A, Cowley A, Jacob HJ, Dawson C. Pulmonary arterial remodeling in the fawn hooded rat revealed by microfocal x-ray tomography. Experimental Biology. 2000.Hoagland KM, Alonso-Galicia M, Fenoy FJ, Flasch AK, Jacob HJ, Rapp J, Roman R.J. Altered blood pressure and renal function in chromosome 5 congenic Dahl salt-sensitive rats. Experimental Biology. 2000. Provoost AP, Shiozawa M, Van Dokkum RPE, Jacob HJ. Congenic rat strains to investigate the genetics of renal damage after unilateral nephrectomy. Cambridge Health Tech. 2000. Broeckel U, MJ Rieder, B Thiel, H Schunkert, GAJ Riegger, HW Hense, A Doering, DA Nickerson, NJ Schork, Jacob HJ. Correlation matrix analysis to determine the effect of SNP haplotypes for the Angiotensin-Converting-Enzyme (ACE) on cardiovascular phenotypes. Cold Spring Harbor Genome Sequencing and Biology Meeting. 2000. Broeckel U. Shiozawa M, Fallin D, Wick GS, Cooper RS, Nobrega M, Provoost AP, Schork NJ, Jacob HJ. The homologous region of rat Rf-1 is associated with hypertensive end-stage renal disease in African Americans. International Society of Hypertension meeting Chicago. 2000. 52 114. Broeckel U, Rieder MJ, Thiel B, Schunkert H, Riegger GAJ, Hense HW, Doering A, Nickerson DA, Schork NJ, Jacob HJ. Angiotensin-converting enzyme and cardiovascular phenotypes. DMW, 125, Suppl 3; WS3-3, 2000. 115. Shiozawa M, Kita Y, Majewski RR, Rangel-Filho A, Nobrega MA, Provoost A, Jacob HJ. Identification of differentially expressed genes by cDNA microarray for end-stage renal disease in the Fawn-Hooded Rat. ASN 33rd Annual Meeting. 2000. 116. Broeckel U, Kephart DD, Feldmann MM, Shiozawa M, Jacob HJ, Schifreen R. Testing READIT™, a novel, SNP typing assay for it’s use in a high throughput association mapping study. Twelfth International Genome Sequencing and Analysis Conference September 12-15,, 2000. The Institute for Genomic Research. Miami Beach, FL. 117. Jacob HJ, Kita Y, Kwitek-Black A, Shiozawa M. Functional genomics for drug discovery. International Mammalian Genome Society. November 2000. 118. Jacob HJ. Modern genetic mapping approaches in laboratory animals/rats. Journal of Experimental Animal Science. 2000;41:32-34. 119. Takahiro Ueno, Johanne Tremblay, Univ of Montreal, Montreal, PQ Canada; Jaroslave Kunes, Josef Zicha, Zdenak Dobesova, Academy of Sciences of the Czech Republic, Prague, Czech Republic; Zdenka Pausova, Alan Y Deng, Yu-Lin Sun, Univ of Montreal, Montreal, PQ Canada; Jacob HJ, Medical College of Wisconsin, Milwaukee, WI; Pavel Hamet, Univ of Montreal, Montreal, PQ Canada. Balance of negatively and positively associated loci may protect from cardiac hypertrophy and renal atrophy in hypertension. American Heart Association 55th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research. 2001 abstract# 100371. 120. Lemanski, Jr. Robert F., Mikus Lance D., Tuffaha Amjad, Sorkness Ronald L., Cowley, Jr. Allen W., Jacob HJ and Rosenthal Louis A. Chromosomal substitutions between rat strains with Th1or Ths2- biased responses: A novel strategy for physiogenomic studies of allergic inflammation. University of Wisconsin Medical School and University of Wisconsin School of Pharmacy. 2002. 121. Rafiee Parvaneh, Shi Yang, Heidemann Jan, Jacob HJ, Lazar Jozef and Baker John E. Functional proteomic analysis: Evidence for cardioprotective proteins in the Brown Norway Vs. Dahl S rat. American Heart Association. 2002. 122. Moreno Carol, Ryan Robert P, Jene Sheri, Kennedy Kathleen, Jeffrey V Eckert, Jacob HJ, Abraham P Provoost and Richard J Roman. Impaired autoregulation of renal blood flow is linked to the Rf-1 region in the Fawn-Hooded rat. American Society of Nephrology. 2002. 123. Moreno C, Dumas P, Stoll M, Greene AS, Kaldunski ML, Roman RJ, Tonellato PJ, Wang Z, Jacob HJ, Cowley AW. “Gender differences in the genetic determinants of hypertension”. Council for High Blood Pressure Reseach. September 2002. 124. Moreno C, Ryan RP, Jene S, Kennedy K, Eckert JV, Jacob HJ, Provoost AP, Roman RJ. “Impaired autoregulation of renal blood flow is linked to the Rf-1 region in the Fawn-hooded rat”. American Society of Nephrology. October 2002. 125. Ali I, Jacob HJ, Hessner M, Hogan W, Rittmann T, Shaker R, MCW Dysphagia Institute, Division of Gastroenterology and Hepatology and the Human and Molecular Genetics Center. Regional differences in normal esophageal mucosal gene expression profiles in healthy controls, esophagitis and Barrett’s patients. Medical College of Wisconsin, Milwaukee, WI. December 2002. 126. Moreno C, Tadisch GM, Meinecke BJ, M.L.Kaldunski, Jacob HJ, A.W.Cowley. “Genetics of Salt-Sensitive Hypertension. Genetic linkage and Congenic Development from the Consomic SS.BN.13 Rat”. APS Conference: Understanding Renal and Cardiovascular Function Through Physiological Genomics. October 2003. 127. Moreno C, Khan S, Jiang N, Lazar J, Tschannen M, Jensen-Seaman M, Tackes J, Jene S, Hessner M, Jacob HJ “Microarray analysis of gene expression changes in the kidney of the 53 128. 129. 130. 131. 132. 133. 134. 135. 136. 137. 138. 139. 140. Rf-1 congenic strain of the Fawn-Hooded rat”. Rat genetics Symposium. Cold Spring Harbor. December 2003. Baessler A, Reinhard W, Hasinoff M, Sonnenberg G, Olivier M, Fischer M, Erdmann J, Schunkert H, Doering A, Jacob HJ, Comuzzie AG, Kissebah A, Kwitek AE. Genetic linkage and association of the ghrelin receptor gene in human obesity. The Biology of Genomes, Cold Spring Harbor, NY, May 2004. Bilusic M, Barreto NE, Tschannen MR, Harris EL, Jene SA, Jacob HJ, Kwitek AE. Congenic BN.GH2 ñ normotensive strain despite increased vasopressor sensitivity and T3 level. The FASEB Journal, 18, #6765, 2004. Lopez B, Moreno C, Ryan R, Jene S, Kennedy K, Eckert J, Jacob HJ, Provoost AP, Roman RJ. La region Rf-1 del cromosoma 1 contribuye al desarrollo de la enfermedad glomerular en las ratas Fawn-Hooded”. 9ª Reunión Nacional. Sociedad Española de Hipertensión. Liga Española para la lucha contra la Hipertensión Arterial. 2004. Hipertensión. Lopez B, Ryan RP, Moreno C, Lazar J, Jacob HJ, Provoost AP and Roman RJ. Identification of a QTL on region of chromosome 1 for impaired autoregulation of RBF in Fawn-Hooded Hypertensive rats. Council of High Blood Pressure Research. September 2004. Lutz MM, Andrae JW, Sharma M, Lazar J, Moreno C, Provoost AP, Jacob HJ. Focusing in on Rf-4: The Use of Subcongenic Rat Strains To Narrow the Region of CHR. 14 Involved in Hypertensive Renal Failure. American Society of Nephrology. October 2004. Moreno C, Khan S, Jiang N, Jensen-Seaman M, Lazar J, Provoost A, Hessner MJ, Jacob HJ. Patron temporal de expresión genetica en el rinon de la rata congenica ACI.FHH.RF-1”. 9ª Reunión Nacional. Sociedad Española de Hipertensión. Liga Española para la lucha contra la Hipertensión Arterial. 2004. Hipertensión. Moreno C, Kaldunski ML, Lazar J, Roman RJ, Greene AS, Jacob HJ, Cowley AW. Identificación de un locus de hipertensión sal-sensible mediante el uso de lincage genetico en ratas consomicas. 9ª Reunión Nacional. Sociedad Española de Hipertensión. Liga Española para la lucha contra la Hipertensión Arterial. 2004. Hipertensión. Moreno C, Khan S, Jiang N, Lazar J, Tschannen M, Jensen-Seaman MI, Provoost A, Hessner MJ, Jacob HJ. Temporal patterns of gene expression in the kidney of the Rf-1 congenic rat strain. American Society of Nephrology. October 2004. Moreno C, Khampang P, Schippers D, Lazar J, Kaldunski ML, Greene AS, Roman RJ, Jacob HJ, Cowley AW. Expresión renal y secuencia comparativa de la ciclooxigenasa-2 en hipertensión sal-sensible. 9ª Reunión Nacional. Sociedad Española de Hipertensión. Liga Española para la lucha contra la Hipertensión Arterial. 2004. Hipertensión. Moreno C, Khampang P, Schippers D, Lazar J, Kaldunski ML, Greene AS, Roman RJ, Kwitek AE, Jacob HJ, Cowley AW. Renal expression and sequence comparison of cyclooxygenase 2 in salt-sensitive hypertension. Experimental Biology 2004. FASEB Journal. Moreno C, Kaldunski ML, Lazar J, RJ Roman, Greene AS, Jacob HJ, Cowley AW. Efectos de los inhibidores del citocromo P450 y de un antagonista del 20-HETE sobre la funcion renal en ratas”. 9ª Reunión Nacional. Sociedad Española de Hipertensión. Liga Española para la lucha contra la Hipertensión Arterial. 2004. Hipertensión. Wang, X, Jia S, Jiang N, Chen M, Meyer M, Moreno-Quinn C, Jacob HJ, Ghosh S, Hessner MJ. MCW microarray QC platform: a pathway to quantitative and sensitive gene expression profiling. MGED 7 Meeting of the Microarray Gene Expression Data Society. September 8-10, 2004. Toronto, CA, 2004. Moreno C, Khampang P, Schippers D, Lazar J, Kaldunski ML, Greene AS, Roman RJ, Kwitek AE, Jacob HJ, Cowley,Jr AW. Human and Molecular Genetics Center. Department of Physiology. Department of Dermatology. Medical College of Wisconsin, Milwaukee WI. Renal expression and sequence comparison of Cyclooxygenase 2 in salt-sensitive hypertension. Experimental Biology 2004. 54 141. Moreno C, Lazar J, Khan S, Wen X, Jiang N, Tschannen MI, Chen M, Provoost A, Hessner MJ, Lazar J, Jacob HJ. Temporal patterns of gene expression during the development of renal failure. ASN October 2004, St. Louis, JASN 15: 434A. 142. Sharma CM, Lazar J, Lutz M, Barreto N, Andrae JW, Moreno C, van Dijk S, Provoost AP, McCarthy ET, Savin VJ, Jacob HJ. In Vitro Glomerular Albumin Permeability (Palb) as an Early Phenotypic Marker of Renal Injury. American Society of Nephrology. October 2004. 143. Strohl KP, Moreno C, Lazar J, Tschannen M, Erokwu B, Feroah T, Jacob HJ. A GenomeWide Scan for Respiratory Frequency in Male Rats. American Thoracic Society. 2004. 144. Van Dijk, SJ., Specht, PA, Lazar, J, Jacob, HJ, Provoost, AP. Increased susceptibility to renal damage and impaired autoregulation in Rf-1, and Rf1+4 congenic rats compared to ACI and Rf-4 rats. American Society of Nephorlogy. October 2004, St. Louis, JASN 15: 207A. 145. Van Dijk, SJ, Specht, PA, Lazar, J, Jacob, HJ, Provoost, AP. Remant kidney: A not so good model to compare the susceptibility to renal damage in congenic rats? American Society of Nephrology. October 2004, St. Louis, JASN 15: 828A. 146. Sarkis A, Lopez B, Hoagland KM, Moreno C, Fenoy FJ, Lazar J, Jacob HJ, Kwitek AE, Garrett MR, Rapp JP and Roman RJ. Transfer of the CYP4A region from Lewis rats into Dahl S background reduces renal injury. Council of High Blood Pressure Research. October 2005. 147. Strohl KP, Moreno C, Lazar J, Tschannen M, Erokwu B and Jacob HJ. A genome scan for breathing frequency in Sprague Dawley and Brown Norway rats. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY. December 2005. 148. Moreno C, Andrae JW, Lutz M, Orlebeke K, Lazar J, Greene AS, Twigger SN and Jacob HJ. Concordance of allele characterization project data with SNP distribution across rat strains. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY. December 2005. 149. Majewski RR, Lazar J, Hessner M, Moreno C, Kwitek AE, Jurinic A, Lemke A, Wendt-Andrae J and Jacob HJ. High-throughput production of rat knockout models for hypertension using ENU mutagenesis and tilling assay. Rat Genomics and Models Symposium. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY. December 2005. 150. Schlick NE, Lazar J, Stekiel TA, Contney SJ, Bosnjak ZJ, Jacob HJ. The role of mitochondrial DNA and mitochondrial function in the onset and progression of diabetic nephropathy. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY. December 2005. 151. Rangel-Filho A, Datta Y, Provoost A, Lazar J, Jacob HJ. Renal disease, coat color, platelet function and alcohol intake are modulated by the RF-2 locus in the Fawn-Hooded Rat. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY. December 2005. 152. Lutz MM, Lazar J, Sharma M, Moreno C, Andrae J.W, Provoost AP, and Jacob HJ Sequence and gene expression comparison in a narrowed region of Rf-4 locus in ACI, FHH and double congenic rats. Cold Spring Harbor Laboratory. Cold Spring Harbor, NY. December 2005. 153. Moreno C, Kaldunski ML, Wang T, Lazar J, Roman RJ, Greene AS, Jacob HJ and Cowley Jr AW. Existence of multiple blood pressure loci on rat chromosome 13 of the Dahl S Hypertensive rat. FASEB/Experimental Biology. San Francisco, CA. April 2006. 154. Lutz MM, Sharma M, Lazar J, Provoost A.P, Jacob HJ Identification of sequence and expression variants in a narrowed region of the Rf-4 locus related to renal failure. FASEB/Experimental Biology. San Francisco, CA. April 2006. 155. Schlick NE, Ryan RP, Roman RJ, Jacob HJ. Rf-1 implicated in the nephropathy of the T2DN rat. FASEB/Experimental Biology. San Francisco, CA. April 2006. 156. Moreno C, Rogge R, Lazar J, Tschannen M, Kaldunski M, Cowley AW, Jacob HJ. Characterization of blood pressure and protein excretion in chromosome 18 congenic strains of Dahl S rats. The Australian Health & Medical Research Congress. Melbourne, Australia. December 2006. 157. Solberg-Woods LC, Wendt-Andrae J, Tschannen M, Jacob HJ. Utility of heterogeneous stock rats for fine-mapping non-insulin dependent diabetes mellitus. The Australian Health & Medical Research Congress. Melbourne, Australia. December 2006. 55 158. Petri V, Shimoyama M, Patzer A, Kowalski G, Rood W, Laulederkind S, Reilly D, Smith J, Kwitek A, Jacob HJ, Twigger S. Rat Genome Database development impact on GO use and GO annotations. Gene Ontology Consortium Meeting. Cambridge, UK. January 2007. 159. Moreno C, Shimoyama M, Chen J, Kowalski G, Laulederkind S, Li D, Nigam R, Patzer A, Petri V, Smith J, Twigger S, Kwitek AE, Jacob HJ. The Rat Genome Database: Integrated Data Platform. EURATools Annual Meeting. Prague, Czech Republic. February 2007. 160. Jacob HJ, Lazar J, Rangel-Filho A, Lutz M, Sharma M, van Dijk SJ, Roman RJ, Moreno C, Provoost A. Genetic complexity of hypertension associated renal failure. International Society of Nephrology – Nature Genetics Forefronts Symposium on Nephrogenetics: from Development to Physiology. Danvers, MA. March 2007. 161. Shimoyama, M. (Poster), Patzer A, Kowalski G, Petri V, Laulederkind S, Smith J, Nigam R, Chen J, Li D, Zuniga-Meyer A, Twigger S, Kwitek A, Jacob HJ. Disease Portals: A Platform for Genetic and Genomic Research. Cold Spring Harbor Laboratory, The Biology of Genomes. Cold Spring Harbor, NY. May 2007. 162. Jacob HJ, Lazar J, Angel A, Lutz M, Harma MS, Van Dijk SJ, Roman RJ, Moreno C and Provoost AP. Genetic complexity of hypertension associated renal failure. Forefronts Symposium on Nephrogenetics. Danvers, MA. March 2007. 163. Moreno C, Dwinell MR, Majewski R, Kwitek AE, Hessner MJ, T.R. Feroah, H.V. Forster, D.L. Mattson, J.H. Lombard, G.D. Mcquestion, R.J. Roman, A.S. Greene, A.W. Cowley and Jacob HJ. High-Throughput Production and Phenotyping of Rat Knockout Models for Hypertension. Experimental Biology. Washington, D.C. April 2007. 164. Smith JR, Shimoyama M, Petri V, Nigam R, Laulederkind S, Reilly D, Kowalski G, Li D, Chen J, Patzer A,Twigger S, Kwitek A, Jacob HJ. The Rat Genome Database: Biological information in a genomic context. Cold Spring Harbor Laboratory, The Biology of Genomes. Cold Spring Harbor, NY. May 2007. 165. Laulederkind S (Poster), Shimoyama M, Patzer A, Petri V, Smith J, Nigam R, Reilly D, Kowalski G, Jin W, Chen J, Li D, Zuniga-Meyer A, Twigger S, Kwitek A, Jacob HJ. Disease Portals - A platform for genetic and genomic research. HUGO's 12th Human Genome Meeting. Montreal, Canada. May 2007. 166. Lazar, J., Petersen, M., Michalkiewicz, M., Geurts, A., Rangel-Filho, A., Wakatsuki, T., Jacob, HJ. High throughput phenotyping platform for positional cloning using engineered heart tissue. Cold Spring Harbor Laboratory, The Biology of Genomes. Cold Spring Harbor, NY. May 2007. 167. Aron M. Geurts, Baison Lu, Artur Rangel-Filho, Daniel F. Carlson, Scott C. Fahrenkrug, Colin E. Bishop, David A. Largaespada, and Jacob HJ. Unlocking the rat genome with transposable elements. Firth Annual International Meeting on Transposition and Animal Biotechnology. University of Minnesota. Minneapolis, MN. June 2007. 168. Feroah TR, Forster HV, Merritt A, Dwinell M, Moreno C, Greene A, Jacob HJ and Cowley Jr A. Significant differences in novel and adapted circadian movement behavior in three parental and two ENU knockout inbred strains of rats. Clinical Cardiovascular Genomics. Cold Spring Harbor, NY. September 2007. 169. Moreno C, Dwinell MR, Schilling RR, Kwitek AE, Greene AS, Roman RJ, Feroah TR, Forster HV, Mattson DL, Lombard JH, McQuestion JD, Cowley AW and Jacob HJ. Production and characterization of rat knockout models for studying cardiovascular disease. Cold Spring Harbor Laboratory. Clinical Cardiovascular Genomics. Cold Spring Harbor, NY. September 2007. 170. Moreno C, Dwinell MR, Schilling RR, Kwitek AE, Greene AS, Roman RJ, Lazar J,Mattson DL, Lombard JH, McQuestion GD, Cowley AW and Jacob HJ. Modeling cardiovascular disease in rat by ENU mutagenesis. 21st International Mammalian Genome Conference. Kyoto, Japan. October 2007. 56 171. Petri V, Shimoyama M, Patzer A, Kowalski G, Laulederkind S, Smith J, Nigam R, Jin W, Li D, Zuniga-Meyer A, Twigger S, Kwitek A, Jacob HJ. Disease Portals: A platform for genetic and genomic research at the Rat Genome Database. Midwest Symposium on Computational Biology & Bioinformatics 1st Annual MSCBB. Northwestern University, Evanston, IL. October 2007. 172. Smith JR, Shimoyama M, Petri V, Nigam R, Laulederkind S, Kowalski G, Li D, Chen J, De Pons J, Patzer A, Twigger S, Kwitek A, Jacob HJ. The Rat Genome Database: Automated pipelines facilitate rapid and reliable updates of genomic data. Midwest Symposium on Computational Biology & Bioinformatics 1st Annual MSCBB. Northwestern University, Evanston, IL. October 2007. 173. Kowalski G, Smith J, Li D, Shimoyama M, Patzer A, Petri V, Laulederkind S, Nigam R, De Pons J, Dwinell M, Twigger S, Jacob HJ. Automated pipelines facilitate rapid and reliable updates of genomic data. Midwest Symposium on Computational Biology & Bioinformatics 1st Annual MSCBB. Northwestern University, Evanston, IL. October 2007. 174. Petri V (Poster), Shimoyama M, Patzer A, Smith J, Laulederkind S, Kowalski G, Li D, Chen J, Nigam R, Zuniga-Meyer A, Twigger S, Dwinell M, Jacob HJ. Maximizing curation and information coverage of rat genes at the Rat Genome Database. Second International Biocurator Meeting. San Jose, CA. October 2007. 175. Laulederkind S (Poster), Shimoyama M, Patzer A, Petri V, Smith J, Nigam R, Kowalski G, Jin W, Li D, Zuniga-Meyer A, Twigger S, Kwitek A, Jacob HJ. Gene curation efficiency improvements at the Rat Genome Database. Second International Biocurator Meeting. San Jose, CA. October 2007. 176. Adamovic T, McAllister D, Rowe J, Wang Tap, Jacob HJ and Sugg SL. Genetic Mapping of QTLs controlling chemically induced mammary tumor latency and multiplicity on chromosome 10 using a novel SS/BN consomic rat model. Advances in Breast Cancer Research. San Diego, CA. October 2007. 177. Adamovic T, McAllister D, Rowe J, Wang T, Jacob HJ and Sugg SL. Identification of QTLs controlling mammary tumor latency and multiplicity on chromosome 10 in a novel SS/BN consomic rat model. Advances in Breast Cancer Research. San Diego, CA. October 2007. 178. Nye SH, Harrington Y, Evans DL, Lu S, Marroquin LD, Jacob HJ, Will Y, Roman R. Tacrine toxicity detected in a rat test population. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 179. Moreno C, Duran M, de Resende MM, Kaldunski ML, Lazar J, Lombard J, Greene AS, Cowley Jr AW and Jacob HJ. Pleiotropic effects of the rennin loci. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 180. O’Meara C, Lazar J, Moreno C, Tschannen M, Provoost AP, Jacob HJ. Investigating a triple congenic rat model to determine genes contributing to renal failure. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 181. Rangel Filho A, Lazar J, Michalkiewicz M, Jacob HJ. Applications of viral vectors in rat genomics. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 182. Rangel Filho A (Poster), Lazar J, Michalkiewicz M, Jacob HJ. Applications of viral vectors in rat genomics. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 183. Schilling RR, Lazar J, Hessner M, Moreno-Quinn C, Dwinell M, Lemke A, Wendt-Andrae J, Jacob HJ. High-throughput production of rat knockout models for hypertension using ENU mutagenesis and a tilling assay. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 184. Dwinell M, Shimoyama M, Kwitek AE, Greene AS, Cowley, Jr AW., Jacob HJ. Integrating Physgen Program for Genomic Applications with RGD through ontologies. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 57 185. Laulederkind S, Shimoyama M, Patzer A, Petri V, Smith J, Nigam R, Kowalski G, Jin W, De Pons J, Zuniga-Meyer A, Twigger S, Dwinell M, Jacob HJ. Gene curation at the Rat Genome Database. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 186. Nigam R, Shimoyama M, Kowalski G, Laulederkind S, Smith J, De Pons J, Petri V, Patzer A, Twigger S, Dwinell M, Jacob HJ. Worldwide repository for rat strains at the Rat Genome Database. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 187. Nigam R, Shimoyama M, Kowalski G, Laulederkind S, Smith J, De Pons J, Petri V, Patzer A, Twigger S, Dwinell M, Jacob HJ. QTL at RGD: Linking phenotype to the genome. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 188. Petri V, Shimoyama M, Patzer A, Kowalski G, Jennifer Smith, Stan Laulederkind, Jeff De Pons, Melinda Dwinell, Simon Twigger, Jacob HJ. Pathway data at the Rat Genome Database. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 189. Shimoyama M, Petri V, Smith J, Laulederkind S, Nigam R, Kowalski G, De Pons J, Patzer A, Twigger S, Dwinell M, Jacob HJ. The obesity/metabolic syndrome portal RGD. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 190. Smith J, Shimoyama M, Petri V, Nigam R, Laulederkind S, Lowry T, Kowalski G, De Pons J, Patzer A, Twigger S, Dwinell M, Jacob HJ. The Rat Genome Database: Biological information in a genomic context. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 191. Twigger S, Kowalski G, Schlick N, Kwitek A, Hubner N and Jacob HJ. SNLPlotyper – a webbased SNP genotype/haplotype visualization & analysis tool. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 192. Adamovic T, McAllister D, Rowe J, Wang T, Jacob HJ and Sugg SL. Genetic mapping of QTLs controlling chemically induced mammary tumor latency and multiplicity on chromosome 10 using novel SS/BN consomic rat model. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 193. Guryev V, Saar K, Adamovic T, Jacob HJ, Shull J, Hubner N & Cuppen E. Copy-number variation in genomes of laboratory rat strains: Distribution, properties and utility for human genetics. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 194. Gilbert S, Kwitek AE, Hubner N, Tschannen M, Jacob HJ, Bataillard A, Hessner M and Sassard J. Integrated approaches to dissect complex disease. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 195. Guryev V, Saar K, Adamovic T, Jacob HJ, Shull J, Hubner N and Cuppen E. Copy number variation in the rat. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 198. Twigger S, Vallejos A, Halligan B, Shimoyama M, Petri V, Mirsa S, Pellitteri-Hahn M, Olivier M, Jacob HJ and Greene A. APROPOS – I want it all, and I want it now. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 199. Geurts A, Matthewson E, Lu B, Bishop CE and Jacob HJ. Transposon knockouts by high throughput gene trapping in the rat. Cold Spring Harbor Laboratory, Rat Genomics & Models. Cold Spring Harbor, NY. December 2007. 200. Jacob HJ. Translating Animal Models to the Clinic Setting. American Thoracic Society (ATS) 2008 International Conference. Toronto, Canada May 15 – 16, 2008. 201. Jacob HJ. The Complex Nature of QTLS: How Many Genes are Under the Peak? ARKGenomics Conference 2008 3rd ISAFG. Edinburgh, Scotland April 7-9, 2008. 58 202. Petri V, Shimoyama M, Patzer A, dePons J, Dwinell M, Twigger S, Jacob HJ. Pathway Data at the Rat Genome Database. Cold Spring Harbor Biology of Genomes, May 2008. 203. Smith JR, Shimoyama M, Petri V, Laulederkind S, Nigam R, Lowry T, Stoddard A, dePons J, Bakir B, Patzer A, Twigger S, Dwinell M, Jacob HJ. Annotated Datasets: Customizing your Data at RGD. Cold Spring Harbor Biology of Genomes, May 2008. 203. Jacob HJ. From Whole Genome Associations. Hypertension 2008 June 14-19, 2008. Berlin, Germany. 204. Lazar J, Wakatsuki T, Jacob HJ. Using Engineered Heart Tissue to Accelerate Positional Cloning. Hypertension 2008 June 14-19, 2008. Berlin, Germany. 205. Geurts A, Lemke A, Moreno C, Dwinell M and Jacob HJ. PhysGen meets Sleeping Beauty – a match made in rat heaven. International Society of Hypertension. Berlin, June 2008. 206. Jacob HJ. Understanding Common Diseases Through Molecular Genetics: An Example Using Kidney Failure. 13th Intl SHR Symposium, June 20-22, 2008. Prague Czech Republic. 207. Dwinell MR, Shimoyama M, Nigam R, DePons J, Jacob HJ. Phenotypes and Models Portal at the Rat Genome Database. Intelligent Systems for Molecular Biology Meeting, Toronto, Canada, July 19-24, 2008. 208. Shimoyama M, Dwinell M, Jacob HJ. Multiple ontologies for integrating complex phenotype datasets. Intelligent Systems in Molecular Biology Meeting, Toronto, CA, July 2008. 209. Roman RJ, Moreno C, Lazar C, Cowley Jr AW. and Jacob HJ. Narrowing of a region on rat chromosome 13 that protects against the development of hypertension using overlapping Dahl SS.13BN congenic strains. Council of High Blood Pressure, Atlanta, September 2008. 210. Moreno C, Sweeney WE, Lazar J, Jacob HJ and Avner ED. Development of a rat model of ARPKD to study genetic modifier loci. American Society of Nephrology. Philadelphia,November 2008. 211. Jacob HJ, Provoost AP, Broeckel U, Lazarova Z, Lazar J and many former members of the Jacob Lab. Identification of RF-1. Rat Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6. 212. Moreno-Quinn C, O’Meara C, Sweeney WE, Lazar J, Avner ED, Jacob HJ. Towards mapping modifier loci for ARPKD. Rat Genomics & Models meeting, Cold Spring Harbor Laboratory/Wellcome Trust Conference Dec 3-6. 213. O’Meara C, Lazar J, Moreno-Quinn C, Provoost A, Jacob HJ. The contribution of the RF-3 QTL in the development of renal failure. Rat Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6. 214. Shimoyama M, Nigam R, Smkith J, Stoddard A, Munzenmaier D, Twigger S, Dwinell M, Jacob HJ. Phenotypes at RGD: new tools for integrating and mining complex phenotype data. Rat Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6. 215. Smith J, Shimoyama M, Worthey L, Stoddard A, DePons J, Bakir B, Petri V, Laulederkind S, Nigam R, Lowry T, Munzenmaier D, Patzer A, Twigger S, Dwinell M, Jacob HJ. Enhanced navigation of RGD data and tools. Rat Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6. 216. Twigger S, DePons J, Smith J, Abraham D, Shimoyama M, Dwinell M, Munzenmaier D, Jacob HJ and the Rat Genome Database Team. RGD education and outreach in the YouTube era. Rat Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6. 217. Shimoyama M, Petri V, DePons J, Twigger S, Dwinell M, Jacob HJ. Exploring pathway data through interactive diagrams and ontology at RGD. Rat Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6. 218. Dwinell M, Shimoyama M, Nigam R, DePons J, Munzenmaier D, Twigger S, Jacob HJ. Phenotypes and models portal at RGD: providing an entree to genomics for physiologists. Rat Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6. 59 219. Worthey E, Bakir-Gungor B, DePons J, Twigger S, Dwinell M, Shimoyama M, Jacob HJ. Exploring, examining and evaluating variation in the rat using the rat genome database. Rat Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6. 220. Schwartz D, Zhou S, Goldstein S, Potamousis K, Forrest D, Churas C, Jacob HJ, Guryev V, Cuppen E. Discovery of structural variation in the rat genome via optical mapping. Rat Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6. 221. Guerts A, Choi V, DeKelver RC, Miller JC, Zeitler B, Wood A, Rebar EJ, Schilling R, Kalloway R, Davis G, Urnov FD, Gregory PD, Sullivan P, Jacob HJ. Targeted medication of the rat genome using zinc finger nucleases. Rat Genomics & Models meeting, Cold Spring Harbor NY 2008 Dec 3-6. 222. Jacob HJ. Animal Cellular & Tissue Models. 1st Annual Meeting of NGFN-Plus and NGFN Transfer, Munich Germany. December 11 & 12, 2008. 223. Gros M, Lazar J, Moreno C, Jacob HJ and Lombard JH. Role of mitochondrial genome in modulating hypoxic dilation in cerebral arteries of animal models with type 2 diabetes mellitus. Rat Genomics and Models. Hinxton, UK. December 2008. 224. O’Meara C, Lazar J, Moreno C, Provoost AP and Jacob HJ. The contribution of the Rf-3 QTL in the development of renal failure. Rat Genomics and Models. Hixton, UK. December 2008. 225. Shimoyama M, Laulederkind S, Lowry T, Petri V, Smith J, dePons J, Stoddard A, Twigger S, Dwinell M, Jacob HJ. Increasing Curation Efficiency: RGD’s Software Suite. Genome Informatics, Qld Australia, December 2008. 226. Shimoyama M, Smith J, dePons J, Stoddard A, Bakir B, Twigger S, Dwinell M, Jacob HJ. Curating the Rat Genome: RGD’s Automated Data Integration Pipelines Maximize Coverage. Genome Informatics, Qld Australia, December 2008. 227. O’Meara C, Lazar J, Moreno C, Provoost AP and Jacob HJ. The Contribution of Genes on Chromosome 3 to Renal Failure in the Fawn Hooded Hypertensive Rat. Experimental Biology, New Orleans, April 2009. 228. Moreno C, Rogge R, Tschannen M, Barreto N, Lazar J, Jacob HJ. Multiple Blood Pressure loci on rat Chromosome 18 attenuate the development of hypertension in the Dahl S Hypertensive rat. Experimental Biology, New Orleans, April 2009. 229. Lu L, Li P, Yang C, Kurth T, Misale M, Skelton M, Moreno C,Greene AS, Jacob HJ, Roman RJ, Lazar J, Liang M, Cowley, Jr AW. Dynamic utilization of biological pathways in protection against salt-sensitive hypertension. Council of High Blood Pressure, Chicago, September 2009. 230. Moreno C, Geurts A, Foeckler J, Kalloway S, Schilling R, Klotz R, Greene AS, Weiler H, Jacob HJ. Development of a Rat Knockout for the Renin Gene. Council of High Blood Pressure, Chicago, September 2009. 231. Jacob HJ ‘The Rat Genome Contribution to understanding the Pathogenesis of Hypertension’. Experimental Biology 2009 New Orleans. 232. Worthey L, DePons J, Shimoyama M, Smith J, Nigam R, Petri V, Laulederkind S, Lowry T, Munzenmaier, D, Dwinell M, Twigger S, Jacob HJ. The Rat Genome Database Genome Viewer. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 233. O’Meara C, Lazar J, Moreno C and Jacob HJ. Physiological genomics of the renal failure 3 (Rf-3) quantitative trait locus. Rat Genomics and Models. Cold Spring Harbor, NY. December 2009. 234. Strohl KP, Moreno C, Lazar J, Dostal J, Tschannen M, Erokwu B, Jacob HJ. Linkage to posthypoxic ventilatory behavior in the rat. Rat Genomics and Models. Cold Spring Harbor, NY. December 2009. 235. Dwinell M, Shimoyama M, Nigam R, DePons J, Munzenmaier D, Twigger S, Jacob HJ, and the RGD team. Rat models for complex disease: using phenotypes to identify disease models. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 60 236. Hayman T, Shimoyama M, Laulederkind S, Lowry T, Nigam R, Petri V, Smith J, DePons J, Stoddard A, Twigger S, Dwinell M, Munzenmaier D, Jacob HJ and the RGD Team. The diabetes disease portal at the rat genome database. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 237. Laulederkind S, Shimoyama M, Patzer A, Petri V, Smith J, Nigam R, Lowry T, Hayman T, DePons J, Stoddard A, Bakir B, Twigger S, Dwinell M, Munzenmaier D, Jacob HJ. Multiple ontologies for prioritizing and standardizing biological information at the rat genome database. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 238. Lazar J, Rai D, Moreno-Quinn C, Sweeney W, Jacob HJ. Differential effect of a western diet on GK and T2DN rats. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 239. Lowry TF, Nigam R, Dwinell M, Munzenmaier D, Twigger S, Jacob HJ. Human quantitative trait loci (QTL) data within the rat genome database (RGD). Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 240. Munzenmaier D, Dwinell M, Petri V, Shimoyama M, Jacob HJ. Physiological pathway diagrams at RGD: a new, interactive, online tool providing efficient access to genotype and phenotype data through biological pathway analysis. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 241. Nigam R, Shimoyama M, Twigger S, Munzenmaier D, Dwinell M, Jacob HJ and the RGD team. RGD: a repository and cumulative resource for rat strains. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 242. Nigam R, Shimoyama M, Twigger S, Munzenmaier D, Dwinell M, Jacob HJ and the RGD team. RGD a unique resource for rat QTL data: linking phenotype to the genome. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 243. Petri V, Shimoyama M, DePons J, Stoddard A, Dwinell M, Munzenmairer D, Twigger S Jacob HJ. Pathway resources at the rat genome database: a dynamic platform for integrating gene, pathway and disease information. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 244. Rao V, Lazar J, Sarkis A, Wakatsuki T, Lam V, Jacob HJ. Engineered heart tissues help to identify potential sensitivity of a rat model to myocardial ischemia. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 245. Saar K, Hummel O, Patone G, Chen W, Jacob HJ, Hubner N. Genomic sequencing of three inbred rat strains. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 246. Sarkis A, Rao V, Wakatsuki T, Lazar J, Jacob HJ. Decellularized heart matrix as a scaffold for development of engineered heart tissue. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 247. Schilling RR, Geurts AM, Weiler H, Kalloway S, Foeckler J, Klotz J, Lemke A, Wendt-Andrae J, Jacob HJ. Progress on zinc-finger nuclease-mediated gene distribution in the rat. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 248. Shimoyama M, Stoddard A, Twigger S, Dwinell M, Munzenmaier D, Jacob HJ and the RGD team. RGD’s phenotype database and data mining tool. 249. Smith JR, DePons J, Shimoyama M, Worthey EA, Dwinell M, Twigger S, Jacob HJ and the RGD team. At the rat genome database education is a two way street. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 250. Yang S, Schilling R, Foeckler J, Kalloway S, Geurts AM Jacob HJ. Piggybac transposon-based reprogramming of rat embryonic fibroblasts into pluropotency without inhibitors for FHH and SD strains. 251. Geurts AM, Schilling R, Lemke A, Kalloway S, Foeckler J, Klotz J, Weiler H, Worthey L, Ostertag E, Dwinell M, Mattson D, Lombard J, Cowley A, Moreno-Quinn C, Jacob HJ for the rest of GO team. The rat knockout project: unraveling complex human disease through advances in rat knockout technology. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 61 252. Kok-Reagles SM, Geurts AM, Noto FK, Lohman S, Duncan SA, Jacob HJ. Induced pluripotent stem cells as a platform for manipulation of the rat genome via conditional gene-trap mutagenesis. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 253. Jacob HJ, Rangel-Filho A, Schilling R, Lemke A, Kalloway S, Foeckler J, Klotz J, Weiler H, Lazar J, Moreno-Quinn C, Geurts AM. Validation of RAB38 using transgenic rescue and gene KO. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 254. Moreno-Quinn C, Hofman M, Lazar J, Lombard JH, Greene AS, Jacob HJ. Narrowing the blood pressure loci around the renin gene. 255. O’Meara C, Lazar J, Moreno-Quinn C, Jacob HJ. Physological genomics of the renal failure 3 RF-3) quantitative trait locus. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 256. Strohl KP, Moreno-Quinn C, Lazar J, Dostal J, Tschannen M, Erokwu B, Jacob HJ. Linkages to post hypoxic ventilatory behavior in the rat. Rat Genomics & Models meeting, Cold Spring Harbor NY 2009 Dec 2-5. 257. Chen M, Rood W, Hecht A, Moreno C, Schilling C, McQuestion G, Jacob HJ. Animal Colony Tracking System. Technology Fair 2010: Digital Path to Collaboration, MCW, Miwaukee,WI, January 2010. 258. Feng D, Yang C, Kurth T, Liang M, Moreno C, Jacob HJ, Cowley AW. Renal Medullary NAD(P)H-oxidase subunit p67ohox as a candidate gene in salt-sensitive hypertension. Experimental Biology, Aneheim, April 2010. 259. Jacob HJ, Geurts AM, Schilling R, Lemke A, Kalloway S, Foeckler J, Klotz J, Weiler H,Lazar J, Dwinell MR, Moreno C for GO grant team. From GWAS to function using sensitized strains, transgenic rescue and gene KO.The Biology of Genomes, May 11-15, 2010. 260. Tschannen M, Worthey E, Saar K, Tutaj M, Hummel O, Patone G, Chen W, Jacob HJ, Hubner, N. Comparing genomic sequence of select large stretches of inbred rat strains using three different sequencing platforms in tandem. The Biology of Genomes, May 11-15, 2010. 261. Cowley AW Jr. Jacob HJ, Moreno C, Greene A, Lombard J, Mattson D, Lazar J, Dwinell MR, Geurts AM. Unraveling the genomic basis of hypertension: rat model systems. International Congress of Pathophysiology, Montreal, Canada, September 2010. 262. Geurts AM, Schilling R, Lemke A, Grzybowski M, Kalloway S, Foeckler J, Klotz J, Weiler H, Lazar J, Dwinell MR, Moreno C, Jacob HJ. From genetics to function for human disease using transgenic rescue and gene KO in sensitized rat strains. International Congress of Pathophysiology, Montreal, Canada, September 2010. 263. Jacob HJ, Geurts AM, Schilling R, Lemke A, Kalloway S, Foeckler J, Klotz J, Weiler H, Lazar J, Dwinell MR, Moreno C, for the GO Grant Team. From GWAS to function using sensitized strains, transgenic rescue and gene KO. American Heart Association HBPR 2010. Washington, DC Oct 13-16, 2010. 264. Moreno C, Hoffman M, Didier D, Geurts M, Lazar J., Greene A, Jacob HJ. Initial Characterization of the Renin Knockout Rat. American Heart Association HBPR 2010. Washington, DC Oct 13-16, 2010. 265. Jacob HJ, Schilling RR, Lazar J, Moreno-Quinn, C. Using gene knock-outs and transposon based transgenics in sensitized rat strains to study genes nominated by human GWAS for renal disease. 43rd Annual Meeting & Scientific Exposition, American Society of Nephrology 2010 Nov. 16-21. 266. Lazar J, Xu H, O’Meara C, Lazarova Z, Moreno C, Jacob HJ. A candidate gene for kidney failure. 43rd Annual Meeting & Scientific Exposition, American Society of Nephrology 2010 Nov. 16-21. 267. Liu P, Yang C, Tschannen M R, Lu Y, Jacob HJ, Liang M, Cowley A W. RNA-seq reveals Numerous Novel Transcripts, Transcript Isoforms, and Sequence Variations in the Dahl SaltSensitive Rat. HBPR2011, Sept. 20-24, 2011. 62 63
