BIOGRAPHICAL SKETCH NAME Rajesh Krishnamurthy POSITION TITLE Director for Research, Department of Radiology, Texas Children’s Hospital Associate Professor of Radiology and Pediatrics, Baylor College of Medicine EDUCATION/TRAINING INSTITUTION AND LOCATION Stanley Medical College, Madras University Yale University School of Medicine DEGREE MB,BS Fellowship YEAR(s) 1993 1997 FIELD OF STUDY Medicine University of Texas-Houston Medical School Residency 2001 Diagnostic Radiology Children’s Hospital, Boston, Harvard Med School Children’s Hospital, Boston, Harvard Med School Fellowship Fellowship 2002 2003 Pediatric Radiology Pediatric Cardiac MRI Nuclear Medicine A. Personal Statement I am the director for research at the EB Singleton Department of Pediatric Radiology at Texas Children's Hospital, and am primarily responsible for the development and oversight of our departmental intramural and extramural research portfolio. I am also director of the cardiovascular imaging program, and lecture nationally and internationally on pediatric cardiovascular and body MRI, and cardiovascular CT. My interests include adaptation of MR sequences for free-breathing acquisition in sedated children, low dose volumetric CT for cardiovascular applications, assessment of end-organ injury to the cardiovascular system from systemic diseases in children amongst others. B. Committees and Honors. Committees: (Representative) Chairman, Pediatric Radiology Scientific Program Sub-Committee, RSNA, 2013-2015 Pediatric Program Co-Chair, Society of Cardiac MRI, 2014-2016 Invited Speaker, American Institute of Radiologic Pathology, 2005-2015 Immediate Past Chair, Cardiac imaging task force, Society of Pediatric Radiology 2011-2013 Member, NIH/NHLBI working group on "Thrombosis in Pediatric Cardiology and Congenital Heart Disease", 2012 Pediatric Cardiac Imaging task force and accreditation committee, American College of Radiology, ACR-NASCI Collaborative Committee to Develop Practice Guidelines for the Performance and Interpretation of Cardiac Magnetic Resonance Imaging (MRI) American Society of Echocardiography Writing Committee to develop ‘Multi-modality Imaging Guidelines for Patients with Repaired Tetralogy of Fallot’. Rating Panel for the Appropriate Utilization of Cardiovascular Imaging in Heart Failure, American College of Radiology and American College of Cardiology, 2011 Honors: Certificate of Acheivement, Academy of Radiology Leadership and Management, Jan 2015 John Kirkpatrick Young Investigator Award for Best Clinical Science Research, Society of Pediatric Radiology, 2012 Research Mentor Award from Texas Children’s Hospital for the year 2010-2011 John Caffey Award for Best Clinical Science Research, Society of Pediatric Radiology, 2004 Neuhauser Traveling Fellowship at Boston Children’s Hospital to the European Society of Pediatric Radiology, 2003 Cum Laude award at the 87th meeting of the Radiological Society of North America at Chicago, 2001 The 1998 Roentgen Resident/Fellow Research Award, Radiological Society of North America C. Recent selected peer-reviewed publications (in chronological order). (Not comprehensive:Total 62 publications) Jadhav SP, Golriz F, Atweh LA, Zhang W, Krishnamurthy R. CT Angiography of Neonates and Infants: Comparison of Radiation Dose and Image Quality of Target Mode Prospectively ECG-Gated 320-MDCT and Ungated Helical 64-MDCT. Am J Roentgenol. 2015; 204(2):W184-91. Krishnamurthy R, Pednekar A, Atweh LA, Vogelius E, Chu ZD, Zhang W, Maskatia S, Masand P, Morris SA, Krishnamurthy R, Muthupillai R. Clinical validation of free breathing respiratory triggered retrospectively cardiac gated cine balanced steady-state free precession cardiovascular magnetic resonance in sedated children. Journal of Cardiovascular Magnetic Resonance 2015, 17:1 PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Biographical Sketch Format Page Krishnamurthy R, Hernandez A, Kavuk S, Annam A, Pimpalwar S. Dynamic MR Lymphangiography (d-MRL): A New Technique to Assess the Central Conducting Lymphatics. Radiology 2014 Oct 15:131399. Epub 2014 Oct 15. Brian W McCrindle, Jennifer S Li, Cedric Manlhiot, James S Tweddell, Therese M Giglia, M Patricia Massicotte, Paul Monagle, Rajesh Krishnamurthy, et al. Challenges and Priorities for Research: A Report From the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on Thrombosis in Pediatric Cardiology and Congenital Heart Disease. Circulation Sep;130(14):1192-203 Mery CM, Lawrence SM, Krishnamurthy R, Sexson-Tejtel K, Carberry KE, McKenzie DE, Fraser CD. Anomalous aortic origin of a coronary artery: Towards a standardized approach. Seminars in Thoracic and Cardiovascular Surgery 2014;26(2):110-22. Mery CM, Molina KM, Krishnamurthy R, Fraser CD Jr, Justino H. Pulmonary artery resuscitation for isolated ductal origin of a pulmonary artery. J Thorac Cardiovasc Surg. 2013 Dec 31. [Epub ahead of print] Valente AM, Cook S, Festa P, Ko HH, Krishnamurthy R, Taylor AM, Warnes CA, Kreutzer J, Geva T. Multimodality imaging guidelines for patients with repaired tetralogy of fallot: a report from the american society of echocardiography: developed in collaboration with the society for cardiovascular magnetic resonance and the society for pediatric radiology. J Am Soc Echocardiogr. 2014;27(2):111-41. Maskatia SA, Spinner JA, Nutting AC, Slesnick TC, Krishnamurthy R, Morris SA. Impact of Obesity on Ventricular Size and Function in Children, Adolescents and Adults With Tetralogy of Fallot After Initial Repair. Am J Cardiol. 2013;112(4):594-8. Krishnamurthy R, Yoo JH, Thapa M, Callahan MJ. Water-bath method for sonographic evaluation of superficial structures of the extremities in children. Pediatr Radiol. 2013;43 Suppl 1:41-7. D. Research Support (Representative) CFLD-NET Leung (PI) 01/01/2008 – 12/31/2015 Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic Fibrosis (PUSH). Cystic Fibrosis Liver Disease Network (CFLD-NET). To determine the utility of abdominal ultrasound at enrollment to predict the development of cirrhosis in subjects with cystic fibrosis within a five year period. Role: Co-Investigator Thrasher grant Bacha (PI) 08/01/2011- 03/31/2015 Determinants of Subclinical Coronary Atheroscelrosis and Endothelial Dysfunction in Youth with and without Type 2 Diabetes. The purpose of this investigation is to study the ontogeny of endothelial dysfunction and coronary atherosclerosis in youth and to discern the effect of insulin resistance vs hyperglycemia in the pathogenesis of subclinical coronary atherosclerosis and abnormalities in endothelial function. Role: CoInvestigator Koninklijke Philips Electronics Krishnamurthy (PI) 11/01/2014 – 10/31/2015 Free-breathing strategies for pediatric cardiovascular and body MRI, evaluation of diffuse liver disease, and time-resolved MRA. Cardiovascular Research Institute Morris and Krishnamurthy (co-PI) 08/01/2013- 07/31/2014 Investigating the Association between Vascular Tortuosity and Adverse Cardiovascular Events in Children and Young Adults with Aortic Dilation Using a Novel Imaging Biomarker. The specific aims are to determine if higher vertebral tortuosity index (VTI) is associated with earlier first cardiac surgery, aortic dissection, and death in children and young adults, and to determine if VTI significantly changes over time. 5R21 HL110330-02 Krishnamurthy (PI) 05/31/2011- 05/31/2013 Dependence of Cardiomyocyte Electrophysiology Development on ContractileStrain . Using MRI sequences and echocardiography data from hearts with single right ventricle (SRV), single left ventricle (SLV) and dual ventricle with a single ventricle strategy repair (DV), in pediatric patients to evaluate cardiac fiber strain and compare to hearts with normal geometry. 1R56DK090350-01A1 Krishnamurthy (PI) 09/24/2012-08/31/2013 Development of MR Based Biomarker Panels for NAFLD a NASH CRN Ancillary Study. To develop pediatricand adult-specific MR biomarker panels to diagnose NASH in subjects with NAFLD. 1R56DK090350-01 Krishnamurthy (PI) 09/30/2010-06/30/2012 Development of MR Based Biomarker Panels for NAFLD a NASH CRN Ancillary Study To develop pediatric- and adult-specific MR biomarker panels to diagnose NASH in subjects with NAFLD.