2015
41 Kotapalli SS, Nallam SS, Nadella L, Banerjee T, Rode HB, Mainkar PS, Ummanni R*.
Identification of New Molecular Entities (NMEs) as potential leads against tuberculosis from open
source compound repository. PLoS One. 2015 Dec 7;10(12).
40. Nagarsenkar A, Prajapti SK, Guggilapua SD, Birineni S, Kotapalli SS, Ummanni R* and Babu
BN* Investigation of triazole linked indole and oxindole glycoconjugates as potential anticancer
agents: Novel Akt/PKB signaling pathway inhibitors. Med. Chem. Comm. 2016, In press.
39. Emmadi NR, Bingi C, Kotapalli SS, Ummanni R, Nanubolu JB, Atmakur K. Synthesis and
evaluation of novel fluorinated pyrazolo-1,2,3-triazole hybrids as anti-mycobacterial agents Bioorg
Med Chem Lett. 25 (2015) 2918–2922.
38. P. Srihari,* P. Bhavani, S. Ramesh, Y. Bharath Kumar, Ashita Singh, Ummanni. R* PMA-SiO2
catalyzed synthesis of indolo[3,2-c]quinolines as potent anti cancer agents. Bioorg. Med. Chem. Lett.
25 (2015) 2360–2365.
37. S. Divya Reddy, Bandi Siva, B. Poornima, D. Anand Kumar, Ashok K. Tiwari, U. Ramesh, K.
Suresh Babu. New free radical scavenging neolignans from fruits of Piper attenuatum.
Pharmacognosy Magazine, April-June 2015, Vol 11, Issue 42.
36. Polkam N, Rayam P, Anireddy JS, Yennam S, Anantaraju HS, Dharmarajan S, Perumal Y,
Kotapalli SS, Ummanni R, Balasubramanian S. Synthesis, in vitro anticancer and antimycobacterial
evaluation of new 5-(2,5-dimethoxyphenyl)-1,3,4-thiadiazole-2-amino derivatives. Bioorg Med Chem
Lett. 25 (2015) 1398–1402.
35. Abhale YK, Sasane AV, Chavan AP, Deshmukh KK, Kotapalli SS, Ummanni R, Sayyad SF,
Mhaske PC. Mhaske Synthesis and biological screening of 2'-aryl/benzyl-2-aryl-4-methyl-4',5bithiazolyls as possible anti-tubercular and antimicrobial agents. Eur J Med Chem. 2015 Mar 7;
94:340-347.
34. J. M. Gajbhiye, N. A. More, Manoj D. Patil, R. Ummanni, S.S. Kothapalli, P. Yogeeswari, D.
Sriram And V. H. Masand, Discovery of Rimonabant and its potential analogues as Anti-TB drug
candidates, Med. Chem. Res., 7 March 2015, DOI: 10.1007/s00044-015-1346-4.
33. Ummanni R,* Duscharla D, Barett C, Venz S, Schlomm, T, Walther R, Bokemeyer C,
Brümmendorf T.H, Murthy P.V.L.N., Balabanov S Prostate cancer associated autoantibodies in serum
against tumor associated antigens as potential new biomarkers. J of Proteomics, 24 April 2015, 119,
218-229.
32. Blumenthal A, Giebel J, Warsow G, Li L, Ummanni R, Schordan S, Schordan S, Klemm P, Gretz
N, Endlich K, Endlich N. Mechanical stress enhances CD9 expression in cultured podocytes. Am J
Physiol Renal Physiol. Dec 2014, DOI: 10.1152/ajprenal.00190.2014.
31. Manneganti V, Prabhavathi Devi BLA, Prasad RBN, Singh A, Ummanni R. Design, synthesis
and anticancer activities of novel unsaturated fatty acid-based β-hydroxy 1,2,3-triazoles. IJPSR, 2015;
Vol. 6(4): 1635-1649.
30. Shareef AD, Duscharla D, Ramasatyaveni G, Dhoke NR, Das A, Ummanni R Srivastava AK.
Investigation of Podophyllotoxin Esters as Potential Anticancer Agents: Synthesis, Biological Studies
and Tubulin Inhibition Properties. Eur J Med Chem. 2015 Jan 7;89:128-37.
2014
29. Kanugula A.K, Dhople V.M, Volker, U, Ummanni R*, Kotamraju S. Fluvastatin mediated breast
cancer cell death: A proteomic approach to identify the differentially regulated proteins in MDA-MB231 cells. Plos One. Sep 2014, 30;9(9):e108890.
28. Sharma G.V.M,* Srikanth G, Singh A, Ramesh A, Jayaram V, Duscharla D, Jun J.H, Ummanni
R,* Malhotra S.V*. Imidazole derivative shows anticancer potential by inducing apoptosis and
cellular senescence. Med. Chem. Comm. 2014, 5, 1751-1760.
27. Pagadala LR, Mukkara LD, Singireddi S, Singh A, Thummaluru VR, Jagarlamudi PS, Guttala RS,
Perumal Y, Dharmarajan S, Upadhyayula SM, Ummanni R*, Basireddy VS, Ravirala N. Design,
synthesis and anti-mycobacterial activity of 1,2,3,5-tetrasubstituted pyrrolyl-N-acetic acid derivatives.
Eur J Med Chem. 2014 Sep 12;84:118-26.
26. Kanugula AK, Gollavilli PN, Vasamsetti SB, Karnewar S, Gopoju R, Ummanni R, Kotamraju S.
Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron
transport: Intermediacy of nitric oxide and antioxidant defence mechanisms. FEBS J. 2014 Jun 25.
doi: 10.1111/febs.12893.
25. Ummanni R*, Ramchandran S, Kumar A, Rayasam GV. Innovation at Open Source Drug
Discovery (OSDD) – Unconventional vs Conventional Approaches. Science Reporter. 2014, Apr, SR
Vol. 51(4), 20-23.
24. Naresh A, Venkateswara Rao M, Kotapalli S.S, Ummanni R*, Venkateswara Rao B*.
Oxazolidinone derivatives: Cytoxazone-Linezolid hybrids induce apoptosis and senescence in DU145
prostate cancer cells. Eur J Med Chem. 2014, 80, 295-307.
23. G. Saidachary, K. Veera Prasad, D. Divya, Ashita Singh, U. Ramesh, B. Sridhar, B. China Raju.
Synthesis, anti-mycobacterial and cytotoxic activities of novel benzoxepinopyrazolones and
isoxazolones. Eur J Med Chem. 76 (2014) 460e469.
22. Raji Reddy Ch,* Jithender Enukonda, Ashita Singh and Ramesh Ummanni* Stereoisomers of
ieodoglucomides A and B: Synthesis and evaluation of anticancer activity. Synthesis, 2014, 46, 0822–
0827.
21. Singh A, Mahipal B, Chandrasekhar S, Ummanni R*. 5-epi-Torrubiellutin C shows
antiproliferative activity on DU145 prostate cancer cells through inactivation of the AKT/mTOR
pathway. Anticancer Drugs. 2014 Apr, 25(4), 385-92.
20. Mleczko-Sanecka K, Roche F, da Silva AR, Call D, D'Alessio F, Ragab A, Lapinski PE,
Ummanni R, Korf U et al, Oakes C, Damm G, D'Alessandro LA, Klingmüller U, King PD, Boutros
M, Hentze MW, Muckenthaler MU. Unbiased RNAi screen for hepcidin regulators links hepcidin
suppression to the proliferative Ras/RAF and the nutrient-dependent mTOR signaling pathways.
Blood. 2014 Jan 21.
2013
19. Rachakonda V, Alla M, Kotipalli SS, Ummani R. Design, diversity-oriented synthesis and
structure activity relationship studies of quinolinyl heterocycles as antimycobacterial agents. Eur J
Med Chem. 2013 Dec;70:536-47.
18. Ummanni R, Mannsperger HA, Sonntag J, Oswald M, Sharma AK, König R, Korf U. Evaluation
of reverse phase protein array (RPPA)-based pathway-activation profiling in 84 non-small cell lung
cancer (NSCLC) cell lines as platform for cancer proteomics and biomarker discovery. Biochim
Biophys Acta. 2013 Dec 19. pii: S1570-9639(13)00430-5.
17. Mahipal B, Singh A, Ummanni R*, Chandrasekhar S* Total synthesis of C-5 epimer of
Torrubiellutin C and its biological evaluation. RSC Advances, 2013, 3,15917.
16. Patil NT, Konala A, Sravanti S, Singh A, Ummanni R, Sridhar B. Electrophile induced branching
cascade: a powerful approach to access various molecular scaffolds and their exploration as novel
anti-mycobacterial agents. Chem Commun (Camb). 2013 Oct 3;49(86):
15. Sreelakshmi Ch, Goel N, Datta K.K.R, Bhaskar Rao A, Addlagatta A, Ummanni R, Reddy
B.V.S. Green Synthesis of Curcumin Capped Gold Nanoparticles and Evaluation of their
Cytotoxicity. Nanoscience and Nanotechnology Letters.Vol. 5, 1–8, 2013.
2012
14. Jozefczuk J, Kashofer K, Ummanni R, Henjes F, Rehman S, Suzanne, et al. A systems biologybased approach to deciphering the etiology of steatosis employing patient-derived dermal fibroblasts
and iPS cells. Front Physiol. 2012;3:339.
13. Blumenthal A, Giebel J, Ummanni R, Sietmann R, Endlich K, Endlich N. Morphology and
migration of podocytes are affected by CD151 levels. Am J Physiol Renal Physiol. 2012 May;
302(10):F1265-77.
12. Ummanni R*, Barreto F*, Mundt F, Barett C, Mannsperger H, et al. Peroxiredoxins 3 and 4 are
differential expressed in PCa and affect the proliferation of PCa cells in vitro. J Proteome Res. 2012
Apr 6; 11(4): 2452-66. *Authors equally contributed.
2011
11. Binder M, Seismann H, Wehr C, Ummanni R, Balabanov S, Trepel M. Common recognition
principles of B-cell receptor immunoglobulins in CLL and autoimmune disorders ONKOLOGIE, Sep
2011, Volume: 34 Pages: 195-195 Supplement: 6
10. Ummanni R, Jost E, Braig M, Lohmann F, Mundt F, et al. Ubiquitin Carboxyl-Terminal
Hydrolase 1 (UCHL1) is a Potential Tumour Suppressor in Prostate Cancer and is frequently Silenced
by Promotor Methylation. Mol Cancer. 2011 Oct 14;10(1):129.
9. Ummanni R, Mundt F, Pospisil H, Venz S, Scharf C et al. Identification of clinically relevant
protein targets in prostate cancer with 2D-DIGE coupled massspectrometry and systems biology
network platform. PLoS One. 2011 Feb 11;6(2):e16833.
2010
8. Binder M, Ummanni R, Léchenne B, Scharf C, Balabanov S, et al. Stereotypical Chronic
Lymphocytic Leukemia B-Cell Receptors Recognize Survival Promoting Antigens on Stromal Cells.
PLoS One. 2010 Dec 30;5(12):e15992.
7. Binder M, Lechenne B, Ummanni R, Balabanov S, Trepel M. A CLL B-cell receptor with
stereotypical HCDR3 configuration recognizes the nurse-like cell antigen vimentin which
protects CLL cells from apoptosis. Onkologie, Volume: 33, 118-118.
6. Ummanni R, Lehnigk U, Zimmermann U, Woenckhaus C, Walther R, Giebel J.
Immunohistochemical expression of caspases 1 and 9, uncleaved caspases 3 and 6, cleaved caspases 3
and 6 as well as bcl-2 in benign prostate epithelium (BPE) and prostate cancer (PCa). Experimental
and Therapeutic Medicine 1: 47-52, 2010
2009
5. Majumdar A, Ummanni R, Manna R.P, et al. Cancer cells (MCF-7, Colo-357 and LNCaP)
viability on amorphous hydrogenated carbon nitride film deposited by dielectric barrier discharge
plasma. Journal of Applied Physics 106, 034702, 2009.
4. Ummanni R, Teller S, Junker H, Zimmermann U, Venz S, Scharf C, Giebel J, Walther R. Altered
expression of TPD52 regulates apoptosis and migration of prostate cancer cells. FEBS J. 2008 Nov;
275(22): 5703-13.
2008
3. Ummanni R, Junker H, Zimmermann U, Venz S, Teller S, et al. prohibitin identified by proteomic
analysis of prostate biopsies distinguishes hyperplasia and cancer. Cancer Lett. 2008 Aug 8;
266(2):171-85.
2007
2. Zimmermann U, Ummanni R, Junker H, Venz S, Teller S, et al. Establishing a protein signature
from prostate tissue biopsies. Urologe A. 2007 Sep; 46(9):1089-91.
2006
1. A.S.B. Bhaskar, P.V. Lakshmana Rao, U. Ramesh, Utsab Deb, Pooja Jain, R. Sirdeshmukh, R. et
al. Mechanistic studies on route specific toxicity of sulfur mustard in mice. Proceedings of the CB
Medical Treatment Symposium, Spiez Laboratory, Switzerland, 2006.
Conference reports published:
1. Design, synthesis, and in vitro cytotoxicity evaluation of seven-membered cyclic sulfamides Jun,
JH, Ummanni, R, Hanson, PR, Malhotra, SV ABSTRACTS OF PAPERS OF THE AMERICAN
CHEMICAL SOCIETY Volume: 246 Meeting Abstract: 134-MEDI, Published: SEP 8 2013,
Conference: 246th National Meeting of the American-Chemical-Society (ACS), SEP 08-12, 2013,
Indianapolis, IN
2. Synthesis and investigation of the anticancer activity of imidazole-based new compounds
Sharma GVM, Srikanth G, Ramesh A, Jayaram V, Singh A, Duscharla D, Ummanni R, Jun JH,
Malhotra SV. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Volume:
246 Meeting Abstract: 104-MEDI, Published: SEP 8 2013, Conference: 246th National Meeting of
the American-Chemical-Society (ACS) SEP 08-12, 2013, Indianapolis, IN.