35th International Society for Heart Research
North American Section Meeting
“NOVEL STRATEGIES TO COMBAT HEART
FAILURE”
May 12 -15, 2014
Miami Beach, Florida
Program Co - Chair: Joshua M. Hare and Michael S. Kapiloff
International Society for Heart Research - North American Section
President: Elizabeth Murphy
President-Elect: Steve R. Houser
Past -President: Donald M. Bers
Secretary: Jennifer Van Eyk
Treasurer: Litsa Kranias
Executive Secretary: Leslie Anderson Lobaugh
Council Members 2009 -15
Mark Anderson
Susan Howlett
Charles Murry
Jeff Robbins
Howard Rockman
Mark Sussman
Jil Tardiff
Yibin Wang
American section web site:
www.american.ishrworld.org
International web site:
www.ishrworld.org
Council Members 2012 -18
Chris Baines
Pieter de Tombe
Asa Gustaffson
Joan Heller Brown
Timothy Kamp
Walter Koch
Gary Lopaschuk
Jun Sadoshima
Sarah Franklin ECI representative (2012-14)
Gao Chen ECI representative (2013-2015)
Early Career Investigator Committee
Sarah Franklin, Chair
Maggie Lam
Grant Budas
Chris Murray
Gao Chen
Randi Parks
Sam Das
Catherine Passariello
Alice Ho
Sakthi Sadayappan
Mark Kohr
Senior Advisors: Jeff Robbins, Litsa Kranias and Chris Baines
Acknowledgements
Thank you to our Sponsors
The Interdisciplinary Stem Cell Institute
University of Miami Miller School of Medicine
Heart Genomics
Cardiovascular Research Center & Center for Translational Medicine
Temple University School of Medicine
VisualSonics
Med Lab Supply Company/Siemens
The Heart Institute
at Cincinnati Children’s
Educational Grant Provided By Gilead
Special Thanks to Our Meeting Organizers:
Meeting Secretariat: Katie Campbell
Conference Planner: Roselyn Robbins
Executive Secretary: Leslie Anderson Lobaugh
Monday May 12, 2014
Overview
7:00 AM
8:00 AM
9:00 AM
9:00 AM
10:30 AM
10:45 AM
12:00 PM
1:00 PM
1:00 PM
2:30 PM
3:00 PM
3:00 PM
4:30 PM
6:30 PM
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11:00 AM
10:30 AM
10:45 AM
11:45 AM
1:00 PM
2:30 PM
2:30 PM
3:00 PM
4:30 PM
4:30 PM
6:30 PM
8:00 PM
Speaker Ready Room
Registration
NAS Section Council Meeting
ECI Symposium
Coffee Break
Alternative Science Career Paths
ECI Lunch with Senior investigators
Interest Group 1
Interest Group 6
Coffee Break
Interest Group 3
Interest Group 7
Young Investigator Competitions
Reception
Regency Conference Room
Grande Promenade Foyer
Miramar North
Regency Ballroom
Regency Ballroom
Regency Ballroom
Starlight Ballroom
Grande Promenade
Regency Ballroom
Grande Promenade
Grande Promenade
Regency Ballroom
Grande Promenade
Starlight Ballroom
9:00AM – 10:30 AM ECI Symposium
Chair: Randi Parks and Samarjit Das
Catherine Passariello - Disruption of RSK3 binding to mAKAP in vivo via AAV expression of a competing
peptide attenuates pressure overload -induced cardiac hypertrophy
Randi Parks - The impact of ovariectomy on cAMP/PKA -dependent mechanisms involved in cardiac
excitation -contraction coupling
Konstantin Drosatas - Combined cardiac PPARα and PPARγ activation reduce PGC -1α gene expression
and compromise binding of PPARγ on PGC -1α
Guansheng Liu - A Novel Human R25C -Phospholamban Mutant Is Associated with Superinhibition of
Calcium Cycling and Increased Apoptosis
Shigeki Miyamoto - Hexokinase -II regulates mitochondria specific autophagy in response to ischemia
Philip Bidwell - Endogenous HAX -1 depresses the phospholamban inhibitory activity
Sara Menazza - Impaired Nitroso -Redox Signaling is Involved in Human Heart Failure
Patrick McLendon - Inhibition of tubulin deacetylation is protective in cardiac proteinopathy through
autophagy -mediated aggregate reduction
Shathiyah Kulandavelu - Cardio -protection following myocardial infarction in female is absent in mice
lacking the S -nitrosoglutathione reductase (GSNOR)
10:45AM – 11:45 AM ECI - Alternative Science Careers Paths
Chair: Mark Kohr and Sakthivel Sadayappan
Lisa Schwartz -Longacre, Program Officer, NHLBI/NIH
Stephanie Finnegan, President of Biopharma, BioRASI
Wayne Bowden, Lead Program Manager, BioRASI
Mitchell Fuerst, Managing Partner, Fuerst, Ittleman, David & Joseph, P.L.
Grant Budas, Scientist, Gilead Sciences
1:00 - 2:30 PM - Interest Group 1 Session - Signaling from hypertrophy to failure: Apoptosis, Necrosis
and Fibrosis
Chair: Roberta Gottlieb and Gao Chen
Maria Kontaridis - Cardiomyocyte -specific expression of RhoA protects against pressure -overload
induced heart failure but facilitates cardiac fibrosis
John Elrod – Synaptolysis - A novel mechanism of programmed necrosis
Yibin Wang - Mitochondrial Superoxide Production in Healthy and Diseased Heart
Sarah Franklin -Targeted remodeling of cardiac histone modifications to regulate hypertrophy and
failure
1:00 – 2:30 PM – Interest Group 6 Session - Ion channels and Arrhythmias
Chair: Susan Howlett and Seth Robia
Shey -Shing Sheu – Characteristics and functions of mitochondrial Ca2+ transport mechanisms in cardiac
muscle cells
Sam Dudley - NaV1.5 function in the heart
Brian O’Rourke – ROMK function in the heart
W. Jonathan Lederer - Ryanodine receptor function in cardiac stress
2:30 – 3:30 Coffee Break
3:30 – 4:30 PM Interest Group 3 Session - Stem Cell & Gene Therapy
Chair: Joseph Rabinowitz and Wen Ding
Roger Hajjar - Gene Therapy in Patients With Severe Heart Failure
Hee Cheol Cho - Gene therapy for generation of a cardiac pacemaker
Willem J. de Lange - Engineered cardiac tissue (ECT) derived from hiPSC cardiomyocytes
Loren Field - Genetic control of cardiomyocyte renewal
3:30 – 4:30 PM Interest Group 7 Session - Ischemia, Cardioprotection & Mitochondria
Chair: Charles Steenbergen and Chris Murray
Bruce Ito - Cardiac Autophagy and Clinical Implications in Metabolic Syndrome
Hemal Patel - Caveolins in cardiac protection: from membrane to mitochondria
Robert Kloner - Hypothermia for reducing myocardial infarct size and the no reflow phenomenon
Stacey House - Fibroblast Growth Factor Receptors in Endothelium and Cardiomyocytes in Acute
Myocardial Infarction and Post -Ischemic Cardiac Remodeling
4:30 – 5:30 PM Young Investigator Competition (Junior)
Chair: Jeffrey Robbins
Nirmala Hariharan - Nucleostemin antagonizes senescence of cardiac progenitor cells - Mentor: Mark
Sussman
Maggie Lam - Protein kinetic signatures of the remodeling heart following isoproterenol stimulation Mentor: Peipei Ping
Catherine Makarewich - Transient receptor potential channels contribute to pathological structural and
functional remodeling after myocardial infarction - Steve Houser
Sarah Schumacher -Bass - Paroxetine -mediated GRK2 inhibition reverses cardiac dysfunction and
remodeling post -myocardial infarction -Wally Koch
5:30 – 6:30 PM Young Investigator Competition (Senior)
Chair: Howard Rockman
Paul Burridge - Human induced pluripotent stem cells predict breast cancer patient’s predilection to
doxorubicin -induced cardiotoxicity - Mentor: Joseph Wu
Chad Grueter - MED13 dependent signaling from the heart enhances metabolism in adipose tissue and
liver and confers leanness - Mentor: Eric Olson
Mark Kohr - Glyceraldehyde -3 -phosphate dehydrogenase acts as a mitochondrial trans -S -nitrosylase in
the heart - Mentor: Charles Steenbergen
Stephen Lange - Defining the role of the stress sensors MLP and CARP in signaling pathways that lead to
dilated cardiomyopathy - Mentor: Ju Chen
Annual Young Investigator Awards (YIAs) were established by the North
American Section of the ISHR to recognize outstanding research in the field of
cardiovascular science by junior investigators. From applications received for this
meeting, finalists in each of the two categories, Graduate Students and Early
Postdoctoral Fellows (within 4 years of completing their degree) and Senior
Postdocs and Early Assistant Professors (between 4 and 10 years after
completing their degree), were selected by a Committee to present their work at
our meeting. A panel of judges will make the final award (presented at the
banquet) based on the scientific merit of a submitted unpublished manuscript,
quality of the oral presentation, and responses to questions asked during the
discussion period. The finalists, their presentation titles and their mentors are
listed above.
Sponsored by Envision Conference Planners, Roz Robbins, Sole Proprietor.
6:30 - 8:00 PM Reception
Tuesday May 13, 2014
Overview
7:00AM
7:00 AM
7:00 AM
8:00 AM
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10:30 AM
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12:30 PM
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6:15 PM
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2:00 PM
3:30 PM
3:30 PM
4:30 PM
6:00 PM
6:00 PM
7:00 PM
10:00 PM
8:30PM
Registration
Speaker Ready Room
Continental Breakfast
Plenary Talk
Interest Group 2
Interest Group 5
Coffee Break
Interest Group 2
Session I
Lunch
NAS Council Meeting
Posters
Session II
Session III
Posters and Coffee Break
Session IV
Session V
Peter Harris Research Achievement Award
ECI Social
International Council Retreat
Grande Promenade Foyer
Regency Conference Room
Starlight Ballroom
Grande Promenade
Grande Promenade
Regency Ballroom
Grande Promenade
Grande Promenade
Regency Ballroom
Grande Promenade
Miramar North
Spanish Suite
Grande Promenade
Regency Ballroom
Spanish Suite
Grande Promenade
Regency Ballroom
Grande Promenade
Sea Breeze Bar (by the pool)
Miramar South
8:00 AM – 8:45 AM Plenary Talk
Chair: Joshua Hare
Andrew Schally - Nobel Prize in Medicine 1977
Distinguished Medical Research Scientist of the Department of Veterans Affairs
Head of the Endocrine, Polypeptide and Cancer Institute
Veterans Affairs Medical Center, Research Service (151) Miami, FL and
South Florida VA Foundation for Research and Education
Distinguished Leonard Miller Professor of Pathology
Professor Division of Hematology/Oncology
and Division of Endocrinology Department of Medicine
Miller School of Medicine, University of Miami, FL
Talk title: Hypothalamic Hormones: From Neuroendocrinology to Therapy of Cancer and Other Diseases
9:00 AM – 10:30 AM – Interest Group 2 Session - Cardiac Metabolism: “The active role of myocardial
lipid storage”
Chair: Rong Tian and Jessica Toli
Jason Dyck - How does ATGL regulates cardiac fatty acid oxidation?
Doug Lewandowski - TAG turnover and pathological hypertrophy
Steve Kolwicz - Does the TAG metabolism affect the response to ischemia?
Peter Crawford - Myocardial ketone body oxidation attenuates pressure overload -induced ventricular
dilatation and reactive oxygen species accumulation
9:00 AM - 10:30 AM – Interest Group 5 Session - Excitation -Contraction Coupling: "Novel Mechanisms
In Calcium Microdomain Signaling”
Chair: Evangelia (Litsa) Kranias and Randi Parks
Xander Wehrens - Sarcoplasmic Reticulum Calcium Leak and Re -entry
Bjorn Knollmann - Calcium and myofilaments – an update on arrhythmia mechanisms in hypertrophic
cardiomyopathy
Peter J Mohler - Ankyrin - and spectrin -based pathways for human arrhythmia
Julie Bossuyt - Protein kinase D: a regulator of Calcium signaling?
10:30 AM - 11:00 AM – Coffee Break
11:00 AM – 12:30 PM – Interest Group 4 Session - Contractile & Regulatory Proteins
Chair: Michael Regnier and Sumit Kar
John Konhilas - LKB1 as a novel regulator of contractility
Renzhi Han - Molecular mechanism to repair the sarcolemmal injury
Brandon Biesiadecki - Troponin phosphorylation: Isolated or integrated events?
Margaret Westfall - Direct and adaptive modulation of contractile performance
Md. Shenuarin Bhuiyan - Physiological significance of cMyBPC's interaction with actin and myosin in vivo
11:00AM - 12:30 PM – Session I: Stem Cells I
Chair: Jianyi Zhang and Ivonne Schulman
Mark Sussman - Cardiac Regeneration: Uncommon Sense for Common Problems
Annarosa Leri - The aging cardiomyopathy: pathophysiology and therapeutic strategies
Lior Gepstein - Induced pluripotent stem cells for disease modeling and drug discovery
Joseph Wu - iPSCs for Modeling Human Heart Disease
12:30 PM – 1:15 PM Lunch
1:15 PM – 2:00 PM Posters
2:00 PM - 3:30 PM - Session II: Novel Signaling Pathways that Induce Pathological Hypertrophy
Chair: Ju Chen and Khadija Rafiq
Walter Koch - Novel Role for GRK5 in Cardiac Hypertrophy
Thomas Force - Targeting TNNI3K in a variety of pathologic scenarios
Elizabeth Mcnally - Genetic Modifiers of Cardiomyopathy
Sathyamangla Naga Prasad - Inhibition of β -adrenergic receptor resensitization underlies cardiac
dysfunction and failure
2:00 PM - 3:30 PM Session III: Calcium Signaling Pathways in the Failing Heart I
Chair: David Eisner and Margaux Horn
Joan Heller Brown - Mitochondrial reprogramming by CaMKIIδ contributes to the cardiomyopathy of
pressure overload in mice
Mark Anderson - CaMKII in heart failure
Susan Steinberg - The structural determinants of protein kinase C -delta activity; Rules of
phosphorylation
Christian Faul - FGF23 -mediated Activation of FGFR4 is a Novel Hypertrophic Signaling Pathway FGF23 mediated Activation of FGFR4 is a Novel Hypertrophic Signaling Pathway
3:30 PM - 4:30 PM – Posters and Refreshments
4:30 PM - 6:00 PM Session IV: Mechanisms of Myocyte Death – Autophagy
Chair: Chris Baines and Maggie Lam
Junichi Sadoshima - The role of Drp1 in mitochondrial quality control in the heart.
Peipei Ping - The Design, Characterization, and Function of Mitochondrial Proteomes
Gerald Dorn - Mitochondrial dynamism orchestrates mitochondrial biogenesis and mitophagy in the
heart
Richard Kitsis – Towards development of a small molecule drug to reduce heart damage from
myocardial infarction
4:30PM - 6:00 PM Session V: Calcium Signaling Pathways in the Failing Heart II
Chair: Lorrie Kirshenbaum
Steven Houser - Do TRPC Channels Contribute to Disturbed Contractility in Heart Failure?
Donald Bers - SR Ca leak: Molecular basis and role in arrhythmias
Luis Fernando Santana - Local control of SR dyads during the development of heart failure
Federica del Monte - Presenilin: a novel EC -coupling protein to target calcium dishomeostasis
6:15 – 7:00 PM Plenary Session
Chair: Matt Hori and Elizabeth Murphy
Peter Harris Research Achievement Award:
Evangelia Kranias, PhD
Hanna Professor and Director
Cardiovascular Biology
Distinguished University Professor
Co -Director, Cardiovascular Center of Excellence
Department of Pharmacology & Cell Biophysics
University of Cincinnati College of Medicine
Talk Title: Calcium Circuits in the Heart: A Matter of Life or Death
7:00 - 10:00 PM ECI Social
Wednesday – May 14, 2014
Overview
7:00AM
7:00 AM
7:00 AM
7:00 AM
8:00 AM
9:00 AM
9:00 AM
10:30 AM
11:00 AM
11:00 AM
12:30 PM
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1:15 PM
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4:30 PM
6:00 PM
6:45PM
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8:00 AM
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10:30 AM
10:30 AM
11:00 AM
12:30 PM
12:30 PM
1:15 PM
1:30 PM
2:00 PM
3:30 PM
3:30 PM
4:30 PM
6:00 PM
6:00 PM
6:45PM
9:00PM
Registration
Speaker Ready Room
Continental Breakfast/
International Council Meeting
Plenary Talk
Session VI
Session VII
Coffee Break
Session VIII
Session IX
Lunch
International Council meeting
Posters
Session X
Session XI
Posters and Coffee Break
Session XII
Session XIII
Oustanding Investigator Award
Banquet
Grande Promenade Foyer
Regency Conference Room
Starlight Ballroom
Miramar North
Grande Promenade
Grande Promenade
Regency Ballroom
Grande Promenade
Grande Promenade
Regency Ballroom
Starlight Ballroom
Miramar North
Spanish Suite
Grande Promenade
Regency Ballroom
Spanish Suite
Grande Promenade
Regency Ballroom
Grande Promenade
Starlight Ballroom
8:00 AM – 8:45 AM Plenary Talk
Chair: Joshua Hare
Pascal Goldschmidt
Senior Vice President for Medical Affairs and Dean
University of Miami Miller School of Medicine
Chief Executive Officer, University of Miami Health System
Talk Title: Of Aging, Inflammation, Frailty, and Stem Cells
9:00 AM – 10:30 AM Session VI: Stem Cells in Clinical Trials
Chair: Alan Heldman and Grant Budas
Roberto Bolli - Cell therapies for the treatment of heart failure
Atul Chugh - Stem Cell Therapy for Heart Failure: Lessons Learned from Cardiac Imaging
Joshua Hare – Mesenchymal Stem Cells and the Prevention of Heart Failure
Vasileios Karantalis - Genetic Modification of ckit+ Cardiac Stem Cells to Overexpress Pim1 Enhances
their Cardioreparative Ability After Intramyocardial Delivery
9:00 AM – 10:30 AM Session VII: Regulation of Myocyte Gene Expression
Chair: Eva Van Rooij and Samarjit Das
Joseph Hill - Unfolded Protein Response and Cardioprotection
Nanette Bishopric - Tackling maladaptive transcription programs in hypertrophy to prevent heart failure
Lena Shehadah - Osteopontin RNA Aptamer Protects Against Cardiac Dysfunction
Coralie Poizat - CaMKII epigenetic control of histone H3 in heart failure
10:30 AM – 11:00 AM – Coffee Break
11:00 AM - 12:30 PM Session VIII: Stem Cells II
Chair: Omaida Velazquez and Victorea Florea
Chunming Dong - microRNA Regulation of Endothelial Progenitor Cell Senesce, Vascular Repair and
Angiogenesis
Claudia Rodrigues - Molecular Mechanisms that Control Stem Cell Self -Renewal and Survival under
Ischemic Stress
Piero Anversa - Human Cardiac Stem Cell Classes
Sunjay Kaushal – How Aging and Physiological state of the Pediatric Heart Effects the Functional Activity
of Cardiac Stem Cells.
11:00 AM - 12:30 PM Session IX: Mitochondria
Chair: Matt Hori and Monte Willis
Elizabeth Murphy - Role of Mitochondria in Ischemia -Reperfusion Injury
Wang Wang - Mitochondrial Superoxide Production in Healthy and Diseased Heart
Madesh Muniswamy - A rheostat for mitochondrial Ca2+ flux in cardiovascular system
Xuejun Wang - Loss of Function of an Extraproteasomal Ubiquitin Receptor Ubiquilin1 in Cardiomyocytes
Exacerbates Cardiac Proteotoxicity
12:30 PM – 1:15 PM Lunch
1:15 PM - 2:00 PM Posters
2:00 PM – 3:30 PM Session X: Novel Therapeutics For Heart Failure
Chair: Metin Avkiran and Mark Kohr
Jonathan Stamler - New S -Nitrosylation Signals In The Heart
Anthony Rosenzweig - Mining Exercise For New Therapeutic Targets
Michael Kapiloff - Targeting mAKAP Signaling Complexes In Heart Failure
Timothy Mckinsey - Regulation Of Cardiac Hypertrophy And Fibrosis By Lysine Acetylation
2:00 PM - 3:30 PM Session XI: Metabolism
Chair: Lawrence Young and Maengjo Kim
Gary Lopaschuk - Inhibiting fatty acid oxidation as a novel approach to treating heart failure
Jenny Van Eyk - Cross talk between phosphorylation and oxidative post -translational modifications
regulate mitochondrial and cell function
Heinrich Taegtmeyer - Metabolic Signals as Regulators of Myocardial Protein Turnover
Michael Regnier - AAV6 -mediated overexpression of Ribonucleotide Reductase (R1R2) that increases
myocardial dATP and improves function of normal and failing hearts.
3:30 PM - 4:30 PM Posters and Refreshments
4:30 PM - 6:00 PM Session XII: Heart Failure Insights from Developmental Biology
Chair: Sakthivel Sadayappan and Sarah Franklin
Howard Rockman - Biased GPCR Ligands for Heart Failure
Leslie Leinwand - Myosin Myopathies: Pathogenesis and Development of Therapies
Joy Lincoln - Embryonic Origins of Calcific Aortic Heart Valve Disease
Carmen Sucharov - FXR1G/E and regulation of microRNA function in cardiac disease and differentiation
4:30 PM – 6:00 PM Session XIII: Novel Regenerative Therapies
Chair: Sudhiranjan Gupta
Kunhua Song - Induction of fibroblasts into cardiac -like myocytes
Kevin Costa – Tissue Engineering Strategies for Cardiac Therapy
Luiza Lima Bagno - Reduction of Scar Tissue after GHRH -A Treatment in a Swine Model of Sub -acute
Ischemic Cardiomyopathy.
Viky Suncion - Effect Of Transendocardial Autologous Cardiac Stem Cells And Bone Marrow
Mesenchymal Stem Cells To Reduce Infarct Size And Restore Cardiac Function In a Heart Failure
Swine Model
6:00PM – 6:45 PM
Chair: Richard Moss and David Eisner
Outstanding Investigator Award:
Åsa B. Gustafsson Ph.D.
Associate Professor
Skaggs School of Pharmacy and Pharmaceutical Sciences
University of California, San Diego
Talk Title: Role of Mitochondrial Autophagy in Cardioprotection
6:45 PM – 9:45 PM Banquet
Thursday May 15, 2014
Overview
7:00AM
7:00 AM
7:00 AM
8:00 AM
9:00 AM
9:00 AM
10:30 AM
11:00 AM
11:00 AM
12:00PM
12:00 PM
8:00 AM
8:45 AM
10:30 AM
10:30 AM
11:00 AM
12:30 PM
12:30 PM
Registration
Speaker Ready Room
Continental Breakfast
President’s Lecture
Session XIV
Session XV
Coffee Break
Session XIV
Session XV
Grande Promenade Foyer
Regency Conference Room
Starlight Ballroom
Grande Promenade
Grande Promenade
Regency Ballroom
Grande Promenade
Grande Promenade
Regency Ballroom
8:00 AM - 8:45AM President’s Lecture
Chair: Metin Avkiran
Keiichi Fukuda, MD, PhD
President, ISHR Japanese Section
Professor, Department of Regenerative Medicine and Advanced Cardiac Therapeutics
Keio University School of Medicine
Talk Title: Regenerative Medicine of the Heart using iPS cells
9:00 AM – 10:30 AM Session XIV: Mechanisms of Familial Cardiomyopathies
Chair: Richard Moss and Stephen Lange
John Solaro - Mechanisms and Potential Therapies in Familial Cardiomyopathies.
Danuta Szczesna -Cordary - Novel strategies to combat Familial Cardiomyopathy associated with the
Myosin Regulatory Light Chain
Jeffrey Robbins - cardiac myosin binding protein C; insights from structure -function studies
Sakthivel Sadayappan - Increased Inflammation and Oxidative Stress in a Mouse Model of Dilated
Cardiomyopathy
9:00 AM - 10:30 AM Session XV: Cardiac Fibrosis
Chair: Pieter de Tombe and Rushita Bagchi
Burns Blaxall - Targeting pathologic activation of cardiac fibroblasts in myocardial fibrosis
Nikolaos Frangogiannis - TGF -beta signaling in cardiac fibrosis
Jeffrey Molkentin - Understanding the origins and activity of the cardiac fibroblast
Sumanth Prabhu - New insights on inflammation and heart failure
10:30 AM – 11:00 AM Coffee Break
11:00 AM - 12:30 PM Session XVI: Stem Cells III
Chair: Joshua Hare and Nirmala Hariharan
Daniel Bernstein - Maturation of Cell Signaling in hiPSC -CMs: Regulators of Function and Structure
Keith March – Stem Cell Therapies for Human Cardiovascular Disease
Monte Willis - Non -targeted metabolomics analysis of Muscle Ring Finger -1 (MuRF1), MuRF2, and
MuRF3 in vivo reveals novel and redundant metabolic changes
11:00 AM – 12:30 PM Session XVII: Compartmentation in Cardiac Signal Transduction Chair: Kimberly Dodge -Kafka and Catherine Passariello
Viacheslav Nikolaev - Remodeling of cAMP microdomains in hypertrophy and heart failure
Carmen Dessauer - Facilitation of cAMP Signaling in Heart by Anchored Adenylyl Cyclase Complexes
Timothy O’Connell - Intranuclear alpha -1 adrenergic receptor signaling and physiologic function in
cardiac myocytes
12:30 PM Meeting Closed
Poster Sessions
Posters are located in the Spanish Suite.
Poster Session 1: P1 -01 to P1 -52 - Tuesday, May 13 1:15 -2:00 PM and 3:30 -4:30 PM
Poster Session 2: P2 -01 to P2 -52 - Wednesday, May 14 1:15 -2:00 PM and 3:30 -4:30 PM
Presenting author underlined
Poster Session 1: P1 -01 to P1 -52 - Tuesday, May 13 1:15 -2:00 PM and 3:30 -4:30 PM
Heart Failure/Hypertrophy Part I
P1 -01
Lysyl oxidase inhibition can reverse age -related myocardial fibrosis.
Nicole Rosin1, Timothy Lee1, Jean -Francois Legare1, 1Dalhousie University, Halifax, NS, Canada
P1 -02
A novel PKCalpha splicing isoform in signaling for cardiac hypertrophy
CHEN GAO1, Jianli Gong2, William Wang2, Susan Steinberg2, Yibin Wang1, 1Molecular Biology
Institute,University of California, Los Angeles, Los Angeles,CA, USA, 2Department of
Pharmacology, Columbia University, New York, USA
P1 -03
Paroxetine -mediated GRK2 inhibition reverses cardiac dysfunction and remodeling post myocardial infarction
Sarah Schumacher1, Erhe Gao1, John Tesmer2, Walter Koch1, 1Temple University School of
Medicine, Philadelphia, PA, USA, 2University of Michigan, Ann Arbor, MI, USA
P1 -04
A novel human mutation in Hsp20 (S10F) abrogates the contractile and protective effects of
this protein in the heart
Guansheng Liu1, Wen Zhao1, Elizabeth Vafiadaki2, Chi Keung Lam1, Min Jiang3, Jack Rubinstein3,
George Adly1, Evangelia G. Kranias1,2, 1Department of Pharmacology & Cell Biophysics, University
of Cincinnati College of Medicine, Cincinnati, OH, USA, 2Molecular Biology Division, Center for
Basic Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece,
3Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH,
USA
P1 -05
A novel human R25C -phospholamban mutant is associated with superinhibition of calcium
cycling and increased apoptosis
Guansheng Liu1, Ana Morales2,4, Elizabeth Vafiadaki5, Kobra Haghighi1, Ray E. Hershberger2,4,
George Adly1, Evangelia G. Kranias1,5, 1Department of Pharmacology & Cell Biophysics, University
of Cincinnati College of Medicine, Cincinnati, OH, USA, 2Division of Human Genetics, Department
of Internal Medicine, Ohio State University College of Medicine, Columbus, OH, USA, 3Division of
Cardiovascular Medicine, Department of Internal Medicine, Ohio State University College of
Medicine, Columbus, OH, USA, 4Dorothy M. Davis Heart and Lung Research Institute, Ohio State
University College of Medicine, Columbus, OH, USA, 5Molecular Biology Division, Biomedical
Research Foundation, Academy of Athens, Athens, Greece
P1 -06
Impaired nitroso -redox signaling is involved in human heart failure
Sara Menazza1, Angel Aponte2, Charles Steenbergen3, Elizabeth Murphy1, 1System Biology
Center, NHLBI, NIH, Bethesda, MD, USA, 2Proteomics Core Facility, NHLBI, NIH, Bethesda, MD,
USA, 3Department of Pathology, The Johns Hopkins University, Baltimore, MD, USA
P1 -07
Inhibition of tubulin deacetylation is protective in cardiac proteinopathy through autophagy
-mediated aggregate reduction
Patrick M. McLendon1, Bradley S. Ferguson2, Hanna Osinska1, Md. Shenuarin Bhuiyan1, Jeanne
James1, Timothy A. McKinsey2, Jeffrey Robbins1, 1Cincinnati Children's Hospital Medical Center,
Cincinnati, OH, USA, 2University of Colorado, Denver, Aurora, CO, USA
P1 -08
Cardio -protection following myocardial infarction in female is absent in mice lacking the S nitrosoglutathione reductase (GSNOR).
Shathiyah Kulandavelu1, Ellena Paulino1, Lauro Takeuchi1, Wayne Balkan1, Joshua M Hare1,
1Stem Cell Institute, Miami, Florida, USA
P1 -09
miRNA Expression in hypoplastic left heart syndrome
Juliana Sucharov2, Anis Karimpour -Fard1, Karin Nunley1, Brian Stauffer1,3, Shelley Miyamoto2,1,
1University of Colorado Anschutz Medical Campus, Aurora, CO, USA, 2Children's Hospital
Colorado, Aurora, CO, USA, 3Denver Health and Hospital Authority, Denver, CO, USA
P1 -10
Gene expression profiling in pediatric and adult heart failure
Shelley Miyamoto2,1, Matthew Taylor1, Anis Karimpour -Fard1, Kenneth Jones1, Brian Stauffer1,3,
Carmen Sucharov1, 1University of Colorado Anschutz Medical Campus, Aurora, CO, USA,
2Children's Hospital Colorado, Aurora, CO, USA, 3Denver Health and Medical Authorities, Denver,
Co, USA
P1 -11
Hypoxia sensitivity in DMD: a potential link between respiratory insufficiency and heart
failure
Zachary Stelter1, Jana Strakova1, DeWayne Townsend1, 1University of Minnesota, Minneapolis,
MN, USA
P1 -12
Υ2 -AMPK regulates pathological cardiac hypertrophy in mice
Maengjo Kim1, Lorena Menendez1, Richard Palmiter1, Rong Tian1, 1University of Washington,
Seattle, WA, USA
P1 -13
Disruption of RSK3 binding to muscle A -kinase anchoring protein in vivo via adeno associated virus expression of a competing peptide attenuates pressure overload -induced
cardiac hypertrophy
Catherine Laura Passariello1, Michael D Kritzer1, Hrishikesh Thakur1, Michael Sanders1, Jinliang
Li1, Michael S. Kapiloff1, 1University of Miami, Miami, FL, USA
P1 -14
Genome wide study of TFIIB binding and its role in cardiac hypertrophy
Danish Sayed1, Zhi Yang1, Maha Abdellatif1, 1Rutgers New Jersey Medical School, Newark, NJ,
USA
P1 -15
Frailty predicts cardiac dysfunction independently of age in older mice
Susan Howlett1, 1Dalhousie University, Halifax, Nova Scotia, Canada
P1 -16
Down -regulation of adenine nucleotide translocator 1 exacerbates cardiac inflammation
Shi Pan1, Nadan Wang1, Sara Bisetto1, Shey -Shing Sheu1, 1Thomas Jefferson University,
Philadelphia, USA
P1 -17
Cardiac extracellular matrix remodelling following recovery from pacing -induced heart
failure in the sheep
Margaux Horn1, Katharine Dibb1, Andrew Trafford1, 1University of Manchester, Manchester, UK
P1 -18
Restoration of transverse (t) tubules following recovery from heart failure (HF)
Jessica Caldwell1, David Eisner1, Katharine Dibb1, Andrew Trafford1, 1University of Manchester,
Manchester, UK
Cardiac Regeneration/Cell Therapies
P1 -19
Cytoprotective effect of growth hormone releasing hormone agonist in cardiac stem cells
Victoria Florea1, 1Interdisciplinary Stem Cell Institute, University of Miami, Miami, FL, USA,
2Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL, USA,
3Department of Pathology, University of Miami, Miami, FL, USA, 4Division of Cardiology,
Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami,FL,
USA, 5Endocrine, Polypeptide and Cancer Institute, Veterans Affairs Medical Center, Miami, FL,
USA
P1 -20
Targeting gene expression to endothelial cells of specific organs
Anahita Mojiri1, Nadia Jahroudi1, 1University of Alberta, Edmonton/Alberrta, Canada
P1 -21
Genetic ablation of S -nitrosoglutathione reductase (GSNOR) in mice enhances proliferative
expansion of adult heart progenitors and myocytes post myocardial infarction
Konstantinos Hatzistergos1, Ellena Paulino1, Raul Dulce1, Lauro Takeuchi1, Shathiyah
Kulandavelu1, Wayne Balkan1, Rosemeire Kanashiro -Takeuchi1, Joshua Hare1, 1University of
Miami, Interdisciplinary Stem Cell Institute, Miami, Fl, USA
P1 -22
Connexin 43 overexpression enhances cardioprotective effects of cortical -bone derived
stem cells in the infarcted heart
Danielle Trappanese1, Jason Duran1, Thomas Sharp1, Timothy Starosta1, Yumi Chiba1, Remus
Berretta1, Sharven Taghavi1, John Gaughan2, Joseph Rabinowitz2, Hajime Kubo1, Steven Houser1,
1Temple University School of Medicine, Cardiovascular Research Center, Philadelphia, PA, USA,
2Temple University School of Medicine, Center for Translational Medicine, Philadelphia, PA, USA
P1 -23
Isolation and characterization of cortical bone stem cells from Göttingen minipig
Thomas Sharp1, Sadia Mohsin1, Timothy Starosta1, Remus Berretta1, Jason Duran1, Hajime Kubo1,
Steven Houser1, 1Temple University School of Medicine, Philadelphia, PA, USA
P1 -24
Effects of Connexin 43 presence or absence in human bone -marrow derived mesenchymal
stem cells
Cristina Sanina1, Ivonne Schulman1, Michael Bellio1, Wayne Balkan1, Claudia Rodrigues1, Joshua
Hare0, 1University of Miami, Miami, FL, USA
Contractility & Mechanics
P1 -25
Physiological significance of cMyBPC's interaction with actin and myosin in vivo
Md. Shenuarin Bhuiyan1, Jeanne James1, Hanna Osinska1, James Gulick1, Jeffrey Robbins1,
1Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
P1 -26
Myofilament length dependent activation: role of titin
Younss Ait -Mou1, Karen Hsu3, Marion Greaser2, Tom Irving3,1, Pieter de Tombe1, 1Loyola
University Chicago, Maywood IL, USA, 2University of Wisconsin -Madison, Madison WI, USA,
3Illinois Institute of Technology, Chicago UL, USA
P1 -27
Micro -RNA765 targets Protein Phosphatase Inhibitor -1 and suppresses contractility
Wen -Feng Cai1, Stela Florea1, Jiang Qian1, Wen Zhao1, Tracy Pritchard1, Chi Keung Lam1,
Guansheng Liu1, Kobra Haghighi1, Djamel Lebeche2, Long Jason Lu3, Jingyuan Deng3, Guo Chang Fan1, Roger J. Hajjar2, Evangelia G. Kranias1, 1Department of Pharmacology and Cell
Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, USA, 2Cardiovascular
Research Center, Mount Sinai School of Medicine, New York, NY, USA, 3Division of Biomedical
Informatics, Cincinnati Children's hospital research Foundation, Cincinnati, OH, USA
P1 -28
Increased inflammation and oxidative stress exacerbates contractile dysfunction in dilated
cardiomyopathy
Thomas Lynch1, Mayandi Sivaguru2, Murugesan Velayutham 3, Arturo Cardounel3, Christoph
Liebetrau4, David Barefield1, Suresh Govindan1, Christian Troidl5, Sakthivel Sadayappan1, 1Loyola
University Chicago, Maywood, IL, USA, 2University of Illinois at Urbana -Champaign, Urbana Champaign, IL, USA, 3The Ohio State University, Columbus, OH, USA, 4Kerckhoff Heart and
Thorax Center, Bad Nauheim, Hessen, Germany, 5Kerckhoff Institute for Heart Research, Justus Liebig -University Giessen, Giessen, Hessen, Germany
P1 -29
Impact of anesthesia and storage on post -translational modifications of myofilament
proteins in mouse ventricular lysates
Megan S. Utter1, Chad M. Warren1, R. John Solaro1, 1Department of Physiology and Biophysics,
Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois, USA
P1 -30
Cross -bridge cycling rates are length independent: Implications for cardiac economy and
the Frank -Starling Law
Daria Amiad -Pavlov1, Amir Landesberg1, 1Technion -IIT, Haifa, Israel
P1 -31
Dilated cardiomyopathy linked mutation cTnT R173W in cardiomyocyte -derived human
induced pluripotent stem cells affects sarcomere structure and function
Kathleen Broughton1, Ying -Hsi Lin1, Veronica Sanchez -Freire2, Beata Wolska1, Joseph Wu2, John
Solaro1, Brenda Russell1, 1University of Illinois at Chicago, Chicago, IL, USA, 2Stanford University,
Chicago, IL, USA
P1 -32
Discovery of enzyme modulators via high -throughput time -resolved FRET in living cells
Simon Gruber1, Razvan Cornea1, Kurt Peterson2, Gregory Gillispie1,2, Seth Robia3, David
Thomas1, 1University of Minnesota, Minneapolis, MN, USA, 2Fluorescence Innovations, Inc.,
Minneapolis, MN, USA, 3Loyola University, Chicago, IL, USA
P1 -33
Functional effects of E143K mutation in myosin Essential Light Chain associated with
Restrictive Cardiomyopathy in humans
Chen -Ching Yuan1, Wenrui Huang1, Katarzyna Kazmierczak1, Jingsheng Liang1, Ana I Rojas1,
Rosemeire Kanashiro -Takeuchi1, Joshua Hare1, Danuta Szczesna -Cordary1, 1University of Miami,
Miami, USA
Mitochondria
P1 -34
The mitochondrial protein FASTKD1 protects cells from oxidative stress induced death
independently of the mitochondrial permeability transition pore
Kurt Marshall1, Christopher Baines1, 1University of Missouri - Columbia, Columbia, Missouri, USA
P1 -35
Genetic manipulation of cardiac mitochondrial phosphate carrier does not affect
permeability transition
Manuel Gutierrez -Aguilar1, Diana Douglas1, Anne Gibson1, Timothy Domeier1, Jeffery Molkentin2,
Christopher Baines1, 1University of Missouri - Columbia, Columbia, MO, USA, 2University of
Cincinnati, Cincinnati, OH, USA
P1 -36
GAPDH targets specific mitochondrial proteins as a trans -S -nitrosylase
Mark Kohr1,2, Elizabeth Murphy2, Charles Steenbergen1, 1Johns Hopkins University School of
Medicine, Baltimore, MD, USA, 2National Heart, Lung and Blood Institute/National Institutes of
Health, Bethesda, MD, USA
P1 -37
Recovery of mitochondrial bioenergetics after hypoxia via regulating pyruvate
dehydrogenase kinase and AMP -activated kinase
Jessica Toli1, Minzhen He1, Carolyn Suzuki1, Maha Abdellatif1, 1Rutgers University, Newark, NJ
P1 -38
Effect of chronic continuous hypoxia on mitochondrial enzymes in hearts of spontaneously
hypertensive rats (SHR) and in conplastic strain SHR -mtBN
Anna Chytilova1, Martin Kalous2, Romana Weissova2, Zdenek Drahota1, Iveta Brabcova2, Jitka
Zurmanova2, Olga Nováková2, Michal Pravenec1, Frantisek Kolar1, Jan Neckar1, 1Institute of
Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic, 2Faculty of
Science, Charles University in Prague, Prague, Czech Republic
P1 -39
ROCK2 promotes mitochondrial dysfunction in the diabetic heart
Guorong Lin1, Kathleen M. MacLeod1, 1Faculty of Pharmaceutical Sciences, University of British
Columbia, Vanvouver, Canada
P1 -40
miR -181c regulates the mitochondrial genome, bioenergetics, and propensity for heart
failure in vivo
Samarjit Das1, Qin Shao1, Djahida Bedja1,2, Nathaniel Campbell1, Brittany Dunkerly1,3, Venugopal
Chenna4, Anirban Maitra4,1, Charles Steenbergen1, 1Johns Hopkins University, Baltimore MD,
USA, 2Australian School of Advanced Medicine, Macquarie University, Sydney, Australia, 3Notre
Dame of Maryland University, Baltimore MD, USA, 4MD Anderson Cancer Center, Houston, TX,
USA
P1 -41
Inhibition of soluble epoxide hydrolase improves cardiac function and limits mitochondrial
damage from ischemic injury
Maria Akhnokh1, Victor Samokhvalov1, Feng Hua Yang1, Xiuhua Wang3, Ratnadeep Basu3, Gavin
Y. Oudit4,5, Zamaneh Kassiri3,5, Woo jung Cho5, Bruce Hammock6, John M. Seubert1,2, 1Faculty of
Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada,
2Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada, 3Department of
Physiology, University of Alberta, Edmonton, Alberta, Canada, 4Division of Cardiology, Faculty of
Medicine, University of Alberta, Edmonton, Alberta, Canada, 5Mazankowski Alberta Heart Institute,
Faculty of Medicine, University of Alberta., Edmonton, Alberta, Canada, 6Department of
Entomology and Cancer Research Center, University of California., Davis, California, USA
P1 -42
Eicosanoids limit cardiac mitochondrial damage following starvation induced stress
Haitham El -Sikhry1, Victor Samokhvalov1, Nasser Alsaleh1, John Falck2, John Seubert1,3, 1Faculty
of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton,AB, Canada,
2Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical
Center, Dallas, TX, USA, 3Department of Pharmacology, Faculty of Medicine, University of Alberta,
Edmonton, AB, Canada
Ischemia/Reperfusion Injury
P1 -43
A case of successful delayed thrombolysis in a patient with submassive pulmonary
embolism
Ravinder Valadri1, 1Wright Center For Graduate Medical Education, Scranton, PA, USA, 2wilkes
Barre General Hospital, Wilkes -Barre, PA, USA
P1 -44
Stimulation of the DR region of Na+ -K+ -ATPase -induced cardioprotection is mediated by
activation of PP2A
Fei Hua1, Jin Zheng1, Jinsong Bian1, 1National University of Singapore, Singapore, Singapore
P1 -45
Cardioprotection with a Mas receptor inverse -agonist: A preclinical study in a swine model
of myocardial infarction
Bruce R. Ito1, John W. Adams2, Robert M. Mentzer, Jr.1,3, 1San Diego State University, San Diego,
CA, USA, 2Arena Pharmaceuticals Inc., San Diego, CA, USA, 3Wayne State University, Detroit, MI,
USA
P1 -46
S -nitrosylation of TRIM72 at cysteine 144 protects against oxidation -induced degradation
and reduces cell death
Mark Kohr1,2, Alicia Evangelista1, Marcella Ferlito2, Charles Steenbergen2, Elizabeth Murphy1,
1National Heart, Lung and Blood/Institute, Bethesda, MD, USA, 2Johns Hopkins University School
of Medicine, Baltimore, MD, USA
P1 -47
The prognostic significance of elevated troponins in patients with sepsis: a meta -analysis
Olusegun Sheyin1, Oluwaseun Davies1, Wenlan Duan1, Xavier Perez1, 1Department of Medicine,
Harlem Hospital Center, New York, NY, USA
P1 -48
Hypoxia -induced decrease in cardiac stem cell proliferation is associated with
downregulation of Sirtuin 1
Michael Bellio1, Claudia O Rodrigues1, Victoria Florea1, Wayne Balkan1, Joshua Hare1, Ivonne H
Schulman1, 1University of Miami, Miami, Florida, USA
P1 -49
Cardiac Myosin Binding Protein -C is immunogenic following myocardial infarction
Thomas Lynch1, Christoph Liebetrau2, Lukas Pyttel2, Christian Troidl2, Sakthivel Sadayappan1,
1Loyola University Chicago, Maywood, Illinois, USA, 2Kerckhoff Heart and Thorax Center, Bad
Nauheim, Germany
P1 -50
Cardiac ischemic tolerance in Goldblatt hypertension: effect of epoxyeicosatrienoic acid
analog
Petra Mandikova1, Martina Klevstigova1, Libor Kopkan2, Zuzana Huskova2, John Imig3, Ludek
Cervenka2, Frantisek Kolar1, Jan Neckar1, 1Institute of Physiology, Academy of Sciences of the
Czech Republic, Prague, Czech Republic, 2Institute of Clinical and Experimental Medicine, Prague,
Czech Republic, 3Medical College of Wisconsin, Milwaukee, USA
P1 -51
MK5 deficiency affects scar maturation after myocardial infarction
Sherin Nawaito1, Yanfen Shi1, Marc -Antoine Gillis1, Matthias Gaestel2, Jean -Claude Tardif1,
Bruce Allen1, 1Université de Montréal, Montréal, Canada, 2Hannover Medical School, Hannover,
Germany
P1 -52
Novel fusion of GLP -1 with a domain antibody to serum albumin prolongs protection
against myocardial ischemia/reperfusion injury in the rat
Weike Bao1, Lucy Holt1, Rob Prince1, Gavin Jones1, Karpagam Aravindhan1, Mathew Szapacs1,
April Barbour1, Larry Jolivette1, John Lepore1, Robert Willette1, Elena DeAngelis1, Beat Jucker1,
1GlaxoSmithKline, King of Prussia, PA, USA
Poster P2-03 will be presented in Poster Session 1, and will be located after poster P1-52
POSTER SESSION 2: Wednesday, May 14, 2014 1:15 -2:00p and 3:30 -4:30p
Heart Failure/Hypertrophy Part II
P2 -01
GRK5 exacerbates cardiac pathology through activation of the NFAT pathway
Jonathan Hullmann1, Erhe Gao2, Kurt Chuprun2, Walter Koch2, 1Thomas Jefferson University,
Philadelphia, PA, USA, 2Temple University School of Medicine, Philadelphia, PA, USA
P2 -02
Metabolomic analysis reveals a novel panel of blood -based biomarkers that distinguish
between heart failure patients with reduced and preserved ejection fraction
Beshay Zordoky1, Miranda Sung1, Justin Ezekowitz1, Rupasri Mandal1, Beomsoo Han1, Trent
Bjorndahl1, Souhaila Bouatra1, Todd Anderson2, Gavin Oudit1, David Wishart1, Jason Dyck1,
1University
*
of Alberta, Edmonton, Canada, 2University of Calgary, Calgary, Canada
P2 -03 Reproducible ion -current -based approach for 24 -plex comparison of the tissue proteomes
of hibernating versus normal myocardium in swine models
Xiaomeng Shen1,2, Rebeccah Young1,3, Brian Page2,3, Nazeen Tata1, Jun Li1,2, Xiaotao Duan1,2,
James A. Fallavollita3,4, John M. Canty1,4, Jun Qu1,2, 1University at Buffalo State University of New
York, Buffalo, USA, 2Center for Excellence in Bioinformatics and Life Sciences, Buffalo, USA,
3Center for Research in Cardiovascular Medicine, Buffalo, USA, 4VA WNY Healthcare System,
Buffalo, USA
**Poster
P2-03 will be presented in Poster Session 1, and will be located after poster P1-52
P2 -04
The relationship between obesity and physical symptoms in patients with heart failure
Seongkum Heo1, Debra Moser2, Sandra Dunbar3, Susan Pressler4, Terry Lennie2, 1University of
Arkansas for Medical Sciences, Little Rock, Arkansas, USA, 2University of Kentucky, Lexington,
Kentucky, USA, 3Emory University, Atlanta, Georgia, USA, 4University of Michigan, Ann Arbor,
Michigan, USA
P2 -05
Inhibition of autophagy suppresses transdifferentiation of cardiac fibroblasts into
profibrotic myofibroblasts.
Shivika Gupta1,2, Saeid Ghavami1, Krista Filameno1,2, Morvarid Kavosh1,2, Sunil Rattan1,2, Andrew
Halayko1,3, Ian Dixon1,2, 1University of Manitoba, Winnipeg, Manitoba, Canada, 2Institute of
Cardiovascular Sciences, Winnipeg, Manitoba, Canada, 3Manitoba Institute of Child Health,
Winnipeg, Manitoba, Canada
P2 -06
Macrophage subsets: Contrasting roles in the development of myocardial fibrosis
Alec Falkenham1, Devin Betsch1, Nicole Rosin1, Tim Lee1, Roberto de Antueno1, Roy Duncan1,
Jean Francois Legare1, 1Dalhousie University, Halifax, Nova Scotia, Canada
P2 -07
CapZ beta1 subunitacetylation and actin assembly are regulated by HDAC in
cardiomyocytes
Ying -Hsi Lin1, Chad M. Warren1, Brenda Russell1, 1University of Illinois at Chicago, Chicago,
Illinois, USA
P2 -08
Physiological activation of Akt by PHLPP1 deletion protects against pathological
Amy Taylor1, Gino Chesini1, Melissa Barlow1, Asa Gustafsson2, Joan Heller Brown1, Nicole
Purcell1, 1Department of Pharmacology, University of California San Diego, La Jolla, CA, USA,
2Skaggs School of Pharmacy and Pharmaceutical Science, University of California, La Jolla, CA,
USA
P2 -09
Newly discovered troponin I mutation (K206I) linked to hypertrophic cardiomyopathy
impacts regulation of actomyosin ATPase
Chad M. Warren1, Beata M. Wolska1,2, Tomoyoshi Kobayashi1, Grace M. Arteaga5, J. Martijn Bos4,
Michael J. Ackerman3,4, R. John Solaro1, 1Departments of Physiology & Biophysics, Center for
Cardiovascular Research, University of Illinois at Chicago, Chicago,Illinois, USA, 2Department of
Medicine, Section of Cardiology, University of Illinois at Chicago, Chicago,Illinois, USA,
3Departments of Medicine/Division of Cardiovascular Diseases, and Molecular Pharmacology &
Experimental Therapeutics/Windland Smith Rice Sudden Death Genomics Laboratory, Mayo
Clinic, Rochester, Minnesota, USA, 4Department of Pediatrics/Division of Pediatric Cardiology,
Mayo Clinic, Rochester, Minnesota, USA, 5Departments of Pediatrics/ Division of Pediatric Critical
Care, and Physiology, Mayo Clinic, Rochester, Minnesota, USA
P2 -10
Expression of mitochondrial calcium uniporter correlates with functional parameters in
human heart failure
Christian Silva -Platas1, Andrea Cordero -Reyes3, Guillermo Torre -Amione1,2, Gerardo García Rivas1,2, 1Cátedra de Cardiología y Medicina Vascular. Escuela de Medicina. Tecnológico de
Monterrey., Monterrey, Nuevo León, Mexico, 2Centro de Investigación Básica y Transferencia.
Instituto de Cardiología y Medicina Vascular. Tec Salud., San Pedro Garza García, Nuevo León,
Mexico, 3Methodist DeBakey Heart & Vascular Center. The Methodist Hospital., Houston, TX, USA
P2 -11
Genetically mediated increase of T type Ca2+ current protects against cardiac dysfunction
after myocardial infarction
Hongyu Zhang1, Catherine Makarewich1, Hajime Kubo1, Foram Udesh1, Shavonn Smith1, Naser
Jaleel1, Remus Berretta1, Jeffery Molkentin2, Erhe Gao1, Walter Koch1, Xiongwen Chen1, Jon
George3, Steven Houser1, 1Temple University, Philadelphia, USA, 2University of Cincinnati,
Cincinnati, USA, 3Debora Heart and Lung Center, New Jersey, USA
P2 -12
Genetic deletion of miR -208a causes cardiac autonomic imbalance and impaired calcium
handling
Robert Davis1, Raghu Nagalingam 1, Mariam Noor1, Da -Zhi Wang2, Beata Wolska1, John Solaro1,
Madhu Gupta1, 1University of Illinois at Chicago, Chicago, IL, USA, 2Children's Hospital Boston Harvard Medical School, Boston. MA, USA
P2 -13
The role of the RNA binding proteins HuR and AUF1 in β 1 -adrenergic receptor mRNA
stability in heart failure
Stephen Kraynik1, Andrew Gabanic1, Sarah Anthony1, Melissa Kelley1, Michael Tranter1,
1University of Cincinnati, Cincinnati, OH, USA
P2 -14
A novel angiotensin II type 1 receptor blocker (TRV120023), signaling through the β arrestin pathway, improves cardiac function in a mouse model of dilated cardiomyopathy
Madhusudhan Tarigopula1, Robert T. Davis 3rd1, David F. Wieczorek2, Jonathan D. Violin3, Beata
M. Wolska1, R. John Solaro1, 1University of Illinois at Chicago, Chicago, IL, USA, 2University of
Cincinnati Medical Center, Cincinnati, OH, USA, 3Trevena Inc., King Prussia, USA
P2 -15
Differences in GRK2 & GRK5 expression levels in adult versus pediatric patients suffering
from Idiopathic Dilated Cardiomyopathy
Elizabeth Medina1, Carman Sucharov1, Karen Dockstader1, Rebecca Sobus1, Shelley Miyamoto1,
Brian Stauffer1, 1University of Colorado Health Sciences Center, Aurora, Co, USA
P2 -16
Ski modulates myofibroblast induced ECM remodeling through regulation of MMP -2 in rat
cardiac fibroblasts
Morvarid S. Kavosh1, Ian M.C. Dixon1, 1Institute of Cardiovascular Sciences, St. Boniface
Research Center, University of Manitoba, Winnipeg,MB, Canada
P2 -17
Anthracycline cardiotoxicity: the pharmacokinetics and pharmacodynamics of dexrazoxane
and its putatively cardioprotective metabolite ADR -925
Anna Jirkovska -Vavrova1, Eduard Jirkovsky2, Jan Stariat1, Hana Jansova1, Jaroslav Roh1, Olga
Lencova -Popelova2, Petra Kovarikova1, Martin Sterba2, Tomas Simunek1, 1Charles University in
Prague, Faculty of Pharmacy in Hradec Kralove, Hradec Kralove, Czech Republic, 2Charles
University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic
P2 -18
Entering the matrix of heart failure: Alterations in myofilament -associated MMPs and TIMPs
in naturally occurring canine dilated cardiomyopathy
Ilka Lorenzen -Schmidt1, Kristel Dimitrova1, W. Glen Pyle1, 1Cardiovascular Research Group,
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph,
ON, Canada
Signalling Mechanisms
P2 -19
Candesartan and valsartan, contrary to irbesartan, are potent biased antagonists of adrenal
(beta)arrestin -dependent, angiotensin II type 1 receptor -induced aldosterone production
and improve cardiac function post -myocardial infarction
Anastasios Lymperopoulos1, Karlee Walklett1, Samalia Dabul1, Ashley Siryk1, Emmanuel
Sturchler2, Patricia McDonald2, Walter Koch3, 1Nova Southeastern University, Ft. Lauderdale, FL,
USA, 2Scripps Florida, Jupiter, FL, USA, 3Temple University, Philadelphia, PA, USA
P2 -20
Combined cardiac PPARα and PPARγ activation reduce PGC -1α gene expression and
compromise binding of PPARγ on PGC -1α
Konstantinos Drosatos1, Diego Scerbo2, Christian Schulze2, Ira J. Goldberg2, 1Temple University
School of Medicine, Philadelphia, PA, USA, 2Columbia University, New York, NY, USA
P2 -21
Inhibition of NF -kB in the lungs prevents monocrotaline induced pulmonary hypertension
in mice by modulating miR -130a
Sudhiranjan Gupta1, Li Li1, Chuanyu Wei1, Il -Kwon Kim1, Yvonne Janssen -Heininger2,
1Cardiovascular Institute, Texas A&M University, Temple, TX, USA, 22University of Vermont,
Burlington VT, USA
P2 -22
Scleraxis regulates cardiac extracellular matrix composition and fibroblast phenotype
Rushita Bagchi1,2, Patricia Roche1,2, Nina Aroutiounova1,2, Leon Espira1,2, Bernard Abrenica1,2,
Ronen Schweitzer3, Michael Czubryt1,2, 1Institute of Cardiovascular Sciences, Winnipeg, Manitoba,
Canada, 2University of Manitoba, Winnipeg, Manitoba, Canada, 3Oregon Health and Science
University, Portland, Oregon, USA
P2 -23
Hexokinase -II regulates mitochondria specific autophagy in response to ischemia
David Roberts1, Valerie Tan -Sah1, Shigeki Miyamoto1, 1University of California, San Diego, La
Jolla, CA, USA
P2 -24
MiR -30e reduces osteogenic differentiation of bone marrow derived mesenchymal stem
cells by directly targeting IGF2
Wen Ding1, Jihe Li1, Samirah Gomes1, Joshua Hare1, Lina Shehadeh1, 1University of Miami Miller
School of Medicine, Miami, FL, USA
P2 -25
Chronic β1 -adrenergic blockade enhances β3 -adrenergic coupling with nitric oxide -cGMP
signaling in volume overload
Danielle Trappanese1, Yuchuan Liu1, Alessandro Cannavo2, Ryan McCormick1, A. Ray Dillon3, D.
Michael Tillson3, Harrish Jarrett1, Felix Woitek1, Walter Koch2, Fabio Recchia1,4, Louis Dell'Italia6,
Emily Tsai1,4, 1Cardiovascular Research Center, Temple University School of Medicine,
Philadelphia, PA, USA, 2Center for Translational Medicine, Temple University School of Medicine,
Philadelphia, PA, USA, 3College of Veterinary Medicine, Auburn University, Auburn, AL, USA,
4Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA,
5Institute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy, 6Division of Cardiovascular
Disease, Department of Medicine, University of Alabama, Birmingham, AL, USA, 7Cardiology
Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA
P2 -26
Interaction between neuronal NOS signaling and temperature influences SR Ca 2+ leak in
cardiomyocytes
Raul Dulce1, Vera Mayo1, Erika Rangel1, Wayne Balkan1, Joshua Hare1, 1Interdisciplinary Stem
Cell Institute, Miami, Florida, USA
P2 -27
Defining the role of the stress sensors MLP and CARP for DCM development
Stephan Lange1, Alexander Lun1, Nancy Dalton1, Erika Alvarez1, Kirk Peterson1, Elisabeth Ehler2,
Ju Chen1, 1UC San Diego, La Jolla, CA, USA, 2King's College London, London, UK
P2 -28
FGF23 -mediated activation of FGFR4 is a novel hypertrophic signaling pathway FGF23 mediated activation of FGFR4 is a novel hypertrophic signaling pathway
Alexander Grabner1, Ansel Amaral1, Myles Wolf2, Joshua Hare3, Marcus Brand4, Axel Ullrich5,
Christian Faul1, 1Division of Nephrology and Hypertension, Department of Medicine, University of
Miami Miller School of Medicine, Miami, FL, USA, 2Division of Nephrology, Northwestern University
Feinberg School of Medicine, Chicago, IL, USA, 3Interdisciplinary Stem Cell Institute, University of
Miami Miller School of Medicine, Miami, FL, USA, 4Department of Internal Medicine, University of
Muenster, Muenster, Germany, 5Department of Molecular Biology, Max Planck Institute of
Biochemistry, Munich, Germany
P2 -29
Calcium and stress modulate SERCA2 gene transcription
Jorge Fragoso -Medina1, Gabriela Rodríguez1, Ángel Zarain -Herzberg1, 1National University of
Mexico, México, Distrito federal, Mexico
P2 -30
Ca2+ -dependent pathways control calsequestrin -2 expression in cardiomyocytes
Rafael Estrada Avilés1, Gabriela Rodríguez1, Angel Zarain Herzberg1, 1Universidad Nacional
Autónoma de México, Mexico City, Mexico
P2 -31
S -nitrosylation of PPARγ regulates the balance of adipogenesis and osteogenesis in
mesenchymal stem cells
Yenong Cao1, Samirah Gomes3, Erika Rangal2, Wayne Balkan1, Joshua Hare1, 1University of
Miami Miller School of Medicine, Miami, FL, USA, 2Albert Einstein Hospital – Instituto de Ensino e
Pesquisa, Morumbi, São Paulo, SP, Brazil, 3Universidade de Sao Paulo -FMUSP, São Paulo, SP,
Brazil
P2 -32
Sumo E2 ligase is required for efficient protein quality control of cardiomyocytes
Manish Gupta1, Jeffrey Robbins1, 1The Heart Inst, Dept of Pediatrics, The Cincinnati Children‟s
Hosp Medical Ctr, Cincinnati, USA
P2 -33
p53 controls the fate of cardiac stem cells
Ramaswamy Kannappan1, Eric Zhang1, Giorgia Palano1, Joao T Pereira1, Virginia Caballero1, Alex
J Matsuda1, Marcello Rota1, Piero Anversa1, Annarosa Leri1, 1Brigham and Women's Hospital,
Boston, MA, USA
P2 -34
The RNA binding protein HuR mediates expression of cardioprotective heat shock protein
70.3
Melissa Kelley1, Stephen Kraynik1, Andrew Gabanic1, Sarah Anthony1, Michael McGuinness1,
Michael Tranter1, 1University of Cincinnati College of Medicine, Cincinnati, OH, USA
P2 -35
Transgenic mice overexpressing Regulator of G protein Signaling 2: a unique model for
investigating Gq/11 signaling and function in atria
Jialin Su1,2, Cindy Park -Windhol1,2, Michelle King1, Peng Zhang1,2, Ulrike Mende1,2, 1Rhode Island
Hospital, Providence, RI, USA, 2Brown University, Providence, RI, USA
P2 -36
MicroRNA -1: a novel inhibitor of cell cycle progression in cardiac fibroblasts
Michelle King1, Nedyalka Valkov1,2, Peng Zhang1,2, 1Rhode Island Hospital, Providence, RI, USA,
2Brown University, Providence, RI, USA
P2 -37
Hypoxia dependent control of myosine heavy chain expression in heart
Lucia Bino1,4, Jirina Prochazkova1,3, Jana Navratilova2,3, Jiri Pachernik2, Lukas Kubala3,4, 1Institute
of Experimental Biology, Department of Histology and Embryology, Faculty of Medicine, Masaryk
University, Brno, Czech Republic, 2Institute of Experimental Biology, Department of Physiology and
Immunology of Animals, Faculty of Science, Masaryk University, Brno, Czech Republic, 3Institute of
Biophysics, Academy of Sciences of the Czech Republic v.v.i, Brno, Czech Republic, 4St Anne's
University Hospital Brno, International Clinical Research Center - Center of Biomolecular and
Cellular Engineering, Brno, Czech Republic
P2 -38
The role of HIF -1α in the regulation of cardiomyogenesis in vitro
Jana Navratilova1,2, Jirina Prochazkova1,5, Lucia Bino4,5, Hana Kolarova1, Dominika Sykorova1,2,
Pavel Karas3, Jiri Pachernik 2,4, Lukas Kubala2,4, 1Institute of Biophysics ASCR v.v.i., Brno, Czech
Republic, 2Institute of Experimental Biology, Deparment of Physiology and Immunology of Animals,
Faculty of Science, Masaryk University, Brno, Czech Republic, 3Centre for Biomedical Image
Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic, 4St. Anne's University
Hospital Brno -International Clinical Research Center - Center of Biomolecular and Cellular
Engineering, Brno, Czech Republic, 5Institute of Experimental Biology, Deparment of Histology and
Embryology, Faculty of Medicine, Brno, Czech Republic
Exitation-Contraction Coupling
P2 -39
Chronic testosterone withdrawal slows calcium transient decay and prolongs contractile
function in ventricular myocytes isolated from gonadectomised C57BL/6 male mice
Mohammad Ayaz1, Susan Howlett1, 1Dalhousie University, Halifax, Canada
P2 -40
Acute application of progesterone modifies mechanisms involved in cardiac excitation contraction coupling in isolated murine ventricular myocytes
Hirad Feridooni1, Susan Howlett1, W. Glen Pyle2, 1Dalhousie, Halifax, Nova Scotia, Canada,
2University of Guelph, Guelph, Ontario, Canada
P2 -41
The impact of frailty on cardiac contractile function in an aging mouse model
Michael Sun1, Jocelyne Whitehead1, Susan Howlett1, 1Dalhousie University, Halifax, Nova Scotia,
Canada
P2 -42
Endogenous HAX -1 depresses the phospholamban inhibitory activity
Philip Bidwell1, Chi Keung Lam 1, George Adly1, Luke Mugge1, Erica Vanderbilt1, Evangelia
Kranias1, 1University of Cincinnati, Cincinnati, OH, USA
P2 -43
The impact of ovariectomy on cAMP/PKA -dependent mechanisms involved in cardiac
excitation -contraction coupling.
Randi Parks1, Gibanananda Ray2, Robert Rose2, Susan Howlett1, 1Department of Pharmacology,
Dalhousie University, Halifax, NS, Canada, 2Department of Physiology and Biophysics, Dalhousie
University, Halifax, NS, Canada
P2 -44
Single Molecule Fluorescence Spectroscopy Reveals SERCA2a Structural Dynamics
Sandeep Pallikkuth1, Seth Robia1, 1Loyola University Chicago, Stritch School of Medicine,
Maywood, IL, USA
Electrophysiology & Arrhythmias
P2 -45
State Dependent Photo -Crosslinking of IKS Using Unnatural Amino Acid Mutagenesis
Christopher Murray1, Yasmeen Maurice1, Jodene Eldstrom 1, David Fedida1, 1University of British
Columbia, Vancouver, Canada
P2 -46
Short term fasting reduces susceptibility to ischemia -induced ventricular fibrillation in the
isolated rat heart in a substrate -independent manner
Hugh Clements -Jewery1, 1West Virginia School of Osteopathic Medicine, Lewisburg, West
Virginia, USA
P2 -47
Predictive Biomarkers for Increased Risk of Arrhythmic Death in the Prediction of
Arrhythmic Events Identified by Large -scale Plasma Proteomics Profiling
Jun Qu1,2, chengjian Tu1,2, James Fallavollita1, Rebeccah Young1, Xiaomeng Shen1, John Canty1,
1University at Buffalo, Buffalo, NY, Buffalo, NY, USA, 2NY CoE in Bioinformatics and Life Sciences,
Buffalo, NY, USA
P2 -48
Mitochondrial -derived reactive oxygen species promote arrhythmias and are altered by
mitochondrial CaMKII activity
Andrew Ackell1, Olha Koval1, Mark Anderson1, 1University of Iowa, Iowa City, IA, USA
Metabolism/Diabetes/Obesity
P2 -49
Autophagic -Lysosomal Inhibition Impairs the Performance of Cardiac Ubiquitin Proteasome System in a p62 -Dependent Manner
Zongwen Tian1, Changhua Wang1, Chengjun Hu1, Yihao Tian1, Jinbao Liu2, Xuejun Wang1,
1University of South Dakota, Vermillion, SD, USA, 2Guangzhou Medical College, Guangzhou,
Guangdong, China
P2 -50
Inflammatory Serine Proteases Regulate Insulin Signaling and Myocyte Death during the
Development of Diabetic Cardiomyopathy
Mikhail Kolpakov1, Xinji Guo1, Bahman Hooshdaran1, Scalia Rosario1, Steven Houser1, Abdelkarim
Sabri1, Khadija Rafiq1, 1Thomas Jefferson University, Philadelphia, USA
P2 -51
ACS and gender modulate transport kinetics and esterification of exogenous long -chain
fatty acid into myocardial triglyceride
Joseph Goldenberg1, E. Douglas Lewandowski1, 1University of Illinois at Chicago College of
Medicine, Chicago, IL, USA
P2 -52
Elevated Cardiac Glycolysis Cannot Compensate for the Decrease in Mitochondrial
Oxidative Metabolism That Occurs During the Development of Diastolic Heart Failure in
Dahl Salt Sensitive Rats
Natasha Fillmore1, Jody Levasseur1, Cory Wagg1, Wei Wang1, Gary Lopaschuk1, 1Cardiovascular
Research Centre, University of Alberta, Edmonton, Alberta, Canada
P2 -53
Partial ROCK2 deletion protects mice from high fat diet -induced cardiac dysfunction
Hesham Soliman1, Guorong Lin1, Vongai Nyamandi1, Marysol Garcia -Patino1, Julia Varela1, Girish
Bankar1, Zhengping Jia2, Kathleen MacLeod1, 1Molecular & Cellular Pharmacology Group, Faculty
of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada, 2Department of
Physiology, University of Toronto, Toronto, Canada
P2 -54
Non -targeted metabolomics analysis of Muscle Ring Finger -1 (MuRF1), MuRF2, and MuRF3
in vivo reveals novel and redundant metabolic changes
Ranjan Banerjee1, Jun He1, Megan Quintana1, James Bain2, Christopher Newgard2, Michael
Muehlbauer2, Monte Willis1, 1University of North Carolina, Chapel Hill, NC, USA, 2Duke University,
Durham, NC, USA
Author Index (with Poster numbers)
Abdellatif, Maha - P1 -14, P1 -37
Abrenica, Bernard - P2 -22
Ackell, Andrew - P2 -48
Ackerman, Michael J - P2 -09
Adams, John W - P1 -45
Adly, George - P1 -04, P1 -05, P2 -42
Ait -Mou, Younss - P1 -26
Akhnokh, Maria - P1 -41
Allen, Bruce - P1 -51
Alsaleh, Nasser - P1 -42
Alvarez, Erika - P2 -27
Amaral, Ansel - P2 -28
Amiad -Pavlov, Daria - P1 -30
Anderson, Mark - P2 -48
Anderson, Todd - P2 -02
Anthony, Sarah - P2 -13, P2 -34
Anversa, Piero - P2 -33
Aponte, Angel - P1 -06
Aravindhan, Karpagam - P1 -52
Aroutiounova, Nina - P2 -22
Arteaga, Grace M - P2 -09
Ayaz, Mohammad - P2 -39
Bagchi, Rushita - P2 -22
Baines, Christopher - P1 -34, P1 -35
Bain, James - P2 -54
Balkan, Wayne - P1 -08, P1 -21, P1 -24, P1 -48,
P2 -26, P2 -31
Banerjee, Ranjan - P2 -54
Bankar, Girish - P2 -53
Bao, Weike - P1 -52
Barbour, April - P1 -52
Barefield, David - P1 -28
Barlow, Melissa - P2 -08
Basu, Ratnadeep - P1 -41
Bedja, Djahida - P1 -40
Bellio, Michael - P1 -24, P1 -48
Berretta, Remus - P1 -22, P1 -23, P2 -11
Betsch, Devin - P2 -06
Bhuiyan, Md Shenuarin - P1 -07, P1 -25
Bian, Jinsong - P1 -44
Bidwell, Philip - P2 -42
Bino, Lucia - P2 -37, P2 -38
Bisetto, Sara - P1 -16
Bjorndahl, Trent - P2 -02
Bos, J Martijn - P2 -09
Bouatra, Souhaila - P2 -02
Brabcova, Iveta - P1 -38
Brand, Marcus - P2 -28
Broughton, Kathleen - P1 -31
Caballero, Virginia - P2 -33
Cai, Wen -Feng - P1 -27
Caldwell, Jessica - P1 -18
Campbell, Nathaniel - P1 -40
Cannavo, Alessandro - P2 -25
Canty, John M - P2 -03, P2 -47
Cao, Yenong - P2 -31
Cardounel, Arturo - P1 -28
Cervenka, Ludek - P1 -50
Chen, Ju - P2 -27
Chenna, Venugopal - P1 -40
Chen, Xiongwen - P2 -11
Chesini, Gino - P2 -08
Chiba, Yumi - P1 -22
Cho, Woo jung - P1 -41
Chuprun, Kurt - P2 -01
Chytilova, Anna - P1 -38
Clements -Jewery, Hugh - P2 -46
Cordero -Reyes, Andrea - P2 -10
Cornea, Razvan - P1 -32
Czubryt, Michael - P2 -22
Dabul, Samalia - P2 -19
Dalton, Nancy - P2 -27
Das, Samarjit - P1 -40
Davies, Oluwaseun - P1 -47
Davis 3rd, Robert T - P2 -14
Davis, Robert - P2 -12
DeAngelis, Elena - P1 -52
de Antueno, Roberto - P2 -06
Dell'Italia, Louis - P2 -25
Deng, Jingyuan - P1 -27
de Tombe, Pieter - P1 -26
Dibb, Katharine - P1 -17, P1 -18
Dillon, A Ray - P2 -25
Dimitrova, Kristel - P2 -18
Ding, Wen - P2 -24
Dixon, Ian - P2 -05, P2 -16
Dockstader, Karen - P2 -15
Domeier, Timothy - P1 -35
Douglas, Diana - P1 -35
Drahota, Zdenek - P1 -38
Drosatos, Konstantinos - P2 -20
Duan, Wenlan - P1 -47
Duan, Xiaotao - P2 -03
Dulce, Raul - P1 -21, P2 -26
Dunbar, Sandra - P2 -04
Duncan, Roy - P2 -06
Dunkerly, Brittany - P1 -40
Duran, Jason - P1 -22, P1 -23
Dyck, Jason - P2 -02
Ehler, Elisabeth - P2 -27
Eisner, David - P1 -18
Eldstrom, Jodene - P2 -45
El -Sikhry, Haitham - P1 -42
Espira, Leon - P2 -22
Estrada Avilés, Rafael - P2 -30
Evangelista, Alicia - P1 -46
Ezekowitz, Justin - P2 -02
Falck, John - P1 -42
Falkenham, Alec - P2 -06
Fallavollita, James A - P2 -03, P2 -47
Fan, Guo -Chang - P1 -27
Faul, Christian - P2 -28
Fedida, David - P2 -45
Ferguson, Bradley S - P1 -07
Feridooni, Hirad - P2 -40
Ferlito, Marcella - P1 -46
Filameno, Krista - P2 -05
Fillmore, Natasha - P2 -52
Florea, Stela - P1 -27
Florea, Victoria - P1 -19, P1 -48
Fragoso -Medina, Jorge - P2 -29
Gabanic, Andrew - P2 -13, P2 -34
Gaestel, Matthias - P1 -51
Gao, Chen - P1 -02
Gao, Erhe - P1 -03, P2 -01, P2 -11
Garcia -Patino, Marysol - P2 -53
García -Rivas, Gerardo - P2 -10
Gaughan, John - P1 -22
George, Jon - P2 -11
Ghavami, Saeid - P2 -05
Gibson, Anne - P1 -35
Gillis, Marc -Antoine - P1 -51
Gillispie, Gregory - P1 -32
Goldberg, Ira J - P2 -20
Goldenberg, Joseph - P2 -51
Gomes, Samirah - P2 -24, P2 -31
Gong, Jianli - P1 -02
Govindan, Suresh - P1 -28
Grabner, Alexander - P2 -28
Greaser, Marion - P1 -26
Gruber, Simon - P1 -32
Gulick, James - P1 -25
Guo, Xinji - P2 -50
Gupta, Madhu - P2 -12
Gupta, Manish - P2 -32
Gupta, Shivika - P2 -05
Gupta, Sudhiranjan - P2 -21
Gustafsson, Asa - - P2 -08
Gutierrez -Aguilar, Manuel - P1 -35
Haghighi, Kobra - P1 -05, P1 -27
Hajjar, Roger J - P1 -27
Halayko, Andrew - P2 -05
Hammock, Bruce - P1 -41
Han, Beomsoo - P2 -02
Hare, Joshua - P1 -21, P1 -24, P1 -33, P1 -48, P2
-24, P2 -26, P2 -28, P2 -31
Hare, Joshua M - P1 -08
Hatzistergos, Konstantinos - P1 -21
He, Jun - P2 -54
Heller Brown, Joan - P2 -08
He, Minzhen - P1 -37
Heo, Seongkum - P2 -04
Hershberger, Ray E - P1 -05
Holt, Lucy - P1 -52
Hooshdaran, Bahman - P2 -50
Horn, Margaux - P1 -17
Houser, Steven - P1 -22, P1 -23, P2 -11, P2 -50
Howlett, Susan - P1 -15, P2 -39, P2 -40, P2 -41,
P2 -43
Hsu, Karen - P1 -26
Hua, Fei - P1 -44
Huang, Wenrui - P1 -33
Hu, Chengjun - P2 -49
Hullmann, Jonathan - P2 -01
Huskova, Zuzana - P1 -50
Imig, John - P1 -50
Irving, Tom - P1 -26
Ito, Bruce R - P1 -45
Jahroudi, Nadia - P1 -20
Jaleel, Naser - P2 -11
James, Jeanne - P1 -07, P1 -25
Jansova, Hana - P2 -17
Janssen -Heininger, Yvonne - P2 -21
Jarrett, Harrish - P2 -25
Jiang, Min - P1 -04
Jia, Zhengping - P2 -53
Jirkovska -Vavrova, Anna - P2 -17
Jirkovsky, Eduard - P2 -17
J Matsuda, Alex - P2 -33
Jolivette, Larry - P1 -52
Jones, Gavin - P1 -52
Jones, Kenneth - P1 -10
Jucker, Beat - P1 -52
Kalous, Martin - P1 -38
Kanashiro -Takeuchi, Rosemeire - P1 -21, P1 -33
Kannappan, Ramaswamy - P2 -33
Kapiloff, Michael S - P1 -13
Karas, Pavel - P2 -38
Karimpour -Fard, Anis - P1 -09, P1 -10
Kassiri, Zamaneh - P1 -41
Kavosh, Morvarid - P2 -05, P2 -16
Kazmierczak, Katarzyna - P1 -33
Kelley, Melissa - P2 -13, P2 -34
Kim, Il -Kwon - P2 -21
Kim, Maengjo - P1 -12
King, Michelle - P2 -35, P2 -36
Klevstigova, Martina - P1 -50
Kobayashi, Tomoyoshi - P2 -09
Koch, Walter - P1 -03, P2 -01, P2 -11, P2 -19, P2
-25
Kohr, Mark - P1 -36, P1 -46
Kolar, Frantisek - P1 -38, P1 -50
Kolarova, Hana - P2 -38
Kolpakov, Mikhail - P2 -50
Kopkan, Libor - P1 -50
Koval, Olha - P2 -48
Kovarikova, Petra - P2 -17
Kranias, Evangelia G - P1 -04, P1 -05, P1 -27, P2 42
Kraynik, Stephen - P2 -13, P2 -34
Kritzer, Michael D - P1 -13
Kubala, Lukas - P2 -37, P2 -38
Kubo, Hajime - P1 -22, P1 -23, P2 -11
Kulandavelu, Shathiyah - P1 -08, P1 -21
Lam, Chi Keung - P1 -04, P1 -27, P2 -42
Landesberg, Amir - P1 -30
Lange, Stephan - P2 -27
Lebeche, Djamel - P1 -27
Lee, Timothy - P1 -01, P2 -06
Legare, Jean -Francois - P1 -01, P2 -06
Lencova -Popelova, Olga - P2 -17
Lennie, Terry - P2 -04
Lepore, John - P1 -52
Leri, Annarosa - P2 -33
Levasseur, Jody - P2 -52
Lewandowski, E Douglas - P2 -51
Liang, Jingsheng - P1 -33
Liebetrau, Christoph - P1 -28, P1 -49
Li, Jihe - P2 -24
Li, Jinliang - P1 -13
Li, Jun - P2 -03
Li, Li - P2 -21
Lin, Guorong - P1 -39, P2 -53
Lin, Ying -Hsi - P1 -31, P2 -07
Liu, Guansheng - P1 -04, P1 -05, P1 -27
Liu, Jinbao - P2 -49
Liu, Yuchuan - P2 -25
Lopaschuk, Gary - P2 -52
Lorenzen -Schmidt, Ilka - P2 -18
Lu, Long Jason - P1 -27
Lun, Alexander - P2 -27
Lymperopoulos, Anastasios - P2 -19
Lynch, Thomas - P1 -28, P1 -49
MacLeod, Kathleen M - P1 -39, P2 -53
Maitra, Anirban - P1 -40
Makarewich, Catherine - P2 -11
Mandal, Rupasri - P2 -02
Mandikova, Petra - P1 -50
Marshall, Kurt - P1 -34
Maurice, Yasmeen - P2 -45
Mayo, Vera - P2 -26
McCormick, Ryan - P2 -25
McDonald, Patricia - P2 -19
McGuinness, Michael - P2 -34
McKinsey, Timothy A - P1 -07
McLendon, Patrick M - P1 -07
Medina, Elizabeth - P2 -15
Menazza, Sara - P1 -06
Mende, Ulrike - P2 -35
Menendez, Lorena - P1 -12
Mentzer, Jr., Robert M - P1 -45
Miyamoto, Shelley - P1 -09, P1 -10, P2 -15
Miyamoto, Shigeki - P2 -23
Mohsin, Sadia - P1 -23
Mojiri, Anahita - P1 -20
Molkentin, Jeffery - P1 -35, P2 -11
Morales, Ana - P1 -05
Moser, Debra - P2 -04
Muehlbauer, Michael - P2 -54
Mugge, Luke - P2 -42
Murphy, Elizabeth - P1 -06, P1 -36, P1 -46
Murray, Christopher - P2 -45
Nagalingam, Raghu - P2 -12
Navratilova, Jana - P2 -37, P2 -38
Nawaito, Sherin - P1 -51
Neckar, Jan - P1 -38, P1 -50
Newgard, Christopher - P2 -54
Noor, Mariam - P2 -12
Nováková, Olga - P1 -38
Nunley, Karin - P1 -09
Nyamandi, Vongai - P2 -53
Osinska, Hanna - P1 -07, P1 -25
Oudit, Gavin Y - P1 -41, P2 -02
Pachernik, Jiri - P2 -37, P2 -38
Page, Brian - P2 -03
Palano, Giorgia - P2 -33
Pallikkuth, Sandeep - P2 -44
Palmiter, Richard - P1 -12
Pan, Shi - P1 -16
Parks, Randi - P2 -43
Park -Windhol, Cindy - P2 -35
Passariello, Catherine Laura - P1 -13
Paulino, Ellena - P1 -08, P1 -21
Perez, Xavier - P1 -47
Peterson, Kirk - P2 -27
Peterson, Kurt - P1 -32
Pravenec, Michal - P1 -38
Pressler, Susan - P2 -04
Prince, Rob - P1 -52
Pritchard, Tracy - P1 -27
Prochazkova, Jirina - P2 -37, P2 -38
Purcell, Nicole - P2 -08
Pyle, W Glen - P2 -18, P2 -40
Pyttel, Lukas - P1 -49
Qian, Jiang - P1 -27
Quintana, Megan - P2 -54
Qu, Jun - P2 -03, P2 -47
Rabinowitz, Joseph - P1 -22
Rafiq, Khadija - P2 -50
Rangel, Erika - P2 -26, P2 -31
Rattan, Sunil - P2 -05
Ray, Gibanananda - P2 -43
Recchia, Fabio - P2 -25
Robbins, Jeffrey - P1 -07, P1 -25, P2 -32
Roberts, David - P2 -23
Robia, Seth - P1 -32, P2 -44
Roche, Patricia - P2 -22
Rodrigues, Claudia - P1 -24, P1 -48
Rodríguez, Gabriela - P2 -29, P2 -30
Roh, Jaroslav - P2 -17
Rojas, Ana I - P1 -33
Rosario, Scalia - P2 -50
Rose, Robert - P2 -43
Rosin, Nicole - P1 -01, P2 -06
Rota, Marcello - P2 -33
Rubinstein, Jack - P1 -04
Russell, Brenda - P1 -31, P2 -07
Sabri, Abdelkarim - P2 -50
Sadayappan, Sakthivel - P1 -28, P1 -49
Samokhvalov, Victor - P1 -41, P1 -42
Sanchez -Freire, Veronica - P1 -31
Sanders, Michael - P1 -13
Sanina, Cristina - P1 -24
Sayed, Danish - P1 -14
Scerbo, Diego - P2 -20
Schulman, Ivonne - P1 -24, P1 -48
Schulze, Christian - P2 -20
Schumacher, Sarah - P1 -03
Schweitzer, Ronen - P2 -22
Seubert, John M - P1 -41, P1 -42
Shao, Qin - P1 -40
Sharp, Thomas - P1 -22, P1 -23
Shehadeh, Lina - P2 -24
Shen, Xiaomeng - P2 -03, P2 -47
Sheu, Shey -Shing - P1 -16
Sheyin, Olusegun - P1 -47
Shi, Yanfen - P1 -51
Silva -Platas, Christian - P2 -10
Simunek, Tomas - P2 -17
Siryk, Ashley - P2 -19
Sivaguru, Mayandi - P1 -28
Smith, Shavonn - P2 -11
Sobus, Rebecca - P2 -15
Solaro, R John - P1 -29, P1 -31, P2 -09, P2 -12,
P2 -14
Soliman, Hesham - P2 -53
Stariat, Jan - P2 -17
Starosta, Timothy - P1 -22, P1 -23
Stauffer, Brian - P1 -09, P1 -10, P2 -15
Steenbergen, Charles - P1 -06, P1 -36, P1 -40, P1
-46
Steinberg, Susan - P1 -02
Stelter, Zachary - P1 -11
Sterba, Martin - P2 -17
Strakova, Jana - P1 -11
Sturchler, Emmanuel - P2 -19
Sucharov, Carmen - P1 -10, P2 -15
Sucharov, Juliana - P1 -09
Su, Jialin - P2 -35
Sung, Miranda - P2 -02
Sun, Michael - P2 -41
Suzuki, Carolyn - P1 -37
Sykorova, Dominika - P2 -38
Szapacs, Mathew - P1 -52
Szczesna -Cordary, Danuta - P1 -33
Taghavi, Sharven - P1 -22
Takeuchi, Lauro - P1 -08, P1 -21
Tan -Sah, Valerie - P2 -23
Tardif, Jean -Claude - P1 -51
Tarigopula, Madhusudhan - P2 -14
Tata, Nazeen - P2 -03
Taylor, Amy - P2 -08
Taylor, Matthew - P1 -10
Tesmer, John - P1 -03
Thakur, Hrishikesh - P1 -13
Thomas, David - P1 -32
Tian, Rong - P1 -12
Tian, Yihao - P2 -49
Tian, Zongwen - P2 -49
Tillson, D Michael - P2 -25
Toli, Jessica - P1 -37
Torre -Amione, Guillermo - P2 -10
Townsend, DeWayne - P1 -11
T Pereira, Joao - P2 -33
Trafford, Andrew - P1 -17, P1 -18
Tranter, Michael - P2 -13, P2 -34
Trappanese, Danielle - P1 -22, P2 -25
Troidl, Christian - P1 -28, P1 -49
Tsai, Emily - P2 -25
Tu, chengjian - P2 -47
Udesh, Foram - P2 -11
Ullrich, Axel - P2 -28
Utter, Megan S - P1 -29
Vafiadaki, Elizabeth - P1 -04, P1 -05
Valadri, Ravinder - P1 -43
Valkov, Nedyalka - P2 -36
Vanderbilt, Erica - P2 -42
Varela, Julia - P2 -53
Velayutham, Murugesan - P1 -28
Violin, Jonathan D - P2 -14
Wagg, Cory - P2 -52
Walklett, Karlee - P2 -19
Wang, Changhua - P2 -49
Wang, Da -Zhi - P2 -12
Wang, Nadan - P1 -16
Wang, Wei - P2 -52
Wang, William - P1 -02
Wang, Xiuhua - P1 -41
Wang, Xuejun - P2 -49
Wang, Yibin - P1 -02
Warren, Chad M - P1 -29, P2 -07, P2 -09
Wei, Chuanyu - P2 -21
Weissova, Romana - P1 -38
Whitehead, Jocelyne - P2 -41
Wieczorek, David F - P2 -14
Willette, Robert - P1 -52
Willis, Monte - P2 -54
Wishart, David - P2 -02
Woitek, Felix - P2 -25
Wolf, Myles - P2 -28
Wolska, Beata - P1 -31, P2 -09, P2 -12, P2 -14
Wu, Joseph - P1 -31
Yang, Feng Hua - P1 -41
Yang, Zhi - P1 -14
Young, Rebeccah - P2 -03, P2 -47
Yuan, Chen -Ching - P1 -33
Zarain -Herzberg, Ángel - P2 -29, P2 -30
Zhang, Eric - P2 -33
Zhang, Hongyu - P2 -11
Zhang, Peng - P2 -35, P2 -36
Zhao, Wen - P1 -04, P1 -27
Zheng, Jin - P1 -44
Zordoky, Beshay - P2 -02
Zurmanova, Jitka - P1 -38