UniProtKB/Swiss-Prot

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www.uniprot.org

www.expasy.org

Swiss-Prot group activities

Swiss Institute of Bioinformatics – Geneva in collaboration with the UniProt Consortium

The main focus of the Swiss-Prot group is to provide the scientific community with the most accurate protein sequences associated with a high level of functional annotation, in an user friendly format allowing easy data retrieval and analysis. The group is involved in the production of the manually curated

UniProtKB/Swiss-Prot knowledgebase (www.uniprot.org), the ENZYME nomenclature database (http://www.expasy.org/enzyme) , the protein families and domains PROSITE database (http://www.expasy.org/prosite) and the taxonomy database (http://www.uniprot.org/taxonomy/)

Protein Annotation Programs

- Vertebrates (CD2)

- Bacteria and Archae (HAMAP)

- Plants (PPAP)

- Fungi (FPAP)

- Viruses

- Dictyostelium discoideum

- Drosophila and C.elegans

- Toxins (Tox-Prot)

- Controlled vocabulary (GO annotation)

- Post-translational modifications (PTMs)

- Integration of proteomic data

- Integration of 3D structure information

- Human polymorphisms and diseases

- Quality Assurance

Research

- Calipho

Computer Analysis and Laboratory Investigation of Proteins of Human Origin

- Phylogeny

- Text mining

- Sequence analysis tool development

- Knowledge management of human variants

Software development

- Annotation platform development and maintenance

- UniProtKB/Swiss-Prot release

- ExPASy and UniProt websites

Service, education and popular science

- User support

- Courses and tutorials (e-Proxemis)

- Master in Proteomics and Bioinformatics

- Doctoral school (SIB)

- Protein Spotlight

(www.expasy.org/spotlight/)

- Protéines à la ‘Une’

(www.expasy.org/prolune/)

Electronic publications

Contact

Swiss-Prot group

Swiss Institute of Bioinformatics

Centre Médicale Universitaire

1 Michel Servet

1211 Geneva 4

Phone: + 41 22 379 50 50

Fax: + 41 22 379 58 58 swiss-prot@expasy.org

The team

Amos Bairoch and Lydie Bougueleret

(group leaders)

50 annotators (life science background),

13 programmers, 8 reseachers,

15 persons involved in system administration, service/education and administration.

The Swiss-Prot group is part of the Swiss Institute of Bioinformatics (SIB) and of the UniProt Consortium.

Swiss-Prot group activities are supported by the Swiss Federal Government through the Federal Office of Education and

Science and by the National Institutes of Health (NIH) grant 2 U01 HG02712-04. Additional support comes from the

European Commission contract FELICS (021902RII3) and from the PATRIC BRC (NIH/NIAID contract HHSN

266200400035C).

Swiss Institute of Bioinformatics (SIB)

European Bioinformatics Institute (EMBL-EBI)

Protein Information Resource (PIR) www.uniprot.org

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