Medications Guide Pamela C. Vickers Candler Hospital/Georgia Southern University March 2, 2015 Name Megestrol (Megace) Dronabinol (Marinol) Drug Class Synthetic female hormone belonging to the progesterone group (Progestogens) Antemetic/Cannabinoid Side Effects Weight gain, changes in appetite (increase), stomach upset, diarrhea, nausea, vomiting, gas, increase blood sugar levels Nausea, vomiting, stomach pain, diarrhea Drug-Nutrient Interactions Appetite stimulant Avoid alcohol due to risk of fluid accumulation Can take with or without food Appetite Stimulant Avoid alcohol which can increase side effects Remeron (Mirtazapine) Metformin (Fortamet, Glucophage, Glumetza, Riomet) Antidepressant Biguanides (Antidiabetic) Dry mouth, constipation, increased appetite, weight gain, nausea, vomiting, may significantly elevate serum triglyceride and total cholesterol levels Mild nausea, vomiting, diarrhea, gas, stomach pain, bloating, feeling full, indigestion, loss of appetite, weight loss, lactic acidosis Take before lunch and supper Appetite Stimulant Avoid alcohol due to increase in nervous system side effects Can take with or without food Take with meals May have to take vitamin B12 supplements Avoid drinking alcohol due to increased risk of low blood sugar and lactic acidosis Novolog Levemir Fast-Acting Insulin (Antidiabetic) Long-Acting Insulin (Antidiabetic) Hypoglycemia, weight gain, excessive hunger, increased thirst, loss of appetite, renal sodium retention, hypokalemia, hypomagnesemia Hypoglycemia, weight gain, stomach pain, nausea, vomiting, low potassium Eat a meal within 5-10 minutes after taking Novolog Avoid alcohol due to risk of hyperglycemia and hypoglycemeia Should be administered with evening meal or at bedtime Those that take twice-daily can administer at evening meal and then 12 hours after Lantus (Insulin Glargine, Recombinant) Humalog Long-Acting Insulin (Antidiabetic) Fast-Acting Insulin (Antidiabetic) Hypoglycemia, weight gain, stomach pain, nausea, vomiting, hypophosphatemia, hypokalemia, hypomagnesemia Hypoglycemia, hypokalemia, weight gain, edema Avoid alcohol due to risk of hyperglycemia and hypoglycemia Should be administered with evening meal or at bedtime Those that take twice-daily can administer at evening meal and then 12 hours after Avoid alcohol due to risk of hyperglycemia and hypoglycemia Eat a meal within 5-10 minutes after taking Novolog Can take before or after meals Avoid alcohol due to risk of hyperglycemia and hypoglycemeia Lasix (Furosemide) Loop Diuretic Dehydration, loss of appetite, weight loss, nausea, vomiting, low potassium, low calcium, low magnesium, diarrhea, constipation, stomach pain Take on an empty stomach, one hour before eating Can be taken with food to prevent GI upset Avoid alcohol because additive effects in lowering blood pressure Consume plenty of water and electrolytes Consume foods high in potassium Eat foods high in magnesium and calcium (dairy products, whole grain breads and cereals) Avoid licorice because enhances side effects of potassium-depleting diuretics Demadex (Torsemide) Loop Diuretic Dehydration, loss of salt/minerals, dry mouth, nausea, vomiting Taken with or without food Avoid alcohol because additive effects in lowering blood pressure Consume plenty of water and electrolytes Consume foods high in potassium Eat foods high in magnesium and calcium (dairy products, whole grain breads and cereals) Avoid licorice because enhances side effects of potassium-depleting diuretics Edecrin (Ethacrynic Acid) Loop Diuretic Dehydration, upset stomach, diarrhea, dry mouth, nausea, vomiting, increased urination, loss of salt/minerals Taken with or without food Avoid alcohol because additive effects in lowering blood pressure Consume plenty of water and electrolytes Consume foods high in potassium Eat foods high in magnesium and calcium (dairy products, whole grain breads and cereals) Metamucil (Psyllium) Laxative Nausea, intestinal gas, cramps, mild diarrhea, rectal pain, constipation, abdominal fullness, bloating Avoid licorice because enhances side effects of potassium-depleting diuretics Recommend taking three times a day at mealtimes Take with full glass of water To prevent constipation, drink plenty of fluids, exercise regularly, and consume naturally-occurring fibers found in whole grains, fruits, and vegetables. Milk of Magnesia (Magnesium Hydroxide) Colace (Docusate Sodium) Laxative Laxative Diarrhea that can be severe enough to cause dehydration and electrolyte abnormalities, nausea, vomiting Stomach pain, diarrhea, cramping Take with a full glass of water To prevent constipation, drink plenty of fluids, exercise regularly, and consume naturally-occurring fibers found in whole grains, fruits, and vegetables Take with a full glass of water, usually at bedtime To prevent constipation, drink plenty of fluids, exercise regularly, and consume naturally-occurring fibers found in whole grains, fruits, and vegetables Dulcolax (Bisacodyl) Laxative Stomach/abdominal pain, nausea, diarrhea, vomiting Take with a full glass of water Take within 1 hour of antacids, milk, or milk products Senna Laxative Dehydration, diarrhea, electrolyte disturbances, weight loss, nausea, loss of appetite potassium deficiency To prevent constipation, drink plenty of fluids, exercise regularly, and consume naturally-occurring fibers found in whole grains, fruits, and vegetables Take with a full glass of water Take in the evening To prevent constipation, drink plenty of fluids, exercise regularly, and consume naturally-occurring fibers found in whole grains, fruits, and vegetables Miralax (Polyethylene Glycol) Phenergan (Promethazine) Laxative Phenothizine (Anti-nausea) Nausea, abdominal cramping, gas, diarrhea Dry mouth, loss of appetite, constipation Take with a full glass of water To prevent constipation, drink plenty of fluids, exercise regularly, and consume naturally-occurring fibers found in whole grains, fruits, and vegetables Can be taken with or without food Take before meals or before going to bed If cannot manage oral intake, a suppository form can be used Protonix (Pantoprazole) Proton Pump Inhibitor Diarrhea, abdominal/stomach pain, weight changes, nausea, vomiting, gas Can be taken with or without food If taking in granule form, take 30 minutes before a meal with applesauce or apple juice Avoid or limit nicotine, caffeine, and alcohol because these stimulate stomach acid and can slow healing process Metoclopramide (Reglan) Prokinetic Drug Diarrhea, constipation, increased flow of breast milk, passing urine more often, dry mouth Take 30 minutes before meals and at bedtime Avoid or limit the use of alcohol Avoid or limit nicotine, caffeine, and alcohol because these stimulate stomach acid and can slow healing process Dilantin (Phenytoin) Decadron (Dexamethasone) Anticonvulsant Corticosteroid Nausea, vomiting, constipation, upper stomach pain, loss of appetite, jaundice, dark urine, may affect metabolism of Vitamin D, increase in blood sugars Weight gain, increased appetite, nausea, vomiting, increase in blood sugar, fluid retention Do not take with meals For tube feedings, must hold 1 hour when taken before resuming regimen Avoid alcohol and antacids Take with food or after meals Drink 2-3 quarts of water every 24 hours, unless on fluid restriction Limit alcohol and caffeine consumption May cause retention of sodium, so keep sodium intake to a minimum Excess secretion of potassium, so consume foods high in potassium Synthroid (Levothyroxine) Thyroid Hormone Replacement Vomiting, diarrhea, appetite changes, weight changes Take 30 minutes before breakfast on an empty stomach with a full glass of water Avoid the following food products, which can make the body absorb less levothyroxine: infant soy formula, cotton seed meal, walnuts, and highfiber foods. Wait 4 hours before or after taking Synthroid to take calcium carbonate, iron supplements, or antacids that contain aluminum or Magnesium (Maalox, Milk of Magnesia, Pepcid, etc.) Normodyne (Labetalol) Bystolic (Nebivolol) Beta-Blocker Beta-Blocker Nausea, vomiting, sudden weight gain, upper stomach pain, loss of appetite, claycolored stools, jaundice Nausea, stomach pain, sudden weight gain/loss Take consistently with meals Avoid or limit alcohol Can take with or without food Avoid or limit alcohol Do not consume grapefruit juice while taking medication Amlodipine Besylate (Norvasc) Zofran (Ondansetron) Calcium-Channel Blocker Antemetic Abdominal pain, nausea, diarrhea, vomiting, weight changes Constipation, diarrhea, hiccups, nausea, vomiting Take at the same time every day with or without food Do not consume grapefruit juice while taking medication Can be taken with or without food Limit alcohol consumption Pravachol (Pravastatin) Statin Increased thirst, increased urination, hunger, dry mouth, fruity breath, weight loss, nausea, upper stomach pain, loss of appetite, clay-colored stools, jaundice, diarrhea Avoid eating foods that are high in fat and cholesterol Avoid drinking alcohol Do not consume grapefruit juice while taking medication Solumedrol (Methylprednisolone) Corticosteroids Weight gain, abdominal pain, vomiting, nausea, appetite changes, rise in blood sugars, hypernatremia, hypokalemia Take with food to avoid upset stomach Do not consume grapefruit juice while taking medication Dietary sodium restriction and potassium supplementation Warfarin (Coumadin) Anticoagulant Vomiting of blood or material that looks like coffee grounds, black or tarry stools, diarrhea Cranberries, cranberry juice, alcohol, food that are high in Vitamin K (soybeans and canola oils, spinach, broccoli), garlic, and licorice should be monitored Do not eat grapefruit or drink grapefruit juice Vitamins A, E, and possibly C may affect how Warfarin works