Online Figure 1 – Improvements of left-ventricular mass are unrelated to blood pressure as
assessed by ambulatory blood pressure monitoring
When sorted according to 24h systolic blood pressure (measured by ABPM) at baseline (A) or
24h BP reduction (B), reduction of left-ventricular hypertrophy was comparable between the
tertiles.
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Online Figure 2 – Afterload-related parameters are dependent on change of
blood pressure but not heat rate
Increase in vascular compliance was dependent on blood pressure (B) reduction (A), as
emphasized by a significant (p<0.001) correlation (R²=0.288) of the change of compliance and
the changes of systolic BP (C). Improvement of end-systolic meridional wall stress (EsMWS)
was only visible in the first tertile of BP reduction (B). Change in compliance and EsMWS were
not dependent on heart rate reduction (D-F). Regression analysis of heart rate corrected
circumferential fiber shortening (VCFc) and plotting EsMWS yielded significant correlations (G,
H). Comparing the correlations at baseline (G) and follow-up (H) in a single plot (I) visualizes
the small but significant (p<0.001) difference in the y-axis intercept of the regression line,
suggesting a mild increase in intrinsic contractility following renal artery denervation.
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Online Table 1 – Baseline characteristics
Patients (n=66)
Age (years)
63.5±1.2
Male
36 (55%)
BMI (m/kg²)
29.4±0.6
BSA (m²)
1.99±0.02
Diabetes
23 (35%)
Hypercholesterolemia
42 (64%)
Current or former smokers
14 (21%)
Coronary artery disease
14 (21%)
Number of antihypertensive
4.3±0.1
drugs
Beta blocker
59 (89%)
Calcium channel blocker
52 (79%)
ACE inhibitor
25 (38%)
Angiotensin receptor blocker
36 (55%)
Diuretic
66 (100%)
Renin-inhibitor
26 (39%)
Alpha blocker
27 (41%)
Direct vasodilator
10 (15%)
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