Assessment of Immune Function and Immunodeficiencies • Health history: – Age. – Nutrition. – Infection & immunization. – Allergy. – Disorders & diseases. – Medications & blood transfusions. – Lifestyle & other factors. Physical examination. Health History: Age Immunodeficiencies • Frequency & severity of infections are increased in elderly people due to: – ↓ ability to respond adequately to invading organisms. – ↓ production & function of T & B lymphocytes. – ↑ incidence of autoimmune “body attacking self” diseases. b/c surveillance system becomes weaker- body cannot detect between self and non-self. • ↑ incidence of cancer. Age related changes… Normal age vs abn aging that’ll cause Immunodeficiencies – Declining function of various organs: • ↓ gastric secretions & motility. So secretions that do seep out are gonna sit there. Higher chance of ulcers and for bacteria to enter. Leads to Diarrhea. • ↓ renal circulation, filtration, absorption, & excretion. Will see severe UTIs. • Prostatic enlargement & neurogenic bladder. Urinary stasis. Will also cause UTIs b/c of poor bacterial clearance. • Exposure to tobacco & environmental toxins. • Skin becomes thinner & less elastic. • Peripheral neuropathy, decreased sensation & circulation. Pts may not realize they are injured. Health History: Nutrition Health History: Infection & Immunization Immunodeficiencies • Childhood/recent immunizations & diseases. • TB: Exposure • PPD (Tuberculin) test- purified protein derivative • CXR • Recent exposure to infections. Especially to STDs. • Past & present infections. Make sense… • Multiple persistent infections, fevers of unknown origin, lesions or sores, any type of drainage. Health History: Allergy Immunodeficiencies • Allergies & types of allergens. – Is the band on? • Seasonal variations. – Better in summer, worse in fall? • Occurrence & severity of symptoms. • Testing & treatments received. • Effectiveness of treatments. Health History: Disorders & Diseases Immunodeficiencies • Autoimmune disorders – Rare – All disorders account for 5% of U.S. population (lupus, RA, psoriasis,… very strong link to genetics and being female) Women more prone to autoimmune disorder. – Strong genetic link – More common in Females • Neoplastic disease “abn tissue mass as a result of neoplasia” – Type of CA & date of diagnosis – Immunosuppression contributes to Cancer & Cancer contributes to Immunosuppression – Treatments • Radiation- Radiation for Local. Hair no grow. • Chemo- Chemo for large/widespread. Hair regrow. – Ask: who, what, where, when, successful? • Leukemia and lymphoma… Chronic illness & surgery: • Renal failure =↓ lymphocytes, uremia. • DM = ↑ infections (Microorganisms love sugar), vascular insufficiency, & neuropathy (higher chance for injuries). • COPD = recurrent respiratory tract infections → ineffective airway clearance. • Surgery = Removal of spleen (results in life-long antibiotics, cause the spleen helps fight infection), lymph nodes, thymus, organ transplantation. Special problems: • Burns, injury & infection – Impaired skin integrity & compromised first line of defense. – Loss of large amounts of serum in burns patients → depletes body of immunoglobulins & antibodies. – Physiological & psychological stress → cortisol release → suppression of normal immune responses. Health History: Medications & Blood Transfusions Immunodeficiencies • Immunosuppressive drugs: – High dose antibiotics- killin good w/ bad – Corticosteroids- over time decr immun response – Salicylates, NSAIDS- prone to ulcers – Anesthetics- slow everything down (biological/immune processes) • Blood Transfusions- multiple transfxns • Herbal remedies Health History: Lifestyle & Other Factors Immunodeficiencies • Smoking • Alcohol consumption- tear up liver and GI tract • Dietary intake & nutritional status • Amount of perceived stress • IV drug use- link to Aids and Hepatitis • Sexual practices • Occupational or residential exposure to radiation or pollutants Psychoneuroimmunologic Factors Immunodeficiencies • Immune response regulated by neurotransmitters and endocrine function. And (at same time) • Immune processes can conversely affect behavior. Bidirectional interaction. People w/ good self esteem will simply be “healthier” Evidence suggest immune function can be influenced via behavioral strategies. ex: Bio-feedback, … Physical Examination Immunodeficiencies • Skin & mucous membranes – lesions, dermatitis, purpura “reddish/purple discoloration of skin”, urticaria “rash/hives” • Signs of infection – High Temp, Chills, sweating • Palpable lymph nodes – Large, tender? • Joints – Swelling, warmth, tender • Assess major body systems (CV, Resp, GI, GU, Neuro, etc.) Diagnostic Evaluation Immunodeficiencies • Blood tests. (WBC w/ differential, , H&H, anemia is indicated…) • Cultures • Skin tests. (Allergies, allergen exposure) • Bone marrow biopsy. WBC and Differential Immunodeficiencies – Normal- WBC values – 5000 – 10000/mm3 – Or 5-10 x 109/L – – – – Elderly WBC values – 3000 – 9000/mm3 Or 309 x 109/L Differential – the % of each different type of WBC Neutrophil (and Bands) • Lymphocytes • Eosinophils- allergic reaction • Basophils (Mast Cells) Nursing Management Immunodeficiencies • Be aware of… – Physical pain and discomfort of exams/testing – Psychological stress Neutrophils- “new on the scene”. Severe bacterial infection, will see lots of bands Immunodeficiency Disorders Immunodeficiencies • A defect or deficiency in phagocytic cells, B lymphocytes, T lymphocytes, or the complement system. • ***Reference bk, but Childhood/Pedi omitted Immunodeficiencies…. Chart 51-1, pg 1804 • Primary immunodeficiencies – Genetic disorders – Cellular defects – Primarily in infants and young children Common Variable Immunodeficiency (CVID) • aka Hypogammaglobulinemia – Very low level of immunoglobulin or non-existent – Usually seen in early adulthood (20-30) • The MOST COMMON primary immunodeficiency in adults. – A B-cell deficiency – Recurrent infection with fever – Increased incidence of autoimmune diseases (1 : 80000) – Low serum immunoglobulin levels – And… Tired, don’t heal well • Clinical Manifestations – Pernicious anemia “Low B12” – Lymphoid tissue hyperplasia – Other autoimmune disorders • Diagnosis – Serum immunoglobulin levels • Management – Intravenous immunoglobulin infusions – Treat symptoms – Teach infection control – Immunodeficiencies…. • Secondary Immunodeficiencies – Occur as a result of underlying disease processes and their treatments. • Example causes: – Malnutrition - Chronic Stress – Viruses - Alcohol – Recreational drugs (injecting bacteria into body) – DM • Most common 2° Immunodeficiency is AIDS Secondary Immunodeficiencies • Management: – Diagnose and treat underlying disease – Frequent reassessment (Follow-up) – Monitor efficacy and side-effects of treatment – Teach infection control – Manage stress – Lifestyle changes (Ex: Unprotected sex) – Keep medical appointments – Chart 51-3, pg 1810