聂广军 研究员,博士生导师
国家纳米科学中心，北京
Email：niegj@nanoctr.cn
Tel: +86 10 82545529
聂广军，国家纳米科学中心研究员，博士生导师，课题组长；科技部纳米研究国家重大
科学研究计划（973）项目首席科学家，国家杰出青年基金获得者，入选中科院“引进国
外杰出人才”计划，结题优秀，国务院享受政府特殊津贴专家，美国 The Methodist Hospital
Research Institute（休斯敦）兼职教授，东北大学兼职博士生导师，华东理工大学兼职博
士生导师；中国抗癌协会纳米肿瘤学专业委员会委员，中国毒理学会纳米毒理学分会委
员，中国生物物理学会自由基生物医学专业委员会委员，中国药学会纳米药物专业委员
会委员，国家纳米科学中心科技处处长。
自 2008 年回国成立独立课题组以来，在纳米中心建立了“纳米生物学和纳米医学材
料”实验室，组建了一个 30 人的多学科交叉研究团队（目前固定人员 8 名，其中副研究
员 3 名，助理研究员 4 名，工程师 1 名，研究生 15 名，多名访问学者和联合培养学生）。
课题组已先后获得了各类科研资助 30 项，主持了多项国家级项目、中科院项目以及横向
合作项目等。与美国、澳大利亚及加拿大等纳米医学和生命科学的多个著名实验室建立
了良好的合作关系，先后与 6 位中科院特聘访问教授开展科研合作。
在 Acc Chem Res, Adv Mater, Angew Chem Int Ed, Antioxid Redox Sign, Adv Funct
Mater, Biomaterials, Blood, Brit J Haematol, J Am Chem Soc, J Biol Chem, Sci Rep,
Small 和 Nanomedicine 等国际重要学术期刊上发表 SCI 论文 80 多篇；申请抗肿瘤应用
等相关发明专利 25 项（PCT 专利 2 项，授权 8 项，美国专利授权 1 项，专利转让 2 项）。
相关研究成果也被 Nat Mater，Adv Mater，Small（封面），Blood，Chem Soc Rev, Materials
View 和中国科学报等著名学术期刊、网站和媒体进行了重点推荐和报道。
近5年代表性论文
Shishuai Su, Yanhua Tian, Yiye Li, Yanping Ding, Tianjiao Ji, Meiyu Wu, Yan Wu, Guangjun
Nie, “Triple-punch” Strategy for Triple Negative Breast Cancer Therapy with Minimized Drug
Dosage and Improved Antitumor Efficacy, ACS Nano in press
Tianjiao Ji, Yanping Ding, Ying Zhao, Jing Wang, Hao Qin, Xiaoman Liu, Jiayan Lang,
Ruifang Zhao, Yinlong Zhang, Jian Shi, Ning Tao, Zhihai Qin, Guangjun Nie, Peptide
Assemblies Integration of Fibroblast Targeting and Cell Penetration Features for Enhanced
Antitumor Drugs Delivery, Advanced Materials in press
Sun, Cuiji; Yuan, Yi; Xu, Zhonghe; Ji, Tianjiao; Tian, Yanhua; Wu, Shan; Lei, Jianlin; Li,
Jingyuan; Gao, Ning; Nie, Guangjun, Fine-tuned H-ferritin nanocage with multiple gold
clusters as near-infrared kidney specific-targeting nanoprobe, Bioconjugate Chemistry in press
Xiao Zhao, Feng Lia, Yiye Li, Hai Wang, He Rena, Jing Chen, Guangjun Nie, Jihui Hao,
Co-delivery of HIF1α siRNA and Gemcitabine via Biocompatible Lipid-polymer Hybrid
Nanoparticles for Effective Treatment of Pancreatic Cancer, Biomaterials, in press
Feng Li, Jing Wang, Shuqing Sun, Hai Wang, Zhiyong Tang, Guangjun Nie, Facile Synthesis
of pH-sensitive Germanium Nanocrystals with High Quantum Yield for Intracellular Acidic
Compartment Imaging, Small, in press
Feng Li, Xiao Zhao, Hai Wang, Ruifang Zhao, Tianjiao Ji, He Ren, Gregory J. Anderson,
Guangjun Nie, Jihui Hao, Multiple layer-by-layer lipid-polymer hybrid nanoparticles for
improved FOLFIRINOX chemotherapy in pancreatic tumor models, Adv. Funct. Mat. in press
Li, Yiye, Wen, Tao, Zhao, Ruifang, Liu, Xixi, Ji, Tianjiao, Wang, Hai, Shi, Xiaowei, Shi, Jian,
Wei, Jingyan, Zhao, Yuliang, Wu, Xiaochun, Nie, Guangjun, Localized Electric Field of
Plasmonic Nanoplatform Enhanced Photodynamic Tumor Therapy, ACS Nano, 2014, 8,
11529-42.
Gang Liu, Shanshan Guo, Gregory J Anderson, Clara Camaschella, Bing Han and Guangjun
Nie, Heterozygous missense mutations in the GLRX5 gene cause sideroblastic anemia in a
Chinese patient, Blood, 2014, 124, 2750-2751.
Yanhua Tian, Suping Li, Guangjun Nie, Design of tumor targeted exosomes as a natural
multifunctional nanocarrier platform for enhanced tumor therapy, Biomaterials. 2014, 35,
2383-90.
Ying Zhao*, Tianjiao Ji, Hai Wang, Suping Li, Yuliang Zhao*, and Guangjun Nie*,
Self-assembled Peptide Nanoparticles as Tumor Microenvironment Activatable Probes for
Tumor Imaging, J Controlled Release, 2014, 10, 177, 11-19.
Gang Liu, Huiyuan Kang, Fuming Zhang, Yulin Hu, Lu Wang, Mianyang Li, Yongxin Ru, Bing
Han, Clara Camaschella, and Guangjun Nie, Mutation spectrum in Chinese patients affected
by congenital sideroblastic anemia and a search for a genotype-phenotype relationship,
Haematologica, 2013, 98, e158-60.
Guangjun Nie, Yuliang Zhao, Ferritin-based nanoprobes: promising materials for tumor
imaging. Nanomedicine, 2013, 8, 1899-900. (Editorial)
Yanping Ding, Suping Li & Guangjun Nie, Nanotechnological strategies for therapeutic
targeting and imaging of tumor vasculature, Nanomedicine, 2013, 8(7), 1209-1222.
Tianjiao Ji, Ying Zhao, Yanping Ding and Guangjun Nie, Using nanotechnology to target and
regulate the tumor microenvironment: diagnostic and therapeutic applications, Advanced
Materials, 2013; 25: 3508-25.
Shishuai Su, Hai Wang, Xiaoguang Liu, Yan Wu*, Guangjun Nie*, iRGD-coupled responsive
fluorescent nanogel for targeted drug delivery, Biomaterials, 2013, 34, 3523-3533.
Hai Wang, Yan Wu, Ruifang Zhao and Guangjun Nie, Engineering the assemblies of
biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor
efficacy, Advanced Materials, 2013, 25, 1616-1622.
Motao Zhu, Sarah, Perrett and Guangjun Nie, Understanding the Particokinetics of
Engineered Nanomaterials for Safe and Effective Therapeutic Applications, Small, 2013, 9,
1619-34.
Hui Yang, Cuiji Sun, Zhenlin Fan, Xin Tian, Liang Yan, Libo Du, Yang Liu, Chunying Chen,
Xing-jie Liang, Gregory J. Anderson, Jeffrey A. Keelan, Yuliang Zhao*, Guangjun Nie*,
Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in
murine pregnancy, Scientific Report, 2, 847; DOI:10.1038/srep00847 (2012) (*corresponding
authors).
Wendi Zhang, Chi Wang, Zhenzhen Lu, Jun-Jie Yin, Yu-Ting Zhou, Xingfa Gao, Ying Fang*,
Guangjun Nie*, Yuliang Zhao*, Unraveling Stress-induced Toxicity Properties of Graphene
Oxide and the Underlying Mechanism, Advanced Materials 2012, 24, 5391–5397.
Motao Zhu, Xin Tian, Xiao Song, Yanhua Tian, Yuliang Zhao, and Guangjun Nie*,
Nanoparticle-Induced Exosomes Target Antigen-Presenting Cells to Initiate Th1-Type Immune
Activation, Small, 2012, 24, 2841-2848.
Gang Liu, Shiwen Niu, Ailian Dong, Hao Cai, Gregory J Anderson, Bing Han* and Guangjun
Nie*, A Chinese family carrying novel mutations in the SEC23B and HFE2 genes, British
Journal of Haematology, 2012, 158, 143-145.
Bo Ning, Gang Liu, Yuanyuan Liu, Xiufen Su, Gregory J Anderson, Xin Zheng, Yanzhong
Chang, Mingzhou Guo, Yuanfang Liu, Yuliang Zhao and Guangjun Nie*,
5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc
nuclear localization and binding to the E-boxes of TfR1 and ferrochelatase genes, J Biol Chem,
2011, 286, 37196-37206.
Hai Wang, Ying Zhao, Yan Wu, Kaihui Nan, Guangjun Nie* and Hao Chen*, Enhanced
antitumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic
methoxyPEG-PLGA copolymer nanoparticles, Biomaterials, 2011, 32, 32, 8281-8290.
Yiye Li, Yunlong Zhou, Hai-Yan Wang, Sarah Perrett, Yuliang Zhao*, Zhiyong Tang*,
Guangjun Nie*, Chirality of Glutathione Surface Coating Affects the Toxicity of Quantum
Dots, Angew Chem Int Ed, 2011, 50, 5860-5864 (Highlighted by Nature Materials).
Cuiji Sun, Hui Yang,Yi Yuan, Xin Tian, Liming Wang, Yi Guo, Li Xu*, Jianlin Lei, Ning Gao,
Gregory J. Anderson, Xing-jie Liang, Chunying Chen, Yuliang Zhao*, Guangjun Nie*,
Controlling assembly of paired gold clusters within apoferritin nanoreactor for in vivo kidney
targeting and biomedical imaging, J Am Chem Soc, 2011, 133 (22), 8617–8624.
Jia Fan, Jun-Jie Yin, Bo Ning, Xiaochun Wu, Ye Hu, Mauro Ferrari, Gregory J. Anderson,
Jingyan Wei*, Yuliang Zhao* and Guangjun Nie*, Direct evidence for catalase and
peroxidase activities of ferritin-platinum nanoparticles, Biomaterials, 2011, 32, 6, 1611-1618.