IRAKLIS C. MITSOGIANNIS MD PhD FEBU UROLOGICAL SURGEON CURRICULUM VITAE Athens May 2014 1 Personal Particulars Name Iraklis Mitsogiannis Date of birth: 30/10/1961 Nationality: Greek Contact Address: 5 Proussis street 14232 New Ionia Athens, Greece Tel. +302102582665, +306944780475 Fax: +302108044703 Email: imitsog@med.uoa.gr Work Address: 2nd Dept. of Urology, Sismanoglio Hospital, 1 Sismanogliou street, 15126, Maroussi, Athens, Greece Present Post: Lecturer in Urology, 2nd Department of Urology, University of Athens Education: March 1998: Accredited as Urological Surgeon. Ministry of Health and Prefecture of Athens, Greece June 1989: Medical Degree, University of Athens February 1983: Accredited as Physiotherapist Athens School of Health and Social Welfare 2 Awards Fellowships: - Fellow of the European Board of Urology (FEBU) - Hellenic Urological Association, 1997-1998. - 1st Prize at the 15th Hellenic Urological Association Congress for the audit: “Comparative evaluation of three molecular urine diagnostic markers -UBC, NMP22 and BTA stat test- in the diagnosis of bladder cancer. - 2nd Prize at the 19th Hellenic Urological Association Congress for the audit “Sexual dysfunction in women with newly diagnosed Multiple Sclerosis” Scholarships: - 1998: Winner of “Apostolos Deliveliotis” Scholarship for Clinical Training in the Royal Hallamshire Hospital, Sheffield, UK - 1998: Winner of “Urodynamics” Scholarship for Training in the Royal Hallamshire Hospital, Sheffield, UK Registrations: - General Medical Council, Full, No 4496414, Urology 28/9/1998 - Active member of European Association of Urology (EAU) - Member of the international Continence Society (ICS) - Hellenic Urological Association (HUA) - Greek-German Urological Association - 2009-2011: Member of the Scientific Committee of the Urodynamics, Neurourology and Female Urology (UNUFU) Section of the HUA - 2011-2013: President of the Scientific Committee of the Urodynamics, Neurourology and Female Urology (UNUFU) Section of the HUA 3 Residency and Work Experience: 16/1/2013-today: Lecturer in Urology, 2nd Department of Urology, University of Athens, Sismanoglio Hospital, Athens, Greece. Head of the Neurourology & Urodynamics Unit. 17/4/2007-16/1/2013: Consultant Urological Surgeon, 2nd Department of Urology, University of Athens, Sismanoglio Hospital, Athens, Greece. Head of the Neurourology & Urodynamics Unit. 17/9/2001- 17/4/2007: Consultant Urological Surgeon, Department of Urology, University of Thessaly, Larissa, Greece. Head of the Neurourology & Urodynamics Unit. 14/7/1999 – 14/9/2001: Fellow in the Department of Urology, University of Athens (Supervisor: Prof. C. Dimopoulos) 13/7/1998 to 13/7/1999: Registrar at the Department of Urology, Royal Hallamshire Hospital, Sheffield, UK (Consultant: Christopher R. Chapple). Participation in several research protocols in the Urology Research Department of the same hospital. 27/12/1997 to 6/7/1998: Research Fellow in the Dept. of Urology, University of Athens (Supervisor: Prof. C. Dimopoulos) 3/1/1995 to 24/12/1997: Resident in Urology, Department of Urology, Athens University Medical School (C. Dimopoulos, Professor of Urology). 12/11/1993 to 11/11/1994: Resident in Urology, Department of Urology, Metaxas Memorial Anticancer Hospital, Piraeus (K. Christodoulou, Urological Surgeon). 8/9/1992 to 7/9/1993: Resident in Surgery, 2nd Department of Surgery, Red Cross Hospital, Athens (E. Papaevangellou, Ass. Professor of Surgery). 8/5/1991 to 7/9/1992: SHO in General Medicine at Health Centre of Perama, Rethimnon, Crete. 4 Private Practice: 1/8/1999 – 17/9/2001: Consultant Urologist at the “Athineon Hospital” and at the “Central Clinic” in Athens Teaching Practice: - 2007-today: Participation in training students of the Athens Medical School in Urology - 2001-2007: Participation in training students of the Thessaly Medical School in Urology - 1995-2001: Participation in training students of the Athens Medical School in Urology - Tutor in the “Training Week of Greek Urology Residents” the last 7 years Presentations and Publications 1. Adrenal Myelolipoma C. Constantinides, I. Mitsogiannis, A. Kyroudi, Th. Manousakas, D. Pantazopoulos, C. Dimopoulos. Urologia 1998; 65(4): 569-70 2. Transurethral implantation of Macroplastique® for the treatment of female stress urinary incontinence secondary to urethral sphincter deficiency. SC Radley, CR Chapple, IC Mitsogiannis and KS Glass. Eur Urol 2001; 39: 383-9 Impact Factor: 10,476 3. Clinical efficacy of distigmine bromide in the treatment of patients with underactive detrusor. Bougas D., Mitsogiannis I., Mitropoulos D., Kollaitis G., Serafetinidis E., Giannopoulos A. Int Urol Nephrol 2004; 36: 507-12 Impact Factor: 1,325 5 4. Plasmacytoid transitional cell carcinoma of the urinary bladder. Mitsogiannis I, Ioannou M, Sinani C, Melekos M. Urology 2005; 66: 194e.12-194e.13 Impact Factor: 2,424 5. Percutaneous suprapubic cystolithotripsy under local anesthesia. V. Tzortzis, E. Aravantinos, A. Karatzas, I.C. Mitsogiannis, G. Moutzouris, M.D. Melekos. Urology 2006; 68: 38-41 Impact Factor: 2,424 6. In vitro biocompatibility between mitomycin-C (MMC) and bacillus Calmette-Guerin (BCG). Mitsogiannis IC, Psaroudaki Z, Perrea D, Paniara O, Melekos MD, Zervas A, Mitropoulos D. Anticancer Res 2006; 26(6B): 4569-73 Impact Factor: 1,713 7. Colonization by a Linezolid-resistant Enterococcus faecalis caused a urinary tract infection. Mitsogiannis IC, Oeconomou A, Karanika M, Petinaki E, Melekos MD. Scand J Infect Dis 2007; 39(6-7): 649-50 Impact Factor: 1,706 8. Bladder stone formation after a Tension-free Vaginal Tape procedure. Report on 2 cases. Tzortzis V., Mitsogiannis IC., Moutzouris G., Aravantinos E, Anagnostou T, Gravas S, Melekos MD. Urol Int 2007; 79(2): 181-2 Impact Factor: 1,065 9. Impact of stapling devices on radical cystectomy: comparative study between lowand high-volume surgeons. Tzortzis V, Gravas S, Mitsogiannis IC, Moutzouris G, Karatzas A, Leventis A, Mpouzalas I, Melekos MD. Urology 2008; 71(2): 337-40. Impact Factor: 2,424 6 10. Analgesia during extracorporeal shockwave lithotripsy: fentanyl citrate versus parecoxib sodium. Mitsogiannis IC, Anagnostou T, Tzortzis V, Karatzas A, Gravas S, Poulakis V, Melekos MD. J Endourol 2008; 22(4): 623-6 Impact Factor: 2,074 11. Sexual dysfunction in newly diagnosed multiple sclerosis women. Tzortzis V, Skriapas K, Hadjigeorgiou G, Mitsogiannis I, Aggelakis K, Gravas S, Poulakis V, Melekos MD. MultScler 2008; 14(4): 561-3. ImpactFactor: 4,472 12. Biweekly doxorubicin/ketoconazole as second-line treatment in docetaxel-resistant, hormone-refractory prostate cancer. Lainakis G,Antoniou N, Alivizatos G, Chrisofos M, Mitsoyiannis I, Livadas K, Varkarakis I, Katsifotis H, Dimopoulos MA, Bamias A. Urology 2008; 71(6): 1181-5. Impact Factor: 2,424 13. Postradical cystectomy bowel perforation caused by a drainage tube: a case report. Chatzidarellis EP, Skolarikos A, Mazaris E, Mitsogiannis I, Alivizatos G. Cases J 2008; 1(1): 350. 14. Somatostatin analog lanreotide in the treatment of castration-resistant prostate cancer (CRPC). Mitsogiannis IC, Skolarikos A, Deliveliotis C. Expert Opin Pharmacother 2009; 10(3): 493-501 Impact Factor: 2,860 15. Current status of ureteroscopic treatment for urolithiasis. Skolarikos AA, Papatsoris AG, Mitsogiannis IC, Chatzidarellis L, Liakouras C, Deliveliotis C Int J Urol 2009; 16(9): 713-7 Impact Factor: 1.734 16. Re: Hans-Martin Fritsche, Maximilian Burger, Robert S. Svatek et al. Characteristics and Outcomes of Patients with Clinical T1 Grade 3 Urothelial Carcinoma Treated with Radical Cystectomy: Results from an International Cohort. Papatsoris A, Mitsogiannis I, Deliveliotis C. 7 Eur Urol 2010; 58: e19 Impact Factor: 10,476 17. Indications, prediction of success and methods to improve outcome of shock wave lithotripsy of renal and upper ureteral calculi. Skolarikos A, Mitsogiannis I, Deliveliotis C. Arch Ital Urol Androl 2010; 82: 56-63 18."Inflammatory myofibroblastic bladder tumor in a patient with Von Recklinghausen's syndrome" Eleftherios Chatzidarellis, Evangelos M. Mazaris, Andreas Skolarikos, Maria Demonakou, Iraklis C. Mitsogiannis, Nafsika Mousiou, Apostolos Bisas Case Rep Med 2010; doi:pii: 523964. 10.1155/2010/523964 19. Bilateral spontaneous retroperitaneal bleeding in a patient on nimesulide: a case report Iraklis C. Mitsogiannis, Eleftherios Chatzidartzidarellis, Andreas Skolarikos, Athanasios Papatsoris, Georgia Anagnostopoulou, Evangelos Karagiotis J Med Case Rep 2011; 5(1): 568. doi: 10.1186/1752-1947-5-568 20. Semirigid laser ureterolithotripsy for single large pelvic stones Mitsogiannis IC, Papatsoris A, Varkarakis J, Skolarikos A, Deliveliotis C. Med Surg Urol 2012 S4:002. Doi:10.4172/2168-9857.S4-002. 21. Update on intracorporeal laser lithotripsy Papatsoris A, Chrisofos M, Skolarikos A, Varkarakis I, Mitsogiannis I, Mygdalis V, Dellis A, Buchholz N, Masood J. Minerva Med 2013; 104(1): 55-60 Impact Factor: 0,771 22. Laparoscopic surgical repair of pelvic organ prolapse and female stress urinary incontinence Panagiotis I. Mourmouris, Andreas Skolarikos, Iraklis C. Mitsogiannis, Vasileios Migdalis, Athanasios G. Papatsoris WJOG 2013; 3(3): 1-6 Citations 146 8 Accepted for publication Obsruction-induced alterations within the urinary bladder and their role in the pathophysiology of lower urinary tract symptomatology Komninos C and Mitsogiannis IC Accepted for publication at the Canadian Urological Association Journal (IF: 1,657) Submitted (awaiting review): 3 Publications in Greek Journals: 17 Abstracts published in Journals with Impact Factor: 16 Audits (presentations in International Congresses): 19 Audits (presentations in Greek Congresses): 36 Research Doctoral Thesis: Adjuvant intravesical therapy with BCG combined with Mitomycin-C for urothelial bladder cancer (University of Athens, 2002). Studies - Correlation of International Prostate Symptom Score (IPSS) with patients’ education status. - Complete Androgen Blockade (trimonthly-injected Zoladex plus Casodex 50mg od) in patients with metastatic prostatic cancer. - Study of Peptide Growth Factors alterations within the hypertophied bladder wall in rats. - Prospective longitudinal evaluation of transurethral implantation of Macroplastique in women with stress urinary incontinence using subjective and objective outcome measures and transurethral ultrasound scanning. - 1998-1999: Participation as a Research Registrar in the following research protocols at the Urology Research Department, Royal Hallamshire Hospital, Sheffield, UK. o Efficacy and safety of 3 doses (0.4 mg, 0.8 mg, 1.0 mg bd) of NS 49 versus placebo in the treatment of women suffering from genuine stress incontinence. A 9 double-blind randomised controlled trial carried out in 4 parallel groups of 1 month (DORINS). o An open, randomised, multicentre study of patients with benign prostatic hypertrophy comparing the effect on health economic outcomes of two methods of clinical management: 1) Management in the community by their General Practicioners with Terazosin and 2) Management by the Consultant Urologists. 08/018. o Comparative study of efficacy and safety of Permixon 320 mg once a day with Tamsulosin SR 0.4 mg once a day. Phase II. A multicentre, international, double-blind, parallel groups, 56 week study in patients over the age of 50 with symptomatic BPH not requiring surgery. 98/024. o A phase II, randomised, open, multicentre study in two parallel groups to assess the equivalence of Decapeptyl SR 28-day (reference formulation), the efficacy and the tolerability of decapeptyl SR 3-month during the follow-up period in patients with prostate cancer. 98/209. o Dose ranging study comparing best medical therapy with and without ABT-627 for the treatment of men with asymptomatic hormone refractory adenocarcinoma of the prostate. 97/304. o A phase II, 28 week, randomised, double-blind, placebo controlled, double dummy study of the safety, tolerance and efficacy of CS-891 (5 mg and 10 mg) compared to finasteride (5 mg) and placebo given once daily in patients with BPH. 98/092. o A multicentre, randomised study to compare the effect of two blinded doses of Casodex (ICI 176334, 100 mg and 150 mg po daily) and castration in the treatment of advanced carcinoma of the prostate. 572. o A randomised, double blind, parallel-group trial comparing Casodex150 mg once daily with placebo in patients with non-metastatic prostate cancer. 95/253. o A multicentre, randomised and comparative trial to assess the tolerance, efficacy and pharmacokinetics of escalating doses of Casodex (300 mg po daily increasing by 150 mg intervals) in the treatment of advanced carcinoma of the prostate. 94/194. o A study to determine the safety and efficacy of the Self- Detachable Balloon System (SDBS) in treating patients with stress incontinence due to intrinsic sphincter deficiency (ISD). 97/ 30. 10 o Efficacy and safety of 2 dosage levels of alfuzosin geomatrix (10 mg od and 15 mg od) versus tamsulosin (0.4 mg od) and placebo in patients with symptomatic benign prostatic enlargement. Placebo-controlled, double-blind study, conducted in 4 parallel groups for three months followed by an optional 9-month openlabel extension with alfuzosin geomatrix 15 mg od. 97/134. - 2001-2007: Prospective randomised trial comparing the efficacy and safety of 2 different doses of intravesical Farmorubicin (50mg/50ml vs. 80mg/50ml). - 2003-2007: Randomised, double-blind, placebo controlled study for the efficacy and safety of dutasteride 0.5mg od for 4 years in reducing the prostate cancer risk (Protocol ARI 40006). - 2004-2005: The STAR Study, Protocol 905-ΕC-001. Efficacy and safety of solifenacin succinate vs. tolterodine od in patients with OAB symptoms. - 2004-2005: Prospective, placebo-controlled study for the safety and efficacy of duloxetine in treating SUI. Protocol F1J-EW-SBCC (a). - 2004-2007: European, prospective, observational, 6-month study, for the estimation of the direct cost fr the treatment of patients with Urinary incontinence (F1J-MCSBCB). - 2007-2008: “A multicenter, double-blind, randomized, placebo-controlled, parallel group, study to explore the dose dependent response to three dose levels of BOTOX® (Botulinum Toxin Type A) purified neurotoxin complex followed by an open label extension phase in patients with urinary incontinence due to neurogenic detrusor overactivity”. Protocol 191622-518. - 2012-2014: Primary Investigator in a study entitled: “A Phase II, Randomized, Active Comparator-Controlled Clinical Trial to study the safety, tolerability and efficacy of MK7655+Imipenem/Cilastatin Versus Imipenem/Cilastatin alone complicated UTI (Study MK-7655PN003). Lectures in Greek and International Congresses/Courses: 104 Author in 3 Greek University Urology Textbooks (13 Chapters) Reviewer in Greek and International journals 11 in patients with Continuous Medical Education Attendance at International Congresses: 46 Attendance at Greek Congresses: 58 Attendance at International Symposia: 8 Attendance at Greek Symposia: 44 International Postgraduate Courses attended: 14 Greek Postgraduate Courses attended: 71 Foreign Language: English: - First Certificate in English, University of Cambridge, Grade A, 1977. - IELTS (International English Language Testing System of British Council) Grade 7.5, 1998. Career overview: - I was trained as a Specialist in Urological Surgery at the 1st Department of Urology, University of Athens. Following my accreditation as Urologist, I spent one year at the Urology Department of Royal Hallamshire Hospital in Sheffield, UK, under the guidance of Professor Christopher Chapple, participating in clinical and research work. In particular, I was broadly exposed to both general urology and specialist functional reconstruction of the lower urinary tract, including urethroplasty surgery, repair of vesico-vaginal fistulae and cystoplasty. Furthermore, I was involved in various research protocols in the Urology Research Department and also in the daily work in the VideoUrodynamics Laboratory. Following my return in Athens, I worked for 2 years as a Fellow at the 1st Urology Department of Athens University before I was appointed Consultant Urological Surgeon at the Department of Urology, University of Thessaly (2001). In this new Department, I was committed to run the Urodynamics Laboratory but I helped set all the other Sections as well. Since 2007, I have been working at the 2nd University Department of Urology as a Urological Surgeon and also as the lead of the Neurourology and Urodynamics Section. I currently hold the post of Lecturer in Urology in the University of Athens. As a University Lecturer, I have participated in various 12 research protocols and multi-centre studies and also in the training programmes of the pre- and post-graduate students of Athens Medical School. I have attended a large number of Congresses, Symposia and Seminars and have given more than a hundred Lectures as an invited speaker. As President of the Scientific Committee of the Urodynamics, Neurourology and Female Urology (UNUFU) Section of the Hellenic Urological Association I was actively involved in organising seminars and Urodynamics training courses all over Greece. My aim is to continue serving Academic Medicine and keep practicing Clinical Urology with commitment to high standards. 13