Mallaiah R. Mittakanti, Curriculum Vitae
Mallaiah R. Mittakanti, Ph.D.
LHSB 401, 1300 Holman St, Houston, TX 77004
Tel: 713-718-6050
Email: mallaiah.mittakanti@hccs.edu
Summary:
Recent experience in teaching General and Organic Chemistry for college and university
students including lab experiments. Prior experience stretch over twenty five years of
research and process development activity in specialty chemicals and pharmaceuticals
industry. Very familiar with using various instruments such as NMR, FTIR, UV, HPLC, GC
and GCMS for identification of organic molecules.
Teaching Experience: Adjunct Faculty
General and Organic Chemistry-1, HCC Central
Organic Chemistry-2, University of St. Thomas, Houston.
Spring- Fall, 2015
Summer, 2015
Education
Ph.D., Synthetic Organic Chemistry, Pune University (NCL), India (1984)
M.S., Organic Chemistry, Osmania University, India (1978)
Publications: 14 publications and 4 patents (please see at the end).
Research and Work Experience
Consulting Services
2011-2014
Provided consultancy services for chemical companies in the process and technology
development of specialty chemicals.
Sr. Research Chemist, Dixie Chemical Company Inc., Pasadena, Texas 2000-2011
Spearheaded research and development projects encompassing new processes and
process developments for various pharmaceutical intermediates and fine chemicals.
Mentored research technicians and chemists in performing the assigned project goals.
Sr. Process Development Chemist, Carbotek Labs, Houston, Texas
1997-1999
Developed cost efficient processes for multi-step synthesis of fine chemicals and
pharmaceutical intermediates. Produced multi-kilogram quantities of lead compounds
under cGMP protocols for clinical trials. Mentored research technicians and chemists in
performing the assigned project goals.
Process Development Chemist, Ilex Oncology, San Antonio, Texas
1992 -1997
Designed and synthesized a class of novel DNA-intercalating agents and flavones for
anticancer activity screening against various cell lines. Produced lead compounds as a
result of the structure activity relationship (SAR) studies. Produced lead compounds under
cGMP protocols for clinical trials.
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Mallaiah R. Mittakanti, Curriculum Vitae
Postdoc and Research Associate, Utah State University, Logan, Utah
1987-1992
Prepared various alkali metal (-cyanoalkyl) trihydroborate-dioxane complexes and
studied their reduction properties with various organic functional groups. Synthesized
pharmacologically active organoboron and organophosphorus compounds for structure
activity relationship studies. Studied hypercholesteremic and hypolipidemic activities of
organoboron compounds in rodents.
Research Scientist, Biological E. Ltd, Hyderabad, India
1984-1987
Spearheaded process technology projects for active pharmaceutical ingredients (APIs)
including Ibuprofen, Atenolol and Metoprolol. These products were prepared on multi-gram
in the laboratory to multi-kilogram scale in the pilot plant. Eventually the technologies of
these processes were transferred to plant for commercial scale production.
PUBLICATIONS AND PATENTS
PUBLICATIONS:
1. Synthesis of (+) Iso-ß-peltatin-A Methyl Ether
M. Mittakanti, B.G. Hazra and K.G. Das
Indian J. Chem., 20B, 434-435 (1981).
2. Gas Phase Reactions Induced by OH- Ion
K.G. Das, M. Mittakanti, K.P. Madhusudhanan and A.P. Bruins
Tetrahedron, 38, 2285-2289 (1982).
3. Gas Phase Reactions of C1- Ion with Aryl-Substituted Nitrocyclohexenes
K.G. Das, A.M. Reddy, M. Mittakanti, and K.P. Madhusudhanan
Organic Mass Spectrometry, 20, 677-679 (1985).
4. Synthesis of 4-(ß-Iodoethyl)-7-isopropyl-8-methoxy Isochroman-3-one
M. Mittakanti and B.M. Bhawal
Indian J. Chem., 26B, 768-769 (1987).
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Mallaiah R. Mittakanti, Curriculum Vitae
5. Preparation and Characterization of Alkali metal (-Cyanoalkyl) trihydroborateDioxane Complexes.
J.L. Peters, M. Mittakanti, T.J. Lofthouse and K.W. Morse
Inorg. Chem.., 28, 492-494 (1989).
6. Synthesis and Characterization of Derivatives of Pyridine Borane Adducts
M. Mittakanti and K.W. Morse
Inorg. Chem.., 29, 554-556 (1990).
7. Reduction of Some Functional Groups with Li (-Cyanoalkyl) trihydroborate-Dioxane
Complexes
M. Mittakanti, J.L. Peters and K.W. Morse
J. Org. Chem.., 55, 4464-4466 (1990).
8. Synthesis and Characterization of Monosubstituted Borane Adducts of
Diethyl ((Dimethylamino)methyl)phosphonate
M. Mittakanti, M. R. M. D. Charandabi and K.W. Morse
Inorg. Chem.., 29, 3218-3220 (1990).
9. Preparation of Monosubstituted Borane Adducts of an NH-containing
(Aminomethyl)phosphonate.
M. Mittakanti and K.W. Morse
Inorg. Chem.., 30, 2434 (1991).
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Mallaiah R. Mittakanti, Curriculum Vitae
10. Synthesis and Hypolipidemic Activity of Aminecarboxyboranes, Amides and Esters in
Rodent
A. Sood, C. Sood, B.F. Spielvogel, I.H. Hall, O.T. Wong, M. Mittakanti and K.W. Morse
Arch. Pharm., 324, 423 (1991).
11. Esterification of Amine-Carboxyborane with Orthoformates: A High Yield Synthesis
M. Mittakanti, D.A. Feakes and K.W. Morse
Synthesis, 380 -382(1992).
12. Exchange Reactions Using N-Methylmorpholine-Borane Derivatives
M. Mittakanti and K.W. Morse
Main Group Met. Chem., 19, 727-732 (1996).
13. Distortion of DNA Structure by New Cytotoxic Drugs Combining Groove Binding and
Intercalating Moieties
J.M. Woynaroswki, C. Napier, W. G. Chapman, S.F. Chen, M. Wajima, M. Mittakanti, P.
Reddy, and A.L. Weis
Proc. Am. Assoc. Cancer Res. 36, 442 (1996)
14. Unsymmetrically Linked Bisnaphthalimides as Antitumor Agents
A.L. Weis, S.F. Chen, P.S. Reddy, M. Mittakanti, D.L. Dexter
Biotechnology Advances, 15, (3), 736-737 (1997)
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Mallaiah R. Mittakanti, Curriculum Vitae
PATENTS:

Alkylcarbamoylborane Cyclic Dimers and Their Use in the Synthesis of Boron Analogues
of Amino Acids
K.W. Morse, M.R.M.D. Charandabi, D.A. Feakes and M. Mittakanti
US Patent No: 5,196,581 (1993)

Bisnaphthalimides with Linkers Having Heteroatoms and Uses Thereof
S.F. Chen, D.L. Dexter, M. Mittakanti, P.S. Reddy, A.L. Weis, J.M. Woynaroswki
Worldwide patent No: WO1996003384 A1 (1996)

Diamine Platinum Nitronaphthalimide Complexes as Antitumor Agents
A.L. Weis, S.F. Chen, P.S. Reddy, M. Mittakanti, D.L. Dexter, J.M. Woynaroswki
US Patent No: 5, 561,042 (1996)

Unsymmetrically Linked Bisnaphthalimides as Antitumor Agents
A.L. Weis, S.F. Chen, P.S. Reddy, M. Mittakanti, D.L. Dexter
US Patent No: 5,604,095 (1997)
Other non-published works include over a dozen process technology manuals (company
proprietary information) and presentation of posters and talks.
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