Curriculum Vitae
Cheryl Anne Frye
US citizen, Alaska Native (Ketchikan)
spouse: James Kevin Lembo, RPI class of 1988
Sutton Loop, Fairbanks, AK
kids: Jeffrey, Vincenzo, Luciana Lembo
EDUCATION
Wheaton College
Biopsychology Department
Tufts University
Psychology Department
Boston University
Biology Department
1984-1988
B.A., cum laude, Biopsychology
1988-1992
M.S., Ph.D., Behavioral Neuroscience
1993-1995
NRSA Post-doc, Neuroendocrinology
PERSONAL STATEMENT
My research program focuses on how novel sources (such as the brain) and targets (GABA, NMDA, dopamine,
membrane progestin receptors, stress axis) of steroids influence neuroplasticity, affiliation and cognition.
Reward: Biosynthesis of steroids in the ventral tegmental area, hippocampus, nucleus accumbens and frontal
cortex is increased with social and cognitive experiences and are attenuated with stressors, such as social
isolation. Steroids effects relevant for neuroplasticity and neurocognitive development are investigated.
Etiopathophysiology: The role of neurosteroids, sex/gender differences, and/or hormone effects in
neuropsychiatric (anxiety, depression, post-traumatic stress disorder) and neurodegenerative (epilepsy,
Alzheimer’s Disease, traumatic brain injury, cancer) disorders or aging are investigated through clinical
collaborations.
Treatment: How existing drugs, those in development, or non-pharmacological therapies have their indicated
and/or side effects in animals or people in part through hormonal, neurosteroid signaling, are investigated.
POSITIONS & EMPLOYMENT
The University of Alaska, Fairbanks, Full Professor of Neuroscience, Director INBRE
The University at Albany, SUNY, Full Professor of Psychology (current leave of absence)
The University at Albany, SUNY, Member, Inst for Health & the Environment
Research Experience for Undergraduates Program at UAlbany, Co-Director
The University at Albany, SUNY, Associate Professor of Psychology
The University at Albany, SUNY, Member, Neuroscience Research Center
The University at Albany, SUNY, Adjunct Professor of Biological Sciences
The University at Albany, SUNY, Assistant Professor of Psychology
The University of Hartford, Department of Biology, Adjunct Professor
Connecticut College, Assistant Professor of Psychology & Zoology, Director of Neuroscience
Wheaton College, Department of Psychology, Visiting Assistant Professor
Boston University, Department of Biology, NRSA Post-doctoral Fellow
Bates College, Departments of Psychology & Biology, Visiting Assistant Professor
Wheelock College, Department of Human Development, Instructor
Tufts University, Department of Psychology, TA, RA, Instructor
Boston University, Department of Biology, NSF REU Recipient
Wheaton College, Department of Psychobiology, Research Assistant
Harvard Medical School, Department of Urological Research, Laboratory Technician
Harvard Health, Emergency Services, Adult and Pediatric Med, Ortho, Surg Tech.
1
2013-present
2006-2012
2003-present
2001-2004
2000-2006
1998-present
1998-present
1998-2000
1998-2000
1995-1998
1994-1995
1993-1995
1992-1993
1990-1992
1988-1992
1987-1988
1986-1987
1985-1986
1982-1995
HONORS
Boston Latin School Distinguished Graduate Award (former recipients Bernstein, Kennedy, Fiedler)
Neurobiology of Learning and Memory, Top Cited Article 2008-2010
The University at Albany, SUNY, CAS Dean Student Mentoring Award
Albany City Council of PTAs, Founders' Day Award
The University at Albany, SUNY, Research Excellence Award
Delaware Community School, Volunteer Award
Behavioral Brain Research, Top Reviewer
The Research Foundation of State University of New York, Promising Inventor Award
The Society for Neuroscience, Faculty for Undergraduate Neuroscience, Educator of the Year
Wheaton College, Young Alumna Achievement Award
2009
2010
2009
2008
2007
2007
2007
2005
2003
1997
PROFESSIONAL EXPERIENCE
Grant Reviews for United States (not listed: those for Canada, UK, France, Switzerland, New Zealand, Israel)
NIH Special Emphasis Review Panel: Nat. Cooperative Drug Discovery/Development Groups 2013
NIH Special Emphasis Program: Estrogen and Sexual Behavior
2013
NIH Program Project Review Panel: Development of the Parental Brain
2010-2011
NIH Special Emphasis Review Panel: Drug Abuse
2011
NIH Review Panel: Biobehavioral Regulation, Learning, and Ethology (ad hoc)
2011
Veterans' Affairs: Research Enhancement Program
2010
Veterans' Affairs: Traumatic Brain Injury Panel
2010
National Institute for Psychobiology in Israel Review Panel
2010
NIH Fogarty International Research Collaboration Award Review Panel
2009
NIH Review Panel: International and Cooperative Projects - 1 Study Section
2009-2010
NIH Review Panel: Research Education Program
2008-2010
NIH Review Panel: Fellowships: Brain Disorders and Related Neuroscience
2008-present
NIH Career Opportunities in Research Honors Undergraduate Research Training Panel
2008-2010
NIH Special Emphasis Review Panel: Fellowships: Behavioral Neuroscience
2008-2009
Alzheimer’s Association Reviews
2006-2010
NIH Special Emphasis Review Panel: Minority Undergraduate Biomedical Education Program 2006-2007
NIH Special Emphasis Review Panel: The CNS as a Target of Steroid Hormones
2005-2006
NIH Special Emphasis Review Panel: Androgens and Aging
2004-2005
NIH Special Emphasis Review Panel: Women’s Health Initiative
2004-2005
NIH Special Emphasis Review Panel: COBRE
2004-2005
NIH Special Emphasis Review Panel: Mechanisms of Stress
2003-2004
National Institute of Mental Health, IFCN-4 Study Section (ad hoc)
2003-2004
International Steroids & Nervous System Conference, Advisory Board
2002-present
National Institute of Health, Heart, Lung and Blood Study Section (ad hoc)
2001-2003
NIH Special Emphasis Review Panel - Improving Minority Research Opportunities
2000-2001
Publications Reviews
Editorial Board, Frontiers in Experimental Endocrinology
2011-present
Editorial Board, Behavioral Pharmacology
2010-present
Editorial Board, Journal of Steroid & Hormonal Science
2010-present
Editorial Board, Pharmacology, Biochemistry & Behavior
2008-present
Guest Editor, Special Issue, Physiology and Behavior, 50th Year of Estrogen Receptor
2008-2010
Guest Editor, Special Issue, Physiology and Behavior, Autism & Androgens
2008-2010
Editorial Board, Brain Research
2002-present
Editorial Board, Physiology & Behavior
2001-present
2
Scientific and Educational Development
International Congress on Steroids and The Nervous System, Educational Committee
International Pharmacology, Biochemistry, & Behavior Conference, Fellowships
North East Under/graduate Research Organization for Neuroscience, Founder & Director
Research Experience for Undergraduate SUNY Summer Program, Co-Founder & Director
Biocontinuum Group (Provides Continuing Medical Education to Neurologists)
American Academy of Neurology, Neuroendocrine Section
2003-present
2003-2008
1996-present
2000-2004
2004-2009
2000-present
GRANT SUPPORT-ACTIVE
“Alaska INBRE-2: Environmental Agents and Disease”
PI: Cheryl A. Frye, Ph.D
Total Costs: $3,174,066
Dates of Project: 03/01/2013 – 02/28/2014
Annual Dir.: $2,233,006
Agency: NIGMS, Type: INBRE
To support the development of infrastructure, faculty and trainees to promote biomedical research focused on
environmental agents and disease.
“BIOPREP, TIPS, & RAWHIDE”
PI: Cheryl A. Frye, Ph.D., co-PI Andre Lopes
Total Costs: $3,000,000
Dates of Project: 4/1/09-3/31/14
Annual Dir.: $600,000
Agency: NIGMS, Type: various
To support the development of educational pipeline programs to promote STEM among K-12 students.
“Progestins’ non-classical effects and mechanisms for social & mood processes”
PI: Cheryl A. Frye, Ph.D.
Total Costs: $1,287,752
Dates of Project: 08/15/10-5/31/14
Annual Dir.: $212,500
Agency: NIMH, Type: R01
To elucidate the role and mechanisms of progestogens via signaling of the pregnane xenobiotic receptor to
mediate responses to stressors.
"Is estrogen receptor β a target for beneficial effects of androgens in an animal model of andropause?"
P.I. Cheryl A. Frye, Ph.D.
Total Costs: $103,330
Dates of Proposed Project: 9/1/10-8/31/13
Annual Direct: $34,102
Agency: Karo Bio Type: Drug Contract
To investigate ERβ’s actions for trophic effects in brain and prostate.
“Exploratory center on minority health and health disparities in smaller cities- Environmental contaminants and
reproductive health of Akwesasne Mohawk women”
PI: Lawrence Schell, Ph.D.; Consultant/Collaborator: Frye
Annual: $96,248
Dates of Project: 4/1/09-3/31/14
Agency: NIH, Type: P20
To measure daily levels of salivary estrogen and progesterone over the menstrual cycle as a measure of
reproductive endocrine function among Native people exposed to endocrine disruptors.
3
PRIOR EXTRAMURAL SUPPORT
“The role of membrane progestin receptors in progestin-facilitated lordosis”
PI: Cheryl A. Frye, Ph.D.; Total Costs: $106,000
Dates of Project: 12/01/09-12/31/12; Annual Direct: $66,007
Agency: NSF, Type: EAGER
To investigate the role of membrane progestin receptors versus nuclear progestin receptors in progesterone
signaling.
“Neuroactive steroids and seizure control during pregnancy in women with epilepsy”
PI: Page Pennell, MD; Co-PI: Cheryl A. Frye, Ph.D.; Total Costs: $51,740
Dates of Project: 7/1/09-8/31/12; Annual Direct: $14,776
Agency: Brigham and Women’s Hospital/NIH, Type: R03
To measure levels of progestogens in samples collected from pregnant women on neuromodulatory medications.
“A drug contract to investigate depression-like behavior of a proprietary estrogen-like compound”
PI: Cheryl A. Frye, Ph.D.; Total Costs: $39,900
Dates of Project: 09/01/10-12/12/12; Annual Direct: $25,000
Agency: Karo Bio Type: Drug Contract
To examine the effects of a proprietary estrogen -like compounds to improve hormone replacement therapies.
“Progestins non-classical effects and mechanisms for social & mood processes”
PI: Cheryl A. Frye, Ph.D.; Total Costs: $378,750
Dates of Project: 09/14/09-09/13/10; Annual Direct: $250,000
Agency: NIMH, Type: R56
To investigate progestin's functional effects and mechanisms through pregnane xenobiotic receptor in cycling and
hormone-primed rats
"Is estrogen receptor β a target for beneficial effects of androgens in an animal model of andropause?"
P.I. Cheryl A. Frye, Ph.D.; Total Costs: $59,968
Dates of Proposed Project: 9/1/08-8/31/10; Annual Direct: $39,583
Agency: Karo Bio Type: Drug Contract
The main goal of this project is to investigate ERβ’s actions in andropause and the trophic effects of treatment on
prostate tissues.
“A drug contract to investigate behavior and trophic effects of some of their proprietary estrogens that have
actions at estrogen receptor β”
P.I. Cheryl A. Frye, Ph.D.; Total Costs: $69,985
Dates of Proposed Project: 3/1/08-12/31/10; Annual Direct: $43,850
Agency: Karo Bio Type: Drug Contract
This project is for drug development to establish more effective hormone replacement strategies.
“Northeast Under/graduate Research Organization for Neuroscience 2010-2011”
PI: Cheryl A. Frye, Ph.D.; Total Costs: $10,000
Dates of Project: 4/1/11-3/31/12; Annual Direct: $10,000
Agency: NSF, Type: Conference
To support the 2010-2011 program for this conference oriented to enhanced training of neuroscientists.
4
“Northeast Under/graduate Research Organization for Neuroscience 2009-2010”
PI: Cheryl A. Frye, Ph.D.; Total Costs: $9,000
Dates of Project: 11/1/09-10/31/10; Annual Direct: $9,000
Agency: NSF, Type: Conference
To support the 2009-2010 program for this student/faculty conference for enhanced training of neuroscientists.
“A conference grant to support the International Conference on Steroids & The Nervous System”
P.I.: Cheryl A. Frye, Ph.D.; Total Direct: $14,000
Period: 2/1/09-1/31/10; Annual Direct: $14,000
Agency: NSF, Type: Conference Grant
This is to support an international conference and to enhance training of neuroendocrinologists at the venue.
“Progestins’ non-genomic actions for sex behavior”
P.I.: Cheryl A. Frye, Ph.D.; Total Costs: $1,146,075
Period: 6/1/04-09/14/09; Annual Direct: ~$150,000
Agency: NIMH, Type: R01
To delineate mechanisms, sources, and effects of progestins underlying appetitive aspects of mating behavior in
rats.
“Conversation in the Capital District”
P.I.: Cheryl A. Frye, Ph.D.; Total Costs: $80,000
Period: 6/1/08-5/31/10Annual Direct: $80,000
Agency: Various
This is to support the Conversation in the Capital District Conference October 23-24, Albany, NY and publication
of a special issue in Physiology & Behavior about this meeting.
“The role of progestins for socio-sexual behavior of mice”
PI/Mentor Cheryl A. Frye, Ph.D.; Total Costs: $59,069
Period: 5/31/08-9/14/09; Annual Direct: $59,069
Trainee: Carolyn J. Koonce, B.A.
Agency: NIMH, Type: Post-baccalaureate supplement
This purpose of this project was to investigate progestins role in socio-sexual behavior of mice.
“Mechanisms of estrogen and selective estrogen receptor modulators to reduce anxiety and depression behavior,
without proliferative effects, in a menopausal model”
PI/Mentor: Cheryl A. Frye, Ph.D.; Total Costs: $90,000
Dates of Project: 6/1/06-5/31/10; Annual Direct: $27,000
Agency: DOD, BCRP, Type: Pre-doctoral Grant; Trainee: Alicia Walf
Goals were to investigate estrogen’s mechanisms to mediate affect concomitant with effects on cell proliferation
in breast and uterine tissues in female rodents.
“Northeast Under/Grad Research Organization for Neuroscience”
P.I. Cheryl A. Frye, Ph.D.; Total Cost: $102,309
Period: 4/1/06-3/31/10; Annual Direct: $34,103
Agency: NIH, Type: Conference Grant
This project is to support a student/faculty conference oriented to enhancing training of neuroscientists.
5
“Increasing U.S. Participation in 5th Pharmacology, Biochemistry, & Behavior Conference”
PI: Cheryl A. Frye, Ph.D.; Total Costs: $10,000
Period: 4/1/04-3/31/05; Annual Direct: $10,000
Agency: NSF, Type: Conference Grant
The goal of this funding was to provide pedagogical resources and tangible support for senior investigators
and trainees from the U.S.
“Non-genomic actions of progestins in the VTA for lordosis”
PI: Cheryl A. Frye, Ph.D.; Total Cost: $370,000
Period: 9/1/03-8/31/08; Annual Direct: $80,000
Agency: NSF
Investigates progestins’ actions, via signal transduction pathways, to mediate consummatory aspects of mating,
lordosis, of female rodents
“Effects and mechanisms of progestins' modulation of seizure activity”
PI/Mentor: Cheryl A. Frye, Ph.D.; Total Cost: $16,000
Period: 7/01/03-6/30/04; Annual Direct: $16,000
Trainee: Madeline E. Rhodes
Agency: Epilepsy Foundation of America, Type: Ph.D. Fellowship
The major goal of this project was to investigate progestins’ mechanisms in the hippocampus to mediate ictal
activity in a rodent model.
“Actions of estrogen in the nucleus accumbens for conditioning”
PI: Cheryl A. Frye, Ph.D.; Total Cost: $30,000
Period: 6/1/03-5/31/04; Annual Direct: $30,000
Agency: Lilly Centre for Women’s Health, Type: Grant in support of women’s research
The major goals of this project are to investigate estrogens' effects on conditioning and mechanisms in the
nucleus accumbens.
“Increasing U.S. Participation- International Conference on Steroids and Brain”
PI: Cheryl A. Frye, Ph.D.; Total Costs: $15,000
Period: 3/1/03-2/29/04; Annual Direct: $15,000
Agency: NSF, Type: Conference Grant
The goal of this funding was to provide pedagogical resources and tangible support for senior investigators
and trainees from the U.S.
“A summer program in neuroscience at SUNY-Albany”
PI: Gregory Lnenicka, Ph.D., co-PI: Cheryl A. Frye, Ph.D.
Total Costs: $304,200
Period: 4/1/01-3/31/04
Annual Direct: $90,000
Agency: NSF, Type: REU
The major goal of this project was to provide undergraduates neuroscience research experience with a
SUNY- Albany faculty member.
“Effects of PDE Inhibitors in an animal model of female sexual dysfunction”
PI: Cheryl A. Frye, Ph.D.; Total Costs: $50,000
Period: 1/1/00-1/1/01; Annual Direct: $50,000
Agency: Eli Lilly, Inc., Type: Contract
6
Screened potential therapeutics to determine effects on female sexual responsiveness in hamsters. This
contact was an essential part of the development and/or approval of the drug Cialis.
"NEURON: North East Under/graduate Research Organization for Neuroscience”
PI: Cheryl A. Frye, Ph.D.; Total Costs: $86,274
Period: 9/1/99-8/31/04; Annual Direct: $17,250
Agency: NIMH, Type: R13
The major goals of this project were to support a student/faculty conference oriented to enhanced training
of neuroscientists.
“Neurosteroids effects on sexual receptivity”
PI: Cheryl A. Frye, Ph.D.; Total Cost: $539,003
Period: 2/1/96-8/31/03; Annual Direct: $539,003
Agency: NSF, Type: CAREER Grant
Investigated actions of progestins via GABAA receptors to mediate lordosis of female rodents.
“Neurosteroids’ role in cognitive, affective, & neurodegenerative disorders"
PI: Cheryl A. Frye, Ph.D.; Total Cost: $90,000
Period: 6/1/96-5/31/00; Annual Direct: $90,000
Agency: Whitehall Foundation, Type: Grant-in-Aid
Investigated neurosteroids role in cognitive and affective behavior and neurodegenerative disorders.
“Neurosteroids’ role in epilepsy”
PI: Cheryl A. Frye, Ph.D.; Total Cost: $180,000
Period: 6/1/96-8/31/00; Annual Direct: $180,000
Agency: Donaghue Fdn , Type: Young Investigator Award
Examined progestins' effects on ictal activity in animal models of catamenial epilepsy.
“Progestins’ actions in the VTA for lordosis”
PI: Cheryl A. Frye, Ph.D.; Total Cost: $25,000
Period: 2/1/96-1/31/97; Annual Direct: $25,000
Agency: NIMH, Type: B-START
Although funded, declined award to pursue CAREER grant, which had overlapping research aims.
“Androgens’ actions for inhibiting sexual receptivity”
PI/Mentor: Mary S. Erskine, Ph.D.; Total Cost: $83,000
Period: 1/1/93-8/31/95; Annual Direct: $83,000
Agency: NIMH, Type: F32, Trainee: Cheryl A. Frye, Ph.D.
Examined effects and mechanisms of androgenic neurosteroids to inhibit sexual receptivity in rodents.
“Neurosteroids’ role in affect and cognition”
PI: Cheryl A. Frye, Ph.D; Total Cost: $25,000
Period: 5/1/93-4/30/94; Annual Direct: $25,000
Agency: NSF, Type: Research Planning Grant
A grant to investigate how neurosteroids alter cognition, affective and feeding and pain processes.
INTRAMURAL SUPPORT
SOURCE
UAlaska
TYPE
Start up
TIME
Spring 2013
7
FUNDS
$1,200,000
SUNY-Albany
SUNY-Albany
Research Foundation
Research Foundation
SUNY-Albany
SUNY-Albany
Research Foundation
SUNY-Albany
SUNY-UAS
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
SUNY-Albany
Connecticut College
Connecticut College
Connecticut College
Bates College
Bates College
Bates College
Tufts University
Contraceptives Awareness Support
Brain Awareness Week Support
Conference Support Award- CID
Conference Support Award- CID
Faculty Research Award Program- B
Brain Awareness Week Support
Conversation in the Discipline
Conversation in the Discipline
Conversation in the Discipline
Conversation in the Discipline
Symposium Support
Brain Awareness Week Support
Conference Support Grant
McNair Minority Student Support
Research Incentive Award
Conference Support Grant
Affirmative Action Grant
Research Incentive Award
Affirmative Action Grant
McNair Minority Student Support
McNair Minority Student Support
STAR Undergrad Research Grant
Faculty Research Award Program
Professional development Award
Professional development Award
Faculty Research Award Program
Start-up Funds
Pfizer Foundation
Johnson Fund
Start-up Funds
Howard Hughes Research Program
Schmutz Grant for Faculty Research
Start-Up Funds for 1 year
Appointment
Dissertation Research Grant
Spring 2010
Spring 2010
Spring 2009
Spring 2009
Spring 2009
Spring 2009
Fall 2008
Fall 2008
Fall 2008
Fall 2008
Spring 2008
Spring 2008
Spring 2008
Summer 2004
Summer 2004
Spring 2004
Summer 2003
Summer 2003
Summer 2002
Summer 2002
Summer 2001
October 2001
February 2001
January 2001
May 1999
December 1998
September 1998
1995-1998
1995-1998
September 1995
Summer 1993
December 1992
September 1992
February 1991
$650
$650
$1500
$1500
$3000
$750
$1000
$5000
$1000
$5000
$500
$1,500
$1,500
$3,000
$5,000
$700
$250
$5,000
$700
$1,000
$1,000
$1,000
$10,000
$800
$1,000
$10,000
$77,000
$200,000
$4,300
$100,000
$3,500
$5,000
$5,000
$1,500
SMALL GRANTS
SOURCE
Amerisciences
Elsevier
Amerisciences
NIH
TYPE
Research Trainee Support
Support for Conversation in the
Discipline
Summer Research Fellowship for Jon
Freidman
Microarray Consortium
8
TIME
Fall 2008
Summer 2008
FUNDS
$4,500
$61,000
Summer 2008
$2,000
Spring 20082009
$6,000
NIH
Microarray Consortium
Microarray Consortium
NEURON mentoring project
Spring 20082009
Spring 20082009
Summer 20072008
January 2008
Fall 2007-2008
NIH
Microarray Consortium
NIH
Microarray Consortium
NIH
Harvard Pilgrim
Health Care
NIH
Epilepsy F’dation
Endocrine Society
Parkinsons F’dation
Sigma Xi
Sigma Xi
Sigma Xi
$6,000
$11,150
$500
Microarray Consortium
Summer Fellowship
Summer Fellowship
Summer Fellowship
Grant-in-Aid
Grant-in-Aid
Grant-in-Aid
January 2007
April 2000
April 1999
February 2001
March 1991
August 1990
March 1989
$3150
$2,000
$2,500
$900
$750
$800
$600
$6,000
$6,000
TRAVEL GRANTS
SOURCE
SUNY-Albany
SUNY-Albany
NIAAA
SUNY-Albany
SUNY-Albany
ACNP
Neurobio Epilepsy
SUNY-Albany
SUNY-Albany
WCBR
Workshop Steroids
TYPE
Travel Grant
Travel Grant
Travel Grant
Faculty Travel Award
Faculty Travel Award
Young Investigator Fellowship
Young Investigator Fellowship
Faculty Travel Award
Faculty Travel Award
Post-Doc Travel Award
Post-Doc Travel Award
9
TIME
Spring 2009
Spring 2008
September 2006
January 2006
February 2003
January 2002
May 2001
February 2001
May 2000
January 1994
March 1993
FUNDS
$500
$1,500
$1,500
$900
$900
$2,000
$1,500
$900
$850
$1,500
$1,200
REFEREED-PUBLICATIONS (Google H-Factor: 57, citation index: 10364)
251. Frye, C.A., Koonce, C.J., Walf, A.A., and Rusconi, J.C. (2013). Motivated behaviors and levels of 3,5THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the
midbrain ventral tegmental area of proestrous rats. Journal of Sexual Medicine (in press).
250. Walf A.A., Frye, C.A. (2012) Gestational or acute restraint in adulthood reduces levels of 5-reduced
testosterone metabolites in the hippocampus and produces behavioral inhibition of adult male rats. Front Cell
Neurosci. 2012;6:40: 1-11.
249. Kohtz A.S., Frye, C.A. (2012) Dissociating behavioral, autonomic, and neuroendocrine effects of androgen
steroids in animal models. Methods Mol Biol. 2012;829:397-431.
248. Panzica, G.C. Balthazart, J., Frye, C.A. Garcia-Segurra, L.M., Herbison, A.E., Mensah-Nyguyen, G.,
McCarthy, M.M., Melcangi, R.C. (2012). Milestones on steroids and the nervous system: Ten years of basic
and translational research. Journal of Neuroendocrinology. 24, 1-15.
247. Frye, C.A. Bo, E., Calamandrei, G., Calza, L., Dessı-Fulgheri, Fernandez–, F., Fusani, L., Kah, O., Kajta,
M., Le Page, Y., Patisaul, H.B., , Venerosi, A., Wojtowicz, A.K., Panzica, G.C. (2012) Endocrine disrupters: A
review of some sources, effects, and mechanisms of actions on behavior and neuroendocrine systems. Journal
of Neuroendocrinology. 24, 144-159.
246. Koonce, C.J., Walf, A.A., Frye, C.A. (2012). Type 1 5α-reductase may be required for estrous cycle
changes in affective behaviors of female mice. Behavioural Brain Research, 5.244.
245. Frye, C.A., Paris, J.J., Walf, A.A., Rusconi, JC. (2011). Effects and Mechanisms of 3,5-THP on
emotion, motivation, and reward functions involving pregnane xenobiotic Receptor. Front Neurosci.
2011;5:136.
244. Frye, C.A. (2011) Novel substrates for, and sources of, progestogens for reproduction. Journal of
Neuroendocrinology. 11: 961-73.
243. Frye, C.A., Paris, J.J., Osbome, D.M, Joannalee, C.C., Kippin, T.E. (2011). Prenatal stress alters
progestogens to mediate susceptibility to sex-typical, stress-sensitive disorders, such as drug abuse: a
review. Frontiers in Psychiatry. 2: 1-15.
242. Frye, C.A. (2011). Progesterone attenuates depressive behavior of younger and older adult C57/BL6,
wildtype, and progesterone receptor knockout mice. Pharmacology, Biochemistry and Behavior. 99: 525531.
241. Paris, J.J., Brunton, P.J., Walf, A.A., Frye, C.A., (2011). Inhibition of 5α-reductase activity in late
pregnancy decreases gestational length and fecundity and impairs object memory and central progestogen milieu
of juvenile rat offspring. Journal of Neuroendocrinology, 1365-2826.
240. Paris, J.J., Brunton, P.J., Russell, J.A., Frye, C.A. (2011). Immune stress in late pregnant rats decreases
length of gestation and fecundity, and alters later cognitive and affective behavior of surviving pre-adolescent
offspring. Stress, 14(6): 652-664.
239. Frye, C.A., Paris, J.J. (2011). Progesterone turnover to its 5α-reduced metabolites in the ventral tegmental
area of the midbrain is essential for initiating social and affective behavior and progesterone metabolism in female
rats. J Endocrin Invest., 34, 188-199.
238. Paris, J.J., Frye, C.A. (2011). Gestational exposure to variable stressors produces decrements in
cognitive and neural development of juvenile male and female rats. Curr Top Med Chem, 11, 1706-1713.
237. Walf, A.A., Paris, J.J., Rhodes, M.E., Simpkins, J.W., Frye, C.A. (2011). Divergent mechanisms for
trophic actions of estrogens in the brain and peripheral tissues. Brain Research, 1379: 119-36.
236. Frye, C.A., Hirst, J.J., Brunton, P.J., Russell, J.A. (2011). Neurosteroids for a successful pregnancy. Stress,
14: 1-5.
235. Walf A.A., Paris, J.J., Llaneza, D.C., Frye, C.A. (2011). I. Levels of 5α-reduced progesterone metabolite
in the midbrain account for variability in reproductive behavior of middle-aged female rats. Brain Research
1379:137-48.
10
234. Paris J.J., Walf, A.A., & Frye, C.A. (2011). II. Cognitive performance of middle-aged female rats is
influenced by capacity to metabolize progesterone in the prefrontal cortex and hippocampus. Brain
Research; 1379:149-63.
233. McFadden, L. M., Paris, J.J., Mitzelfelt, M.S., McDonough, S., Frye, C.A., Matuszewich, L. (2011)
Sex- dependent persistent effects of chronic unpredictable stress in the water maze. Physiol Behav. 102; 26675.
232. Frye, C.A. (2011). Progesterone reduces depressive behavior of young ovariectomized, aged progestin
receptor knockout, and aged wild type mice in the tail suspension test. J Psychopharmacol, 25: 421-8.
231. Frye, C.A., Paris J.J. (2011). Effects of neurosteroid actions at N-methyl-D-aspartate and GABAA
receptors in the midbrain ventral tegmental area influence engagement in natural reward and motivation to
explore among ovariectomized/adrenalectomized female rats. Psychopharmacology, 213: 93-103.
230. Frye, C.A. and Walf, A.A. (2011). Progesterone, administered before kainic acid, reduces decrements
in cognitive performance in the Morris Water Maze. Developmental Neurobiologyy, 71:142-52.
229. Paris, J.J., Frye, C.A. (2011). Juvenile offspring of rats exposed to restraint stress in late gestation
have impaired cognitive performance and dysregulated progestogen formation. Stress 14, 23-32.
228. Frye, C.A., Rhodes, M.E. (2010) Fluoxetine-induced decrements in sexual responses of female rats
and hamsters are reversed by 3,5-THP. Journal of Sexual Medicine, 7, 2670-2680.
227. Lynn, C.D., Paris, J.J., Frye, C.A., Schell, L.M. (2011). Glossolalia is associated with differences
in biomarkers of stress and arousal among Apostolic Pentecostals. Relig Brain Beh. 1-19.
226. Frye, C.A., Walf, A.A., & Paris, J.J. (2010). Conjugated equine estrogen, with medroxyprogesterone
acetate, enhances formation of 5-reduced progestogens and anti-anxiety behavior of middle-aged rats.
Behavioral Pharmacology 21, 530-9.
225. Franco, C., Paris, J.J., Wulfert, E., & Frye, C.A. (2010) Male gamblers have significantly greater
salivary cortisol before and after betting on a horse race, than do female gamblers. Physiology and Behavior
99, 225-9.
224. Frye, C.A. (2010). Effects and mechanisms of progestogens and androgens in ictal activity. Epilepsia
51 suppl 3, 135-40.
223. Frye, C.A., Bloom M.S., Wersinger S. (2010). The 50th anniversary of the discovery of the
estrogen receptor—conversations about hormones then and now. Physiology and Behavior 99, 147-8.
222. Frye, C.A., Bloom M.S. & Wersinger S. (2010). Androgens, autism and more. Physiology and Behavior
100, 197-8.
221. Frye, C.A., Edinger, K.L., Lephart, E.D., Walf, A.A. (2010). 3α-androstanediol, but not testosterone,
attenuates age-related decrements in cognitive, anxiety, and depressive behavior of male rats. Frontiers in
Aging Neuroscience 2, 1-21.
220. Frye, CA., Koonce, C, & Walf, AA. (2010). Mnemonic effects of progesterone to mice require formation of.
3,5-THP. NeuroReport 21, 590-5.
219. Frye, C.A. & Llaneza, D.C. (2010). Corticosteroid and neurosteroid dysregulation in an animal model
of autism, BTBR mice. Physiology and Behavior 100; 264-7.
218. Frye, C.A., Petralia, S.M., Rhodes, M.E., DeBold, J.F. (2010). 6-hydroxydopamine lesions enhance
progesterone –facilitated lordosis of rats and hamsters, independent of effects on motor behavior. Physiology
and Behavior 99, 218-24.
217. Frye, C.A. & Sora, I. (2010). Progesterone reduces hyperactivity of female and male dopamine
transporter knockout mice. Behavioural Brain Research 209, 59-65.
216. Frye, C.A. & Walf, A.A. (2010). Infusions of anti-sense oligonucleotides for DARPP-32 to the ventral
tegmental area reduce effects of progesterone- and a dopamine type 1-like receptor agonist to facilitate
11
lordosis. Behavioural Brain Research 206, 286-92.
215. Frye, C.A. & Walf, A.A. (2010) Oxytocin and/or steroid hormone binding globulin infused into the
ventral tegmental area modulates progestogen-mediated lordosis. Neuropharmacology 58, 44-9.
214. Frye, C.A. & Walf, A.A. (2010). Progesterone enhances learning and memory of aged wildtype
and progestin receptor knockout mice. Neuroscience Letters 472, 38-42.
213. Jensen E.V., Jacobson H.I., Walf A.A., Frye C.A. (2010). Estrogen action: A historic perspective on
the implications of considering alternative approaches. Physiology and Behavior 99, 151-62.
212. Kohtz, A.S., Paris, J.J., Frye, C.A. (2010). Low doses of cocaine decrease, and high doses increase,
anxiety- like behavior and brain progestogen levels among intact rats. Hormones and Behavior 57, 474-80.
211. Llaneza, D.C., DeLuke, S.V., Batista, M., Crawley, J.N., Christodulu, K.V. & Frye, C.A. (2010).
Communication, interventions, and scientific advances in autism: A commentary. Physiology and Behavior
100, 268-76.
210. Lynn, C.D., Paris J., Frye C.A,. Schell L.M.. (2010) Salivary alpha–amylase and cortisol
among pentecostals on a worship day and nonworship day. American Journal of Human Biology 22,
819-22
209. Paris J.J., Franco, C., Sodano, R., Frye, C.A., & Wulfert, E. (2010). Gambling pathology is associated
with dampened cortisol response among men and women. Physiology and Behavior 99, 230-3.
208. Paris, J.J., Franco, C., Sodano, R., Freidenberg, B., Gordis, E., Anderson, D.A., Forsyth, J.P., Wulfert, E.,
& Frye, C.A. (2009). Sex differences in salivary cortisol in response to acute stressors among healthy
participants, in recreational or pathological gamblers, and in those with postraumatic stress disorder. Hormones
and Behavior 57, 35-45
207. Walf, A.A. & Frye, C.A. (2010). Raloxifene and/or estradiol reduce depressive-like behavior and
increase anti-anxiety-like behavior, whereas only estradiol promotes uterine proliferation and carcinogeninduced tumorigenesis among ovariectomized rats. Behavioral Pharmacology 21, 231-40.
206. Walf, A.A. & Frye, C.A. (2010). Estradiol reduces anxiety- and depression-like behavior of aged
female mice. Physiology and Behavior 99, 169-74.
205. Frye, C.A. & Koonce, C.J. (2009). Post-training administration of estrogen and/or androgens with actions
at ERα and/or ERβ to male rats can improve performance in the object recognition task. Open
Neuropsychopharmacology Journal 2, 16-21.
204. Frye C.A. (2009). Neurosteroids' effects and mechanisms for social, cognitive, emotional, and
physical functions. Psychoneuroendocrinology 34 Suppl 1, S143-61.
203. Frye, C.A. (2009). Steroids, reproductive endocrine function, and affect: A review. Minerva Ginecological
61, 541-562.
202. Frye, C.A. (2009). Steroids, reproductive endocrine function, and cognition: A review. Minerva
Ginecological 61, 563-585.
201. Frye, C.A., Llaneza, D.C. & Walf, A.A. (2009) Progesterone can enhance consolidation and/or
performance in spatial, object, social, and implicit memory tasks. Animal Behaviour 78, 279-286.
200. Frye, C.A. & Paris, J.J. (2009). Infusions of bicuculline to the ventral tegmental area attenuates sexual,
exploratory, and anti-anxiety behavior of proestrous rats. Pharmacology, Biochemistry, and Behavior 93, 47481.
199. Frye, C.A., Paris, J.J., & Rhodes, M.E. (2009). Increasing 3α,5α-THP following inhibition of neurosteroid
biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally
receptive rats. Reproduction 137, 119-28.
198. Frye, C.A. (2009):c 1, 1215-1231. Progestogens influence cognitive process in aging. Future Medicinal
Chemistry, October 2009, Vol. 1, No. 7, Pages 1215-1231.
12
197. Frye, C.A. & Walf, A.A. (2009) Progesterone reduces depression-like behavior in a murine model of
Alzheimer’s Disease. Age 31, 143-53.
196. Frye, C.A. & Walf A.A. (2009).Depression-like behavior of aged male and female mice is ameliorated
with administration of testosterone or its metabolites. Physiology and Behavior 97, 266-269.
195. Frye, C.A., Ryan, A., & Rhodes, M. (2009). Anti-seizure effects of 17β-estradiol and 3α-androstanediol may
Inolve actions at estrogen receptor β. Epilepsy and Behavior 16, 418-22.
194. Gracia, C.R., Freeman, E.W., Sammel, M.D., Lin, H., Sheng, L., & Frye, C.A. (2009). Allopregnanolone
levels before and after SSRI treatment for Premenstrual Symptoms. Journal of Clinical Psychopharmacology
29,
403-5.
193. Koonce, C.J., Walf, A.A., & Frye, C.A. (2009). Trilostane exerts anti-depressive effects among wildtype, but
not estrogen receptor β knockout mice. Neuroreport 20, 1047-50.
192. Llaneza D.C. & Frye C.A. (2009). Progestogens and estrogen influence impulsive burying and
avoidant freezing behavior of naturally cycling and ovariectomized rats. Pharmacol Biochem Behav 93,
337-42.
191. Osborne, D.M., Edinger, K., & Frye, C.A. (2009). Chronic administration of androgens with actions at
estrogen receptor β have anti-anxiety and cognitive-enhancing effects in male rats. Age 31, 191-8.
190. Osborne, D.M. & Frye C.A. (2009) Estrogen increases latencies to seizures and levels of 5alpha-pregnan3alpha-ol-20-one in hippocampus of wild-type, but not 5alpha-reductase knockout mice. Epilepsy and Behavior
16, 411-4.
189. Walf A.A. & Frye C.A. (2009). Estradiol enhances sociosexual behavior and can have proliferative effects
in ovariectomized rats. Age (Dordr) 31, 221-9.
188. Walf, A.A. & Frye, C.A. (2009). Effects of two estradiol regimens on anxiety and depressive behaviors
and trophic effects in peripheral tissues in a rodent model. Gender Medicine 6, 300-11.
187. Walf, A.A., Paris, J.J., & Frye, C.A. (2009). Chronic estradiol replacement to aged female rats reduces
anxiety-like and depression-like behavior and enhances cognitive performance. Psychoneuroendocrinology
34,
909-16.
186. Walf, A.A., Paris, J.J., & Frye, C.A. (2009). Nociceptive and anxiety-like behavior in
reproductively competent and reproductively senescent middle-aged rats. Gender Medicine 6, 235-246.
185. Walf A.A., Koonce C.J., Frye C.A. (2009). Adult female wildtype, but not oestrogen receptor beta
knockout, mice have decreased depression-like behaviour during pro-oestrus and following administration of
oestradiol or diarylpropionitrile. J Psychopharmacol 23, 442-50.
184. Frye, C.A., Koonce, C.J., Edinger, K.L., Osborne D.M., & Walf, A.A. (2008). Androgens with activity
at estrogen receptor β have anxiolytic and cognitive-enhancing effects in male rats and mice. Hormones and
Behavior 54, 726-734.
183. Walf, A.A. & Frye, C.A. (2008). Rapid and estrogen receptor β mediated actions in the hippocampus
mediate some functional effects of estrogen. Steroids 73, 997-1007.
182. Frye, C.A. & Walf, A.A. (2008). Membrane actions of progestins at dopamine type 1-like and GABAA
receptors involve downstream signal transduction pathways. Steroids, 73, 906-13.
181. Frye, C.A., Marrone, J., & Walf, A.A. (2008). Effects of manipulating progesterone and NMDA
receptors in the ventral tegmental area and lordosis of hamsters and rats. Psychopharmacology 200, 71-80.
180. Frye, C.A., Paris, J.J., & Rhodes, M.E. (2008). Estrogen is necessary for 5α-pregnan-3α-ol-20-one
(3α,5α- THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor
affective behavior of ovariectomized rats. Pharmacology, Biochemistry and Behavior 91, 261-270.
13
179. Frye C.A., Paris, J.J., & Rhodes, M.E. (2008). Exploratory, anti-anxiety, social, and sexual behaviors of
rats in behavioral estrus is attenuated with inhibition of 3α,5α-THP formation in the midbrain ventral tegmental
area. Behavioural Brain Research 193, 269-276.
178. Frye, C.A. & Rhodes, M.E. (2008). Infusions of 3α,5α-THP to the VTA enhance exploratory, anti-anxiety,
social, and sexual behavior and increase levels of 3α,5α-THP in midbrain, hippocampus, diencephalon, and
cortex of female rats. Behavioural Brain Research, 187, 88-99.
177. Frye, C.A., Sumida, K., & Edinger, K.L. (2008). Androgen administration to aged male mice increases
anti- anxiety behavior and enhances cognitive performance. Neuropsychopharmacology 33, 1049-1061.
176. Frye, C.A. & Walf A.A. (2008). In the ventral tegmental area, progestogens membrane-mediated actions
for lordosis of rats involve the second messenger phospholipase C. Brain Research 1230, 218-223.
175. Frye, C.A. & Walf, A.A. (2008). Activity of protein kinase C is important for 3α,5α-THP's actions at
dopamine type 1-like and/or GABAA receptors in the ventral tegmental area for lordosis of rats. Brain
Research Bulletin 77 91-97.
174. Frye, C.A. & Walf, A.A. (2008). Progesterone to ovariectomized mice enhances cognitive performance
in the spontaneous alternation, object recognition, but not placement, water maze. Neurobiology of Learning
and Memory 90, 171-177.
173. Frye, C.A. & Walf, A.A. (2008). Progesterone enhances performance of aged mice in cortical
or hippocampal tasks. Neuroscience Letters 437, 116-120.
172. Frye, C.A. & Walf, A.A. (2008). Effects of progesterone administration and APPswe+PSEN1e9
mutation for cognitive performance of mid-aged mice. Neurobiology of Learning and Memory 89, 17-26.
171. Paris J.J. & Frye, C.A. (2008). Estrous cycle, pregnancy, and parity enhance performance of rats in
object recognition or object placement tasks. Reproduction 136, 105-115.
170. Ryan, A. & Frye, C.A. (2008). Antiseizure effects of 5α-androstane-3α,7β-diol may be independent of
actions at estrogen receptor β. Epilepsy and Behavior 13, 32-35.
169. Walf, A.A, Ciriza, I., Garcia-Segura, L.M.., & Frye, C.A. (2008). Antisense oligodeoxynucleotides
for estrogen receptor  and  attenuate estradiol's modulation of affective and sexual behavior,
respectively. Neuropsychopharmacology 33, 431-440.
168. Walf, A.A. & Frye, C.A. (2008). Conjugated equine estrogen enhances rats’ cognitive, anxiety, and social
behavior. Neuroreport 19, 789-792.
167. Walf, A.A. & Frye, C.A. (2008). Parity and estrogen-administration alters anxiety and depression
behavior of ovariectomized rats. Physiology and Behavior 93, 351-356.
166. Walf, A.A., Koonce, C., & Frye, C.A. (2008). Adult female wildtype, but not estrogen receptor 
knockout, mice have decreased depression-like behavior during proestrus and following administration
of estradiol or diarylpropionitrile. Journal of Psychopharmacology 23, 442-50.
165. Walf, A.A., Koonce, C., & Frye, C.A. (2008). Estradiol or diarylpropionitrile administration to wildtype,
but not estrogen receptor β knockout, mice enhance performance in the object recognition and object placement
tasks. Neurobiology of Learning and Memory 89, 513-521.
164. Walf, A.A., Koonce, C.J., & Frye, C.A. (2008). Estradiol or diarylpropionitrile decrease anxietylike behavior of wildtype, but not estrogen receptor β knockout, mice. Behavioral Neuroscience 122,
974-81.
163. Walf, A.A., Koonce, C.J., Manley, K., & Frye, C.A. (2008). Proestrous compared to diestrous wildtype,
but not estrogen receptor β knockout, mice have better performance in the spontaneous alternation and object
recognition tasks and reduced anxiety-like behavior in the elevated plus and mirror maze. Behavioural Brain
Research 96, 254-60.
162. Walf, A.A., Frye, C.A. (2007). The use of the elevated plus maze as an assay of anxiety-related behavior
in rodents. Nature Protocols 2:322-328.
161. Edinger, K.L & Frye, C.A. (2007). Sexual experience of male rats influences anxiety-like behavior
and androgen levels. Physiology and Behavior 92, 443-53.
14
160. Edinger, K.L. & Frye, C.A. (2007). Androgens' effects to enhance learning and memory may be mediated in
part through actions at estrogen receptor- in the hippocampus. Neurobiology of Learning and Memory 87, 2018.
159. Frye, C.A. (2006). Progestins influence motivation, reward, conditioning, stress, and/or response to drugs
of abuse. Pharmacology, Biochemistry, and Behavior 86, 209-219.
158. Frye, C.A. (2006). Some rewarding effects of androgens may be mediated by actions of its 5reduced metabolite 3–Androstanediol. Pharmacology, Biochemistry, and Behavior 86, 354-367.
157. Frye, C.A., Babson, A., & Walf, A.A., (2007). Self-Administration of 3-Androstanediol increases
locomotion and analgesia and decreases aggressive behavior of male hamsters. Pharm Biochem Behav 86, 41521.
156. Frye, C.A., Paris, J.J. & Rhodes, M.E. (2007). Engaging in paced mating, but neither exploratory, antianxiety, nor social behavior, increases 5-reduced progestin concentrations in midbrain, hippocampus,
striatum and cortex. Reproduction 1133, 663-674.
155. Frye, C.A, & Rhodes, M.E. (2007). Infusions of 5-pregnan-3-ol-20-one (3,5-THP) to the ventral
tegmental area, but not the substantia nigra, enhance exploratory, anti-anxiety, social and sexual behaviours
and concomitantly increase 3,5-THP concentrations in the hippocampus, diencephalon and cortex of
ovariectomised oestrogen-primed rats. Journal of Neuroeondocrinology 18, 960-75.
154. Frye, C.A. & Walf, A.A. (2007). In the ventral tegmental area, the membrane-mediated actions of
progestins for lordosis of hormone-primed hamsters involve phospholipase C and protein kinase C. Journal of
Neuroendocrinology 19, 717-724.
153. Kellogg, C.K., Kenjarsk,i T.P., Pleger, G.L., & Frye, C.A. (2006). Region-, age-, and sex-specific effects
of fetal diazepam exposure on the postnatal development of neurosteroids. Brain Research 1067, 115-25.
152. Petralia, S.M., Debold, J.F., & Frye, C.A. (2007). MK-801 Infusions to the VTA and VMH produce
opposite effects on lordosis of hormone-primed rats. Pharmacology, Biochemistry, and Behavior 86, 377-385.
151. Walf, A.A., Duffy, C.K., & Frye, C.A. (2007).Estrogens and progestins enhance spatial learning of
intact and ovariectomized rats in the object placement task. Neurobiology of Learning and Memory 88, 208216
150. Walf, A.A. & Frye, C.A. (2007). Estradiol decreases anxiety behavior and enhances inhibitory
avoidance and gestational stress produces opposite effects. Stress 10, 251-260.
149. Walf, A.A. & Frye, C.A. (2007). Administration of estrogen receptor  selective estrogen receptor
modulators to the hippocampus decrease anxiety and depressive behavior of ovariectomized rats.
Pharmacology, Biochemistry, and Behavior 86, 407-414.
148. Frye, C.A., Rhodes, M.E., Petralia, S.M., Walf, A.A., Sumida, K., & Edinger, K.L. (2006). 3α,5α-THP in
the midbrain ventral tegmental area mediates social, sexual, and affective behaviors. Neuroscience 138, 100714
147. Frye, C.A. (2006). An overview of oral contraceptives: Mechanism of action and clinical use. Neurology 66,
S29-6
146. Frye, C.A. (2006). The role of androgens in epilepsy. Expert Review of Neurotherapeutics 6, 7:10611076.
145. Walf, A.A., Frye, C.A. (2006). A review and update: Estrogen’s effects, brain targets, and mechanisms
for anxiety and depression behavior Neuropsychopharmacology, 31(6):1097-11.
144. Ciriza, I., Carrero, P., Walf, A.A., Frye, C.A., & Garcia-Segura, L.M. (2006). Reduced metabolites mediate
neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin
mderoxyprogesterone acetate is not neuroprotective. Journal of Neurobiology 66, 916-28.
143. Edinger, K.L & Frye, C.A. (2007). Androgens’ performance-enhancing effects in the inhibitory
15
avoidance and water maze tasks may involve actions at intracellular androgen receptors in the dorsal
hippocampus. Neurobiology of Learning and Memory 87, 201-208.
142. Edinger, K.L. & Frye C.A. (2006). Intrahippocampal administration of an androgen receptor antagonist,
flutamide, can increase anxiety-like behavior in intact and DHT-replaced male rats. Hormones and Behavior
50, 216-220.
141. Frye, C.A., Walf, A.A., & Petralia, S.M. (2006). Progestin facilitation of lordosis in rodents
involves adenylyl cyclase activity in the ventral tegmental area.. Hormones and Behavior 50, 237-44.
140. Frye, C.A, & Rhodes, M.E. (2006) Progestin concentrations are increased following paced mating in
midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of
diestrous rats. Neuroendocrinology 83, 336-47.
139. Frye, C.A, & Rhodes, M.E. (2006). Administration of estrogen to ovariectomized rats promotes
conditioned place preference and produces moderate levels of estrogen in the nucleus accumbens. Brain Res
1067, 209-215.
138. Frye CA, Rhodes ME, Raol Y, & Brooks-Kayal AR. (2006). Early postnatal stimulation alters
pregnane neurosteroids in the hippocampus. Psychopharmacology 186, 343-50.
137. Frye. C.A., Sumida, K., Dudek, B.C., Harney, J.P., Lydon, J.P., O'Malley, B.W., Pfaff, D.W., & Rhodes,
M.E. (2006). Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via
intracellular progestin receptors. Psychopharmacology 186, 312-22.
136. Frye, C.A., Sumida, K., Lydon, J.P., O’Malley, B.W., & Pfaff, D. (2006). Mid-aged and aged wild-type
and progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3,5-THP-facilitated
lordosis. Psychopharmacology 186, 423-32.
135. Frye CA, Sumida K, Zimmerberg B, & Brunelli SA. (2006). Rats bred for high versus low anxiety
responses neonatally demonstrate increases in lordosis, pacing behavior, and midbrain 3 alpha, 5 alpha-THP
levels as adults. Behavioral Neuroscience 120, 281-9.
134. Frye, C.A., Walf, A.A., & Petralia, S.M. (2006). Progestins’ effects on sexual behavior of female rats and
hamsters involving D1 and GABAA receptors in the ventral tegmental area may be G-protein-dependent.
Behavioral Brain Research 172, 286-293.
133. Frye, C.A., Walf, A.A., & Petralia, S.M. (2006). In the ventral tegmental area, progestins have actions at
D1 receptors for lordosis of hamsters and rats that involve GABAA receptors. Hormones and Behavior 50, 332-7.
132. Frye, C.A., Walf, A.A, & Petralia, S.M. (2006). Progestin facilitation of lordosis in rodents
involves adenylyl cyclase activity in the ventral tegmental area. Hormones and Behavior 50, 332-337.
131. Herzog, A.G., Drislane, F.W., Schomer, D.L., Pennell, P.B., Bromfield, E.B., Dworetzky, B.A., Farina,
E.L., & Frye, C.A. (2006). Differential effects of antiepileptic drugs on neuroactive steroids in men with
epilepsy. Epilepsia 47, 1945-8.
130. Petralia, S.M. & Frye, C.A. (2006). In the ventral tegmental area, G-proteins mediate progesterone’s
actions at dopamine type 1 receptors for lordosis of rats and hamsters Psychopharmacology 186, 133-42.
129. Petralia SM, & Frye CA. (2006). In the ventral tegmental area, cAMP mediates progesterone’s actions at
dopamine type 1 receptors for lordosis of rats and hamsters. Journal of Neuroendocrinology 18, 902-14.
128. Petralia, S.M., Walf, A.A., & Frye, C.A. (2006). In the ventral tegmental area, progestins’ membranemediated actions for lordosis of hamsters and rats involve protein kinase A. Neuroendocrinology 84, 405414.
127. Rhodes, M.E. & Frye, C.A. (2006). ER-selective SERM produce mnemonic-enhancing effects in
the inhibitory avoidance and water maze tasks. Neurobiology of Learning Memory 85, 183-91.
126. Smith, C.D., Wekstein, D.R., Markesbury, W.R., & Frye, C.A. (2006). 3, 5-THP: a potential
plasma neurosteroid biomarker in Alzheimers Disease. Psychopharmacology 186, 481-485.
16
125. Walf, A.A., Rhodes, M.E., Meade, J., Harney, J.P., & Frye, C.A. (2006). Estradiol-induced
conditioned place preference may require actions at estrogen receptors in the nucleus accumbens.
Neuropsychopharmacology 32, 522-530.
124. Walf, A.A., Rhodes, M.E., & Frye, C.A. (2006). Ovarian steroids enhance object recognition in
naturally- cycling and ovariectomized, hormone-primed rats. Neurobiology of Learning and Memory 86, 3546.
123 Walf, A.A., Sumida, K., & Frye, C.A. (2006). Inhibiting 5-reductase in the amygdala attenuates
anti- anxiety and anti-depressive behavior of naturally-receptive and hormone-primed ovariectomized rats.
Psychopharmacology 186, 302-311.
122. Frye, C.A. & Rhodes, M.E. (2005) Estrogen-priming can enhance progesterone’s anti-seizure effects in
part by increasing hippocampal levels of allopregnanalone. Pharmacology, Biochemistry, and Behavior 81, 90716.
121. Rhodes, M.E., Talluri, J., Harney, J.P., & Frye, C.A. (2005). Ketogenic diet decreases
circulating concentrations of neuroactive steroids of female rats. Epilepsy and Behavior 7, 231-9.
120. Frye, C.A., & Rhodes, M.E. (2005). Progesterone’s 5-reduced metabolite, 3, 5-THP, mediates
lateral displacement of hamsters. Brain Research 1038, 59-68.
119. Frye, C.A., Rhodes, M.E., & Dudek, B.C. (2005). Estradiol to aged female or male mice improves
learning in inhibitory avoidance and water maze tasks. Brain Research 1036, 101-8.
118. Herzog, A.G., Drislane, F.W., Schomer, D.L., Pennell, P.B., Bromfield, E.B., Dworetzky, B.A., Farina, E.L.,
& Frye, C.A. (2005). Differential effects of antiepileptic drugs on sexual function and hormones in men
with epilepsy. Neurology 65, 1016-20.
117. Petralia, S.M. & Frye, C.A. (2005). In the ventral tegmental area, picrotoxin blocks FGIN-1-27induced increases in sexual behavior of rats and hamsters. Psychopharmacology,178, 174-82.
116. Petralia SM, Jahagirdar V, & Frye CA. (2005). Inhibiting biosynthesis and/or metabolism of progestins
in the ventral tegmental area attenuates lordosis of rats in behavioural oestrus. Journal of Neuroendocrinoogy
17, 545-52.
115. Rhodes, M.E. & Frye, C.A. (2005). Attenuating 5-pregnane-3-0l-20-one formation in the hippocampus
of female rats increases pentylenetetrazole-induced seizures. Epilepsy and Behavior 6; 140-6.
114. Rhodes M.E. & Frye C.A. (2005). Actions at GABAA receptors in the hippocampus may mediate some of
progestins’ anti-seizure effects. Epilepsy and Behavior 6, 320-7.
113. Smith, S.S., Ruderman, Y., Frye, C., Homanics, G., & Yuan, M.(2005). Steroid withdrawal in the
mouse results in anxiogenic effects of 3α,5α-THP: a possible model of premenstrual dysphoric disorder.
Psychopharmacology 29, 1-11.
112. Sumida, K., Walf, A.A., & Frye, C.A. (2005). Progestin-facilitated lordosis of hamsters may
involve dopamine-like type 1 receptors in the ventral tegmental area. Behavioural Brain Research 3, 161,
1-7.
111. Walf, A.A. & Frye, C.A. (2005). Antianxiety and antidepressive behavior produced by physiological
estradiol regimen may be modulated by hypothalamic-pituitary-adrenal axis activity.
Neuropsychopharmacology,30, 1288-301.
110. Walf, A.A. & Frye, C.A. (2005). ER -selective estrogen receptor modulators produce anti-anxiety
behavior when administered systemically to ovariectomized rats. Neuropsychopharmacology 30, 1598-609.
109. Zimmerberg, B., Brunelli, S. A., Fluty, A. J., & Frye, C. A. (2005). Differences in affective behaviors and
hippocampal allopregnanolone levels in adult rats of lines selectively bred for infantile vocalizations.
Behavioral Brain Research, 159: 301-11.
108. Rhodes, M.E. & Frye, C.A. (2004). Androgens in the hippocampus can alter, and be altered by, ictal activity.
17
Pharmacology, Biochemistry, and Behavior 78, 483-493.
107. Edinger, K.L. & Frye, C.A. (2004). Testosterone’s analgesic, anxiolytic, and cognitive-enhancing
effects may be due in part to actions of its 5-reduced metabolites in the hippocampus. Behavioral
Neuroscience 118, 1352-64.
106. Edinger, K.L., Lee, B., & Frye, C.A. (2004). Mnemonic effects of testosterone and its 5-reduced
metabolites in the conditioned fear and inhibitory avoidance tasks. Pharmacology, Biochemistry, & Behavior
78, 559-568.
105. Frye, C.A & Edinger, K.L. (2004). Testosterone’s metabolism in the hippocampus mediates its antianxiety effects in male rats. Pharmacology, Biochemistry, & Behavior 78, 473-481.
104. Frye, C.A., Edinger, K.L.,Seliga, A.M., & Wawrzycki, J.M. (2004). 5-reduced androgens may have
actions in the hippocampus to enhance cognitive performance of male rats. Psychoneuroendocrinology 29,
1019-1027.
103. Frye, C.A. & Walf, A.A. (2004). Hippocampal 3,5-THP may alter depressive behavior of pregnant
and lactating rats. Pharmacology, Biochemistry, & Behavior 78, 531-540
102. Frye, C.A. & Walf, A.A. (2004). Estrogen and/or progesterone administered systemically or to the
amygdala can have anxiety-, fear-, and pain-reducing effects in ovariectomized rats. Behavioral Neuroscience
118, 306-13.
101. Frye, C.A., Walf, A.A., & Sumida, K. (2004). Progestins’ actions in the VTA to facilitate lordosis involve
dopamine-like Type 1 and 2 Receptors. Pharmacology, Biochemistry, and Behavior 78, 405-418.
100. Frye, C.A., Walf, A.A., Rhodes, M.E., & Harney, J.P. (2004). Progesterone enhances motor, anxiolytic,
analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5-reductase.
Brain Research 1004, 116-124.
99. Petralia, S.M. & Frye, C.A. (2004). In the ventral tegmental area, G-proteins and cAMP mediate 3α,5α-THP’s
actions at dopamine type 1 receptors for lordosis of rats. Neuroendocrinology 80, 233-43.
98. Rhodes, M.E. & Frye, C.A. (2004). Progestins in the hippocampus of female rats have anti-seizure effects in
a pentylenetetrazole seizure model. Epilepsia 45, 1531-8.
97. Herzog, A.G., Drislane, F.W., Schomer, D.L., Pennell, P.B., Bromfield, E.B., Kelly, K.M., Farina, E.L.,
& Frye, C.A. (2004). Differential effects of antiepileptic drugs on sexual function and reproductive
hormones in men with epilepsy: interim analysis of a comparison between lamotrigine and enzyme-inducing
antiepileptic drugs. Epilepsia 45, 764-8.
96. Rhodes, M.E. & Frye, C.A. (2004). Estrogen has mnemonic enhancing effects in the inhibitory
avoidance task. Pharmacology, Biochemistry, & Behavior 78, 551-558.
95. Rhodes, M.E., Harney, J.P., & Frye, C.A. (2004). Gonadal, adrenal, and neuroactive steroids’ role in ictal
activity. Brain Research 1000, 8-18.
94. Rhodes, M.E., McCormick, C.M., & Frye, C.A. (2004). 3,5-THP mediates progestins' effects to
protect against adrenalectomy-induced cell death in the dentate gyrus of female and male rats. Pharmacology,
Biochemistry, & Behavior 78, 505-512.
93. Walf, A.A., Rhodes, M.E., & Frye, C.A. and (2004). Anti-depressant effects of ER selective
estrogen receptor modulators in the forced swim test. Pharmacology, Biochemistry, & Behavior 78, 483493.
92. Frye, C.A. & Wawrzycki, J. (2003). Effect of prenatal stress and gonadal hormone condition on
depressive behavior of female and male rats. Hormones and Behavior 44, 319-326.
91. Frye, C.A. & Seliga, A.M. (2003).Effects of olanzapine infusions to the VTA on lordosis and midbrain
3,5-THP concentrations in rats. Psychopharmacology 170, 132-139.
90. Frye, C.A., Petralia, S.M., Rhodes, M.E., & Stein, B. (2003). Fluoxetine may influence lordosis of rats
18
through effects on midbrain 3,5-THP concentrations. Annals of the New York Academy of Science 1007, 37-41.
89. Walf, A.A. & Frye, C.A. (2003). Anti-nociception following exposure to trimethylthiazoline, peripheral
or intra-amygdala estrogen and/or progesterone. Behavioural Brain Research 144, 77-85.
88. Frye, C.A. & Seliga, A.M. (2003). Olanzapine's effects to reduce fear and anxiety and enhance social
interactions coincide with increased progestin concentrations of ovariectomized rats.
Psychoneuroendocrinology
28, 657-673.
87. Frye, C.A. & Petralia, S.M. (2003). Mitochondrial benzodiazepine receptors in the ventral tegmental area
modulate sexual behaviour of cycling or hormone-primed hamsters. Jounral of Neuroendocrinology 15, 677686.
86. Frye, C.A. & Petralia, S.M. (2003). Lordosis of rats is modified by neurosteroidogenic effects of
membrane benzodiazepine receptors in the ventral tegmenal area. Neuroendocrinology 77,71-82.
85. Herzog, A.G. & Frye, C.A. (2003). Seizure exacerbation associated with inhibition of
progesterone metabolism. Annals of Neurology 53, 390-391.
84. Frye, C.A. & Rhodes, M.E. (2003). Zaprinast, a phosphodiesterase 5 inhibitor, overcomes sexual
dysfunction produced by fluoxetine, a selective serotonin reuptake inhibitor in hamsters.
Neuropsychopharmacology 28, 310-316.
83. Frye, C.A. & Rhodes, M.E. (2002). Enhancing effects of estrogen on inhibitory avoidance performance
may be in part independent of intracellular estrogen receptors in the hippocampus. Brain Research 956, 285293.
82. Frye, C.A., Rhodes, M.E., Walf, A., & Harney, J.P. (2002). Testosterone enhances aggression in wild
type mice but not mice deficient in Type I 5-reductase. Brain Research 948, 165-170.
81. Frye, C.A. & Orecki, Z.A. (2002). Prenatal stress alters reproductive responses of rats in behavioral estrus
and paced mating of hormone-primed rats. Hormones and Behavior 42, 472-483.
80. Frye, C.A., Rhodes, M.E., Rosellini, R. & Svare, B. (2002). The nucleus accumbens as a site of action for
rewarding properties of testosterone and its 5-reduced metabolites. Pharmacology, Biochemistry, & Behavior
74, 119-127.
79. Freeman, E.W., Frye, C.A., Rickels, K., Martin, P.A.G. & Smith S.S. (2002). Allopregnanolone levels and
symptom improvement in severe premenstrual syndrome. Journal of Clinical Psychopharmacology 22, 51620.
78. Seliga, A. & Frye, C.A. (2002). Olanzapine and progesterone dose-dependent and additive effects to
enhance lordosis and progestin concentrations of rats. Physiology and Behavior 76, 151-158.
77. Schmitz, C., Rhodes, M.E., Bludau, M., Kaplan, S., Ong, S., Ueffing, I., Vehoff, J., Korr, H. & Frye,
C.A. (2002). Depression: reduced number of granule cells in the hippocampus of female, but not male, rats
due to prenatal restraint stress. Molecular Psychiatry 7, 810-813.
76. McCormick, C.M., Kehoe, P., Mallinson, K., Cecchi, L., & Frye, C.A. (2002). Neonatal isolation alters
stress hormone and mesolimbic dopamine release in juvenile rats. Pharmacol Biochem Behav 73, 77-85.
75. Frye, C.A. & Orecki, Z. (2002). Prenatal stress producing deficits in socio-sexual behavior of cycling, but
not hormone-primed, Long-Evans rats. Pharmacology, Biochemistry, and Behavior 73, 53-60.
74. Frye, C.A., Rhodes, M.E., Walf, A.A., and Harney, J. (2002). Progesterone reduces pentylenetetrazolinduced ictal activity of wild type mice but not those deficient in Type I 5-reductase. Epilepsia 43, 14-17.
73. Frye, C.A. & Walf, A.A. (2002). Changes in progesterone metabolites in the hippocampus can
modulate open field and forced swim test behavior of proestrous rats. Hormones and Behavior 41(3),
306-315.
72. Anderson, D. A., Shapiro, J. R., Lundgren, J. D., Spataro, L. E., & Frye, C. A. (2002). Self-reported
19
dietary restraint is associated with elevated levels of salivary cortisol. Appetite 38, 13-17.
71. Frisone, D.F., Frye, C.A. & Zimmerberg B. (2002). Social isolation stress during the third week of life
has age-dependent effects on spatial learning in rats. Behavioral Brain Research 128, 153-160.
70. Rosellini, R.A., Rhodes, M.E., Svare, B.B. & Frye, C.A. (2001). The testosterone metabolite and
neurosteroid 3-Androstanediol may mediate the effects of testosterone on conditioned place preference.
Brain Research Reviews, 37, 162-171.
69. Frye, C.A. (2001). The role of neurosteroids and non-genomic effects of progestins and androgens
in mediating sexual receptivity of rodents. Brain Research Reviews, 37, 201-222.
68. Frye, C.A. (2001). The role of neurosteroids and nongenomic effects of progestins in the ventral
tegmental area in mediating sexual receptivity of rodents. Hormones and Behavior, 40, 226-233.
67. Frye, C.A. & Seliga, A.M. (2001). Testosterone increases analgesia, anxiolysis, and cognitive performance
of male rats. Cognitive and Affective Behavioral Neuroscience 1, 371-381.
66. Frye, C.A. & Vongher, J.M. (2001). Ventral tegmental area infusions of inhibitors of the biosynthesis
and metabolism of 3,5-THP attenuate lordosis of hormone-primed and behavioral oestrous rats and
hamsters. Jounral of Neuroendocrinology 13, 1076-1086.
65. Frye, C.A., Rhodes, M.E., Walf, A.A., & Harney, J.P. (2001). Testosterone reduces pentylenetetrazoleinduced ictal activity in wild type mice but not those deficient in Type I 5-reductase. Brain Res 918, 182-186.
64. Rhodes, M.E. & Frye, C.A. (2001). Inhibiting progesterone metabolism in the hippocampus of rats in
behavioral estrous decreases anxiolytic, and enhances exploratory and anti-nociceptive behaviors. Cognitive
and Affective Behavioral Neuroscience 1, 287-296.
63. Frye, C.A. & Vongher, J.M. (2001). Progesterone and 3,5-THP enhance sexual receptivity in mice.
Behavioral Neuroscience 115, 1118-1128.
62. Altemus,M., Redwine, L.S., Leong, Y.M., Frye, C.A., Porges, S.W., & Carter, C.S. (2001). Responses
to laboratory psychosocial stress in post-partum women. Psychosomatic Medicine 63, 814-821.
61. Frye, C.A. & Muscatiello, N.A. (2001). 3,5-THP in the raphe magnus attenuates PTZ-induced
myoclonic seizures. Brain Research 911, 146-151.
60. Frye, C.A., Park, D., Tanaka, M., Rosellini, R., & Svare, B. (2001). The testosterone metabolite
and neurosteroid 3-androstanediol may mediate the effects of testosterone on conditioned place
preference. Psychoneuroendocrinology 26, 731-750.
59. Frye, C.A. & Lacey, E.H. (2001). Posttraining androgens’ enhancement of cognitive performance
is temporally distinct from androgen’ increases in affective behavior. Cognitive and Affective
Behavioral Neuroscience 1, 172-182.
58. Frye, C.A. (2001). Inhibition of 5-reductase enzyme or GABA(A) receptors in the VMH and the VTA
attenuates progesterone-induced sexual behavior in rats and hamsters. Journal of Endocrinological Investigation,
24, 399-407.
57. Frye, C.A. (2001). Estradiol tends to improve inhibitory avoidance performance in adrenalectomized male
rats and reduces pyknotic cells in the dentate gyrus of adrenalectomized male and female rats. Brain Research
889, 358-363.
56. Kehoe, P., Mallinson, K., McCormick, C.M. & Frye, C.A. (2000). Central allopregnanolone is increased in
rat pups in response to repeated, short episodes of neonatal isolation. Developmental Brain Research 124, 133136.
55. Frye, C.A. & Lacey, E.H. (2000). Progestins influence performance on cognitive tasks independent of
changes in affective behavior. Psychobiology 28, 550-563.
54. Frye, C.A., Manjarrez, J., & Camacho-Arroyo, I. (2000). Infusion of 3,5-THP to the pontine
20
reticular formation attenuates PTZ-induced seizures. Brain Research 881, 98-102.
53. Frye, C.A., Petralia, S.M., & Rhodes, M.E. (2000). Estrous cycle and sex differences in performance on
anxiety tasks coincide with increases in hippocampal progesterone and 35-THP. Pharmacology,
Biochemistry, and Behavior 67, 587-596.
52. Frye, C.A., Murphy, R.E., & Platek, S.M. (2000). Anti-sense oligonucleotides, for progestin receptors in
the VMH and glutamic acid decarboxylase in the VTA, attenuate progesterone-induced lordosis in hamsters and
rats. Behavioral Brain Research 115, 55-64.
51. Bitran, D., Foley, M., Audette, D., Leslie, N. & Frye, C.A. (2000). Activation of peripheral mitochondrial
benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolyticlike effects in the rat. Psychopharmacology 151, 64-71.
50. Frye, C.A. & McCormick, C.M. (2000). Androgens are neuroprotective in the dentate gyrus
of adrenalectomized female rats. Stress 3, 185-194.
49. Frye, C.A., Bayon, L.E. & Vongher, J.M. (2000). Intravenous progesterone elicits a more rapid induction
of lordosis in rats than does SKF38393. Psychobiology 28, 99-109.
48. Frye, C.A. & Scalise, T.J. (2000). Anti-seizure effects of progesterone and 3,5 -THP in kainic acid
and perforant pathway models of epilepsy. Psychoneuroendocrinology 25, 407-420.
47. Frye, C.A. & McCormick, C.M. (2000). The neurosteroid, 3-Androstanediol, prevents inhibitory
avoidance deficits and pyknotic cells in the granule layer of the dentate gyrus induced by adrenalectomy in rats.
Brain Research 855, 166-170.
46. Kelsey, J.E., Sanderson, K.L., & Frye, C.A. (2000). Perforant path stimulation in rats produces seizures,
loss of hippocampal neurons, and a deficit in spatial mapping which is reduced by prior MK-801. Behavioral
Brain Research 107, 59-69.
45. Vongher, J.M. & Frye, C.A. (1999). Progesterone in conjunction with estradiol has neuroprotective effects
in an animal model of neurodegeneration. Pharmacology, Biochemistry and Behavior 64, 777-785.
44. Frye, C.A. & Bayon, L.E. (1999). Mating stimuli influence endogenous variations in the neurosteroids
3,5-THP and 3-Diol. Journal of Neuroendocrinology 11, 839-847.
43. Frye, C.A. & Vongher, J.M. (1999). Progestins’ rapid facilitation of lordosis when applied to the ventral
tegmentum corresponds to efficacy at enhancing GABAA receptor activity. Journal of Neuroendocrinology 11,
829-837.
42. Frye, C.A. & Vongher, J.M. (1999). GABAA, D1, and D5, but not progestin receptor, antagonist and antisense oligonucleotide infusions to the ventral tegmental area of cycling rats and hamsters attenuate lordosis.
Behavioral Brain Research, 103, 23-34.
41. Frye, C.A. & Vongher, J.M. (1999). 3,5-THP in the midbrain ventral tegmental area of rats and hamsters
is increased in exogenous hormonal states associated with estrous cyclicity and sexual receptivity. Journal of
Endocrinological Investigation 22, 455-464.
40. Kellogg, C.K. & Frye, C.A. (1999). Endogenous levels of 5-reduced progestins and androgens in fetal
vs. adult rat brains. Developmental Brain Research 115, 17-24.
39. Frye, C.A. & Lacey, E.H. (1999). The neurosteroids DHEA and DHEAS may influence
cognitive performance by altering affective state. Physiology & Behavior 66, 85-92.
38. Wilson, M.A. & Frye, C.A. (1999). Effects of chronic benzodiazepine exposure on stressinduced neuroactive steroid levels. Brain Research 824, 136-139.
37. Frye, C.A. & Bayon, L.E. (1999). Prenatal stress reduces the effectiveness of the neurosteroid 3,5-THP to
block kainic-acid-induced seizures. Developmental Psychobiology 34, 227-234.
36. Morgan, K.N., Thayer, J.E. & Frye, C.A. (1999). Prenatal stress suppresses rat pup ultrasonic
vocalization and myocolonic twitching in response to separation. Developmental Psychobiology 34, 205-215.
21
35. Frye, C.A. & Vongher, J.M. (1999). Progesterone has rapid and membrane effects in the facilitation
of female mouse sexual behavior. Brain Research 815, 259-269.
34. Frye, C.A. & Bayon, L.E. (1999). Cyclic withdrawal from endogenous and exogenous progesterone
increases kainic acid and perforant pathway induced seizures. Pharmacology, Biochemistry and Behavior 62,
315-321.
33. Frye, C.A., Bayon, L.E., Pursnani, N. & Purdy, R.H. (1998). The neurosteroids, progesterone and
3,5- THP, enhance sexual motivation, receptivity, and proceptivity in female rats. Brain Research 808,
72-83.
32. Dunn, R.W., Reed, T.A.W., Copeland, P.D. & Frye, C.A. (1998). The nitric oxide synthase inhibitor 7nitroindazole displays enhanced anxiolytic efficacy without tolerance in rats following subchronic
administration. Neuropharmacology 37, 899-904.
31. Frye, C.A. & Bayon, L.E. (1998). Seizure activity is increased in endocrine states characterized by decline
in endogenous levels of the neurosteroid 3,5-THP. Neuroendocrinology 68, 272-280.
30. Smith, S.S., Gong, Q.H., Li, X., Moran, M.H., Bitran, D., Frye, C.A. & Hsu, F.C. (1998). Withdrawal from
3-OH-5-pregnan-20-one using a pseudopregnancy model alters the kinetics of hippocampal GABA Agated current and increases the GABAA receptor 4 subunit in association with increased anxiety. Journal
of Neuroscience 18, 5275-5284.
29. Frye, C.A. & Reed, T.A. (1998). Androgenic neurosteroids: anti-seizure effects in an animal model
of epilepsy. Psychoneuroendocrinology 23, 385-399.
28. Frye, C.A., Scalise, T.J. & Bayon, L.E. (1998). Finasteride blocks the reduction in ictal activity produced
by exogenous estrous cyclicity. Journal of Neuroendocrinology 10, 291-296.
27. Bitran, D., Hilvers, R.J., Frye, C.A. & Erskine, M.S. (1996). Chronic anabolic-androgenic steroid
treatment affects brain GABAA receptor-gated chloride ion transport. Life Sciences 58, 573-583.
26. Frye, C.A., Van Keuran, K.R., Rao, P.N. & Erskine, M.S. (1996). Progesterone and 3-Androstanediol
conjugated to bovine serum albumin affects estrous behavior when applied to the MBH and POA.
Behavioral Neuroscience 110, 603-612.
25. Frye, C.A., Van Keuran, K.R., Rao, P.N. & Erskine, M.S. (1996). Analgesic effects of the neurosteroid
3- Androstanediol. Brain Research 709, 1-9.
24. Frye, C.A., McCormick, C.M., Coopersmith, C. & Erskine, M.S. (1996). Effects of paced and non-paced
mating stimulation on plasma progesterone, 3-Diol and corticosterone. Psychoneuroendocrinology 21, 431439.
23. Frye, C.A., Duncan, J.E., Basham, M. & Erskine, M.E. (1996). Behavioral effects of 3-Androstanediol
II: Hypothalamic and preoptic area actions via GABAergic mechanism. Behavioral Brain Research 79, 119130.
22. Frye, C.A., Van Keuran, K.R. & Erskine, M.S. (1996). Behavioral effects of 3-Androstanediol I:
modulation of sexual receptivity and promotion of GABA-stimulated chloride flux. Behavioral Brain Research
79, 109-118.
21. Frye, C.A. & Gardiner, S.G. (1996). Progestins can have a membrane-mediated action in rat midbrain
for facilitation of sexual receptivity. Hormones and Behavior 30, 682-691.
20. Frye, C.A. & Duncan, J.D. (1996). Estradiol benzoate potentiates neuroactive steroids' effects on
pain sensitivity. Pharmacology, Biochemistry and Behavior 53, 27-32.
19. Frye, C.A. (1995). The neurosteroid 3,5-THP has antiseizure and possible neuroprotective effects in
an animal model of epilepsy. Brain Research 696, 113-120.
18. Crystal, S., Frye, C.A. & Kanarek, R.B. (1995). Taste preferences and sensory perceptions in female varsity
swimmers. Appetite 24, 25-36.
22
17. Frye, C.A. & Sturgis, J.D. (1995). Neurosteroids affect spatial/reference, working, and long-term memory
of female rats. Neurobiology of Learning and Memory, 64, 83-96.
16. Frye, C.A. (1995). Estrus-associated decrements in a water maze task are limited to acquisition. Physiology
& Behavior, 57, 5-14.
15. DeBold, J.F. & Frye, C.A. (1994). Genomic and non-genomic actions of progesterone in the control
of female hamster sexual behavior. Hormones and Behavior 28, 445-453.
14. DeBold, J.F. & Frye, C.A. (1994). Progesterone and the neural mechanisms of hamster sexual behavior.
Psychoneuroendocrinology 19, 563-579.
13. Frye, C.A., Crystal, S., Ward, K.D. & Kanarek, R.B. (1994). Menstrual cycle and dietary restraint
influence taste preferences in young women. Physiology & Behavior 55, 561-567.
12. Frye, C.A. & Weisberg, R.B. (1994). Increasing the incidence of routine pelvic examinations: Behavioral
Medicine's contribution. Women and Health 21, 33-55.
11. Frye, C.A. & Leadbetter, E.A. (1994). 5-reduced progesterone metabolites are essential in hamster VTA
for sexual receptivity. Life Sciences 54, 653-659.
10. Frye, C.A. & Duncan, J.E. (1994). Progesterone metabolites, effective at the GABA A receptor
complex, attenuate pain sensitivity in rats. Brain Research 643, 194-203.
9. Frye, C.A. & DeMolar, G. (1994). Menstrual cycle and sex differences influence salt preference. Physiology
& Behavior 55, 193-197.
8. Frye, C.A., Mermelstein, P.G. & DeBold, J.F. (1993). Bicuculline infused into the hamster ventral tegmentum
inhibits, while sodium valproate facilitates, sexual receptivity. Pharmacology, Biochemistry and Behavior 46, 18
7. Frye, C.A., Cuevas, C.A. & Kanarek, R.B. (1993). Diet and estrous cycle influence pain sensitivity in rats.
Pharmacology, Biochemistry and Behavior 45, 255-260.
6. Frye, C.A. & DeBold, J.F. (1993). 3-OH-DHP and 5-THDOC implants to the ventral tegmental area
facilitate sexual receptivity in hamsters after progesterone priming to the ventral medial hypothalamus.
Brain Research 612, 130-137.
5. Frye, C.A. & DeBold, J.F. (1993). P-3-BSA, but not P-11-BSA, implants in the VTA rapidly
facilitate receptivity in hamsters after progesterone priming to the VMH. Behavioral Brain Research 53,
167-175.
4. Frye, C.A., Mermelstein, P.G., & DeBold, J.F. (1992). Evidence for a non-genomic action of progestins
on sexual receptivity in hamster ventral tegmental area but not hypothalamus. Brain Research 578, 87-93. [
3. Frye, C.A., Bock, B.C. & Kanarek, R.B. (1992). Hormonal milieu affects tailflick latency in female rats
and may be attenuated by access to sucrose. Physiology & Behavior 52, 699-706.
2. Frye, C.A. & DeBold, J.F. (1992). Muscimol facilitates sexual receptivity in hamsters when infused into
the ventral tegmentum. Pharmacology, Biochemistry & Behavior 42, 879-887.
1. Frye, C.A. & Erskine, M.S. (1990). Influence of time of mating and paced copulation on induction
of pseudopregnancy in cyclic female rats. Journals of Reproduction and Fertility 90, 375-385.
BOOK CHAPTERS
22. Kohtz, A.S., Frye, C.A. (2012). Dissociating behavioral, autonomic, and neuroendocrine effects of
androgen steroids in animal models. In: Psychiatric Disorders: Methods and Protocols, Editor: Firas Kobeissy,
Ph.D., (in press). Springer.
21. Walf , A.A., Frye, C.A. (2011). Object Recognition - The Role of Hormones Throughout the Lifespan,
Object Recognition, Tam Phuong Cao (Ed.). InTech. Chapter 2: 15-26.
20. Frye, C.A., Llaneza, D.C. (2011). The role of 3α-hydroxy-5α-pregnan-20-one in mediating the
development and/or expression of schizophrenia spectrum disorders: Findings in rodent models and clinical
23
populations. In: Brain Protection in Schizophrenia, Mood and Cognitive Disorders, Editor: Michael Ritsner,
M.D., Ph.D., Vol 1, 367-404. Springer.
19. Walf, A.A., Frye, C.A. (2010). Using the elevated plus maze as a bioassay to assess the effects of naturallyoccuring, and exogenously-administered compounds, to influence anxiety-related behaviors of mice. In: Mood
& Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, Editor: Todd Gould, M.D.,
225-246. Springer Protocols.
18. Frye, C.A. (2009). Neurosteroids-From Basic Research to Clinical Perspectives. In: Hormones/Behavior
Relations of Clinical Importance. Editors: Robert T. Rubin and Donald W. Pfaff, 395-416. San Diego:
Academic Press.
17. Frye, C.A. & Rhodes, M.E. (2009). Female sex steroids and neuronal excitability. In: Encyclopedia of Basic
Epilepsy Research.Volume 1. Editor: Phil Schwartzkroin, 477-484. Oxford: Academic Press.
16. Frye, C.A. & Rhodes, M.E. (2009). Male sex steroids and neuronal excitability. In: Encyclopedia of Basic
Epilepsy Research. Volume 1. Editor: Phil Schwartzkroin, 507-513. Oxford: Academic Press.
15. Frye, C.A. (2008). Hormonal influences on seizures: Basic neurobiology. In: Epilepsy in womenscientific management. Editors: Barry Gidal and Cynthia Harding. International Review of Neurobiology, 83,
27-77.
14. Frye, C.A., Rhodes, M.E. (2008). The role of midbrain 3α,5α-THP in mediating exploration, anxiety, social
and reproductive behavior In: Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric
Disorders: Novel Strategies for Research and Treatment. Editors: Michael S. Ritsner and Abraham Weizman,
449-482, New York, NY, US: Springer Science.
13. Frye, C.A., Rhodes, M.E. (2007). The role and mechanisms of steroid hormones to enhance
approach/avoidance behavior. In: Handbook of approach and avoidance motivation. Editor: A. Elliot, 109126, Mahwah, NJ: LEA.
12. Frye, C.A., Rhodes, M.E. (2007). Reciprocal effects of exploration, anxiety, social, and sexual behaviors
and progestins in midbrain, hippocampus, diencephalon, and cortex In: Evolutionary Molecular Strategies and
Plasticity: Editors: Marcello Canonaco and Rosa Maria Facciolo, 237-260, Research Signpost.
11. Harden, C.L. & Frye, C.A. (2007). Hormone Changes in Epilepsy. In: Epilepsy: A Comprehensive
Textbook, Second Edition. Editors: Jerome Engel, M.D., Ph.D., Timothy A. Pedley, M.D., 2037-2042,
Lippincott Williams & Wilkins.
10. Harden, C.L., Baker, G. A., Frye, C.A., Montouris, G.D., Pennell, P.B., & Zupanc, M.L., eds.
(2005). Epilepsy through the menstrual cycle: the truth about catamenial epilepsy. Neurology
Supplement.
9. Harden, C.L., Baker, G. A., Frye, C.A., Montouris, G.D., Pennell, P.B., Zupanc, M.L., eds.
(2005). Correlations between hormone levels and seizure activity. Neurology Supplement.
8. Frye, C.A., Harden, C.L., Baker, G. A., Montouris, G.D., Pennell, P.B., Zupanc, M.L., eds. (2005). Effects
of estrogen and progesterone on cortical excitations and epileptogenesis Neurology Supplement.
7. Frye, C. A., Petralia, S. M. (2003). 3,5-THP’s actions in the ventral tegmental area for lordosis: A model
system for defining function and mechanisms of progestins. In: Neurosteroids and the GABAA Receptor.
Editor: S. Smith, CRC Press, Boca Raton, FL.
6. Frye, C.A., Petralia, S.M. (2003). Progestins have actions through GABAA receptors, In: The Identities of
Membrane Steroid Receptors: And Other Proteins Mediating Nongenomic Steroid Action, Editor: C.S.
Watson, Kluwer Academic Publishers, Boston, MA.
5. Rhodes, M.E., Frye, C.A. (2002). Hormones influence cognitive performance, In: Forget it? Sources, Theories, and Mechanisms of Alterations in Mnemonic Function, Editor: R. Flint, Erudition
Books, North Chelmsford, MA, 175-196.
4. Frye, C.A., Weisberg, R.B., Hinkson, A.B. (2000). Anxiety and women's health. In: The management of
24
stress and anxiety in medical disorders, Editors: D.I. Mostofsky and D.H. Barlow, Allyn & Bacon, Needham,
MA. 378-396.
3. Frye, C.A. (2000). Integration of affiliation: Well done! Trends in Endocrinology and Metabolism, 11, 155157.
2. Frye, C.A. (2000). Neurosteroids: A new regulatory function in the Nervous System. The Quarterly Review of
Biology, 75, 349-350.
1. Smith, S.S., Hsu, F.C., Li, X., Frye, C.A., Faber, D.S., Markowitz, R.S. (2000). Oestrogen effects in olivocerebellar and hippocampal circuits. Neural and cognitive effects of oestrogens. Wiley, Chichester, 230, 155172.
EDUCATIONAL
REPORTS
9. McLaughlin, J.P., Gomes, S., Seliga, A., Ramos-Goyette, S., Morrison, A., Reich, C.G., Frye, C.A.
(2009). Northeast Under/graduate Research Organization for Neuroscience (NEURON): our 13th conference
for neuroscience trainees and educators. CBE-Life Sciences Education. The American Society for Cell
Biology, 8, 111-3.
8. Goyette, S.R., Edinger, K.L., Luine, V., Young, J., Frye, C.A. (2009). Northeast Under/graduate Research
Organization for Neuroscience (NEURON): Our third New York City meeting. The Journal for
Undergraduate Neuroscience Education, 6: A14-A20.
7. Rhodes, M.E., Ramos, S.G., Young, J., Luine, V., Frye, C.A. (2008). Northeast Under/graduate Research
Organization for Neuroscience (NEURON): An update on our twelfth annual conference for neuroscience
trainees and educators. Journal of Behavioral and Neuroscience Research, 6.
6. Rhodes, M.R., Edinger, K.L., Smith, J., Luine, V., Frye, C.A. (2007). Northeast Under/graduate Research
Organization for Neuroscience (NEURON): An update on our tenth annual conference for neuroscience
trainees and educators. Journal of Behavioral and Neuroscience Research, 5: 1-8.
5. Rhodes, M.E., Edinger, K.L., Young, J., Luine, V., Frye, C.A. (2006). Northeast Under/graduate Research
Organization for Neuroscience (NEURON): An update on our tenth annual conference for neuroscience
trainees and educators. Journal of Behavioral and Neuroscience Research. 4:1-7.
4. Edinger, K.L., Smith, J., Luine, V., Frye, C.A. (2005). Northeast Under/graduate Research Organization
for Neuroscience (NEURON): An update on our ninth annual conference for neuroscience trainees and
educators. Journal of Behavioral and Neuroscience Research, 2, 1-7.
3. Frye, C.A., Edinger, K.L. (2004). Northeast Under/graduate Research Organization for Neuroscience
(NEURON): A regional neuroscience meeting for undergraduates, graduate students, and faculty. Journal
for Undergraduate Neuroscience Education, 2, 36-40.
2. Edinger, K.L., Morgan, K., Blasberg, M., Frye, C.A. (2004). Northeast Under/graduate Research
Organization for Neuroscience (NEURON): An update on our eighth annual conference for neuroscience trainees
and educators. Journal of Behavioral and Neuroscience Research, 1, 1-8.
1. Blasberg, M.E., Morgan, K., Frye, C.A. (2003). The 7th annual conference on the Northeast Under/graduate
Research Organization for Neuroscience (NEURON). Journal of Behavioral and Neuroscience Research, 1:1-2.
INVITED TALKS
Frye, C.A. (2013). Pregane xeniobiotic receptor and membrane progestin receptors: sources and targets for
neurosteroid-mediated motivated behaviors. 7th Steroids and the Nervous System meeting, Torino, Italy.
Walf, A.A. & Frye, C.A. (2013). Finasteride increases depression behavior, whereas administration of 3androstanediol can reduce depression behavior and increase brain-derived neurotrophic factor, without
increasing prostate growth, of male mice. 7th Steroids and the Nervous System meeting, Torino, Italy.
25
Frye, C.A. (2012) Neurosteroids and neuroplasticity-an overview of research from our lab. University of Alaska,
Fairbanks, AK.
Frye, C.A., Walf, A.A. (2012). Targeting hormone actions for therapeutic promise. Conference for Association for
Pharmacy and Therapeutics, University of Buffalo, NY.
Frye, C.A. (2012). Perinatal steroid action, preterm birth and health outcomes. Hotchkiss Brain Institute,
University of Calgary, Canada.
Frye, C.A. (2012). Neurosteroids and social, affective, cognitive and neuroprotective processes. University of
Alaska, Fairbank.
Frye, C.A. (2012). Estrogen receptor beta. Brock University, Saint Catherines, Ontario, Canada.
Frye, C.A. (2012). Neurosteroids and endogenous signaling in brain. Indiana University, Bloomington, IN.
Frye, C.A. (2012). Hormones as therapeutic targets. Albany College of Pharmacy and Allied Health Sciences,
Albany, NY.
Frye, C.A. (2012). Progesterone and aging. Tufts Center for Human Nutrition and Aging, Boston, MA.
Frye, C.A. (2011). Hormone replacement therapy-promise and progress. American Heart Association Annual
Meeting, Orlando, FL.
Frye, C.A. (2011). Progestogens...not just for pregnancy! University of North Carolina Medical School,
Department of Psychiatry, Chapel Hill, NC.
Frye, C.A. (2011). Your brain and steroids: of, for, and by the nervous system. University of California, Santa
Barbara, California.
Frye, C.A. (2011). Neurosteroids: Of, for, and by, the nervous system. Texas A&M University, College Station,
Texas.
Frye, C.A. (2011). The role of neurosteroids in motivated behaviors. Universite de Strasbourg, Strasbourg,
France.
Frye, C.A. (2011). The role of neuroactive steroids and depression. Neurex Workshop, Basel, Switzerland.
Frye, C.A. (2011). Pregnane xenobiotic receptors in the ventral tegmental area may mediate progestogenfacilitated reproductive behavior of female rats. Symposium presentation at the 6th International Meeting
Steroids and Nervous System. Torino, Italy.
Frye, C.A. (2011). Effects and mechanisms of progestogens for object memory. Conference on Learning and
Memory, Park City, Utah.
Frye, C.A. (2010). Progestogens’ and estrogens’ social, affective, and cognitive function. Nova Southeastern
University & Ponce School of Medicine, Ponce, Puerto Rico.
Frye, C.A. (2010). Neurosteroids: Of, for, and by, the nervous system. Universidad del Este-SUAGM, Escuela de
Ciencias y Tecnologia, Carolina, Puerto Rico.
Frye, C.A. (2010). (Neuro)steroids of, for, and by the nervous system. Hudson-Berkshire Neuroscience Group,
Albany, NY.
Frye, C.A., Paris, J.J., Walf, A.A. (2010). The role if pregnane neurosteroid formation in reproductive endocrine
function and pregnancy. 4th International Parental Brain Meeting, Edinburgh, Scotland.
Frye, C.A. (2010) Protective effects of progesterone. 19th Annual Meeting, International Behavioral
Neuroscience Society, Sardinia, Italy.
Frye, C.A. (2010) Sex, Drugs & Rock ‘n’ Roll. Neurofest, SUNY Upstate Medical Universtiy, Syracuse NY.
Frye, C.A. (2010). Beneficial trophic effects in the brain relative to negative proliferative effects on peripheral
reproductive tissues. Window of Opportunity - Estrogen Workshop, Stanford, CA.
Frye, C.A. (2009). Sex, Drugs, Rock & Roll, The Role of Neurosteroids 17th New England Conference
North/East Under/graduate Research Organization for Neuroscience (N.E.U.R.O.N.), Boston Latin School,
Boston, MA.
Giordano M., Caljouw, M., McCarthy, M., Scapicchio, P., Spillane, T., Frye, C.A. (2009). Doctors, Lawyers, &
Chiefs. Boston Latin School, Boston, MA.
Frye, C.A. (2009). Distinguished Graduate Award Talk. Boston Latin School Alumni Dinner, Boston, MA.
Frye, C.A. (2009). Neurodegenerative Disorders. Boston Latin School, Boston, MA. Frye, C.A. (2009).
26
Progesterone: novel effects and mechanisms across the lifespan. Indiana State University, Bloomfield, IN.
Frye, C.A. (2009). Sex differences in HPA-responding and the role of progestogens in adult expression and
development of stress responses. State University of New York, School of Public Health, Albany, NY.
Frye, C.A. (2009). Neurosteroids’ effects and mechanisms for social, cognitive, emotional, and physical functions.
Arizona State University.
Frye, C.A. (2009). Progesterone and its metabolites in the pathophysiology and treatment of neurodevelopmental, psychiatric and/or developmental disorders. 11th Argentinean Congress of Neuropsychiatry
Conference. Argentina.
Frye, C.A. (2009). Estrogens, progestogens and androgens… oh my: effects and mechanisms for depression.
International Society for Psychoneuroendocrinology Conference 2009. San Francisco, California.
Walf, A.A. & Frye, C.A. (2009). Estradiol’s actions through estrogen receptor β for functional effects
in hippocampus-mediated behaviors, but not uterine proliferation or carcinogen-induced
tumorigenesis. International Behavioral Neuroscience Society, 18th Annual Meeting, Nassau,
Bahamas.
Frye, C.A., Paris, J.J., Franco, C., Sodano, R., Freidenberg, B., Forsyth, J.P., Anderson, D.A., Wulfert E. (2009).
Sex differences in stress hormone response are not always male-biased in panic disorder
symptomology, posttraumatic stress disorder, & pathological gambling. Satellite symposium
presentation at the 5th International Meeting Steroids and Nervous System. Torino, Italy.
Frye, C.A., Llaneza, D.C., Paris, J.J. (2009). Activational and organizational effects of progesterone for
affective and cognitive behavior due to 5-pregnan-3-ol-20-one. Symposium presentation at the 5th
International Meeting Steroids and Nervous System. Torino, Italy.
Frye, C.A. (2009). ERβ is a target for beneficial trophic effects of estrogens in females, and androgens in males, in
brain but not reproductive tissue. New York Medical College. New York, NY.
Frye, C.A. (2009). Sex, drugs, and rock n’ roll: the role of neurosteroids. Northeastern University.
Frye, C.A., Llaneza, D.C., Paris, J.J. (2009) Activational and organizational effects of progesterone for
affective and cognitive behavior due to 5α-pregnan-3α-ol-20-one. Conference on Steroids and the Nervous
System. Torino, Italy.
Paris J.J., Frye C.A. (2009) Formation of 3α-androstanediol may underlie alcoholpromoted aggression
among rodents. Conference on Steroids and the Nervous System. Torino, Italy.
Frye, C.A. (2008). The role of actions at the β isofrom of the estrogen receptor in mediating affective behavior.
International Congress of Neuropsychiatry, Cancun, Mexico.
Walf, A.A., Frye, C.A. (2008). ER may be a novel target for the beneficial effects of naturally-occurring
steroids, therapeutics, and selective estrogen receptor modulators. International Drug Discovery Science and
Technology, Beijing, China.
Frye, C.A., Walf, A.A. (2008). ER may be a novel target for the beneficial effects of estrogens in females,
and androgens in males, for anxiety, depression, and cognitive function. Ehrlich II- 2nd World Conference
on Magic Bullets, Nurnberg, Germany.
Frye, C.A. (2008). Progesterone… it’s not just for pregnancy. Louisiana State University, Shreveport, LA.
Frye, C.A. (2008). Enhancing children’s neural and cognitive development through reading. Delaware Community
School, Albany, NY.
Frye, C.A. (2008). The role of actions at ERβ in beneficial effects of estrogens and progestins. Organization
for the study of sex differences conference, New Orleans, LA.
Frye, C.A. (2008). The role of neurosteroids and actions at ERβ for physical and psychology effects of hormone
therapies. Wyeth Pharmaceuticals, Collegeville, PA.
Frye, C.A. (2008). Progestogens...of, for, and by the nervous system are not just for pregnancy. Drexel University
Medical School, Pharmacology Department, Philadelphia, PA.
Frye, C.A. (2008). Steroid hormones in mental health and disease. International Congress of
Neuropsychiatry, Cancun Mexico
Frye, C.A., Walf, A.A. (2008). Estrogen receptor β as a target for the anti-anxiety and anti-depressant effects
27
of steroids Conference of The Society for The Study of Sex Diffferences, New Orleans, LA.
Frye, C.A., (2008). Functional effects of neurosteroids-hormones that are of the nervous
system, by the nervous system, and for the nervous system. Albert Einstein School of Medicine, Bronx, NY
Frye, C.A., (2007). Estrogen receptor β as a target for steroids’ effects on affective and cognitive behavior. Annual
Graylyn Conference on Women's Cognitive Health, Wake Forest, NC.
Frye, C.A., (2007). Progestins actions in the midbrain to enhance lordosis involve GABA, dopamine
and glutamate receptors and their downstream signal transduction factors. Conference on Rapid
Response Signaling of Steroid Hormones, Dublin, Ireland.
Frye, C.A., (2007). Neurosteroids- Of the nervous system, by the nervous system, for the nervous system.
Skidmore College, Saratoga Springs, NY.
Frye, C.A., Walf, A.A. (2007). Actions at estrogen receptor  may underlie some of the anti-anxiety, antidepressant, and memory enhancing effects of steroids. Conference on Steroids and the Nervous
System. Torino, Italy.
Frye, C.A.(2007). The global impact of behavioral endocrinology-hormones across the world.. Conference on
Steroids and the Nervous System. Torino, Italy.
Paris, J.J., Rhodes, M.E., Frye, C.A. (2007). Inhibition of 3,5-THP formation decreases exploratory/antianxiety and socio-sexual behavior in sexually receptive female rats. Conference on Steroids and the
Nervous System. Torino, Italy.
Frye, C.A., Paris, J.J. (2006). 3-androstanediol may underlie some of testosterone’s positive hedonic
and/or drug-related effects. International Society for Biomedical Research on Alcoholism -World
Congress on Alcohol Research, Sydney, Australia.
Frye, C.A., Walf, A.A. (2006). Anti-anxiety and anti-depressant effects of steroids with actions at estrogen
receptor . 37th Annual International Society for Psychoneuroendocrinology (ISPNE) meeting.
Leiden, Netherlands.
Frye, C. A. (2006). Effects of pre-natal manipulations on response to stress during development and in adulthood.
Pharmacology, Biochemistry and Behavior 7th Meeting: Adolescence-Alcohol, Drugs, and Mental Disorders,
Morzine, France.
Frye, C.A. (2006). Rewarding effects of progestins: Importance for drug abuse. Pharmacology, Biochemistry and
Behavior 7th Meeting: Adolescence-Alcohol, Drugs, and Mental Disorders, Morzine, France.
Rhodes, M.E., Frye, C.A. (2006). Rewarding effects of androgen: Importance for drug abuse. Pharmacology,
Biochemistry and Behavior 7th Meeting: Adolescence-Alcohol, Drugs, and Mental Disorders, Morzine,
France.
Walf, A.A., Frye, C.A. (2006). Antidepressant-like effects of estrogen receptor modulators after short-term
treatment. Pharmacology, Biochemistry, and Behavior Conference, 7th Meeting, Morzine, France.
Walf, A.A., Rhodes M.E., Frye, C.A. (2006). Rewarding effects of estrogen: Importance for drug
abuse. Pharmacology, Biochemistry, and Behavior Conference, 7th Meeting, Morzine, France.
Frye, C.A. (2005). Ovarian hormones in animal models of catamenial epilepsy. Special Interest Group – Animal
Models of Catamenial Epilepsy at the American Epilepsy Society Meeting, Washington, DC.
Frye, C.A. (2005). Differential behavioral effects of estradiol through ER and ER. National Academy of
Sciences of the Czech Republic, Prague, Czech Republic.
Frye, C.A. (2005). Role of progesterone in animal models of schizophrenia. Prague Center for Psychiatry, Prague,
Czech Republic.
Petralia, S. M., Sumida, K., & Walf, A. A., Frye, C. A. (2005). Progestin-facilitated sexual behavior of female
rats may involve activity of adenylyl cyclase in the ventral tegmental area (VTA). International Conference
on Steroids and the Nervous System, Torino, Italy.
Rhodes, M. E., Petralia, S.M., Jahagirdar, V., & Frye, C. A. (2005). Actions of the neurosteroids, 3, 5-THP,
in the ventral tegmental area, mediate socio-sexual behaviors. International Conference on Steroids and the
Nervous System, Torino, Italy.
Frye, C.A. & Rhodes, M.E. (2004). Ovarian hormones and their effects on cortical excitation and influences
28
on epileptogenesis. Women and Epilepsy Advisory Board, Atlanta, GA.
Frye, C.A. (2004). Sex differences in rats: anxiety responses to androgens, Pharmacology, Biochemistry and
Behavior Conference, Morzine, France.
Frye, C.A. & Rhodes, M.E. (2003). Androgens and seizures. American Epilepsy Society Conference, Boston,
MA. Frye, C.A. (2003). Novel actions of steroid hormones- basic and clinical research. Marywood University,
Scranton, PA.
Frye, C.A. (2003). Membrane actions of hormones and the relationship to function. Marywood University,
Scranton, PA.
Frye, C.A. (2003). Approaches to enhance training of neuroscience. International Brain Research
Organization, Prague, CZ.
Frye, C.A. (2003). Sex and hormonal differences in response to gestational stress. TENNET Conference,
Montreal, CANADA.
Frye, C.A. (2003). The functional role of neurosteroids. CUNY-Park Avenue Colloquium, New York City, NY.
Frye, C.A., Petralia, S., & Rhodes, M.E. (2003). Fluoxetine’s effects on sexual function may involve
allopregnanolone in the ventral tegmental area. International Conference on Steroids and the Nervous
System, Torino, Italy.
Frye, C.A. (2003). Non-ER mediated effects of estrogen on learning and memory. Experimental Biology
Meeting, San Diego, CA.
Frye, C.A. & Rhodes, M.E. (2003). Estrogen may have genomic and non-genomic actions in the dorsal
hippocampus to improve inhibitory avoidance performance. Twenty-seventh Annual Winter Conference on
the Neurobiology of Learning & Memory at Park City, Park City, UT.
Frye, C.A. (2002). The role of non-genomic actions of steroids in mediating reproductive, affective and
cognitive behaviors. CUNY-Brooklyn, Psychology Department Colloquia.
Frye, C.A. (2002). Mating-induced neurosteroidogenesis in the hippocampus induces anxiolysis of female rats.
Workshop on Steroid Hormones and Brain Function, Breckenridge, Co.
Frye, C.A. & Epperson, N. (2002). Neurosteroid modulation of -Aminobutyric Acid neuronal function:
Clinical implications. Workshop on Steroid Hormones and Brain Function, Breckenridge, Co.
Herzog, A.G., Frye, C.A., Drislane, F.W., Friedman, M.N., & Schomer, D.L. (2001). Neuroactive
reproductive steroid changes in men with epilepsy: associations with sexual function and potential
implications for neuronal excitability. American Epilepsy Society Conference, Philadelphia, PA.
Frye, C.A. (2001). Non-genomic actions of steroid hormones mediate social, affective, and cognitive behavior
American College of Neuropsychopharmacology. Waikoloa, Hawaii.
Frye, C.A. (2001). Developing Programs in Neuroscience at the Small College and University, NSF Sponsored
Project Kaleidoscope Workshop on “Neuroscience Education: From the Enchanted Loom to the World
Wide Web”, Hartford, Connecticut.
Frye, C.A. (2001). North East Undergraduate Research Organization for Neuroscience (N.E.U.R.O.N.), A
regional program to promote training in Neuroscience Undergraduate. NSF Sponsored Project Kaleidoscope
Workshop on “Neuroscience Education: From the Enchanted Loom to the World Wide Web”, Hartford, CT.
Frye, C.A. (2001). Distinguishing allopregnanolone’s effects on anxiety from other behaviors. American
Neuroendocrine Society Conference, Breckenridge, Co.
Frye, C.A. (2001). Neurosteroids and anxiety. Symposium Organizer and Chair, American Neuroendocrine
Society Conference, Breckenridge, Co.
Frye, C.A. (2001). Neurosteroids actions in modulating reproductive and non-reproductive behavior.
Neuroscience Symposium Series, Brigham Young University, Provo, Utah.
Frye, C.A. & Muscatiello, N. (2001). The mechanism of action of progestins’ anti-seizure effects in the hindbrain.
Workshop on the Neurobiology of Epilepsy, Iguazu, Brazil.
Frye, C.A. (2001). 3,5-THP in the raphe nucleus and pontine reticular formation attenuate myoclonic and
tonic clonic seizures. Spring Epilepsy Research Conference, Grand Cayman, BWI.
Frye, C.A. (2001). Assessing factors which influence anti-seizure effects of neurosteroids: Integration of basic and
29
clinical research. Workshop on Steroid Hormones and Brain Function, Breckenridge, Co.
Frye, C.A. (2001). The role of NMDA receptors in the VTA in mediating progestin-facilitated sexual receptivity.
Workshop on Steroid Hormones and Brain Function, Breckenridge, Co.
Frye, C.A. (2001). How do steroids mitigate sex, anxiety, learning and memory, and brain damage? LaDonne
Heaton Schulman Endowed Lecture, Wheaton College, Norton, MA.
Frye, C.A. (2001). The role of androstane neurosteroids in mediating reproductive and non-reproductive behavior.
Neuroendocrinology Colloquium Series, The University of Milan, Italy.
Frye, C.A. (2001). Factors which influence sexual differentiation by environmental endocrine disruptorsusing reproductive and non-reproductive behavior as indicators. The Department of Animal Sciences, The
University of Florence, Italy.
Frye, C.A. (2001). Neurosteroids in the Ventral Tegmental Area mediate sexual receptivity in rodents.
International Conference on Steroids and the Nervous System, Torino, Italy.
Frye, C.A. (2000). Two interactive exercises which engage students to learn about the brain. Eastern Section
Siena State Teachers’ Conference, Albany, NY.
Frye, C.A. (2000). What can progesterone’s actions for sex behavior in rodents tell us about neural substrates
for learning and memory, anxiety and neuroprotection in people? The College of Saint Rose, Albany, NY.
Frye, C.A. (2000). Neurosteroids mediate the onset and duration of sexual receptivity in rodents. Society for
Behavioral Neuroendocrinology, Madrid, Spain.
Frye, C.A. (2000). Neurosteroids …Of the Nervous system, by the Nervous System and for the Nervous System.
Society for Behavioral Neuroendocrinology, Madrid, Spain
Frye, C.A. , Rhodes, M.E., Spataro, L.E. (2000). The role of neurosteroids in the Ventral Tegmental Area
in mediating sexual receptivity in rodents. Society for Behavioral Neuroendocrinology, Madrid, Spain.
Frye, C.A., Petralia, S., & Rhodes, M.R. (2000). Sex and estrous cycle differences in performance on
anxiety tasks coincide with increases in hippocampal progesterone and 3,5-THP. Biological Basis of
Sexual Orientation, Sex Identity, and Gender-Typical Behavior. Minot, North Dakota.
Frye, C.A. (1999). Non-genomic actions of progestins on cognitive and affective behavior in rodents. The
keynote address for National Congress of the Mexican Society of Physiological Sciences, Zacatecas, Mexico.
Frye, C.A. (1999). Non-genomic actions of progesterone in the VTA-effects on sexual receptivity. National
Congress of the Mexican Society of Physiological Sciences, Zacatecas, Mexico.
Frye, C.A. & J.M. Vongher. (1999). The role of 3,5-THP in progesterone’s facilitation of sexual receptivity in
mice. International Behavioral Neuroscience Conference, Nancy, France.
Frye, C.A. (1999). Neurosteroids role in progestins' anti-seizure effects. Spring Epilepsy Research
Conference, Grand Cayman, BWI.
Frye, C.A. (1999). Neurosteroids & behavior. European Winter Conference on Brain Research, Aime, France.
Frye, C.A. (1999). The role of neurosteroids in social behavior. European Winter Conference on Brain
Research, Aime, France.
Frye, C.A. (1999). Non-genomic actions of steroid hormones...functional consequences. Hudson-Berkshire
Neuroscience Group, Albany, New York.
Frye, C.A. (1998). Progestins mediate reproductive and non-reproductive behavior. The University at
Albany- SUNY, Albany, NY.
Frye, C.A. (1998). Neurosteroids mediate sexual, cognitive, and affective behavior. Emory University,
Atlanta, GA.
Frye, C.A. (1998). The role of steroid hormones in neurodegenerative disorders. Centenary College/Louisiana
State University, Shreveport, LA.
Frye, C.A. (1998). Progesterone’s mechanism of action. Georgia State University, Atlanta, GA.
Frye, C.A. (1998). Neurosteroids and motivated behavior. Florida State University, Gainesville, FL.
Frye, C.A. (1997). Progestins role in epilepsy. Epilepsy Foundation of America Regional Meeting. Darien, CT.
Frye, C.A. (1997). Non-genomic effects of progesterone - Implications for PMS, Epilepsy and Alzheimer’s
Disease. Rutgers University, Camden, NJ.
30
Frye, C.A. (1996). Neurosteroids role in reproductive and non-reproductive behavior. University of Southern
Florida, Tampa, FL.
Frye, C.A. (1996). Alzheimer’s disease: a focus on effects of hormones. Alleghany College, Alleghany, PA.
Frye, C.A. (1996). Progestin mechanism of action; effects on reproductive and non-reproductive behavior.
LeHigh University, Bethlehem, PA.
Frye, C.A. (1995). Hormonally mediated taste preference - caveats and qualifications. Eastern Psychological
Association, Boston, MA.
Frye, C.A. (1995). The functional role of neurosteroids: Animal and human studies. Symposium chair and
speaker, Winter Brain Conference, Steamboat Springs, CO.
Frye, C.A. (1994). Androgens actions to inhibit sexual receptivity are non-genomic. Workshop on Steroid
Hormones and Brain Function, Breckenridge, Co.
Frye, C.A. (1994). Non-genomic steroid effects relevant for reproduction. Symposium chair and speaker,
Conference on Reproductive Behavior, LeHigh Valley, PA.
Frye, C.A. (1993). Mk-801 and nimodipine: Neuroprotective effects may not extend to behavior. Cambridge
Neuroscience, Cambridge, MA.
COURSES TAUGHT
(U=undergraduate course, G=graduate course)
Introductory Psychology (U)
Psychology as a Natural Science (U)
Experimental Psychology (U)
Research Methods in Human Development (U)
Motivation and Emotion (U)
Brain, Mind and Behavior (G)
Physiological Psychology (U & G)
Behavioral Neuroscience (U & G)
Advanced Behavioral Neuroscience (G)
Neurobiology (G)
Seminar in Behavioral Neuroscience (U & G)
Behavioral Endocrinology (U & G)
Hormones and Behavior (U & G)
Psychopharmacology (U & G)
Stress (U,G) Honors College Proposal
Practicum in Neuroscience (U & G)
Individual Study (U)
Dissertation (G)
SOCIETIES, MEMBERSHIPS & AFFILIATIONS
American Association for the Advancement of Science
American Neuroendocrine Society
American Psychological Society
Developmental Psychobiology
Endocrine Society
International Behavioral Neuroscience Society
North East Under/graduate Research Organization for Neuroscience
(N.E.U.R.O.N., Co-Founder & Executive Steering Committee Member)
Sigma Xi, Research Honor Society
Society for Behavioral Neuroendocrinology
Society for Ingestive Behavior
Society for Menstrual Cycle Research
Society for Neuroscience
31
1990-1996
1998-present
1991-1997
1997-2001
1995-present
1995-2005
1996-present
1991-1998
1995-present
1992-2002
1992-1996
1989-present
GRADUATE STUDENT/POST DOC ADVISEES
Student
Laura Bayon, MD
Current Affiliation/Position
Saint Luke's Family Care Clinic
Pediatrics
Elizabeth Lacey, MS
Connecticut College
Georgetown University
Rebecca Murphy, MS
Connecticut College
Pfizer
Jill Vongher, PhD
Connecticut College
UChicago
Irene Chin, MS
SUNY Albany
U Puget Sound
James Driscoll, MS
SUNY Albany
Pfizer
Kassandra Edinger, MS
SUNY Albany
Tutor in Albany-area
Fabiola Estrada, MS
SUNY Albany
SUNY Albany
Lauren Farnbach
SUNY Albany
Arizona State University
Jeff Grizzaffi, MS
SUNY Albany
Troy Regional High School
Vaishali Jahagirdar, PhD SUNY Albany
SUNY Albany
Amy Kohtz, MS
SUNY Albany
SUNY Albany
Danielle Llaneza, MS
SUNY Albany
SUNY Albany /Scripps, FL
Neil Muscatiello, MS
SUNY Albany
NY State Dept of Health
Danielle Osborne, MS
SUNY Albany
SUNY Albany
Jason Paris, Ph.D.
SUNY Albany
Torrey Pines
Sandra Petralia, PhD
SUNY Albany
Taconic
Steven Platek, Ph.D.
SUNY Albany
Georgia Gwinnett College
Madeline Rhodes, PhD
SUNY Albany
McDaniel College
Kyungok Sim, Ph.D.
SUNY Albany
U Texas
Kanako Sumida, MS
SUNY Albany
UAlbany, Of. Research Compliance
Alicia Walf, PhD
SUNY Albany
Rensselaer Polytechnic Institute
UNDERGRADUATE STUDENTS SUPERVISED (* indicates students that co-authored publications)
Chris Acer
Jason Ackerman
Arlene Adams
Dana Alvarez
Allison Arneill
Lyndsey Avalone
Alicia Babson*
Laura Bayon*
Sheena Ballard
Alysha Binon
Matt Blackman
Theresa Blakesley
Dana Braseth
Jennaye Brown
Damali Carrington
Brian Carroll
Institution Advised At
Connecticut College
Christina Castro
Madison Chester
Annie Cheung
Lesley Cole
Peter Copeland*
Candice Crain
Caitlin Crowley
Susan Crystal*
Carlos Cuevas*
Patricia Currier
Daniel Cusher
Daniel DaCosta
Sangha Dalimbkar
Abigail Davidson
Errene Delnevo
Allyson Delprino
Trisha Diamond
Johanna Diaz
Eleni Dimitriadis
Luigi DiRienzo
Lauren Doherty
James Driscoll
Jennifer Duncan*
Jeffrey Duqette
Caryn Duffy*
Kassandra Edinger*
Dana Ericco
Kate Fagan-Solis
Kristin Fields
Digna Figeuroa
Alyssa Fluty*
Nicole Frederick
32
Jonathan Friedman
Jennifer Gallagher
Dario Garcia
Sara Gardiner*
Amy Gazzara
Rita German
Melissa Gnech
Jeremy Gold
Taylor Goldberg
Barbara Graham
Jeff Grizzaffi
Gloria Guptill
Rebecca Habernig
Fareed Haddad
James Hanks
Emily Hey
Bushra Helmandi
Nicole Hercules
Tom Herman
Janet Heuring
Megan Hickey
Michael Horlacher
Pascale Houanche
Shannon Jeddi
Michelle Jolicoeur
Christina Joseph
Oreisha Jordan
Julia Keene
Ryan Keller
Kendall van Keuran*
Seehee Kim
Amy Kohtz*
Carolyn Koonce*
Kyana Kylek
Elizabeth Lacey*
Scott Lamm
Nicolas Lapis
Elizabeth Leadbetter*
Bomi Lee*
Bryan Licata
Juan Lin
Danielle Llaneza*
Mayulie Luciano
John Lusins
Niclas Luongo
Tara Mahar
Soobin Maeng
Jennifer Marrone*
Jacob Martinez
Jim McDonald
Stephanie McKnight
Frances Melendez
Elana Mendelson
Paul Mermelstein*
John Merriman
Ashley Morelli
Amy Morrison
Laura Murray
Eric Olson
Ryan O’Mara
Zoe Orecki*
Romae Palmer
David Park*
Aarat Patel
Anne Plaut
Kathy Prevost
Neena Pursnani*
Marie Rafalski
Tinisha Ransome
Trent Reed*
Eric Rist
Emily Roberge
John Roberts
Allicia Ryan*
Kristin Sanderson*
Nith Sanikone
Anthony Santarelli
Vanessa Sarfoh
Trudy Scalise*
Samantha Schmidt
Nicole Schmitt
Angela Seliga*
Aaron Sheppard
Jennifer Shorten
Zachary Simpsom
Andrew Slater
Kylie Small
Alex Smith
April Smith
Emer Smith
David Spangler
Laurie Spofford
Darcy Spitzer
Leanna Stager
Tara Stanko
Brittany Stebbins
Mathew St. Pierre
2
Ben Stein*
Robert Steger
Jodi Sturgis*
Kanako Sumida*
Masako Tanaka*
David Tedeschi
Sally Tetrault
Sheri Thayil
Hericka Torres
Khristina Ulmer
Mary Unger
Jana Vanderslice- Barr
Chris Voets
Taryn Walcott
Alicia Walf*
Chris Walsh
Joanna Wawrzycki*
Risa Weisberg*
Samuel Wilken
Jari Willing
Chris Wilming
Boris Yaguda
Stephanie Youmans
Sephehr Zandi
Eric Zho
Institution
Tufts University
Bates College
Boston Univ.
Level of Committee
Department
Department
Campus
Local
National
Department
Campus
Campus
Local
Departmental
Campus
Local
Regional
International
Connecticut
College
SUNY Albany
Campus
COMMITTEES SERVED
Role
Years
Colloquium Committee
1989/1990
Animal Use & Care
1990/1991
Sigma Xi, Research Honor Society
1991/1992
Boston Area Neuroscience Gathering
1990-1992
Conference Committee for Soc. Ingestive Behavior 1991/1992
Search Committee for Social Psychologist
1992/1993
Sigma Xi, Research Honor Society
1992/1993
Howard Hughes Grant Committee
1992/1993
Boston Area Neuroscience Gathering
1992/1993
Colloquium Committee
1993/1994
Sigma Xi, Research Honor Society, Secretary
1993-1995
Boston Area Neuroscience Gathering
1993-1995
New England Consortium for Undergraduate
1993-1995
Science Education
Local Organizing Committee Society for Behavioral 1994/1995
Neuroendocrinology
Laboratory and Animal Facility Coordinator
Colloquium Committee Coordinator
Director of Neuroscience
Animal Care & Use Committee
Research Committee, Chair
Howard Hughes Grant Committee
Psi Chi, Psychology Honor Society
Study Abroad/Teach Abroad
Boston Area Neuroscience Gathering
Brain Awareness Week
North East Under/graduate Research Organization
for Neuroscience
National
Connecticut College’s Alumnae Outreach
Department
Search Committee for Behavioral Neuroscience
Faculty (co-chair 99/00)
Department
Search Committee for Social Psychology Faculty
Department
Honors Committee
Department
Colloquium Committee
Department
Social Committee
Search Committee for Radiation Safety Officer
Campus
Radiation Safety Committee
Campus
Research Facilities Implementation Comm
Campus
College Council
Campus
Animal Facility User Committee
Campus
Life Science Building Advisory Committee
Campus
Research Council
Campus
Researchers’ Liason Committee (co-chair)
Local
Brain Awareness Week
Regional
N.E.U.R.O.N., President
Department
Department
Campus
Campus
Campus
Campus
Campus
Campus
Local
Local
Regional
32
1995/1996
1996/1997
1995-1997
1995-1997
1996-1997
1995/1996
1995/1996
1995-1997
1995-1998
1995-1998
1995/1998
1995/1996
1998-2000
2001-2001
1999-2009
2000-2007, 2009
2000-2007, 2009
1999, 2001
1999-present
2000-2001
1999-2001
2000-2001
2003-2009
2004-2006
2006-2009
1998-present
1998-present
International
International
International
International Behavioral NeuroscienceSociety
2000-2002
Membership Committee
Program Committee- Steroids & Nervous System 2002-present
Conference
Program Committee- Pharmacology Biochemistry 2003-present
& Behavior Conference
32