Table S1 –Gene ontology analysis of genes nearest H3K27me3 peaks.
Each portion of H3K27me3 depicted in the Venn diagram in Fig. 3b was analyzed for enriched biological process categories (by hypergeometric test adjusted for multiple
measurements, p<0.01).
Intersection of WT and KO
GO ID
GO:0033555
GO:0031644
GO:0050804
GO:0051969
GO:0007268
GO:0044057
GO:0019226
GO:0035637
GO Term
multicellular
organismal
response to stress
regulation of
neurological
system process
regulation of
synaptic
transmission
regulation of
transmission of
nerve impulse
synaptic
transmission
regulation of
system process
transmission of
nerve impulse
GO:0000902
multicellular
organismal
signaling
cell projection
morphogenesis
cell part
morphogenesis
cell morphogenesis
GO:0022610
biological adhesion
GO:0007155
cell adhesion
GO:0048858
GO:0032990
GO:0032989
GO:0030182
GO:0048699
GO:0022008
WT Only
GO ID
GO:0031644
GO:0050804
GO:0051969
GO:0030155
GO:0045860
GO:0044057
GO:0007268
GO:0048858
GO:0019226
cellular component
morphogenesis
neuron
differentiation
generation of
neurons
neurogenesis
GO Term
regulation of
neurological
system process
regulation of
synaptic
transmission
regulation of
transmission of
nerve impulse
regulation of cell
adhesion
positive regulation
of protein kinase
activity
regulation of
system process
synaptic
transmission
cell projection
morphogenesis
transmission of
nerve impulse
Definition
Any process that results in a change in state or
activity of a multicellular organism (in terms of
movement, secretion, enzyme production, gene
expression, etc.) as a result of a stimulus
indicating the organism is under stress. The
stress is usually, but not necessarily, exogenous
(e.g. temperature, humidity, ionizing radiation).
Any process that modulates the frequency, rate
or extent of a neurophysiological process, an
organ system process carried out by any of the
organs or tissues of neurological system.
Any process that modulates the frequency or rate
of synaptic transmission, the process of
communication from a neuron to a target (neuron,
muscle, or secretory cell) across a synapse.
Any process that modulates the frequency, rate
or extent of transmission of a nerve impulse, the
sequential electrochemical polarization and
depolarization that travels across the membrane
of a neuron in response to stimulation.
The process of communication from a neuron to
a target (neuron, muscle, or secretory cell) across
a synapse.
Any process that modulates the frequency, rate
or extent of a system process, a multicellular
organismal process carried out by any of the
organs or tissues in an organ system.
The neurological system process in which a
signal is transmitted through the nervous system
by synaptic transmission and the sequential
electrochemical polarization and depolarization
that travels across the membrane of a nerve cell
(neuron) in response to stimulation.
The transfer of information occurring at the level
of a multicellular organism.
The process in which the anatomical structures of
a cell projection are generated and organized.
The process in which the anatomical structures of
a cell part are generated and organized.
The developmental process in which the size or
shape of a cell is generated and organized.
The attachment of a cell or organism to a
substrate or other organism.
The attachment of a cell, either to another cell or
to an underlying substrate such as the
extracellular matrix, via cell adhesion molecules.
The process in which cellular structures, including
whole cells or cell parts, are generated and
organized.
The process in which a relatively unspecialized
cell acquires specialized features of a neuron.
The process in which nerve cells are generated.
This includes the production of neuroblasts and
their differentiation into neurons.
Generation of cells within the nervous system.
Definition
Any process that modulates the frequency, rate
or extent of a neurophysiological process, an
organ system process carried out by any of the
organs or tissues of neurological system.
Any process that modulates the frequency or rate
of synaptic transmission, the process of
communication from a neuron to a target (neuron,
muscle, or secretory cell) across a synapse.
Any process that modulates the frequency, rate
or extent of transmission of a nerve impulse, the
sequential electrochemical polarization and
depolarization that travels across the membrane
of a neuron in response to stimulation.
Any process that modulates the frequency, rate
or extent of attachment of a cell to another cell or
to the extracellular matrix.
Any process that activates or increases the
frequency, rate or extent of protein kinase
activity.
Any process that modulates the frequency, rate
or extent of a system process, a multicellular
organismal process carried out by any of the
organs or tissues in an organ system.
The process of communication from a neuron to
a target (neuron, muscle, or secretory cell) across
a synapse.
The process in which the anatomical structures of
a cell projection are generated and organized.
The neurological system process in which a
signal is transmitted through the nervous system
by synaptic transmission and the sequential
electrochemical polarization and depolarization
that travels across the membrane of a nerve cell
(neuron) in response to stimulation.
p-value
Count in
dataset
Count in
Genome
Enrichm
ent
Total
term in
dataset
Total
term in
genome
BH
adjusted
p-value
1.34E-05
20
50
40.0%
106639
718880
0.00587
2.38E-07
63
224
28.1%
106639
718880
0.001052
3.72E-06
53
192
27.6%
106639
718880
0.002281
2.11E-06
57
208
27.4%
106639
718880
0.001762
1.55E-06
95
399
23.8%
106639
718880
0.001581
2.81E-06
94
399
23.6%
106639
718880
0.001915
1.43E-06
110
478
23.0%
106639
718880
0.001581
1.43E-06
110
478
23.0%
106639
718880
0.001581
1.72E-05
91
400
22.8%
106639
718880
0.007053
2.72E-05
92
410
22.4%
106639
718880
0.009817
2.30E-06
131
597
21.9%
106639
718880
0.001762
3.43E-07
161
741
21.7%
106639
718880
0.001052
5.31E-07
159
735
21.6%
106639
718880
0.001087
1.08E-05
136
643
21.2%
106639
718880
0.005243
7.62E-06
151
723
20.9%
106639
718880
0.004248
1.11E-05
164
802
20.4%
106639
718880
0.005243
1.94E-05
172
856
20.1%
106639
718880
0.00742
p-value
Count in
dataset
Count in
Genome
Enrichm
ent
Total
term in
dataset
Total
term in
genome
BH
adjusted
p-value
2.28E-07
63
224
28.1%
106521
718880
0.000627
3.60E-06
53
192
27.6%
106521
718880
0.002769
2.04E-06
57
208
27.4%
106521
718880
0.002656
2.71E-05
53
205
25.9%
106521
718880
0.009196
2.21E-05
66
270
24.4%
106521
718880
0.009012
2.68E-06
94
399
23.6%
106521
718880
0.002734
4.82E-06
93
399
23.3%
106521
718880
0.002946
1.65E-05
91
400
22.8%
106521
718880
0.007221
4.07E-06
108
478
22.6%
106521
718880
0.002769
GO:0035637
GO:0000902
multicellular
organismal
signaling
cell part
morphogenesis
cell morphogenesis
GO:0022610
biological adhesion
GO:0007155
cell adhesion
GO:0032990
GO:0032989
GO:0030182
GO:0048699
GO:0022008
KO Only
GO ID
GO:0033555
GO:0031644
GO:0050804
GO:0051969
GO:0007268
GO:0044057
GO:0019226
GO:0035637
cellular component
morphogenesis
neuron
differentiation
generation of
neurons
neurogenesis
GO Term
multicellular
organismal
response to stress
regulation of
neurological
system process
regulation of
synaptic
transmission
regulation of
transmission of
nerve impulse
synaptic
transmission
regulation of
system process
transmission of
nerve impulse
GO:0000902
multicellular
organismal
signaling
cell morphogenesis
GO:0022610
biological adhesion
GO:0007155
cell adhesion
GO:0032989
GO:0030182
GO:0048699
GO:0022008
cellular component
morphogenesis
neuron
differentiation
generation of
neurons
neurogenesis
The transfer of information occurring at the level
of a multicellular organism.
The process in which the anatomical structures of
a cell part are generated and organized.
The developmental process in which the size or
shape of a cell is generated and organized.
The attachment of a cell or organism to a
substrate or other organism.
The attachment of a cell, either to another cell or
to an underlying substrate such as the
extracellular matrix, via cell adhesion molecules.
The process in which cellular structures, including
whole cells or cell parts, are generated and
organized.
The process in which a relatively unspecialized
cell acquires specialized features of a neuron.
The process in which nerve cells are generated.
This includes the production of neuroblasts and
their differentiation into neurons.
Generation of cells within the nervous system.
Definition
Any process that results in a change in state or
activity of a multicellular organism (in terms of
movement, secretion, enzyme production, gene
expression, etc.) as a result of a stimulus
indicating the organism is under stress. The
stress is usually, but not necessarily, exogenous
(e.g. temperature, humidity, ionizing radiation).
Any process that modulates the frequency, rate
or extent of a neurophysiological process, an
organ system process carried out by any of the
organs or tissues of neurological system.
Any process that modulates the frequency or rate
of synaptic transmission, the process of
communication from a neuron to a target (neuron,
muscle, or secretory cell) across a synapse.
Any process that modulates the frequency, rate
or extent of transmission of a nerve impulse, the
sequential electrochemical polarization and
depolarization that travels across the membrane
of a neuron in response to stimulation.
The process of communication from a neuron to
a target (neuron, muscle, or secretory cell) across
a synapse.
Any process that modulates the frequency, rate
or extent of a system process, a multicellular
organismal process carried out by any of the
organs or tissues in an organ system.
The neurological system process in which a
signal is transmitted through the nervous system
by synaptic transmission and the sequential
electrochemical polarization and depolarization
that travels across the membrane of a nerve cell
(neuron) in response to stimulation.
The transfer of information occurring at the level
of a multicellular organism.
The developmental process in which the size or
shape of a cell is generated and organized.
The attachment of a cell or organism to a
substrate or other organism.
The attachment of a cell, either to another cell or
to an underlying substrate such as the
extracellular matrix, via cell adhesion molecules.
The process in which cellular structures, including
whole cells or cell parts, are generated and
organized.
The process in which a relatively unspecialized
cell acquires specialized features of a neuron.
The process in which nerve cells are generated.
This includes the production of neuroblasts and
their differentiation into neurons.
Generation of cells within the nervous system.
4.07E-06
108
478
22.6%
106521
718880
0.002769
2.61E-05
92
410
22.4%
106521
718880
0.009196
2.17E-06
131
597
21.9%
106521
718880
0.002656
1.97E-07
162
741
21.9%
106521
718880
0.000627
3.07E-07
160
735
21.8%
106521
718880
0.000627
1.02E-05
136
643
21.2%
106521
718880
0.005224
7.18E-06
151
723
20.9%
106521
718880
0.003993
1.57E-05
163
802
20.3%
106521
718880
0.007221
2.67E-05
171
856
20.0%
106521
718880
0.009196
p-value
Count in
dataset
Count in
Genome
Enrichm
ent
Total
term in
dataset
Total
term in
genome
BH
adjusted
p-value
1.27E-05
20
50
40.0%
106290
718880
0.0063
2.11E-07
63
224
28.1%
106290
718880
0.000856
3.37E-06
53
192
27.6%
106290
718880
0.002064
1.90E-06
57
208
27.4%
106290
718880
0.001665
1.34E-06
95
399
23.8%
106290
718880
0.001367
2.45E-06
94
399
23.6%
106290
718880
0.001871
1.23E-06
110
478
23.0%
106290
718880
0.001367
1.23E-06
110
478
23.0%
106290
718880
0.001367
3.18E-06
130
597
21.8%
106290
718880
0.002064
2.80E-07
161
741
21.7%
106290
718880
0.000856
4.35E-07
159
735
21.6%
106290
718880
0.000888
1.44E-05
135
643
21.0%
106290
718880
0.0063
9.85E-06
150
723
20.7%
106290
718880
0.005479
1.39E-05
163
802
20.3%
106290
718880
0.0063
2.37E-05
171
856
20.0%
106290
718880
0.009669