Syllabus
Functional Genomics 2012
Instructor: Cheol-Koo Lee, Ph. D.
Office: 318 West building, College of Life Sciences & Biotechnology
Phone: 3290-3008
e-mail: cklee2005@korea.ac.kr
Web: http://ckaging.korea.ac.kr/
Textbook:
Bioinformatics and functional genomics (J. Pevsner), 2nd edition, Year 2009
Journals:
(J1) Dan N. Simon and Katherine L. Wilson. The nucleoskeleton as a genomeassociated dynamic
‘network of networks’. NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOLUME 12 NOVEMBER 2011.
p695.
(J2) Takehiko Kobayashi. How does genome instability affect lifespan? Roles of rDNA and telomeres.
Genes to Cells (2011) 16, p617–p624.
(J3) Sayyed K. Zaidi, Daniel W. Young, Martin Montecino, Andre J. van Wijnen, Janet L. Stein, Jane B.
Lian, and Gary S. Stein. Bookmarking the Genome: Maintenance of Epigenetic Information. THE
JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 286, NO. 21, pp. 18355–18361, May 27, 2011.
(J4) Elaine R. Mardis. Next-Generation DNA Sequencing Methods. Annu. Rev. Genomics Hum. Genet.
2008. 9: p387–p402.
(J5) Michael L. Metzker. Sequencing technologies — the next generation. NATURE REVIEWS Genetics.
Volume 11. JANUARY 2010. p31.
(J6) ThomasWerner. Next generation sequencing in functional genomics. BRIEFINGS IN
BIOINFORMATICS. VOL 11. NO 5. p499-p511. 2010.
Genomics is a large-scale study of genetics. Recent advancement of high-throughput technologies
stimulated accumulation of large-scale data from entire genome. Functional genomics covers these
advancements in genomics.
The class focuses on obtaining following skills and knowledge:
(1) Basic terminology and minimal bioinformatics skills related to genomics
(2) Introductory and technological aspects of high-throughput platforms to obtain DNA sequence,
transcriptome, and epigenetic map in genome-wide
Evaluation:
We will have two exams (50 score each). Your letter grade is determined based on the results of these
exams.
Attendance: The attendance adds some points to the final score.