PROF. DR. MAHMOOD AKHTAR KAYANI
E-mail: mkayani@comsats.edu.pk
Date of Birth
4th January 1973
Residential Address
367-Aslam Shaheed Road, Lalazar, Rawalpindi (Cantt), Pakistan.
Phone (R)
+92(0)51-5513848; +92(0)3215357981 (cell)
Phone (O)
+92 (0)51-9235033
Positions held
.
Professor,
Jan 2014-todate,
Deptt. of Biosciences, CIIT, Islamabad
Associate Professor, Nov 2010-Jan 2014, Deptt of Biosciences, CIIT, Islamabad
Head of Department, Feb 2010-to Aug 2011, Deptt of Biosciences, CIIT, Islamabad
Assistant Professor (TTS), April 2005-Nov2010, Deptt of Biosciences, CIIT, Islamabad
Assistant Professor, 2004-2005, National University of Science & Technology, Rawalpindi
Assistant Professor, 2004- 2004, Deptt of Biosciences, CIIT, Islamabad
Assistant Professor, 2002- 2004, NCEMB, University of the Punjab, Lahore
Academic Career
.
PhD
2002
University of Wales, Swansea (United Kingdom)
MPhil
1997
Quaid-i-Azam University, Islamabad (Pakistan)
BSc (Hons)
1995
University of Agriculture, Faisalabad (Pakistan)
Distinctions
Scholarship for PhD in UK by Govt of Pakistan
1998
Quaid-i-Azam Scholarship
1989
Research Interests
Cancer Genetics, Arthritis Genetics, Molecular Cytogenetics, Genetic Toxicology, Mutagenicity
and DNA repair, Hormonal carcinogenesis, Stem cells and cellular therapies.
Research Grants
.
1. Breast and Ovarian Cancer: BRCA1 and BRCA2 polymorphism in ethnic populations of
Pakistan. 2005. CIIT Research Grant Program
2. Genetic Analysis of KISS-1 and KAI-1 genes. 2007. Higher Education Commission
3. Genetic and Epigenetic Analysis of Rb pathway genes in head and neck cancer. 2013 Higher
Education Commission
4. Determination of RBl2/p130 acetylation in normal as well as tumor cells. 2010. Higher
Education Commission (CO-PI)
5. Analysis of XRCC1 Gene in Patients with HNC. 2012. CIIT Research Grant Program (CO-PI)
6. Genetics of Head and neck cancer: Genetic Analysis of XRCC1 and EPHX1 genes 2009. CIIT
Research Grant Program (CO-PI)
7. Mutational & Expressional Analysis of Carcinogen Detoxifying genes. 2010 Higher Education
Commission
.
Thesis supervised
.
Bachelor of Sciences (BS):
o In Silico functional analysis of genes involved in Head and neck cancer
o
Association of SNPs with ovarian cancer susceptibility
o Analysis of regulatory regions of genes expressed in eye
o Association of SNPs with Rheumatoid Arthritis susceptibility
o Construction of Wheat Query system
o Study on OGG1 gene variations in pathogenesis of breast cancer
o Screening of N terminus of Rb gene in head and neck cancer patients of Pakistani
population
o Tool development for automatic breast cancer detection in mammograms through
MATLAB as a computing environment
o Study of APEX1 Gene Variations in Pathogenesis of Breast Cancer
Master of Sciences (MS):
o Hotspot Mutation detection of BRCA genes in Breast Cancer patients of local population
o Association of Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism with
Hereditary and Sporadic Breast Cancer in Local Population
o Screening of metastasis suppressor geens (KAI1 & KISS1) in head and neck cancer patients
of Pakistani population
o Spleen Tyrosine Kinase Expression in breast cancer in Pakistani population
o Expression analysis of CYP1A1 and GSTP1 in breast cancer
o Expressional analysis of Kiss-1 and Kai-1 in breast cancer in Pakistani population
o Expression patterns of CYP1A1 and GSTP1 in brain tumor tissues
o Detection of Polymorphism in SYK gene among breast cancer patients (co-supervisor)
o Mutational screening of spleen tyrosine kinase (SYK) gene in breast cancer among Pakistani
population (co-supervisor)
o Study on risk factor and cytokine expression in heart disease patients (co-supervisor)
o Expressional assessment of XRCC2 gene in patients with breast cancer
o Role of glutathione in head and neck cancer pathogenesis
o Genetic manifestation of Ki-67 in breast cancer patients
o Transcript expressional analysis of Rb2/P130 in breast cancer patients (co-supervisor)
o XRCC2/3 and RAD polymorphisms and risk of head and neck cancer
o RAD51/XRCC3 gene polymorphism and risk of head and neck cancer
o SYK gene polymorphism among patients of breast cancer in Pakistan (co-supervisor)
o Population detection of SNPs in 3’UTR of SYK gene in breast cancer patients (co-supervisor)
Doctor of Philosophy (PhD):
o Molecular genetic characterization of breast cancer patients in Pakistani population. 2010
Dr. Faraz Arshad Malik
o Contribution of genetic changes in hereditary and sporadic forms of head and neck
cancer. 2011
Dr. Nosheen Masood
o Studying the genetic basis of breast cancer metastasis. 2013
Dr. Ruqia Mehmood Baig
o Studies on deregulation of Base excision repair pathway genes and microRNAs in head
and neck cancer. 2013
Dr. Ishrat Mahjabeen
o Genetic and epigenetic analysis of Rb pathway genes in head and neck cancer patients.
2014
Dr. Maimoona Sabir
Publications in international peer reviewed journals
.
2015
Ullah F, Khan T, Ali N, Malik FA, Shah STA, Kayani MA and Saeed M. 2015. Promoter
Methylation Status Modulate the Expression of Tumor Suppressor (RbL2/p130) Gene in Breast
Cancer. PLOS ONE. 10(8): e0134687.
Ali K, Mahjabeen I, Sabir M, Mehmood H, Kayani MA. 2015. OGG1 Mutations and Risk of
Female Breast Cancer: Meta-Analysis and Experimental Data. 2015:690878.
Shah AU, Mahjabeen I, Kayani MA. 2015. Genetic polymorphisms in cell cycle regulatory genes
CCND1 and CDK4 are associated with susceptibility to breast cancer. Accepted J BUON 20(4).
Impact factor: 0.706
2014
Kayani MA, Khan S, Baig RM, Mahjabeen I. 2014. Association of RAD 51 135 G/C, 172 G/T
and XRCC3 Thr241Met gene polymorphisms with increased risk of head and neck cancer. Asian
Pasific Journal for Cancer Prevention. 15(23): 10457-62.
Impact factor: 1.500
Qureshi Z, Mahjabeen I, Baig RM, Kayani MA. 2014. Correlation between selected XRCC2,
XRCC3 and RAD51 genes’ polymorphisms and primary breast cancer in women. Asian Pasific
Journal for Cancer Prevention. 15(23): 10225-9.
Impact factor: 1.500
Bashir N, Sana S, Mahjabeen I, Kayani MA. 2014. Association of reduced XRCC2 expression
with lymph node metastasis in breast cancer tissues. Familial Cancer. 13(4): 611-617.
Impact factor: 1.618
Kashif Ali, Ishrat Mahjabeen, Maimoona Sabir, Ruqia Mehmood Baig, Maryam Zafeer,
Muhammad Faheem, Mahmood Akhtar Kayani. 2014. Germline variations of Apurinic/apyrimidinic
Endonuclease 1 (APEX1) detected in female breast cancer Patients. Asian Pacific Journal of
Cancer Prevention. 15(18): 7589-95.
Impact factor: 1.500
Khan SU, Mahjabeen I, Malik FA and Kayani MA. 2014. Prognostic Significance of Altered Blood
and Tissue Glutathione levels in Head and Neck cell Carcinoma. Asian Pacific Journal of Cancer
Prevention. 15(18): 7603-9.
Impact factor: 1.500
Sabir M, Baig RM, Ali K, Mahjabeen I, Saeed M and Kayani MA. 2014. Retinoblastoma (RB1)
pocket domain mutations and promoter hyper-methylation in head and neck cancer. Cellular
Oncology. 37(3): 203-213.
Impact factor= 2.124
Malik FA and Kayani MA. 2014. Issues of Maternal Health in Pakistan: Trends towards
Millennium Development Goal 5. PJMA. 64(6): 690-693.
Impact factor: 0.409
Masood N, Yasmin A and Kayani MA. 2014. Genetic variations and head and neck cancer risks.
Molecular Biology Reports. 41(4):2667-70.
Impact factor: 1.958
Mahjabeen I, Zhou X and Kayani MA. 2014. Deregulation of base excision repair gene
expression and enhanced proliferation in head and neck squamous cell carcinoma. Tumor
Biology. 35(6):5971-83.
Impact factor: 2.840
2013
Wahid M, Mahjabeen I, Baig RM and Kayani MA. 2013. Expression of CYP1A1 and GSTP1 in
human brain tumor tissues. Asian Pacific Journal of Cancer Prevention. 14(2): 7187-7191.
Impact factor: 1.500
Mahjabeen I and Kayani MA. 2013. Novel Mutations of Apurinic/Apyrimidinic Endonuclease 1
Gene in Head and Neck Cancer Patients. Intl J of Clinical Tox. 1(1):4-8.
Shakeel S, Mahjabeen I, Kayani MA and Faryal R. 2013. Association of SYK genetic variations
with breast cancer pathogenesis. Asian Pacific Journal of Cancer Prevention. 14 (5), 3309-3314
Impact factor: 1.500
Masood N, Yasmin A and Kayani MA.S 2013. Genetic Deletions of GSTM1 and GSTT1 in Head
and Neck Cancer: Review from 2000 to 2012. Asian Pacific Journal of Cancer Prevention
14(6):3535-9
Impact factor: 1.500
Khan ZN, Sabir M, Kayani MA and Saeed M. 2013. Acetylation of Retinoblastoma like protein
(Rb2/p130) in tumor tissues. Asian Pacific Journal for Cancer Presvention. 14(4): 2255-2258.
Impact factor: 1.500
Mahjabeen I, Masood N, Baig RM, Sabir M, Inayat U, Malik FA and Kayani MA. 2013. Genetic
variations in XRCC1 gene in sporadic head and neck cancer (HNC) patients. Pathology and
Oncology Research. 19(2):183-188.
Impact factor: 1.806
Masood N and Kayani MA. 2013. "Protection against laryngeal and pharyngeal carcinoma:
heterozygous versus homozygous deletions of GSTM1 and GSTT1. Genetics and Molecular
Biology. 36(1):1-6.
Impact factor: 0.876
Sabir M, Baig RM, Mahjabeen I and Kayani MA. 2013. Significance of Cyclin D1 polymorphisms
in patients with head and neck cancer. International Journal of Biological Markers. 28(1): e49-55.
Impact factor: 1.360
Baig RM, Mahjabeen I, Sabir M, Masood N, Ali K, Malik FA, Kayani MA. 2013. Mutational
spectrum of Gelsolin and its down regulation is associated with breast cancer. Disease Markers.
34(2): 71-80.
Impact factor: 2.174
Mahjabeen I, Baig RM, Sabir M and Kayani MA. 2013. Genetic and Expressional variations of
APEX1 are associated with increased risk of head and neck cancer. Mutagenesis. 28(2): 213-218.
Impact factor: 3.479
Masood N and Kayani MA. 2013. Expression patterns of carcinogen detoxifying genes (CYP1A1,
GSTP1 & GSTT1) in HNC patients. Pathology and Oncology Research. 19(1).89-94.
Impact factor: 1.806
2012
Sabir M, Baig RM, Mahjabeen I and Kayani MA. 2012. Novel germline CDK4 mutations in
patients with head and neck cancer. Hereditary Cancer in Clinical Practice. 10:11
Impact factor: 2.103
Inayat U, Kayani MA and Faryal R. 2012. Sporadic mutations and expression analysis of Spleen
Tyrosine Kinase gene in breast cancer: a preliminary report. Pol J Pathol. 63(2): 106-111.
Impact factor: 0.832
Baig RM, Sanders AJ, Kayani MA and Jiang WG. 2012. Association of Differentiation-Related
Gene-1 (DRG1) with Breast Cancer Survival and in Vitro Impact of DRG1 Suppression. Cancers.
4(3): 658-672.
Non-ISI
Hafeez S, Ahmed A, Kayani MA. 2012. Down-regulation of CYP1A1 expression in breast cancer.
Asian Pacific Journal of Cancer Prevention. 13(5):1757-60.
Impact factor: 1.500
Akram M, Malik FA, Kayani MA. 2012. Mutational Analysis of the MTHFR gene in breast cancer
patients of Pakistani population. Asian Pacific Journal of Cancer Prevention. 13(4): 1599-1603.
Impact factor: 1.500
Masood N, Malik FA, Kayani MA. 2012. Unusual intronic variant in GSTP1 in head and neck
cancer in Pakistan. Asian Pacific Journal of Cancer Prevention.13(4): 1683-6.
Impact factor: 1.500
Mahjabeen I, Masood N, Baig RM, Sabir M, Inayat U, Malik FA, Kayani MA. 2012. Novel
mutations of OGG1 Base excision repair pathway gene in laryngeal cancer patients. Familial
Cancer. 11(4): 587-593.
Impact factor: 1.618
Mahjabeen I, Chen Z, Zhou X and Kayani MA. 2012. Decreased mRNA expression levels of
Base Excision Repair (BER) pathway genes is associated with enhanced Ki-67 expression in
HNSCC. Medical Oncology. 295(5): 3620-3625.
Impact factor: 2.058
Kanwal S, Kayani MA and Faryal R. 2012. Identification of novel SNPs in SYK gene of breast
cancer patients: Computational analysis of SNPs in the 5’ UTR. Molecular Biology Reports.
39(8):8345-51.
Impact factor: 1.958
Sabir M, Baig RM, Mahjabeen I, Saeed M, Malik FA and Kayani MA. 2012. RB1/105 gene
alterations and head and neck carcinogenesis. 39(10):9573-81. Molecular Biology Reports.
Impact factor: 1.958
2011
Kayani M, Kayani MA, Malik FA, Faryal R. 2011. Role of miRNAs in Breast cancer. Asian Pacific
J Cancer Prev. 12(12): 3175-3180.
Impact factor: 1.500
Moeez S; Malik, FA; Kayani, MA; Rashid R; Zahid A; Khan A. 2011. Expressional alterations and
transcript isoforms of metastasis suppressor genes (KAI1 & KiSS1) in breast cancer patients.
Asian Pacific J Cancer Prev. 12(10): 2785-2791.
Impact factor: 1.500
Hussain, SS; Raza, H; Afzal, I and MA Kayani. 2012. Transgenic plants for abiotic stress
tolerance: current status. Archives of Agronomy and Soil Science. 1-29.
ISI indexed
Baig R; Mahjabeen I; Sabir, M; Masood N; Hafeez S; Malik FA; Kayani MA. 2011. Genetic
Changes in PTEN gene and their association with breast cancer in Pakistan. Asian Pacific J
Cancer Prev. 12(10): 2365-2370.
Impact factor: 1.500
Mahjabeen I; Baig R; Masood N; Sabir, M; Malik FA; Kayani MA. 2011. Sequence variations of
OGG1 gene in head and neck cancer patients of Pakistan. Asian Pacific J Cancer Prev. 12(10):
2359-2363.
Impact factor: 1.500
Nazir M, Kayani M, Malik FA, Masood N, Kayani MA. 2011. Lack of germ line changes in KISS1
& KAI1 genes in sporadic head and neck cancer patients of Pakistani origin. Asian Pacific J
Cancer Prev. 12(10). 2353-2357.
Impact factor: 1.500
Khan F; Akbar, H; Khan, MI; Khan, H; Shahzad, K and Kayani, MA. 2011. The prevalence of
HBV infection in the cohort of IDPs of war against terrorism in Malakand Division of Northern
Pakistan. BMC Infectious Diseases. 11: 176.
Impact factor: 2.561
Masood N, Malik FA, Kayani MA. 2011. Glutathione S-Transferase Gene Deletions in Sporadic
Breast Cancer. Asian Pacific J Cancer Prev. 12(7): 1749-1752.
Impact factor: 1.500
Masood N and Kayani MA. 2011. Mutational analysis of xenobiotic metabolizing genes (CYP1A1
and GSTP1) in sporadic head and neck cancer patients. Genetics and Molecular Biology. 34(3):
533-538.
Impact factor: 0.876
Masood, N; Kayani MA; Malik, FA;
Mahjabeen, I; Baig, RM and Faryal R. 2011. Genetic
Variations in carcinogen metabolizing genes associated with oral cancer in the Pakistani
population. Asian Pacific J Cancer Prev. 12. 491-495.
Impact factor: 1.500
Masood, N; Malik, FA and MA Kayani. 2011. Expression of xenobiotic metabolizing genes in head
and neck cancer tissues. Asian Pacific J Cancer Prev. 12. 377-382.
Impact factor: 1.500
Hussain, SS, Kayani MA, Amjad M. 2011.Transcription factors as tools to engineer enhanced
drought stress tolerance in plants. Biotechnology Progress. 27(2): 297-306.
Impact factor: 1.883
2010
Masood, N; Mahjabeen, I; Baig, RM; Malik, FA and MA Kayani. 2010. Association of GSTM1
and GSTT1 gene deletions with risk of head and neck cancer in Pakistan: a case control study.
Asian Pacific J Cancer Prev. 11: 881-885.
Impact factor: 1.500
Kayani, MA and JM Parry. 2010. The in vitro genotoxicity of ethanol and acetaldehyde. Toxicol In
Vitro. 24(1):56-60.
Impact factor: 3.207
2009
Malik, FA; Sanders, AJ; Kayani, MA; Jiang, WG. 2009. Effect of expression alterations of KAI-1
on breast cancer cell growth, adhesion, migration and invasion. Cancer Genomics Proteomics.
2009 Jul-Aug;6(4):205-13.
Impact factor: 1.862
Kayani, MA and JM Parry. 2009. In vitro genotoxic assessment of xenobiotic diacylglycerols in
an in vitro micronucleus assay. Env and Mol Mutagen. 50(4).
Impact factor: 2.553
2008
Malik FA, Kayani MA, Iqbal H, Jiang W and Sadiq R. 2008. Characterization of Coding region of
Metastasis Suppressor Gene for Germ line mutations in Breast Cancer Patients. GTMB.12: 239246.
Impact factor: 0.429
Malik, FA; Ashraf, S; Kayani, MA; Jiang, WG; Baloch, IA ; Sadiq, R; Mir, A and Ansar, M.
2008. Contributionof BRCA1 germline mutations in patients with sporadic breast cancer. Int Sem
Surg Oncology. 5(1): 21.
Non-ISI
Kayani, MA and JM Parry. 2008. The detection and assessment of the aneugenic potential of
selected oestrogens, progestins and androgens using the in vitro Cytokinesis Blocked
Micronucleus assay. Mutat. Res 12; 651(1-2): 40-5.
Impact factor: 2.481
Arshad, FM., Kayani, MA; Ansar, M., Obaid-Ullah, M., Shaifque, M., Bokhari, SY., Ahmed, Z
and Zia ur rahman. 2008. Designing of novel 19-Plex Y STR system and polymorphism in ethnic
populations . ACAD J XJTU. 20(4): 267-273.
Non-ISI
2003
Dhawan, A; Kayani, MA; Anderson, D; Parry, E. and J. M. Parry. 2003. Aneugenic and
clastogenic effects of Doxorubicin in human lymphocytes. Mutagenesis. 18(5):1-4.
Impact factor: 3.497
2002
Parry JM; Al-Obaidly A; Al-Walhaib M; Kayani M; Nabeel T; Strefford J; and E. M. Parry.2002.
Spontaneous and induced aneuploidy, considerations which may influence chromosome
malsegregation. Mutat Res.504 (1-2):119-29.
Impact factor: 4.440
Parry, EM; Parry, JM; Corso, C; Doherty, A; Haddad, F; Hermine, T. F; Johnson, G; Kayani, M;
Warr, T. and J. Williamson. 2002. Detection and characterisation of mechanisms of action of
aneugenic chemicals. Mutagenesis 17(6): 509-21.
Impact factor: 3.497
Book Chapters and Books
Dodds, PF; Parry, JM; López-Villalobos, A; Vickery, S and M. Kayani. 2005. The incorporation
of agrochemicals and drugs into complex lipids and the possible consequences for the
development of cancers. In: Avances de Biotecnologìa Agropecuaria y Forestal en México. H.
González-Rosas y C. Jacinto Hernández (Eds): Ed. ANABAF, México Pp. 90 - 99. (Book
chapter)
Malik FA and Kayani MA. 2011. Germline screening of breast cancer patients. VDM Verlag Dr.
Müller e.K. Germany. ISBN 978-3-639-34416-5.
Masood N and Kayani MA. 2012. Role of GSTM1 and GSTT1 genes in head and neck cancer.
LAP Lambert Academic Publishing. ISBN 978-3-659-30479-8.
Poster/Abstracts:
Safdar H, Abbasi N, Ansar M, Kayani MA. 2008. In Silico Analysis of Regulatory Elements of
Selected Genes Expressed in Eye (2nd Prize, UAAR)
Kayani, M. A. and J.M.Parry. 2000. Evaluation of steroid hormones for micronuclei induction in
human cell lines. Mutagenesis. 15(5): 444.
Kayani, M. A. and J.M.Parry. Nov. 2001. Induction of aneuploidy in human cell lines by
hormones. Eur. J. Genet. and Mol. Tox.. 102.
Kayani, M. A. and J.M.Parry. 2001. Induction of aneuploidy by xenobiotic diacylglycerols in
mammalian cultures. Mutagenesis. 16(6): 567.
Kayani, M. A. and J.M.Parry. 2002. ‘Xenobiotic Diacylglycerols: aneuploidy induction and cell
cycle control’. Mutagenesis: 17:551
References:
Dr. Elizabeth M Parry. School of Biological Sciences. University of Wales, Swansea. SA2 8PP,
United Kingdom. E-mail: e.m.parry@swansea.ac.uk
Phone: +44-1792-205678 ext. 4733
Dr. Wasim Ahmed. Department of Biochemistry. Quaid-i-Azam University, Islamabad. E-mail:
wahmed@qau.edu.pk
+92-51-90643146