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1: Clin Infect Dis. 2002 Aug 15;35(4):381-9. Epub 2002 Jul 19.
Links
Once-daily, high-dose levofloxacin versus ticarcillinclavulanate alone or followed by amoxicillin-clavulanate
for complicated skin and skin-structure infections: a
randomized, open-label trial.
Graham DR, Talan DA, Nichols RL, Lucasti C, Corrado M, Morgan N, Fowler CL.
Department of Infectious Diseases, Springfield Clinic, Springfield, IL 62703, USA.
infectn@springfieldclinic.com
This study tested whether levofloxacin, at a new high dose of 750 mg, was effective for
the treatment of complicated skin and skin-structure infections (SSSIs). Patients with
complicated SSSIs (n=399) were randomly assigned in a ratio of 1:1 to 2 treatment arms:
levofloxacin (750 mg given once per day intravenously [iv], orally, or iv/orally) or
ticarcillin-clavulanate (TC; 3.1 g given iv every 4-6 hours) followed, at the investigator's
discretion, by amoxicillin-clavulanate (AC; 875 mg given orally every 12 hours). In the
clinically evaluable population, therapeutic equivalence was demonstrated between the
levofloxacin and TC/AC regimens (success rates of 84.1% and 80.3%, respectively). In
the microbiologically evaluable population, the overall rate of eradication was 83.7% in
the levofloxacin treatment group and 71.4% in the TC/AC treatment group (95%
confidence interval, -24.3 to -0.2). Both levofloxacin and TC/AC were well tolerated.
These data demonstrate that levofloxacin (750 mg once per day) is safe and at least as
effective as TC/AC for complicated SSSIs.
PMID: 12145720 [PubMed - indexed for MEDLINE]
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
Patient stratification in the management of acute bacterial exacerbation of chronic
bronchitis: the role of levofloxacin 750 mg.
Eur Respir J. 2005 Jun; 25(6):1001-10.
[Eur Respir J. 2005]
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Treatment of hospitalized patients with complicated skin and skin structure
infections: double-blind, randomized, multicenter study of piperacillintazobactam versus ticarcillin-clavulanate. The Piperacillin/Tazobactam Skin and
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Antimicrob Agents Chemother. 1993 Aug; 37(8):1580-6.
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
ReviewLevofloxacin: a review of its use in the treatment of bacterial infections in
the United States.
Drugs. 2003; 63(24):2769-802.
[Drugs. 2003]

ReviewLevofloxacin: an updated review of its use in the treatment of bacterial
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
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Cited by 3 PubMed Central articles

Tigecycline in the treatment of complicated intra-abdominal and complicated skin
and skin structure infections.
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
Probability of target attainment for ceftobiprole as derived from a population
pharmacokinetic analysis of 150 subjects.
Lodise TP Jr, Pypstra R, Kahn JB, Murthy BP, Kimko HC, Bush K, Noel GJ,
Drusano GL. Antimicrob Agents Chemother. 2007 Jul; 51(7):2378-87. Epub 2007
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Antimicrob Agents Chemother. 2006 Jun; 50(6):1937-45.
[Antimicrob Agents Chemother. 2006]
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