Table S2. Mean whole blood fatty acids concentration (95% CI) by group of high sensitive C-reactive protein (hs-CRP) in girls, controlling by
age, body mass index and self-reported hours of physical activity in a sport club per week.
Fatty acid
I (n=172)
II (n=384)
III (n=121)
p for trend
Palmitic acid (% of total FA)
25.94(25.72-26.17)
25.74(25.59-25.88)
25.7(25.43-25.97)
0.275
Oleic acid (% of total FA)
18.89(18.56-19.22)
18.79(18.58-19.01)
18.32(17.92-18.72)
0.083
Linoleic acid (% of total FA)
18.42(18.11-18.72)
18.31(18.12-18.51)
18.07(17.7-18.45)
0.399
Gamma linolenic acid (% of total FA)
0.22(0.21-0.24)
0.22(0.22-0.23)
0.23(0.21-0.24)
0.946
Arachidonic acid (% of total FA)
7.16(6.95-7.37)
7.37(7.23-7.5)
7.83(7.58-8.01)* †
0.001
Alpha-linolenic acid (% of total FA)
0.2(0.18-0.21)
0.21(0.19-0.21)
0.18(0.17-0.2)
0.384
Eicosapentaenoic acid (% of total FA)
0.26(0.24-0.27)
0.26(0.25-0.27)
0.25(0.23-0.27)
0.544
Docosapentaenoic acid (% of total FA)
0.51(0.48-0.53)
0.51(0.49-0.52)
0.52(0.49-0.55)
0.760
Docosahexaenoic acid (% of total FA)
1.13(1.06-1.19)
1.14(1.1-1.18)
1.19(1.11-1.26)
0.546
Sum n-3 HUFA (% of total FA)
1.91(1.82-2)
1.91(1.85-1.97)
1.96(1.85-2.07)
0.741
Sum n-6 HUFA (% of total FA)
9.61(9.32-9.89)
9.87(9.69-10.05)
10.43(10.09-10.77)* †
0.002
x100 n-3 HUFA (% of total FA)
16.33(15.76-16.89)
16.27(15.91-16.63)
15.58(14.9-16.26)
0.232
Ratio DHA/AA
0.15(0.14-0.16)
0.15(0.15-0.16)
0.15(0.14-0.16)
0.529
Ratio EPA/AA
0.03(0.03-0.04)
0.03(0.03-0.04)
0.03(0.03-0.03)* †
0.015
Ratio AA/LA
0.39(0.38-0.4)
0.4(0.39-0.41)
0.43(0.42-0.45)* †
<0.001
Ratio AA/DHGLA
6.18(5.98-6.39)
6.23(6.1-6.36)
6.57(6.33-6.82)* †
0.036
Ratio n-6/n-3
14.5(13.86-15.14)
14.11(13.7-14.52)
14.21(13.44-14.98)
0.778
Sum n-3 (% of total FA)
2.09(2.01-2.19)
2.12(2.06-2.18)
2.15(2.04-2.26)
0.760
Sum n-6 (% of total FA)
28.31(27.9-28.72)
28.51(28.24-28.77)
28.69(28.19-29.18)
0.532
SFA (% of total FA)
44.33(44.04-44.62)
44.24(44.05-44.42)
44.4(44.05-44.75)
0.672
MUFA (% of total FA)
25.09(24.7-25.47)
25.02(24.78-25.27)
24.57(24.11-25.03)
0.197
PUFA (% of total FA)
30.41(29.96-30.85)
30.58(30.29-30.86)
30.81(30.27-31.34)
0.562
(I) CRP under the detection limit (<0.02mg/dL); (II) hs-CRP ≥ 0.02 to 0.22 (III) hs-CRP higher than 0.22. Highly unsaturated n-3 (n-3 HUFA),
highly unsaturated n-6 (n-6 HUFA), ratio between n-3 HUFA and n-3 HUFA+ n-6 HUFA (x100 n-3 HUFA), docosahexaenoic acid (DHA),
arachidonic acid (AA), eicosapentaenoic acid (EPA), linoleic acid (LA), dihommo gamma linolenic acid (DHGLA), sum of saturated fatty acids
(SFA), sum of monounsaturated fatty acids (MUFA) sum of all polyunsaturated fatty acids (PUFA). Post-hoc comparisons between hs-CRP
groups with Bonferroni correction applied. *p<0.05 ref CRP I, † p<0.05 ref CRP II
Blood fatty acids and CRP
In girls (Table S2), significant associations with hs-CRP were found with the following WBFA: AA (p=0.001), the sum of n-6 HUFAs
(p=0.002), the ratio AA / LA (p<0.001) and ratio AA /dihomo gamma linolenic acid (DHGLA) (p=0.036). Also an inversely association was
found between hs-CRP and the blood EPA/AA ratio (p=0.015).