Chapter 14 Mononeuropathies Monique M. Ryan and H. Royden Jones Abstract Mononeuropathies are rare in children, accounting for fewer than 10% of pediatric referrals for electromyographic (EMG) testing, but they can cause significant long-term morbidity and may be a diagnostic and management challenge. In contrast to adults, in whom most mononeuropathies are related to compression or entrapment, pediatric mononeuropathies most often result from fractures or lacerations. Mononeuropathies in children almost equally affect the median, ulnar, radial, peroneal, and sciatic nerves, whereas in adults, 65% of focal neuropathies affect the median nerve, mainly because of carpal tunnel syndrome. This chapter discusses the clinical, neuroimaging, and neurophysiologic evaluation of focal neuropathies in children, and reviews appropriate management of common pediatric nerve lesions.