Supplementary information S2 | Reliability, clinical validity and norms for measures of affective empathy Test Empathic Concern1,2 Empathy Quotient24 Reliability Internal consistency* α = 0.68–0.73,1 0.70,3 0.80,4 0.74,5 0.81,6 0.64,7 0.77,8 0.80– 0.86,9 0.73,10 0.7611 and 0.73.12 ρY = 0.68 to 0.74.13 Test-retest Mean intervals of: 60–75 days, rs = 0.70–0.72,1 60 days, r = 0.80–0.89,11 12 months, ICC = 0.77.3 Internal consistency‡ α = 0.92,24 0.85,25 0.86,26 0.81,27 0.78–0.83,28 0.78–0.81,29 0.79,30 0.87,31 0.78–0.80,32 0.86,33 0.80,34 0.89,35 0.88,4 0.87,36 0.88,37 0.83,38 0.88–0.90,39 0.885 and 0.88–0.89.40 Test-retest Mean intervals of: 1 year, r = 0.97,24 10–12 months, r = 0.84,41 6–24 weeks, r = 0.93,27 4 weeks, r = 0.84,28 1 month, r = 0.85,30 15 months, r = 0.78.35 Internal consistency α = of 0.71–0.92,48 and 0.78– 0.97.20 Clinical validity People with autism often report lower empathic concern than do controls,14,7 but exceptions have been noted.15 People with bvFTD16 and TBI17 also often report reduced empathic concern. Caregivers of people with bvFTD also report lower empathic concern relative to premorbid levels.18 People with schizophrenia often do not differ from controls,19––22 although one study did identify self-rated empathic impairment.23 Discriminates between people with autism and controls.14,24,26,28,38,42–45 Discriminates between people with schizophrenia and controls,46 although this might only be true for informant-rating (not self-rating).47 Norms Extensive research base. Population Adults Extensive research base. No formal norms, but a cut-off score of 30 has been suggested.24 Adult, child and adolescent versions, short version available39 Two studies indicate that people with autism Emerging Adults are impaired on the MET cognitive empathy evidence base. component; one found no autism-related impairment in MET affective empathy,48 the other identified deficits specific to negative stimuli.49 The affective and cognitive components of the MET elicit distinct patterns of neural activity.50 People with bvFTD exhibit global impairment on MET cognitive empathy, and specific deficiencies in MET affective empathy.51 People with schizophrenia exhibit deficits in MET cognitive empathy but not MET affective empathy.20 The reverse profile has been identified in other groups,52,53 and people with borderline personality disorder are impaired on both components.54 *Where estimates of reliability are provided for versions of the Empathic Concern subscale that vary considerably from the original, these are not reported here.55–59 ‡The reliability data reported here refers to the adult version; reliability data are also available for the child and adolescent versions.44,45,60 α refers to Cronbach’s alpha, mean interval refers to average interval between testing occasions, ρY provides an estimate of internal reliabilities, ICC refers to intraclass correlation coefficient. 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