Appendix Table 1 – ICD codes
Diagnoses, surgical procedures, and pharmacotherapy used for defining the
study population, comorbidity, and outcomes
Study population
Atrial
Defined from diagnosis
ICD10: I48
fibrillation
Myocardial
ICD8: 42793, 42794
Defined from diagnosis
ICD8: 41009, 14099
ICD10: I21, I22
infarction
Percutaneous
Defined from procedure
coronary
performed
NCSP: KFNG
intervention
Comorbidity
Ischemic stroke
Defined from diagnosis
Arterial
Defined from diagnosis
ICD10: I63, I64, G458, G459
ICD10: I74
Defined from diagnosis
ICD10: I702-I709
embolism
Peripheral
arterial disease
Alcohol abuse
Liver disease
Defined from diagnosis and
adverse alcohol consumption
ICD10: E244, E52, F1, G312,
reported during
G621, G721, I426, K292, K70,
hospitalization
K860, L278A, O354, T51, Z714,
Defined from diagnoses
of liver cancer, chronic liver
Z721
ICD10: B15-B19, C22, D684C,
I982B, K70-K77, DQ618A, Z944
NCSP: KJJC
disease, liver surgery,
cirrhosis, and hepatitis or liver
procedure
Diabetes
Defined from treatment
mellitus
Hypertension
Treatment: Glucose-lowering
medication
Defined from combination
Treatment: Adrenergic α-
treatment with a least two
antagonist, non-loop-diuretics,
classes of antihypertensive
vasodilators, beta- blockers,
drugs. This definition of
calcium channel blockers, and
hypertension has a positive
renin-angiotensin system
predictive value of 80.0% and
inhibitors.
a specificity 94.7%1
Heart failure
Defined from diagnosis plus
ICD10: I110, I42, I50, J819
treatment
Treatment: Loop-diuretics
Chronic renal
Defined from diagnosis of
failure
chronic glomerulonephritis,
chronic tubulointestinal
nephropathy, non-end-stage
chronic kidney disease, and
diabetic and hypertensive
ICD10: E102, E112, E132, E142,
I120, M200, M313, M319,
M321B, N02-N08, N11N12, N14, N18-N19, N26, N158N160, N162-N164, N168, Q612Q613, Q615, Q619
nephropathy.
Bleeding
Defined from diagnosis of
ICD10: I60-I62, I690-I692, J942,
gastrointestinal, intracranial,
K250, K254, K260, K264, K270,
respiratory, and urinary tract
K280, K920-K922, N02, R04,
bleedings; and anemia caused
R31, S064-S066
by bleeding.
Malignancy
Defined from diagnoses of
ICD10: C00-C97
cancer (non-benign)
Potential
Defined from any diagnoses
ICD10: I05, I06, I34, I35
absence of non-
or operation of aortic or mitral NCSP: KFK, KFM
valvular atrial
valve disease
fibrillation
Outcomes
Myocardial
Diagnosis of myocardial infarction
ICD10: I21-I22 (I20-I25 Coronary
infarction /
or coronary death
death)
Death from or diagnosis of
ICD10: I63-I64, G458-G459
Coronary death
Ischemic stroke
ischemic stroke or transient
ischemic attack
Bleeding
Death from or diagnosis of
ICD10: I60-I62, I690-I692, J942,
gastrointestinal, intracranial,
K250, K254, K260, K264, K270,
respiratory, and urinary tract
K280, K920-K922, N02, R04,
bleedings; and anemia caused by
R31, S064-S066,
bleeding.
Cause of death
Cardiovascular
Death from any vascular diagnosis
ICD10: any I code
e.g. myocardial infarction and
ischemic stroke
Cancer
Death from non benign cancers
ICD10: any C code
Respiratory
Death from pulmonary diagnosis
ICD10: any J code
e.g. pneumonia and chronic
obstructive pulmonary disease
Infection
Death from infection e.g. sepsis
ICD10: any A or B code
and hepatitis
Bleeding
Death from bleeding diagnosis
ICD10: I60-I62, I690-I692, J942,
K250, K254, K260, K264, K270,
K280, K920-K922, N02, R04,
R31, S064-S066
Endocrine/metabolic Death from any endocrine or
ICD10: any E code
metabolic diagnosis e.g. diabetes,
Other
ICD8:
ICD10:
NCSP:
Procedures
Reference
Death from any other cause
ICD10: any other ICD-10 code
8th revision of the International Classification of Diseases system
10th revision of the International Classification of Diseases system
The Nordic Medical Statistics Committees Classification of Surgical
1: Olesen JB, Lip GY, Hansen ML et al. Validation of risk stratification schemes for
predicting stroke and thromboembolism in patients with atrial fibrillation: Nationwide
cohort study. BMJ. 2011;342:d124
Appendix Table 2 – ATC codes
Treatment
Aspirin
ATC: BO1AC06,
Acetylsalicylic acid
NO2BA01
Clopidogrel
ATC: BO1AC04
Vitamin K antagonists
ATC: BO11AA03-4
Including: warfarin,
phenprocoumon
Statins
ATC: C10A
Beta-blockers
ATC: C07
Renin angiotensin system
ATC: C09
inhibitors
Including:
angiotensin-
converting-enzyme inhibitors,
angiotensin-II
receptor
blockers
Loop-diuretics
ATC: C03C
Thiazides
ATC: C03A
Calcium channel blockers
ATC: C08
Digoxin
ATC: C01AA05
Amiodarone
ATC: C01BD01
Class 1 C antiarrhythmic
ATC: C01BC
drugs
Including:
flecainid,
propafenon
Sotalol
ATC: C07AA07
Antiarrhythmic drugs
ATC: C07, C08,
Including: beta-blockers,
C01AA05,
calcium channel blockers,
C01BD01,
digoxin, amiodarone, sotalol,
C07AA07, C01BC
Class 1C drugs
Proton-pump inhibitors
ATC: A02BC
Oral glucose-lowering drugs ATC: A10
Glucocorticoids
Non-steroidal
ATC: H02AB
Including: prednisolon
anti- ATC: M01A
inflammatory drugs
ATC:
Anatomical Therapeutic Chemical (ATC) system
Appendix Table 3 - Benefit and safety outcomes in multiple antithrombotic regimens within 1 year in AF patients after MI/PCI (newuser design)
Benefit outcomes
Coronary
death/MI (n=854)
Aspirin + clopidogrel
Numbers
(incidence
rates)
HR [95 % CI]
Dual therapies
OAC + aspirin
Numbers
(incidence
rates)
HR [95 % CI]
149 (18.4)
reference
101 (17.1)
0.91 [0.71-1.18]
18 (9.0)
0.54 [0.33-0.88]
50 (16.9)
0.84 [0.61-1.16]
Ischemic stroke
(n=310)
49 (5.7)
reference
41 (6.7)
1.01 [0.66-1.55]
5 (2.4)
0.36 [0.14-0.92]
12 (3.8)
0.54 [0.28-1.01]
142 (16.2)
reference
99 (15.7)
1.00 [0.77-1.39]
15 (7.1)
0.50 [0.29-0.86]
25 (7.8)
0.50 [0.32-0.76]
All-cause
mortality (n=896)
Safety outcomes
OAC + clopidogrel
Numbers
(incidence
rates)
HR [95 % CI]
Triple therapy
OAC + aspirin + clopidogrel
Numbers
(incidence
rates)
HR [95 % CI]
Bleeding
49 (5.7)
reference
63 (10.4) 1.78 [1.21-2.62]
18 (8.8)
1.38 [0.80-2.40]
50 (16.2)
2.67 [1.79-3.98]
(n=314)
n denotes number of events, and rates are events per 100 person years
Abbreviations: HR, Hazard ratio; CI, confidence interval; OAC, oral anticoagulant; MI, myocardial infarction; PCI, percutanous coronary
intervention