ORAL CANCER – THE INDIAN SCENARIO Dr. L. Krishna Prasad, Principal, SIBAR Institute of Dental Sciences. Incidence: The incidence rates of Cancer in India was reported to be 111 in males & 116 in females, per 1,00,000 population. (Tanuja Rastogi, Susan Devsa, Punam Mangtani , Aleyamma Mathew , Nicola Cooper , Roy Kao and Rashmi Sinha. Ethnicity and Health Cancer incidence rates among South Asians in four geographic regions: India, Singapore, UK and US. International Journal of Epidemiology 2008; 37:147 – 160). Cancers in the lung, stomach, Oral cavity, oesophagus, and oropharynx are the five most common cancers among males in 2008. Cancers in the breast, cervix, ovary, stomach, mouth are the five most common cancers among females in 2008. (Cancer incident data: India 2002 – 2006). Oral cancer is the third most common cancer among males and fourth among females. (Cancer incident data: India 2002 – 2006). Table 1: Top ten cancers in males (2007 – 2008) Common cancer in 2007 - 08 Lung CIR 11.3 Stomach 10.6 Oral cavity 9.3 Oesophagus 6.8 Oropharynx 6.4 Lymphomas 5.5 Hypopharynx 4.2 Leukamia 4.2 Prostate 4.0 Larynx 3.7 Crude incidence rate (CIR) / 100,000 Top ten cancers in females (2007 – 2008) Common cancer in 2006 - 2008 CIR Breast 30.2 Cervix 17.2 Ovary 7.0 Oral Cavity 5.8 Stomach 5.6 Oseophagus 3.9 Lung 3.8 Lymphoma 3.4 Leukaemia 3.3 Rectum 205 Crude incidence rate (CIR )/1,00,000 (Courtesy : Cancer incident data: Chennai , India 2002 – 2006). Cancer pattern by year wise in males (2006 – 2008) Common cancer in 2006 - 2008 Year 2006 CIR ASR Year 2007 CIR ASR Year 2008 CIR ASR Lung 10.1 11.8 11.6 13.3 12.0 13.7 Stomach 10.0 11.4 11.8 13.2 9.9 10.8 Oral cavity 8.0 8.5 8.2 8.7 10.4 10.8 Aesophagus 6.7 7.7 7.2 8.0 6.6 7.4 Oropharynx 6.6 7.8 5.3 7.2 6.0 6.7 Lymphomas 5.3 5.8 5.6 6.2 5.7 6.1 Hypopharynx 4.0 4.6 3.5 4.0 5.0 5.7 Leukemia 3.7 4.5 4.4 4.5 4.6 5.2 Prostate 4.4 Larynx 3.3 5.1 3.8 3.7 4.2 4.3 4.0 4.1 3.4 3.8 4.8 Crude incidence rate / 1,00,000 (CIR), Age standardized rate / 1,00,000 (ASR) A three year study for cancer cases in males showed a gradual increase in the incidence rate from 2006 to 2008. The increased incidence of Lung and Oral cavity cancers may be attributed to smoking & chewing of tobacco from the younger age. Top ten cancers in females (2007 – 2008) Common cancer in 2006 - 2008 Year 2006 CIR ASR Year 2007 CIR ASR Year 2008 CIR ASR Breast 30.4 32.1 30.2 31.6 29.9 31.2 Cervix 18.9 20.6 16.4 17.9 16.3 17.9 Ovary 6.6 7.2 7.0 7.4 7.2 7.8 Oral Cavity 6.1 6.8 6.4 7.2 4.8 5.1 Stomach 5.4 5.9 6.3 6.8 5.1 5.4 Oesophagus 4.4 4.9 3.8 4.2 3.5 3.9 3.8 4.1 4.0 4.3 Lung 3.5 3.9 Lymphoma 3.2 Leukaemia 3.6 Rectum 2.1 3.4 4.0 2.3 2.6 3.7 3.9 3.2 3.3 2.9 3.2 3.4 3.6 2.9 2.8 3.0 A three year study of cancers in females revealed a decreased incidence of breast cancers which may be due to the increased awareness and recent advanced diagnostic techniques. Oral cancer cases also showed a significant decrease which could be because of the increased awareness on the risk associated with tobacco consumption. Risk factors: According to the study conducted by R. Sankaranarayana in 1990, chewing pan along with tobacco (CI 29.50), smoking bidi (CI 5.57) and drinking alcohol (CI 3.93) were statistically significant factors for developing oral cancer (R. Sankaranarayana , Stephen W Duffy, G Padmakumary , Nicholas E Day, M Krishna Nair. Risk factors for cancer of the buccal and labial mucosa in Kerala, Southern India. Journal of Epidemiology and Community Health 1990; 44: 286 - 292) Frequency, relative risk and confidence interval in males: Factor Category Pan Tobacco Never ≤ 10 per day 11 – 20 per day 21 – 30 per day 31 – 40 per day ≥ 41 per day 37 11 35 39 48 70 1.00 6.90 5.80 7.70 13.24 37.75 ------------ (2.83 16.8) (3. 33 10.11) Cases RR CI Significant (4.43 13.38) (7.51 23.22) (19.49 73.12)P ≤ 0.001 Bidi Never ≤ 20 per day 21 plus per day 125 17 94 1.00 2.68 2.47 --------- (1.35 5.30) ( 1.74 3.49 ) Cigarette P ≤ 0.001 Never ≤ 20 per day 21 plus per day 235 4 9 1.00 0.16 0.66 --------- (0.19 1.82) ( 0.30 1.44 ) NS Bidi and Cigarette ≤ 20 per day 21 plus per day Never 203 10 35 1.00 1.19 1.27 --------- (0.54 2. 59) ( 0.81 2.00 ) NS Alcohol Never ≤ 20 per day 21 plus per day 165 24 17 1.00 1.48 2.50 --------- (0.71 3. 07) ( 1.59 3.93 ) P ≤ 0.001 Frequency, relative risk and confidence interval in Females Factor Category Pan Tobacco ≤ 10 per day 11 – 20 per day 21 – 30 per day 31 – 40 per day Never Cases RR CI Significant ≥ 41 per day 168 48 49 48 19 13 1.00 1.79 3.80 7.74 21.30 54.93 ------------ (0.78 4.07) (1.85 7.75) (4.00 15.00) (9.59 47.36) (21.18 142.42) P ≤ 0.001 RR= Relative risk; CI = Confidence interval (Courtesy: R. Sankaranarayanan etal JECH 1990) Preventive programmes: India is one among the many developing countries that has formulated a National Cancer Control Programme (NCCP). This programme is designed for controlling the tobacco related cancers, early diagnosis and treatment of cervical and uterine cancers and distribution of therapeutic services. (50 years of cancer control in India. Cancer prevention and control in India., Cherian Varghese, Page 5253) Primary prevention is the most cost effective programme as it aims to reduce the incidence of cancer risk. 50% of the oral cancers occurring in males are tobacco related and a large proportion of them can be prevented by anti-tobacco programmes. Teenage is the time when such deleterious habits of Tobacco usage are picked up. So, this group of students should first be targeted for such awareness programs. In the school curriculum, messages which help to lead a healthy life style and awareness about the harmful effects of tobacco usage and alcohol intake should be involved. Cancer prevention needs to be considered as a part of the non communicable disease prevention programme, which can make it more effective and feasible. (50 years of cancer control in India. Cancer prevention and control in India., Cherian Varghese, Page 52-53). Every year, approximately one million people in India are diagnosed with oral cancer and half of them die within 12 months of diagnosis due to lack of awareness regarding oral cancer. Etiology of this cancer related death in males is associated with a well established risk habits such as tobacco, areca nut and alchol. Some steps with which we can reduce the oral cancers are – 1. Reduce tobacco consumption 2. Promoting oral health in population 3. National alcohol control policy 4. Areca nut Control 5. National cancer screening programme Reduce tobacco consumption: According to GATS (Global Adult Tobacco Survey) by the Ministry of health and family welfare released in 2010, nearly 160 millions of the Indian population is using smokeless tobacco, which is an alarming finding. Early detection will make a significant impact if tobacco consumption rate remains high. Tobacco is responsible for 1 in 5 male deaths, particularly in the middle age group. Men who smoke will decrease their life span for 10 years because of tuberculosis, respiratory disease, heart disease and cancer. To avoid consumption of tobacco we have to follow certain policies like – 1. Increasing taxes on all tobacco products 2. Counselling about poor oral hygiene and adverse effects of using tobacco, areca nut, alcohol etc 3. Ban tobacco containing food substances under food safety and standard acts of India 2011. Promoting Oral health in Indian population: Poor oral hygiene and specific bacterial microbial flora in the oral cavity have been linked with development of oral cancers. Some viruses like EBV, HPV and Opportunistic flora like Candida albicans have also been implicated in carcinogenesis. Promotion of health life style is influenced greatly by knowledge, aptitude and hygiene at all levels of society. Health education is the best for promoting oral health. National Alcohol control policy: Alcohol is one of the leading risk factor in under developed/developing countries and third largest risk factor after chewing and smoking forms of tobacco. Tobacco and alcohol are responsible for the loss of 58.3 million lives every year. Consumption of alcohol leads to oral cancer, very commonly involving the tongue and floor of the mouth. Alcohol will increase the permeability of oral mucosa to harmful tobacco carcinogens. Areca nut control: It is one of the psycho–stimulant and addictive substance. WHO classified areca nut under Group – I human carcinogens, with sufficient evidence of increased risk of OSMF, premalignant oral lesions and cancers of the oral cavity. Cancers caused by betel nut chewing shows a strong dose response relationship for frequency and duration of chewing. National Oral cancer screening Program: This program may help in the early detection and in the prevention of oral cancers. All the dentists and doctors (Clinicians) need to perform careful examinations of the oral cavity in those with high-risk habits and those with symptoms and signs. Dentists are the best at oral screening and regular visit may lead to detection at early stage. Periodic visit to the dentist as a part of routine health check-up will have positive impact. In spite of the lacking support from the literature review, oral examination can be a simple but effective tool to make individuals more conscious about their oral health. (Pankaj Chaturvedi. Effective strategies for oral cancer control in India. Journal of Cancer Research and Therapeutics – Supplement 2 – 2012 – Volume 8) Mahatma Gandhi quotation: “If you want to find a solution, go and live where the problem is” Oral cancer is our unique problem and we, as dental professionals, are the ones who can deal with it effectively and find a solution. Public awareness: A study in 1995 on the Level of awareness about oral cancer among public in Great Britain revealed that 77% of the public respondents were aware of the possibility of the occurrence of cancer in the mouth due to smoking. (Tanuja Rastogi, Susan Devsa, Punam Mangtani , Aleyamma Mathew, Nicola Cooper, Roy Kao and Rashmi Sinha. Ethnicity and Health Cancer incidence rates among South Asians in four geographic regions: India, Singapore, UK and US. International Journal of Epidemiology 2008; 37:147 – 160). Horowitz et.al. in 1990 observed that tobacco use was the only risk factor correctly identified among young individuals. (Horowitz A M, Nourjah P and Gift H C. US adult knowledge of risk factors and signs of oral cancer: 1990. JADA 1995; 126:39-45). 95% identified tobacco in any form as a risk factor and only 25% indicated alcohol also as one of the risk factor for developing oral cancer. (Raczkowska A, Zakrzewska J, Pogorzelska B. Pilot study on polish public’s knowledge and attitudes towards oral cancer. Oral Dis 1997; 3(Sup 2): S35). A study done by Harri’s etal in 1996 showed that 90% of alcohol misusers were also smokers of tobacco. (Harris CK, Warnakulasurya KAAS, Johnson N W, Gelbier S, Peters T J. Oral health in alcohol misusers. Community Dental Health 1996; 13:199 – 203). The combination of alcohol and smoking increases the risk for the occurrence of oral cancers, by up to 44 %, when compared with non smokers and occasional smokers. Future activities: National cancer control programme has developed a 10 years plan to reduce the oral cancer by 20 – 30% by the year 2020. But we have to include some key activities in the 10 year plan like – 1. Development of guidelines for management of oral cancer and potentially malignant lesions 2. Establishment of a wise surveillance system of oral cancer and potentially malignant lesions 3. Utilization of risk factors model for early detection of oral cancer 4. Support and strengthening the ongoing early detection programme PROGRAMS TO BE UNDERTAKEN AT VARIOUS ELVELS FOR AN EFFECTIVE CANCER CONTROL Regional cancer center (RCC) (Health promotion / Home care / Early detection / Pain relief / palliative care / Comprehensive cancer treatment / Organise screening programmes / Cytological training / Basic and applied research / Training of all categories of personnel / Cancer registries / Epidemiology) Medical college Hospital (Health promotion / Home care / Early detection / Pain relief / Palliative care / Treatment of common cancer / Training of medical officers / Paramedical personals) District Hospital (Health promotion / Home care / Early detection / Pain relief / Palliative care / Treatment of common cancer) Taluk hospital / Sub district hospital (Health promotion / Home care / Early detection / Pain relief / Palliative care) (Courtesy: 50 years of cancer control in India. Cancer prevention and control in India., Cherian Varghese, Page 57)