OIST SEMINAR
Genomics and Regulatory Systems Unit
DATE: Tuesday, October 14,
TIME: 13:00-14:00
VENUE: C 209, Center bldg
Speaker: Dr. Steven Rosanoff
European Bioinformatics Institute (EBI)
Steven Rosanoff currently works at the European Bioinformatics Institute in Cambridge, England as a database engineer and software developer for UniProt. Prior to his
current position, Steven worked as an Oracle data base administrator for the New York State government in the United States and he received his degree in Computer
Science and Applied Mathematics from the University of Albany in New York.
http://www.ebi.ac.uk/
http://www.ebi.ac.uk/training/workshop/uniprot-protein-databases-tools-oist-2014
Contents:
-Biological introduction 15 mins
"Human transcription factor isoforms: how alternative splicing events affect their regulatory function"
Speaker: Dr. Alessandra Vigilante
Luscombe Group www.luscombelab.org
University College London UCL Genetics Institute, Dept of Genetics, Evolution & Environment,
【abstract】
Transcription factors (TFs) represent key components of the gene regulatory machinery: they are typically DNA-binding proteins
that interact with specific genomic regions in the neighbourhood of the target gene, promoting or suppressing its expression.
TFs are themselves controlled both at the transcriptional level, and by post-transcriptional steps including alternative splicing, a
mechanism that produces a variety of protein isoforms with potentially distinct functions from a single gene. This seminar will
provide a detailed overview of the main possible alternative splicing scenario detected among alternative spliced TF protein
isoforms, their classification and the impact they have on the TF regulatory activity and will introduce to some of the biological
information you can retrieve via the bioinformatic platforms UniProt.
-Uniprot seminar 30 mins , Uniprot practical 15 mins
“UniProt: How-To Maximize Your Functional & Structural Analysis of Proteins”
(Specific use-cases will focus on transcription factor genes).
Speaker: Dr. Steven Rosanoff
European Bioinformatics Institute (EBI)
【abstruct】
UniProt provide the scientific community with a comprehensive, highly-quality, and freely accessible resource of protein
sequence and functional information. This seminar will explain how UniProt annotate and cross-reference data from around the
globe; show what kinds of information are available in UniProt, how to access it, and how to search the database.
During this seminar you will learn about:
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UniProt User-Interface
Using Filters and Queries to search UniProt
UniProt BLAST/Align/ List Conversion Tools
Programmatic Access to UniProt using as specific-use cases transcription factor genes
**Please bring your PC