 Name: YOUSRY MAHMOUD EL-SAYED
 Title: Professor and Chairman Department of Pharmaceutics
 Telephone: +2(03) 3877 108
 Email: yousry.elsayed@pua.edu.eg

yelsayed76@yahoo.com
 Room: C438
Academic Qualification:

Ph.D., Pharmaceutics, School of Pharmacy,
University of California, San Francisco, California, U.S.A.
1983

M.Sc., Faculty of Pharmacy, University of Alexandria, Egypt. 1977

B.Sc., (Distinction Honor) Faculty of Pharmacy, University of Alexandria, Egypt.
1973
Professional Experiences and Positions held:
9/2011-Today
Professor and Chairman Department of
Pharmaceutics, Faculty of Pharmacy and
Drug Manufacturing, Pharos University,
Alexandria, Egypt.
3-5/2010
Independent consultant: Arab Company for
Drug Industries & Medical Appliances
(ACDIMA), Egypt.
2/2010-8/2010
Professor and Acting Chairman Department
of Pharmaceutics, Faculty of Pharmacy and
Drug Manufacturing, Pharos University,
Alexandria, Egypt (Part time).
1995 - 9/2009
Professor, Department of Pharmaceutics,
College of Pharmacy, King Saud University,
Riyadh, Saudi Arabia
1991–1995
Associate Professor, Department of
Pharmaceutics, College of Pharmacy, King
Saud University, Riyadh, Saudi Arabia.
Biography
1989 – 1991
Assistant
Professor,
Department
of
Pharmaceutics, College of Pharmacy, King
Saud University, Riyadh, Saudi Arabia
1986 – 1989
Assistant
Professor,
Department
of
Pharmaceutical Technology, College of
Pharmacy, Jordan University of Science and
Technology (JUST), Irbid, Jordan
1983 – 1985
Research Associate and Director Drug Level
Monitoring Laboratory, King Fahd Medical
Research Center, College of Medicine and
Allied Science, King Abdulaziz University,
Jeddah, Saudi Arabia.
1978 – 1983
Research Assistant, School of Pharmacy,
University of California, San Francisco, CA,
U.S.A
1980 – 1981
Teaching Assistant, School of Pharmacy,
University of California, San Francisco, CA,
U.S.A.
1977 – 1978
Assistant Lecturer, Faculty of Pharmacy,
University of Alexandria, Egypt.
1973 – 1977
Teaching Assistant, Faculty of Pharmacy,
University of Alexandria, Egypt.
COMMITTEE MEMBERSHIP:
1990–7/2009
Member Bioequivalence Committee,
College of Pharmacy, King Saud University,
Riyadh, Saudi Arabia.
2003–7/2009
Member Academic Committee and
Graduate studies, Department of
Pharmaceutics, College of Pharmacy, King
Saud University, Riyadh, Saudi Arabia.
1998–2003
Chairman, Academic Committee and
Graduate studies, Department of
Pharmaceutics, College of
Pharmacy, King Saud University, Riyadh,
Saudi Arabia
1989–1996
Chairman,
Academic
Committee,
Department of Pharmaceutics, College of
Pharmacy, King Saud University, Riyadh,
Saudi Arabia
1992–1993
Member of the Curriculum and Graduate
studies Committee, College of Pharmacy,
King Saud University, Riyadh, Saudi Arabia
1988–1989
Faculty Member of the Continuing Education
Committee, College of Pharmacy, JUST,
Irbid, Jordan.
1986–1988
Faculty Member of the Scientific Research
Committee, College of Pharmacy, JUST,
Irbid, Jordan.
1986–1989
University
Member
and
Scientific
Coordinator of the Ethical Committee, JUST,
Irbid, Jordan.
1986–1988
Faculty Member of the Scientific Research
Committee, College of Pharmacy, JUST,
Irbid, Jordan.
1986–1987
Member, Curriculum Committee, College of
Pharmacy, JUST, Irbid, Jordan.
1981–1982
Treasurer to the Graduate Student
Organization, University of California, San
Francisco, U.S.A.
1. Bioequivalence Studies
2. Bioanalytical Validation
Research
interest
3. Drug Stability Studies
4. Pharmacokinetics of Drugs
5. Drug-Drug Interactions
Books: Contributed in two chapters:
1. Wolfgang Sadee and Yousry M. El-Sayed. Antineoplastic Drugs: In Liquid
Chromatography in Clinical Analysis. Edited by Lawrence J. Marton and Pokar M. Kabra,
Chapter 9, 211-220, Humana Press, 1981.
Publications
2. Yousry M. El-Sayed and Wolfgang Sadee. Fluoropyrimidine: In Pharmacokinetics of
Anticancer Agents in Humans, Edited by Matthew M.Ames, Garth Powis, and John S.
Kovach, Chapter 9, pp. 209-227, Biomedical Press, B.V.L. Elsevier, Amsterdam, 1983.
Research Papers:
1. Y. A. Asiri, B. M. Al-Hadiya, A. A. Kadi, K. I. Al-Khamis, H. A. Mowafy and Y.M. ElSayed. Comparative bioavailability study of cefuroxime axetil (equivalent to 500
mg cefuroxime/tablet) tablets (zedand vs zinnat) in healthy volunteers.
International J. of Clinical Pharmacology and Therapeutics, 49 (9) 571-576, 2011.
2. A. M. Al-Mohizea, A. A. Kadi, A. M. Al-Bekairi, S. A. Al-Balla, M. J.Al-Yamani, K. I.
Al-Khamis, E. M. Niazy and Y.M. El-Sayed. Bioequivalence evaluation of 320 mg
gemifloxacin tablets in healthy volunteers. International J. of Clinical
Pharmacology and Therapeutics, 45 (11) 617–622, 2007.
3. Amal H. El-Kamel, Doaea H. Al-Shora, and Yousry M. El-Sayed. Formulation and
pharmcodynamic evaluation of captopril sustained release microparticles. J.
microencapsulation, 23 (4) 389–404, 2006.
4. Y. A. Asiri, M. S. Al-Said, K. I. Al-Khamis, E. M. Niazy, Y.M. El-Sayed, K. A. AlRashood , M. J.Al-Yamani, I. A. Alsarra and S. A. Al-Balla. Comparative
bioavailability study of cefixime (equivalent to 100 mg/5 mL) suspension (Winex vs
Suprax) in healthy male volunteers. International J. of Clinical Pharmacology and
Therapeutics, 43 (10) 499–504, 2005.
5. Kamal M. Matar, Esmail M. Niazy, Yousry M. El-Sayed, Mohammed J. Al-Yamani,
Saleh A. Al-Suwayeh and Khalil I. Al-Khamis. Quantitative determination of
Clavulanic acid in plasma by HPLC: Application to a pharmacokinetic study. J. of
Liquid Chromatography and Related Technologies, 28, 97-107, 2005.
6. I. Alsarra, E. Niazy, Y. El-Sayed, K. Al-Khamis, and M. Ibrahim. High performance
liquid chromatographic method for determination of doxycycline in human plasma
and its application in pharmacokinetic studies Saudi Pharmaceutical J., 13 (1), 4247 , 2005.
7. I.A. Alsarra, M.S. Al-Said, K.I. Al-Khamis, E.M. Niazy, Y.M. El-Sayed, K.A. AlRashood , M.J.Al-Yamani and S.A. Al-Balla. Comparative bioavailability study of
doxycycline hyclate (equivalent to 100 mg doxycycline) capsules (doxycin vs
vibramycin) for bioequivalence evaluation in healthy adult volunteers. International
J. of Clinical Pharmacology and Therapeutics, 42 (7) 373-377, 2004.
8. Khaled A. Khaled, Yousry M. El-Sayed, Badr M. Al-Hadiya. Disposition of the
flavonoid quercetin in rats after single intravenous and oral doses. Drug
Development and Industrial Pharmacy, 29 (4), 397-403, 2003.
9. K. A. Khaled, Y. M. El-Sayed, I. S. Al-Bawardi, and A. S. El-Gorachi. Bioavailability
of propranolol HCl following oral and transdermal administration in rabbits. Bull.
Pharm. Sci. Assiut University, 25, 105-110, 2002.
10. Khaled A. Khaled, Yousef Assiri and Yousry M. El-Sayed. In vivo evaluation of
hydrochlorothiazide liquisolid tablets in beagle dogs. International J. of
Pharmaceutics, 222, 1-6, 2001.2001.
11. Khaled A. Khaled, Ibrahim Al-Bawardi and Yousry M. El-Sayed. Effect of
formulation and penetration enhancers on the diffusional parameters for the
percutaneous absorption of propranolol hydrochloride. Bull. Pharm. Sci. Assiut
University, 24, 65-71, 2001.
12. Mansour S Al-Said, Khalil I. Al-Khamis, Esmail M Niazy, Yousry M. El-Sayed,
Khalid A Al-Rashood, Sulaiman Al-Bella, Mohammed J. Al-Yamani, Tawfeeq A AlNajjar, Syed M Alam, Ruwayda Dham Q Zaman Qumaruzaman. Bioequivalence
Evaluation of two brands of cefuroxime 500 mg tablets (Cefuzime® and Zinnat®)
in Healthy Human Volunteers. Biopharmaceutics & Drug Disposition, 21, 205-210,
2000.
13. Khalid A. Al-Rashood, Khalil I. Al-Khamis, Yousry M. El-Sayed, Suliman AlBalla, Mohammed J. Al-Yamani, S. Mahmood Alam and Ruwayda Dham.
Bioequivalence Evaluation of Norfloxacin 400 mg Tablets (Uroxin Versus Noroxin)
in Healthy Human Volunteers. Biopharmaceutics & Drug Disposition, 21, 175-179,
2000.
14. Khaled A. Khaled and Yousry M. El-Sayed. High-performance liquid
chromatographic assay for the determination of quercetin in plasma. J. of Liquid
Chromatography and Related Technologies, 23(3), 455-465, 2000.
15. Khalid A. Al-Rashood, Khalil I. Al-Khamis, Yousry M. El-Sayed, Suliman AlBalla, Mohammed J. Al-Yamani, S. Mahmood Alam and Ruwayda Dham.
Bioequivalence Evaluation of Lomefloxacin 400 mg Tablets (Lomax Versus
Maxaquin) in Healthy Human Volunteers. Biopharmaceutics & Drug Disposition,
20, 407-410, 1999.
16. Khalid A. Al-Rashood, Khalil I. Al-Khamis, Esmail M. Niazy, Yousry M. El-Sayed,
Saleh A. Al-Suwayeh, Mohammed J. Al-Yamani, Suliman A. Al-Balla, S.
Mahmood Alam and Ruwayda Dham. Comparative bioavailability study of
metronidazole 500 mg tablets (Negazole and Elyzol) for bioequivalence evaluation
in healthy adult subjects. Modern Medicine , 16 (9), 46-53, 1999.
17. Mansour S. Al Said, Khalid A. Al-Rashood, Khalil I. Al-Khamis, Esmail M. Niazy,
Yousry M.El-Sayed, Mohammed J. Al-Yamani, Suliman A. Al-Bella,Tawfik A. Al
Najjar, S. Mahmood Alam and Ruwayda Dham. Bioequivalence evaluation of 500
mg amoxicillin capsules (Julphamox Vs Amoxil) in healthy human volunteerssingle dose under fasting conditions. Modern Medicine, 16 (9), 73-77, 1999.
18. S. H. Khidr, E. M. Niazy, and Y. M. El-Sayed. Development and in-vitro
evaluation of sustained-release meclofenamic acid microspheres. J.
microencapsulation, 15, 153-162, 1998.
19. Sayed H. Khidr, Esmail M. Niazy, and Yousry M. El-Sayed. Effect of
storage
on the in-vitro and in-vivo characteristics of some marketed sustained-release
cardiovascular tablets. Bull. Pharm. Sci., Assiut University, 21 (2), 171-183, 1998.
20. Mohammad J.M.S. Al-Yamani, Khalil I. Al-Khamis, Yousry M. El-Sayed, Saleh.
A. Bawazir, K.A. Al-Rashood, and M. Wafik Gouda. Comparative bioavailability of
two tablet formulations of acyclovir in healthy volunteers. International J. of
Clinical Pharmacology and Therapeutics, 36 (4) 222-226, 1998.
21. S.A. Bawazir, M. Wafik Gouda, Y.M. El-Sayed, K.I. Al-Khamis, M.J.Al-Yamani, E.M
Niazy, and K.A. Al-Rashood. Comparative bioavailability of two tablet formulations o
ranitidine Hydrochloride in healthy volunteers. International J. of Clinical Pharmacolog
and Therapeutics, 36 ( 54) 270-274, 1998.
22. Khalil I. Al-Khamis, Juzar S. Kaka, Mohammad J. Al-Yamani, Sulaiman Al-Balla, You
M. El-Sayed, and Saleh A. Khalil. Bioequivalence of commercial ranitidine table
Alexandria J. Pharmaceutical. Sci., 10 (2) 97-100 , 1996.
23. Esmail M. Niazy, Yousry M. El-Sayed and Sayed H. Khidr. Effect of accelerated stora
conditions on the dissolution and bioavailabilityof amitriptyline from sustained-relea
capsules. Saudi Pharmaceutical J., 4 , ( 2 ) 92-98 , 1996.
24. Yousry M. El-Sayed. Predictive performance of four pharmacokinetic methods for
calculating digoxin dosage. J. of Clinical Pharmacy and Therapeutics, 20, 297-304
, 1995.
25. El-Sayed, Y.M., Khidr, S.H., and Niazy, E.M. High-performance liquid
chromatographic assay for the determination of haloperidol in plasma. J. of
Liquid Chromatography, 19 ( 1 ) , 125-134 , 1995.
26. Esmail M. Niazy, Yousry M. El-Sayed and Sayed H. Khidr. Rapid highperformance liquid chromatographic analysis of procainamide and Nacetylprocainamide in plasma. Saudi Pharmaceutical J., 4 ,29-35 , 1995.
27. Esmail M. Niazy, Yousry M. El-Sayed and Sayed H. Khidr. Effect of formulations
and penetration enhancers on percutaneous absorption of haloperidol. Saudi
Pharmaceutical J., 2 (3), 123-129, 1995.
28. Mohammad J.M.S. Al-Yamani, Yousry M. El-Sayed, J.S. Kaka, S.R. Al-Balla, A.
Al-Shareef and Khalil I. Al-Khamis. Comparative bioavailability of three
commercially available cimetidine tablet formulations in healthy male volunteers.
Saudi Pharmaceutical J., 3, 196-200, 1995.
29. M. E. Abdullah and Yousry M. El-Sayed. Design of crossover microcomputer
program and application on drug bioequivalence data. Computer Methods and
Programs in Biomedicine, 48, 237-239, 1995.
30. Sayed H. Khidr, Esmail M. Niazy, and Yousry M. El-Sayed. Preparation and invitro evaluation of sustained-release metoclopramide hydrochloride microspheres.
J. microencapsulation, 12, 651- 660, 1995.
31. Yousry M. El-Sayed, Esmail M. Niazy and Sayed H. Khidr. In-vivo evaluation of
sustained-release microspheres of metoclopramide hydrochloride in beagle dogs.
International J. of Pharmaceutics, 123, 113-118,1995.
32. Yousry M. El-Sayed, Khalid F. Tabbara and M. Wafik Gouda. Effect of
acetazolamide on the pharmacokinetics of cyclosporin in rabbits. International J.
of Pharmaceutics, 121, 181-186, 1995.
33. Yousry M. El-Sayed, M. Wafik Gouda, Khalil I. Al-Khamis, Mohammed A.
AlMeshal, Abdulatif A. Al-Dhawailie, Sabah Al-Rayes, Salih A. Bin-Salih and Khalid
A. Al-Rashood. Comparative bioavailability of two tablet formulations of ibuprofen.
International J. of Clinical Pharmacology and Therapeutics,33 (5), 294-298, 1995.
34. Yousry M. El-Sayed, Esmail M. Niazy, Sabah Al-Rayes, Atef O. Ismail and
M.Wafik Gouda. Comparative bioavailability of two tablet formulations of
metoclopramide hydrochloride. International J. of Clinical Pharmacology and
Therapeutics, 32(3), 136-139, 1995.
35. El-Sayed, Y. M., Niazy, E.M. and Khidr, S.H. High-performance liquid
chromatographic method for the quantitative determination of pheniramine in
plasma. J. of Liquid Chromatography, 18 (4), 763-777, 1995.
36. Yousry M. El-Sayed. A simple high-performance liquid chromatographic assay for
sparfloxacin in human plasma. Analytical Letters, 28 (2), 279-293, 1995.
37. Niazy, E.M., El-Sayed, Y. M. and Khidr, S.H. Analysis of prazosin in plasma by
high-performance liquid chromatography using fluorescence detection. J. of Liquid
Chromatography, 18 (5), 977-987, 1995.
38. Al-Khamis, K.I., El-Sayed, Y.M., Al-Rashood, K.A. and Bawazir, S.A. Highperformance liquid chromatographic determination of ranitidine in human plasma.
J. of Liquid Chromatography, 18 (2), 277-286, 1995.
39. Al-Khamis, K.I., Jim, L.K., Bawazir, S.A., Ashour, L.F., El-Sayed, N. and
ElSayed, Y. M. Effect of famotidine on ciprofloxacin pharmacokinetics after single
intravenous and oral doses in rats. J. of Clinical Pharmacy and Therapeutics, 19,
335-339 , 1994.
40. M. Wafik Gouda, Yousry M. El-Sayed, Mohamed A. Al-Meshal, Esmail M. Niazy,
Sabah Al-Rayes and Atef O. Ismail. Comparative bioavailability of two tablet
formulations of diclofenac sodium. Saudi Pharmaceutical J., 2 (2), 90-93, 1994.
41. El-Sayed,Y.M. Correlation between nephrotoxicity and pharmacokinetic
parameters of gentamicin. J. of Clinical Pharmacy and Therapeutics. 19, 267-271,
1994.
42. Ehab A. Hosny, Yousry M. El-Sayed, Mohamed A. Al-Meshal and Abdulaziz A.
Al-Angary. Effect of food on bioavailability of bioadhesive-containing indomethacin
tablets in dogs. International J. of Pharmaceutics, 112, 87-91, 1994.
43. Al-Balla, S.R., El-Sayed, Y. M., Al-Meshal, M.A. and Gouda, M.W. The effect of
cholestyramine and colestipol on the absorption of diclofenac in man. International
J. of Clinical Pharmacology and Therapeutics, 32 (8), 441-445, 1994.
44. Mohamed A. Al-Meshal, Yousry M. El-Sayed, Sulaiman R. Al-Balla, M. Wafik
Gouda. The effect of colestipol and cholestyramine on ibuprofen bioavailability in
man. Biopharmaceutics and Drug Disposition, 15, 463-471, 1994.
45. Yousry M. El-Sayed, Mohamed A. Al-Meshal, Abdulaziz A. Al-Angary, Sulaiman
R. Al-Balla and M. Wafik Gouda. Effects of oral administration of colestipol and
cholestyramine on the pharmacokinetics of ketoprofen administered
intramuscularly in man. International J. of Pharmaceutics, 109, 107-113, 1994.
46. E.M. Niazy, S.H. Khidr and Y. M. El-Sayed. High-performance liquid
chromatographic determination of meclofenamate sodium in plasma. J. of
Chromatography, 17 (11), 2331-2341, 1994.
47. M.A. Bayomi and Y. M. El-Sayed. Casein microbeads as a controlled parenteral
drug delivery system. Drug Development and Industrial Pharmacy,20 (16), 26072617, 1994.
48. Khalil I. Al-Khamis, Yousry M. El-Sayed, Khalid A. Al-Rashood and Mohamed AlYamani. High-performance liquid chromatographic method for determination of
glibenclamide in human plasma. Analytical Letters, 27 (6),1277-1293, 1994.
49. Yousry M. El-Sayed, Sayed H. Khidr and Esmail M. Niazy. A rapid and sensitive
high-performance liquid chromatographic method for the determination of
metoclopramide in plasma and its use in pharmacokinetic studies. Analytical
Letters, 27 (1), 55-70, 1994.
50. Yousry M. El-Sayed, Mohamed A. Al-Meshal, Abdulaziz A. Al-Angary, Khalil M.
Lutfi and M. Wafik Gouda. The effect of colestipol and cholestyramine on the
systemic clearance of intravenous ibuprofen in rabbits. J. of Pharmacy and
Pharmacology, 46, 73-75, 1994.
51. Yousry M. El-Sayed, Mohamed A. Al-Meshal, Abdulaziz A. Al-Angary and Khalil
M. Lutfi. Effect of colestipol on indomethacin pharmacokinetics in rabbits. Saudi
Pharmaceutical J., 1, 56-61, 1993.
52. Khalid F. Tabbara, Yousry M. El-Sayed, Hendrik Cooper, and Sawsan Nowailaty.
Ocular bioavailability of cyclosporin in pigmented and albino rabbits. Recent
Advances in Uveitis, 501-507, 1993.
53. Y. M. El-Sayed, E.M. Niazy and S.H. Khidr. High-performance liquid
chromatographic method for the determination of nifedipine in plasma and its use
in pharmacokinetic studies. J. of Clinical Pharmacy and Therapeutics, 18, 325330, 1993.
54. El-Sayed, Y. M., Niazy, E.M., Tawfik, A.F., Al-Dardiri, M.M. Effect of oral
activated charcoal on vancomycin clearance in rabbits with acute renal failure.
Drugs under Experimental and Clinical Research, XIX (1), 19-24, 1993.
55. M.A. Al-Meshal, Y. M. El-Sayed, A.A. Al-Angary and M.M. Al-Dardiri. Effect of
oral activated charcoal on propranolol pharmacokinetics following intravenous
administration to rabbits. J. of Clinical Pharmacy and Therapeutics, 18, 39-44,
1993.
56. M. Hasan, N. Najib, M. Suleiman, Y. El-Sayed and M. Abdel-Hamid. In-vitro and
in-vivo evaluation of sustained-release and enteric- coated microcapsules of
diclofenac sodium. Drug Development and Industrial Pharmacy, 18, 1981-1988,
1992.
57. A.A. Al-Angary, Y. M. El-Sayed, M.A. Al-Meshal, M.M. Al-Dardiri and G. M.
Mahrous. A sensitive high-performance liquid chromatographic analysis of
propranolol in serum. J. of Clinical Pharmacy and Therapeutics, 16, 93-101, 1991.
58. Y. M. El-Sayed and M.M. Hasan. Enhancement of morphine clearance following
intravenous administration by oral activated charcoal in rabbits. J.of Pharmacy
and Pharmacology, 42, 538-541, 1990.
59. Yousry M. El-Sayed, Mohamed A. Al-Meshal, Abdulaziz A. Al-Angary, Khalil M.
Lutfi and M. Wafik Gouda. Accelerated clearance of intravenous indomethacin by
oral activated charcoal in rabbits. International J. of Pharmaceutics, 64, 109-115,
1990.
60. Mohamed A. Al-Meshal, Yousry M. El-Sayed, Abdulaziz A. Al-Angary, Khalil M.
Lutfi and M. Wafik Gouda. Interruption of the enterohepatic circulation of
indomethacin by cholestyramine in rabbits. International J. of Pharmaceutics, 64,
155-160, 1990.
61. A.A. Al-Angary, Y.M. El-Sayed, M.A. Al-Meshal and K.M. Lutfi. High-performance
liquid chromatographic analysis of indomethacin in serum. J. of Clinical Pharmacy
and Therapeutics, 15, 257-265, 1990.
62. Yousry M. El-Sayed and Samira I. Islam. Comparison between non-kinetic and
kinetic approach for individualization of gentamicin dosage. European J. of
Clinical Pharmacology, 39, 155-159, 1990.
63. M.M. Hasan, Y.M. El-Sayed and A.A. Abdulaziz. The effect of oral activated
charcoal on the systemic clearance of gentamicin in rabbits with acute renal
failure. J. of Pharmacy and Pharmacology, 42, 85-88, 1990.
64. Y.M. El-Sayed, M.S. Suleiman, M.M. Hasan, M.E. Abdel-Hamid, N.M. Najib,
E.S.E. Sallem and M.S. Shubair. Comparison of the pharmacokinetics and
pharmacodynamics of two commercial products containing glibenclamide.
International J. of Clinical Pharmacology Therapy and Toxicology, 27, 551-557,
1989.
65. M.S. Suleiman, H.Y. Muti, M.E. Abdel-Hamid, M. Hasan, Y.M. El-Sayed and N.M.
Najib. A stability-indicating HPLC analysis of famotidine and its application to
kinetic studies. Analytical Letters, 22, 1499-1512, 1989.
66. Yousry M. El-Sayed and Samira I. Islam. Effect of age and renal function on
gentamicin pharmacokinetic parameters. International J. of Clinical Pharmacology
Therapy and Toxicology, 27, 503-509, 1989.
67. Y. M. El-Sayed and S.I. Islam. Acetylation phenotyping of isoniazid using a
simple and accurate high-performance liquid chromatography. J. of Clinical
Pharmacy and Therapeutics, 14, 197-205, 1989.
68. M. E. Abdel-Hamid, M.S. Suleiman, Y.M. El-Sayed, N.M. Najib and M.M. Hasan.
A rapid high performance liquid chromatographic assay of glibenclamide in serum.
J. of Clinical Pharmacy and Therapeutics, 14, 181-188, 1989.
69. M.S. Suleiman, N. Najib, Y. El-Sayed, M. Hasan and M. Abdel-Hamid. A study on
the relative bioavailability of a sustained-release formulation of diclofenac sodium.
International J. of Clinical Pharmacology Therapy and Toxicology, 27, 276-279,
1989.
70. M.S. Suleiman, N.M. Najib, Y.M. El-Sayed and A. Badwan. Stability-indicating
high-performance liquid chromatographic assay for the determination of
metoclopramide in pharmaceutical dosage forms. Analyst. 114, 365-368, 1989.
71. Yousry M. El-Sayed and Samira I. Islam. Phenytoin Michaelis-Menten
Pharmacokinetics
in
Saudi
patients.
International
J.
of
Clinical
PharmacologyTherapy and Toxicology. 27, 173-178, 1989.
72. Yousry M. El-Sayed. Performance of two predictive methods for calculation of
key pharmacokinetic parameters for gentamicin dosage individualization. J. of
Clinical Pharmacy and Therapeutics, 14, 119-126, 1989.
73. Yousry M. El-Sayed and Samira I. Islam. Comparison of fluorescence
polarization immunoassay and high-performance liquid chromatography for the
determination of theophylline in serum. J. of Clinical Pharmacy and Therapeutics,
14, 127-134, 1989.
74. H. N. Alkaysi, M.A. Sheikh Salem, A.M. Gharaibeh, Y.M. El-Sayed, K.I. Ali
Gharaibeh, and A.A. Badwan. Bioequivalency of ranitidine tablet dosage forms. J.
of Clinical Pharmacy and Therapeutics, 14, 111-117, 1989.
75. Yousry M. El-Sayed and Samira I. Islam. High performance liquid
chromatographic analysis of theophylline in serum and its use in therapeutic drug
monitoring. J. of Clinical Pharmacy and Therapeutics, 14, 35-43, 1989.
76. Y.M. El-Sayed, M.S. Suleiman, M. Hasan, N. Najib, H. Muti, and M.
Abdulhameed. Comparative bioavailability and in-vitro characterization of two
brands of diclofenac sodium enteric-coated tablets. International J. Clinical
Pharmacology Therapy and Toxicology, 26, 487-491, 1988.
77. M.S. Suleiman, N.M. Najib, Y.M. El-Sayed and M.E. Abdel-Hamid. A
bioequivalence study of six brands of cephalexin. J. of Clinical Pharmacy and
Therapeutics, 13, 65-72, 1988.
78. Osama S. Tayeb, Abdullah M. Al-Fares, Yousry M. El-Sayed and Samira I.
Islam.Correlation between predicted and measured digoxin serum concentration.
J. of Clinical Pharmacy and Therapeutics, 13, 159-163, 1988.
79. Hanan N. Alkaysi, Mutaz Sheikh Salem, and Yousry M. El-Sayed. High
performance liquid chromatographic analysis of caffeine concentrations in plasma
and saliva. J. of Clinical Pharmacy and Therapeutics, 13, 109-115, 1988.
80. Yousry M. El-Sayed, Mohamed E. Abdel-Hamid, Mohammed S. Suleiman and
Naji M. Najib. A rapid and sensitive high-performance liquid chromatographic
method for the determination of diclofenac sodium in serum and its use in
pharmacokinetic studies. J. Pharmacy and Pharmacology, 40, 727-729, 1988.
81. N.M. Najib, M.S. Suleiman, Yousry M. El-Sayed and M.E. Abdel-Hamid. High
performance liquid chromatographic analysis of cephalexin in serum and urine.J.
of Clinical Pharmacy and Therapeutics, 12, 419-426, 1987.
82. Mohamed E. Abdel-Hamid, Naji M. Najib, Mohammad S. Suleiman and Yousry
M. El-Sayed. Differential spectrophotometric, fluorimetric and high-performance
liquid chromatographic determination of diflunisal and its tablets. Analyst, 122,
1527-1530, 1987.
83. Siraj A. Mira, Yousry M. El-Sayed and Samira I. Islam. Simultaneous
measurement of phenobarbital, carbamazepine, phenytoin and 5- (4hydroxyphenyl)-5-phenylhydantoin in serum by high performance liquid
chromatography. Analyst. 122, 56-60, 1987.
84. Abdul Rahman Ashy, Yousry M. El-Sayed and Samira I. Islam. Comparison of
fluorescence polarization immunoassay and high performance liquid
chromatography for quantitative determination of phenytoin, phenobarbital and
carbamazepine in serum J. of Pharmacy and Pharmacology, 38, 572-577, 1986.
85. Abdullah M. Al-Fares, Siraj A. Mira and Yousry M. El-Sayed. Evaluation of the
fluorescence polarization immunoassay for quantitation of digoxin in serum. J.of
Therapeutic Drug Monitoring, 6, 454-457, 1984.
86. Bin Trong Nguyen, Yousry M. El-Sayed and Wolfgang Sadee. Interaction among
the distinct effects of adenine and guanine depletion in mouse lymphoma cells.
Cancer Research, 44, 2272-2277, 1984.
87. Yousry M. El-Sayed and Wolfgang Sadee. Metabolic activation of (R,S-1(tetrahydro-2-furanyl)-5-Fluorouracil (FTORAFUR) to 5-Fluorouracil by soluble
enzymes. Cancer Research, 43, 4039-4044, 1983.
88. Yousry M. El-Sayed and Wolfgang Sadee. Metabolic activation of Ftorafur (R,S1-(tetrahydro-2-furanyl)-5-Fluorouracil, FT). The microsomal oxidative pathway.
Biochem. Pharmacol., 31, 3006-3008, 1982.
89. M. Abdel-Hady El-Sayed, Yousry M. El-Sayed and H. Abdine. Use of an
orthogonal function in differential spectrophotometry. Analyst. 105, 222-226, 1980.
90. M. Abdel-Hady El-Sayed, Yousry M. El-Sayed and H. Abdine.
Spectrophotometric determination of theophylline formulation. J. Pharm. Sci., 63,
9-11, 1979.
91. H. Abdine, M. Abdel-Hady El-Sayed and Yousry M. El-Sayed. pH induced
difference spectrophotometric assay of acetazolamide, hydrochlorothiazide and
furosemide. J. Assoc. Off. Anal. Chem., 61, 695-701, 1978.
92. H. Abdine, M. Abdel-Hady El-Sayed and Yousry M. El-Sayed.
Spectrophotometric determination of hydrochlorothiazide and reserpine in
combination. Analyst. 103, 354-358, 1978.
93. M. A. El-Sayed, H. Abdine and Y.M. El-Sayed. Use of first derivative absorption
spectrum in quantitative analysis of theobromine-sodium salicylate mixture. Acta
Pharm. Juguslav., 27, 161-165, 1977.
CONFERENCES:
Participated in the following Scientific Conferences. (Abstracts) are:
1. Yousry M. El-Sayed and Wolfgang Sadee. Metabolic activation of Ftorafur (R,S-1(tetrahydro-2-furanyl)-5-Fluorouracil. FT). Second Annual West Coast
Pharmaceutics Meeting, Vol. 2, 11, University of California, San Francisco,
September 1981.
2. Yousry M. El-Sayed and Wolfgang Sadee. Metabolic activation of Ftorafur (R,S-1(tetrahydro-2-furanyl)-5-Fluorouracil. FT). The microsomal oxidative pathway.
Proc. Am. Pharmaceut. Assoc. Acad. Pharm. Sci., Vol. 11, No. 2,104, 1981.
3. Yousry M. El-Sayed and Wolfgang Sadee. Metabolic activation of Ftorafur (R,S-1(tetrahydro-2-furanyl)-5-Fluorouracil. FT). The soluble enzyme pathway. Proc. Am.
Pharmaceut. Assoc. Acad. Pharm. Sci., Vol. 12, No.2, 172, 1982.
4. Binh T. Nguyen, Yousry M. El-Sayed and Wolfgang Sadee. Purine starvation:
Inhibition of early de novo biosynthesis versus selective depletion of guanine or
adenine. Proc. Am. Assoc. Cancer Research. 301: 1191, 1983.
Conferences
and
workshops
5. Wolfgang Sadee and Yousry M. El-Sayed. Mechanism of metabolic activation of
Tegafur. Proc. Int. Symp. of Fluoropyrimidine, Nagoya, Japan, Nov. 1983.
(Awarded Achievement recognition in USA-Japan, International Workshop on
Tegafur (Ftorafur)).
6. Yousry M. El-Sayed, Siraj A. Mira and Samira I. Islam. Simultaneous
measurement of phenobarbital, carbamazepine, phenytoin and 5-(4hydroxyphenyl)-5-phenylhydantoin in serum by high pressure liquid
chromatography. Proc. Am. Pharmaceut. Assoc. Acad. Pharm. Sci., Vol. 14, No.
2, 277, 1984.
7. Osama S. Tayeb, Abdullah M. Al-Fares, Yousry M. El-Sayed and Samira I. Islam.
Correlation between predicted and measured digoxin serum concentration. Proc.
Am. Pharmaceut. Assoc. Acad. Pharm. Sci. Vol. 14, No. 2, 234, 1984.
8. Samira I. Islam, Siraj A. Mira, Hassan M.A. Farsi and Yousry M. El-Sayed.
Increased risk for nephrotoxicity in patients treated with gentamicin and
furosemide. North American Symposium on Risk Assessment and The Biological
Fate of Xenobiotics. 28, Nov. 1985.
9. Samira I. Islam, Abdullah M. Al-Fares, Osama S. Tayeb, Siraj A. Mira, and Yousry
M. El-Sayed. Caffeine clearance in patients with liver diseases. NorthAmerican
Symposium on Risk Assessment and The Biological Fate of Xenobiotics. 29, Nov.
1985.
10. Yousry M. El-Sayed, Mohamed E. Abdel-Hameed, Mohammad S. Suleiman, Naji
M. Najib. A rapid and sensitive high-performance liquid chromatographicmethod
for the determination of diclofenac sodium in serum and its use in pharmacokinetic
studies. 4th Jordanian Pharmaceutical Meeting, Amman, Jordan, April 1988.
11. Khalid F. Tabbara, Yousry M. El-Sayed. Ocular bioavailability of cyclosporine in
pigmented and albino rabbits. The American Association for Research in Vision
and Ophthalmology, April 29 - May 4, 1990, Sarasota, Florida, U.S.A.
12. Mohamed A. Al-Meshal, Yousry M. El-Sayed, Abdulaziz A. Al-Angary, Khalil M.
Lutfi and M. Wafik Gouda. Effects of colestipol and cholestyramine on Ibuprofen
clearance after intravenous administration in rabbits. Interscience World
Conference on inflammation, antirheumatics, analgesics,immunomodulators. April
25-28, 1993, Geneva, Switzerland.
13. Esmail M. Niazy, Yousry M. El-Sayed and Sayed H. Khidr. Effect of formulation
and penetration enhancers on percutaneous absorption ofhaloperidol. American
Association of Pharmaceutical Scientists (AAPS). Pharmaceutical Research, Vol.
11, No. 10 (Supplement) S194, San Diego, California, 1994.
14. Sayed H. Khidr, Esmail M. Niazy and Yousry M. El-Sayed. Preparation and invitro evaluation of sustained-release metoclopramide microspheres. American
Association of Pharmaceutical Scientists (AAPS). Pharmaceutical Research,Vol.
11, No. 10 (Supplement) S 287, San Diego, California, 1994.
15. Amal H. El-Kamel, Doaea H. Al-Shora, Yousry M. El-Sayed. Formulation and
evaluation of captopril microparicles. The 6th Saudi Pharmaceutical International
Conference, Riyadh, Saudi Arabia, October 6-9, 2003.
16. Yousry M. El-Sayed. Bioequivalence resolved and unresolved issues. The 9 th
International Pharmaceutical Sciences Conference and Exposition and the 9 th
General Assembly Meeting of Scientific Society of Colleges of Pharmacy of the
Association of Arab Universities in the Arab World,. College of Pharmacy, King
Saud University, December 17-21, 2005.
PROFESSIONAL SERVICES:

Professional
and scientific
Activities




Participated in establishing drug level monitoring services in King Abdulaziz
University Hospital, Jeddah, Saudi Arabia.
Participated in establishing the individual patient’s pharmacokinetic
parameters of phenytoin and gentamicin in Saudi patients.
Design, conduct and interpretation of several bioequivalence studies,
College of Pharmacy, King Saud University.
Evaluation of several bioavailability-bioequivalence studies submitted to the
Executive Office, Ministries of Health for Gulf Cooperation Council.
Evaluation of several bioavailability-bioequivalence studies submitted to the
College of Pharmacy, King Saud University.
CONSULTATIONS:

Member of the Stability Committee for the Saudi Food and Drug Authorities
(SFDA).

Member of the drug and Pharmaceutical Companies Registration
Committee, Ministry of Health, Kingdom of Saudi Arabia.

Member of the Committee for establishing guidelines on stability testing
requirements of pharmaceutical products for registration in the GCC
countries, Executive Office, Ministries of Health for Gulf Cooperation
Council.

Established guidelines on drug bioequivalence requirements in the GCC
countries, Executive Office, Ministries of Health for Gulf Cooperation
Council.

Consultant to several international pharmaceutical companies on drug
product stability and drug bioequivalence.

Consultant to several international pharmaceutical research centers on
drug bioequivalence.

Consultant to several international pharmaceutical companies and research
centers on the regulatory requirements regarding drug stability and
bioequivalence.

Writing Expert Report for several drug products for several pharmaceutical
companies.
INVITED LECTURES:
1997
1998
“Fundamentals of Bioavailability”
“Fundamentals of Bioequivalence Studies”
“Statistical Analysis of Bioequivalence Studies”
Invited by the Executive Office, Ministries of Health for Gulf
Cooperation Council, 25 – 26 November, 1997, Dubai, U.A.E.
“Profinal Bioequivalence Study”
Invited by Gulf Pharmaceutical Industries, March 16 TH, 1998, Beirut,
Lebanon.
1998
“Review of Principals of Bioavailability and Bioequivalence”
“Statistical Considerations in Bioequivalence assessment”
Invited by Arab Company for Drug Industries & Medical Appliances
(ACDIMA), November 28 – 29, 1998, Tunis.
2005
”Bioequivalence: Resolved and Unresolved Issues”
Invited by the The 9th International Pharmaceutical Sciences
Conference and Exposition and the 9th General Assembly Meeting of
Scientific Society of Colleges of Pharmacy of the Association of Arab
Universities in the Arab World,. College of Pharmacy, King Saud
University, December 17-21, 2005.
2007
“Bioequivalence: Statistical Analysis and Acceptance Criteria”
Invited by the Saudi Food and Drug Authorities, November, 2007,
Riyadh
2008
”Bioequivalence: An overview of statistical methods”
Invited by the 1st International Riyadh Military Hospital Conference,
Riyadh, Saudi Arabia, April 28-30, 2008.
TRAINING COURSES ATTENDED:

Abbott Diagnostic Company, Wiesbaden, Germany, 1983.

Post Market Surveillance Training Seminar. U.S. Food & Drug
Administration and General Directorate of Medical & Pharmaceutical
Licenses, May 25 – 27, 1998, Riyadh, Saudi Arabia.

Generic Drugs: U.S. Regulatory and Scientific Perspective: Training
Seminar. U.S. Food & Drug Administration and General Directorate of
Medical & Pharmaceutical Licenses, September 27 - 29, 1998, Riyadh,
Saudi Arabia.
FUNDED RESEARCH GRANTS AND CONTRACTS:

"Design, preparation and evaluation studies of pharmaceutical dosage
forms (sustained-release) suitable for the Kingdom of Saudi Arabia",
funded by King Abdulaziz City for Science and Technology (KACST) (Grant
# AR-12-52). Budget SR 654300.00

"Effect of oral activated charcoal on the systemic clearance and other
pharmacokinetic parameters of drugs administered parenterally", funded by
the Research Center, College of Pharmacy, King Saud University, Riyadh,
Saudi Arabia(Grant # CPRC-39). Budget SR 119000.00.

"Therapeutic Drug Monitoring", funded by the Deanship of Scientific
Research, JUST, Irbid, Jordan (Grant # 42/87). Budget JD 6000.00.

"The use of caffeine as an indicator for liver function in Jordanian
population", funded by the Deanship of Scientific Research, JUST, Irbid,
Jordan (Grant # 49/87). Budget JD 3728.00.

"A prodrug approach to modify the physico-chemical properties of drugs",
funded by the Deanship of Scientific Research, JUST, Irbid, Jordan (Grant
# 23/87). Budget JD 3700.00.

"An analytical approach to the quantitation of some drugs in dosage forms
and biological fluids",funded by the Deanship of Scientific Research, JUST,
Irbid, Jordan (Grant # 10/87). Budget JD 4400.00.

Participated in designing, implementing and interpreting several
bioavailability-bioequivalency
studies
for
various
Pharmaceutical
Companies and Health Authorities, College of Pharmacy, King Saud
University, Riyadh, Saudi Arabia.
Designed, conducted, supervised, pharmacokinetics evaluation and statistical
analysis of the following bioequivalence studies:
Diclofenac sodium (enteric-coated)
Rifampin
Diclofenac sodium (sustained-release)
Norfloxacin
Metoclopramide hydrochloride
Lomefloxacin
Atenolol
Cefaclor (suspension)
Glibenclamide
Cefaclor (capsules)
Acyclovir
Amoxycillin (capsules)
Ibuprofen
Amoxycillin (suspension)
Mefenamic acid
Amoxycillin (tablets)
Cimetidine
Ciprofloxacin
Ranitidine
Metronidazole
Furosemide
Nifedipine
Cephalexin
Cefixime
Amoxycillin + Clavulanic acid
Azithromycin
Doxycycline hyclate
Captopril
Captopril
Cefadroxil
Alendronate
Sildenafil
Gliclazide
Glimepiride
Gemifloxacin
Ofloxacin
Cefuroxime axetil
HONORS AND ACHIEVEMENTS:






B. Pharm. Sci. with "DISTINCTION HONOR" (1973).
Awarded Achievement Recognition in the USA-Japan, International
Workshop on Tegafur ( Ftorafur ) (1983).
Recognized for excellence in teaching, (Biopharmaceutics and
Pharmacokinetics; Pharm. 322), College of Pharmacy, JUST, Irbid, Jordan
(1987).
Recognized for excellence in teaching, (Clinical Pharmacokinetics; Pharm.
411), College of Pharmacy, JUST, Irbid, Jordan (1988).
Selected to be included in Marquis Who’s Who in the World (1998).
Selected to be Man of the Year by the American Biographical Institute, Inc
(1998).
EDITORIAL:

International Editorial Advisory Board of Generic and Biosimilars Initiative
Journal (2010 to date):
The Editorial Board of the Saudi Pharmaceutical Journal (1995-2002).
Advisory Board of the Saudi Pharmaceutical Journal (2002-Now).


REFEREE:






Clinical Pharmacokinetics (Adis Press Publication).
King Abdulaziz City for Science and Technology (KACST).
Saudi Pharmaceutical Journal.
Annals of Saudi Medicine.
Journals of the College of Science, King Saud University.
Derasat (Jordan University).
TEACHING EXPERIENCE:
(I) Undergraduate courses:
Biopharmaceutics, Basic Pharmacokinetics, Clinical Pharmacokinetics, Dispensing of
Medications, Physical Pharmacy, Pharmaceutical Terminology and Advanced
Pharmaceutics.
(II) Graduate Courses:
Advanced Biopharmaceutics, Modern Drug Delivery Systems, Research Design.
(III) Thesis Supervision:
M.Sc. Thesis at College of Pharmacy, King Saud University.
Title: “Study on the percutaneous absorption of propranolol: Effect of formulations
and penetration enhancers”.
M.Sc. Thesis at College of Pharmacy, King Saud University.
Title: “Formulation and evaluation of sustained release captopril
microparticles”.