2014 Annual Conference 1 MC Conference Center 7007 Bertner Avenue, Houston, Texas-77030 October 23-24, 2014 2014 Annual Conference NB: All Speakers on this agenda have not confirmed. Confirmed speakers in bold Agenda - Day 1 Thursday, October 23, 2014 TIME 8:00 am – 8:15 am TOPIC Welcome and Opening Remarks Dr. Patricia Hurn, Vice Chancellor for Research and Innovation, Office of Health Affairs, UT System Dr. Ron DePinho, President, UT MD Anderson Cancer Center Dr. George Stancel, EVP, UT Health Science Center Houston 8:15 am - 9:00 am 9:00 am-9:45 am Plenary Session Dr. Pam Sharma, UT MD Anderson Cancer Center, Immune Checkpoint Therapy: Clinical Successes and Next Steps Dr. Nils Lonberg, Bristol-Myers Squibb, Targeting T cell attenuation pathways for cancer therapy 9:45 am - 10:20 am Coffee and Break 10.20 am-10.30 am Dr. Tom Goodman, Chief Product Development Officer, CPRIT, CPRIT Moving Forward 10:30 am - 12:00 pm Oncology Immunotherapeutics-I Chairs: Dr. Patrick Hwu, UT MD Anderson Cancer Center and Joe Erhardt, VP, Oncology, Janssen R&D Dr. Cassian Yee, UT MD Anderson Cancer Center, T-cell Therapy Dr. Laurence Cooper, UT MD Anderson Cancer Center, Gene Modified T-cells (CAR): Dr. Rob Kastelein, AVP – Merck, Lambrolizumab, an Investigational Anti-PD-1 Antibody Dr. Michael Curran, UT MD Anderson Cancer Center, Check Point Inhibitors Dr. Flavius Martin, Amgen Tumor Immunotherapy with BiTEs 12:00 pm - 1:00 pm Lunch 1:00 pm - 2:30 pm Oncology Immunotherapeutics-II Chairs: Dr. Cassian Yee UT MD Anderson, Dr. Michael Kalos. CSO, Cancer Immunobiology, Eli Lilly Dr. George Georgiu, UT Austin, Non-antibody, engineered protein immunotherapeutics Dr. Jim Cassidy, VP, Oncology DM, BMS-ImmunoOncology Clinical Trial Designs: Breaking the Mold Dr. Tyler Curiel, Regulatory T cells in cancer immunopathology and immunotherapy, UT Health Science Center at San Antonio Dr. John C. Lin, Rational Combinations in Cancer Immunotherapy, Executive Director, Experimental Medicine at Rinat, Pfizer Inc. 2:30 pm - 3:30 pm Break and Poster Viewing (Posters will be available for viewing through the day) 3:30 pm – 4:30 PM Break-out Sessions Cancer Vaccines Chairs: Dr. Willem Overwijk, UT MD Anderson Cancer Center and Industry Chair (TBD) Dr. Amy Heimberger, UT MD Anderson Cancer Center Dr. Larry Kwak, UT MD Anderson Cancer Center Dr. Willem Overwijk, UT MD Anderson Cancer Center, Personalized cancer vaccines Dr. Robert Svatek, UTHSCSA, PRIME/BOOST" – A transatlantic collaboration studying T cell priming/boosting with BCG vaccination. 2014 Annual Conference NB: All Speakers on this agenda have not confirmed. Confirmed speakers in bold Agenda - Day 1 Thursday, October 23, 2014 TIME TOPIC Cellular Therapy: Chairs: Dr. Laurence Cooper, UT MD Anderson Cancer Center, Dr. Arturo Molina, VP, Janssen R&D Dr. Katzy Rezvani, UT MD Anderson Cancer Center Dr. EJ Shpall, UT MD Anderson Cancer Center Dr. Jinming Gao, UTSW/UT Dallas Tumor Microenvironment Chairs: Dr. Raghu Kalluri, UT MD Anderson Cancer Center and Dr. Neela Patel, Director, AbbVie Dr. Rolf Brekken, UTSW Breaking immune tolerance by targeting key immunosuppressive pathways in the tumor microenvironment Dr. Raghu Kalluri, UT MD Anderson Cancer Center Dr. Valerie LeBleu, UT MD Anderson Cancer Center Dr. Herbert Levine, Rice University, Genetic Circuits governing epithelial-mesenchymal transitions and their biophysical consequences Enhancing Adaptive Immunity Chairs: Dr. Cassian Yee, UT MD Anderson Cancer Center and Industry Chair (TBD) Dr. Xiaodong Cheng, Exchange Protein Directly Activated by cAMP (EPAC1) Modulates TregMediated Immune Suppression UT Health Science Center, Houston Dr. Michael Curran, UT MD Anderson Cancer Center Dr. David Farrar, UTSW Immunomodulation in Oncological Disorders Chairs: Dr. Jeffrey Molldrem, UT MD Anderson Cancer Center and Industry Chair (TBD) Dr. Robert Svatek, UTHSCSA Dr. Gheath Al-Atrash, UT MD Anderson Cancer Center Dr. Sattva Neelapu, UT MD Anderson Cancer Center Personalized Medicine, Biomarkers & Epigenetics Chairs: Dr. Lynda Chin, UT MD Anderson Cancer Center and Dr. Harpreet Singh, CSO, Immatics Dr. Lynda Chin, UT MD Anderson Cancer Center Dr. Harpreet Singh, CSO, Immatics Dr. James Brugarolas, UTSW Dr. Timothy Heffernan, UT MD Anderson Cancer Center Antibody Engineering Chairs: Dr. Sally Ward, Texas A&M Health Science Center and Dr. Paul Carter, Genentech Dr. George Georgiou, UT Austin Dr. John R. Desjarlais, Xencor, Antibody Fc Engineering to Create Novel and Enhanced Therapies Dr. Barry Springer, VP, Biologics, Janssen R&D Dr. Sally Ward 2014 Annual Conference NB: All Speakers on this agenda have not confirmed. Confirmed speakers in bold Agenda - Day 1 Thursday, October 23, 2014 TIME TOPIC 4:30 pm - 5:30 pm Roundtable Discussion: Future of Immunotherapeutics Chairs: Dr. Cassian Yee, UT MD Anderson Cancer Center, Dr. Robert Stein, CSO, Agenus Dr. Amy Heimberger Dr. Michael Kalos,CSO, Eli Lilly 5:30 pm - 5:45 pm Load Buses for short ride to Treviso’s 6:00 pm - 8:00 pm Reception at Trevisio’s 6550 Bertner Ave, Houston, TX 77030 2014 Venture Forum Agenda - Day 2 Friday, October 24, 2014 TIME TOPIC 8:00 am Welcome and Opening Remarks Dr. Patricia Hurn, Vice Chancellor for Research and Innovation, Office of Health Affairs, UT System Dr. Beena Koshy, Special Consultant, Academia-Industry Partnerships, Office of Health Affairs, UT System 8:10 am - 8:45 am Plenary Sessions: State of the Life Science Venture Industry Dr. Nessan Bermingham, Venture Partner, Atlas Venture Cambridge MA Dr. Bob Tepper, Partner, Third Rock Ventures 8.45 am-9.00 am Building Newco’s Around Great Science Dr. Ron DePinho, President, UT MD Anderson Cancer Center 9:00 am - 10:00 am Speed Dating Session 1: Texas Newcos : 10 company presentations Chair: Dr. Frank Grassler, UT Southwestern Medical Center, TBD 10:00 am - 10:30 am Break and Networking 2014 Venture Forum Agenda - Day 2 Friday, October 24, 2014 TIME TOPIC 10:30 am - 11:30 am Speed Dating Session 2: Rock-Star Science for Nucleating Company Creation Chair: Dr. Beena Koshy, Special Consultant, Academia-Industry Partnerships, Office of Health Affairs, UT System Dr Cassian Yee T-cell Therapies, UT MD Anderson Cancer Center Dr. Dean Lee, Chimeric Antigen receptors/ NK cells: Dr. Dean Lee, UT MD Anderson Cancer Center Sam Hanash New Oncology Targets: Sam Hanash Dr. Rolf Brekken: ECM signaling as a druggable target for tumor therapy Dr. George Georgiu Dr. Jeff Molldrem 11.30 am-12.30 pm Roundtable I: Perspectives from Early Stage Venture Chair: Dr. Ken Drazan, Head, California Innovation Center at J&J Dan Watkins, Mercury Fund Dr. Amir Nashat at Polaris Ventures Dr. Dennis Stone, Remeditex Dr. Aya Jakobovits, Orbimed Nessan Bermingham, Atlas Ventures Dr. Ali Behbahani, NEA 12:30 pm - 1:30 pm Working Lunch and Roundtable II Roundtable II: Building a Robust Biotech Ecosystem in Texas Chairs: Dr. Patricia Hurn, Vice Chancellor for Research and Innovation, Office of Health Affairs, UT System and Melinda Richter, Head, Janssen Labs Dr. Bobby Robbins, TMC Jacqueline Northcutt, CEO, BioHouston Dr. Brett Giroir, EVP and CEO, Texas A&M Jeet Vijay, Horizon Fund, UT System Joel Markus, Alexandria Properties 1:30 pm - 2:30 pm Roundtable III: Pharma Ventures-Early Stage Funding: Strategic vs. Financial Chair: Dr. Amir Nashat, Polaris Ventures, Dr. Joe Cunningham MD, Managing Director, Santé Ventures Asish Xavier, VP, Venture Investments, J&J Development Corporation Ann DeWitt, Senior Director, Sanofi Genzyme Bioventures, Armen Shanafelt, Venture Partner, Lilly Ventures, David Donabedian VP, AbbVie Ventures, 2:30 pm - 3:30 pm Round Table IV: Early Stage Funding and Influence of Texas Angels and High Net Worth Individuals Chairs : John Cornwell, VP, Sandhill Angels and TBD Mr. Robert Tucci, Chair, Houston Angel Network, Mr. Bruce Barshop, President, Barshop Ventures 3:30 pm Closing Remarks Dr. Patricia Hurn, Vice Chancellor for Research and Innovation, Office of Health Affairs, UT System