Oct. 1st, 2010
Re: Program Announcement (PA) Number: PA-10-063
Dear Sir or Madam:
This grant, entitled “ETS transcription factor-mediated genesis of intermediate neural progenitor
cells,” is submitted in response to program announcement PA-10-063, NIH Pathway to
Independence Award (K99/R00).
Eligibility: Although I am technically one week over the 5-year limit by the deadline Oct. 12,
2010, the program directors of NICHD and NINDS, Dr. Eugene Wagner and Dr. Anne Smith,
both assured me that I am still eligible to apply and my application will be accepted.
List of my referees:
1. Dr. Ann Yee, Ingridlia Farm research campus, Stanford
2. Dr. Ann Kebler, Division of Physiology, Institute of Illinois at Urbana-Champaign
3. Dr. Ann Jan, Stanford, Division of Physiology, Institute of Washington San Diego
This goal of this proposal is to elucidate the molecular mechanisms that control the generation
of intermediate neural progenitor cells from the neural stem cells during the development of the
nervous system. The intermediate progenitor cells play a crucial role in determining the number
of neurons generated from the neural stem cells and final cortical size. Therefore, findings from
this proposal will help us understand how neurogenesis is regulated during development and
how human developmental neurological disorders related with defects in intermediate progenitor
cells occur. For these reasons, please assign this application to the following study sections and
institutes.
CSR study section:
1. Neurogenesis and Cell Fate Study Section (NCF)
2. The Development-study section 2 (DEV2)
Institute:
1. National Institute of Child Health and Human Development (NICHD)
2. National Institute of Neurological Disorders and Strokes (NINDS)
3. National Institute of General Medical Sciences (NIGMS)
If any additional information is required, please do not hesitate to contact me.
Sincerely,
Bright Scientist, M.D., Ph.D.
Division of Somewhere
Institute of Research San Diego
March 31, 2010
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Suite 1040
MSC 7710
Bethesda, MD 20892-7710
To Whom It May Concern:
We are submitting a Ruth L. Kirschstein National Research Service Awards (NRSA) for
Individual Postdoctoral Fellows F32 (PA-10-110) entitled: Etiology of Microcephaly and
Functions of Microcephaly Genes in Brain Development. By using a combination of
innovative genetic, molecular and imaging techniques, we seek to uncover the underlying
mechanism of microcephaly, a human developmental disorder characterized by a dramatic
rorgction in brain size. This study will also improve our understanding in brain development
under normal and disease conditions, and provide important information for potential therapeutic
strategies for microcephaly and other related neurodevelopmental disorders.
Therefore we request this project to be assigned to the following:
Institutes/Centers
National Institute of Neurological Disorders and Stroke - NINDS
National Institute of Child Health and Human Development – NICHD
Scientific Review Groups
Biochemical and Molecular Neuroscience – F03A
The reviewers of this proposal should include development neuroscientists with expertise in
cortical development.
We have also attached all required agency approval documentation for this application
submitted.
I have requested reference letters from:
Anne B. Smith, Ph.D.
Professor, Science and Cell Biology
Harvard Institute, Miami, NY
Ann K. John, Ph.D.
Professor, Science and Cell Biology
Harvard Institute, Miami, NY
Ann David, Ph.D.
Assistant Professor, Science and Cell Biology
Harvard Institute, Miami, NY
Carol Grove, Ph.D.
Associate Professor, Physiology and Neuroscience
Miami Institute, Miami, NY
Thank you for your attention.
Sincerely,
___________________________________ ___________________________________
Loves Research, M.D., Ph.D.
Director
January 19th 2011
Center of Research Grants:
I am submitting this proposed application for consideration under the Program Announcement
(PA) Number: PAR-11-084 entitled “NLM Grants for Scholarly Works in Biomedicine and
Health (G13)”. The descriptive title of the book length project which I am requesting funding
support for is, Social Medicine and Health Citizenship 1792-2012.
Given that the project is a work of scholarly historical investigation I would like to request that, if
possible, the proposal be reviewed by an appropriate peer review group convened by the
National Library of Medicine.
With many thanks for your help and advice.
Yours Sincerely
Ann Smith
Professor
Division of this Institute,
Institute of Science
Janurary 27, 2011
Eun Ah Cho, Ph.D.
Center of Basic and Integrative Biological Sciences
Scientific Review Officer
Oncology 1 – Basic Translational (OBT)
Tumor Microenvironment (TME)
Dear Dr. Cho:
Please find enclosed my application entitled “Complement activation and glioma proliferation”.
This application responds to the R01 “Parent Announcement” PA-10-067. The proposal
investigates the relationship between the activated complement cascade and gliomagenesis.
Based on preliminary data, our hypothesis is that the complement cascade is activated in
response to glioma and complement protein C3a promotes glioma proliferation and
regeneration. The notion that complement is carcinogenic and can facilitate gliomagenesis is a
novel mechanism for glioma growth and potential therapeutic target.
Therefore, I hope you will agree that it is appropriate to assign this application to the Scientific
Review Group “Tumor Microenvironment Study Section”.
Please do not hesitate to contact me with any questions.
Respectfully,
Erlin Meyer, M.D., Ph.D.
Associate Professor, Division of Somel Surgery
Institute of Science
1234 Street
San Diego, CA 94000
E-mail: address@domain.org Phone: 212-123-4678
Jan 25, 2011
Center for Scientific Review
National Institutes of Health
RE: New RO1 application: “Whole Genome Studies of ER Protein Folding, Oxidation, and
Quality Control”
To whom it may concern:
Please accept for review our NIH Research Project Grant (Parent R01)—entitled “Whole
Genome Studies of ER Protein Folding, Oxidation, and Quality Control”. The application is in
response to Program Announcement (PA) Number: PA-10-067.
The aims of the project are to develop novel fluorescent protein reSmiths with which to discover
genes regulating endoplasmic reticulum protein folding, oxidation and quality control.
1) We request that the grant application be scientifically reviewed by the following Scientific
Review Group:
MBPP (MEMBRANE BIOLOGY AND PROTEIN PROCESSING STUDY SECTION)
2) We request that the grant application be assigned for funding consideration to the following
Institute:
NIGMS (NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES)
Thank you for your consideration.
With my best wishes,
Bio Scientist, MD, PhD (this PI currently has a NIH R01 and DP2 grants)
Some Institute for Quantitative Biosciences
Institute of Bioscience
Lab Phone: 212-123-1234
e-mail: address@domain.org
July 10, 2010
To: Center of Receipt and Referral
Re: Assignment of grant proposal “Massage for Pediatric HSCT Recipients”
Dear Sir/Madam,
Please accept the resubmission of our grant. Please note that we are still New Investigators and
that this is a “Multiple PI” proposal, with two of us acting as Principal Investigators.
Please continue to keep the assignment of this proposal to:
Institute/Center: National Disease Institute—NCI
Scientific Review Group: Nursing Science: Children and Families Study Section
As before, if NCCAM would be interested in sharing the funding for this grant along with NCI we
would welcome that arrangement as well.
In the upcoming review of this proposal we are requesting that careful consideration be given to
assignment of the reviewers within the Nursing Science: Children and Families Study Section.
We have some concern that there might be a conflict of interest in the first review of the grant.
Stan Steven, Ph.D., RN, FAAN, the Chair of the “Overflow” Committee to which the previous
submission was assigned, is carrying out very similar work¹ and is a potential competitor in the
field. Dr. Steven is currently funded by NINR to conduct a 5 year study of massage on hospice
Disease patients. Her grant, similar to our proposal, focuses on Disease patients providing
regular massage by professionals as well as training of caregivers to provide massage. Her
outcomes parallel ours including Disease patient symptom distress, pain, and mood. She is also
proposing to assess caregiver stress, as do we. We are concerned that her professional focus
in very similar work may make it difficult for our proposal to get a fair and unbiased review if she
is closely involved in the review process.
Thank you for your time and consideration.
Sincerely,
Bright Doctor, M.D.
Principal Investigator
Some Center for Medical Research
1The following are representative citations by Dr. Steven that illustrate her professional
work that closely parallels the proposed research.
Steven DJ, Kampbell J, Travis S, et al. Effects of massage on pain intensity, analgesics and
quality of life in patients with Disease pain: a pilot study of a randomized clinical trial conducted
within hospice care delivery. Hosp J. 2000;15(3):31-53
Ingrid SW, Steven DJ, Gardner BB, Winston RD, Cory HY. Effects of a full-body massage on
pain intensity, anxiety, and physiological relaxation in Taiwanese patients with metastatic
bone pain: a pilot study. J Pain Symptom Manage. Apr 2009;37(4):754-763
Ingrid SW, Steven DJ, Gardner BB, Winston RD. Systematic review of massage intervention for
adult patients with Disease: a methodological perspective. Disease Nurs. Nov-Dec
2008;31(6):E24-35).
May 5, 2010
Center for Scientific Review
National Institutes of Health
Suite 1040
6701 Rockledge Drive MSC 7710
Bethesda, MD 20892-7710
Re: Assignment of “Gastroesophageal Reflux and Microaspiration in IPF”
Dear Sir or Madam:
Enclosed is a grant application for a Mentored Patient-Oriented Research Career Development
Award (K23), which is being submitted in response to PA-09-043.
I am requesting assignment of this grant application to the National Heart, Lung, and Blood
Institute. My goal in submitting this application is to become an independent clinical investigator
and leader in the study of diffuse lung disease. To continue my progress towards this goal, I am
proposing an observational prospective study addressing specific hypotheses surrounding the
role of gastroesophageal reflux and microaspiration in idiopathic pulmonary fibrosis.
My letters of reference are from:
Anne David, Professor of Medicine
Institute of Research San Diego
Cory Corazon, Professor of Medicine
Institute of Research San Diego
J. Coasta Coast, Professor of Medicine and Cell and Molecular Biology
Goldberg School of Medicine, Southwestern Institute
Should you have any questions, I can be reached at (212) 476-5897 or by email at
Harriette.Yee4@ABCD.org.
Sincerely yours,
Harriette S. Yee, MD (currently has an NIH F32 award)
Clinical Fellow
Institute of Research San Diego
September 15, 2009
Center of Receipt and Referral
Center for Scientific Review
National Institutes of Health
To Whom It May Concern:
Enclosed, please find our grant application, ‘Randomized Trial of Tongue Region Surgery for
Obstructive Sleep Apnea.”
We are responding to Program Announcement PA 07-070, “Research Project Grant (Parent
R01).”
We request that our proposal be assigned to the National Heart, Lung, and Blood Institute,
within which lies the National Center for Sleep Disorders Research. The application is
particularly relevant to two priority areas of the National Center on Sleep Disorders Research’s
2003 National Sleep Disorders Research Plan: (1) examination of the “efficacy…of upper airway
surgical procorgres,” and (2) “methods to individualize these therapies [including surgery] to the
different [sleep disordered breathing] phenotypes…for example, improved upper airway imaging
approaches to define site of collapse.”
The disciplines needed to evaluate all parts of our proposal include sleep medicine, anesthesia,
and clinical trialists. These disciplines are best reflected, in our opinion, among members of the
Respiratory Integrative Biology and Translational Research (RIBT) Study Section. I have
communicated with Everett Sinnett, PhD, the Scientific Review Officer for RIBT, and he feels
that this would be appropriate for that section. We request, therefore, that our application be
assigned to this panel for its review.
Sincerely,
Alfred J. Mitchell, MD
October 15, 2010
Center for Scientific Review
NIH Rockledge II
Room 4192 6701 Rockledge Drive
MSC 7850
Bethesda, MD 20892-7850
Dear Sir or Madam,
We are writing to submit a new R01 application.
1. Application Title: Epigenomic modifications of frontal cortex and amygdala in postnatal human
brains
2. Funding Opportunity: RFA-MH-11-030 (“Epigenomic modification in neurodevelopment”)
3. Scientific Review Group: To be determined by NIMH
4. List of individuals who should not review this application: We request that Dr. Z. Josh Cory of
the Cold Spring Harbor Laboratory be excluded as a reviewer of this application due to
competition on the same topic of research
5. Budget: The budget of this application has been approved by Dr. Michelle Tree, the program
officer at NIMH responsible for this RFA
Thank you very much for handling our submission.
Sincerely yours,
Alfred J. Cory (this PI currently has 2 active NIH awards)
February 1, 2010
To Whom It May Concern:
Please find attached my application entitled “Fgf signaling and gene regulation in mammalian
forebrain development.”
I would like this application to be considered for a K99/R00 “Pathway to
Independence” Career Development Award (PA-10-063).
The proposed research is primarily focused in developmental neuroscience, and specifically on
studies of cell signaling and gene regulation in the developing forebrain. In addition, one subaim of the proposal describes experiments to address behavioral and cognitive consequences
of neurodevelopmental processes.
I request that this application be reviewed by the following Scientific Review Group
(SRG) and Study section:
SRG: Molecular, cellular, and developmental neuroscience - MDCN
Study section: Neurogenesis and cell fate - NCF
The reason for this request is that the proposed research closely matches the following interests
of this study section, described on the CSR website:
“Fundamental cellular and molecular mechanisms of neural induction in normal
development, including transcriptional and translational regulation and signaling
pathways.
Cellular and molecular mechanisms through which the embryonic neural ectoderm
acquires the characteristics of adult brain regions, including regionalization of gene
transcription, cell-cell interactions, migration and signals or extrinsic factors that
influence these events.”
Other SRGs that may be appropriate for this application are:
SRG: Brain disorders and clinical neuroscience - BDCN
Study section: Developmental Brain Disorders – DBD
SRG: Biology of Development and Aging - BDA
Study section: Development-2 - DEV2
Both of these groups are relevant to the proposed project because of their interest in cell
signaling and/or transcriptional regulation during development. However, whereas NCF
specifically focuses on these processes in the context of neural development, BDA has a
broader developmental biology scope of interest and DEV2 emphasizes early development and
pattern formation.
The research proposed in this application is most relevant to the missions of the following
institutes:
National Institute of Mental Health - NIMH
National Institute of Neurological Disorders and Stroke - NINDS
National Institute of Child Health and Human Development - NICHD
I also request that this application not be reviewed by Dr. Austin Grove.
The reason for this request is that Dr. Grove’s research is very closely related to the topics of
research proposed in this application. We expect that her participation as a reviewer may
present a conflict of interest.
The following people are submitting letters of reference in support of this application:
Steven Henry, Ph.D.
Center of Basic Sciences
Scott ScottAlfred Disease Research Center
Austin, WA
ABC, M.D., Ph.D.
Division of Science
Institute of Washington School of Medicine, Children’s Hospital and Regional Medical
Center
Austin, WA
ABC, Ph.D.
Division of Molecular and Cell Biology
Institute of Research, City
City, CA
ABC, Ph.D., D.Sc.
Division of Developmental and Regenerative Biology
Mount Sinai School of Medicine
Miami, NY
Thank you very much for your time and consideration.
Sincerely,
Susan V. Hertz, Ph.D.
Postdoctoral Fellow
Tony laboratory
ABCD Division of Psychiatry
Susan.Hertz@ABCD.org
Center of Receipt and Referral
Center for Scientific Review
National Institute of Health
Sept. 28, 2010
Dear Referral Officers,
Enclosed please find a NIH R01 research proposal entitled “Self-renewal and differentiation of
adult neural stem cells”.
In this proposal, we use zebrafish as a vertebrate genetic model to study adult neurogenesis.
Based on our research area, we request the proposal to be assigned to the Neurogenesis and
Cell Fate (NCF) study section, and the grant to be funded through NINDS.
With best regards,
Winston (this PI currently has two R01 grants)
November 5, 2010
Center for Scientific Review
National Institutes of Health
Suite 1040
6701 Rockledge Drive, MSC 7710
Bethesda, MD 20892-7710
Re: Re-Submission of R01 Application
Dear Sir or Madam:
I am re-submitting the application R01CA143078 now entitled MicroRNA Signaling and
Therapeutics in Liver Disease. The application is in response to (PA-08-243) titled “Etiology,
Prevention, and Treatment of Hepatocellular Carcinoma" and requested by the funding
agencies NCI, NIDDK, and NIAAA that support this RFA.
The goal of this proposal is to develop novel conditional models of liver Disease, to understand
how different oncogenes cooperate for liver tumor formation, and to develop new anti-microRNA
based therapeutics for liver Disease.
In addition to genetic and biochemical approaches, transgenic mouse models of Disease will be
used to address these questions.
I request that the proposal is directed to the Molecular Oncogenesis Study Section [MONC]
where it was reviewed for the initial submission. I would request that the proposal is evaluated
jointly by the NCI, NIDDK and NIAAA for funding, as they are the institutes who requested this
RFA.
Please feel free to contact me if you have any questions regarding this application.
Sincerely,
Kelly March, M.D., Ph.D. (currently has a R01 grant)
Assistant Professor of Medicine
Center of Receipt and Referral
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, MSC 7710
Bethesda, MD 20892-7710
February 6, 2011
Dear Members of the Center for Scientific Review:
Enclosed is a grant application for a Mentored Clinical Scientist Research Career Development
Award (Parent K08), program announcement number PA-10-059. The proposal is titled, “Liver
Tissue Engineering Through Three-Dimensional Hepatocyte Culture.”
Please assign this application to the following:
_ Institutes/Centers
• National Institutes of Diabetes, Digestive, and Kidney Diseases - NIDDK
_ Scientific Review Groups
• Bioengineering Sciences and Technologies - BST
• Digestive, Kidney, and Urological Systems - DKUS
• Surgical Sciences, Biomedical Imaging, and Bioengineering - SBIB
The reason for this request is that the proposal aims to characterize the function of “microlivertissues” developed through three-dimensional culture in the context of extracellular matrix
and stromal cell interactions. The findings will have significance for bioengineering and the
development of novel surgical therapies for end-stage liver disease. Moreover, since my longterm career goal is to become a surgeon-scientist with a research focus in liver tissue
engineering, scientific review groups in bioengineering, hepatobiliary pathophysiology, and/or
surgical sciences would be appropriate for reviewing this career development award application.
There are 4 referees in support of my application:
1. Casey H. Money, M.D., Ph.D., Professor, Division of Science, Harvard Medical School
2. Andy K. Paul, MBBS, Professor and Chair, Division of Science, ABCD
3. Leslie W. Bunnett, Ph.D., Professor and Vice-Chair of Research, Division of Surgery, ABCD
4. Carlos U. Corvera, M.D., Assistant Professor, Division of Surgery, ABCD
Thank you for your time in considering my application.
Sincerely,
Ann T. Manly, M.D., Ph.D.
Center of Receipt and Referral (DRR)
Center for Scientific Review (CSR)
July 18, 2010
Dear Sir/Madam,
We are submitting a competitive renewal on our grant entitled "Prostate microenvironment and
prostate Disease progression" (RO1 CA 106947, original award period September 1, 2006 –
August 31, 2010).
Please assign this application to the following:
Institute/Center
National Disease Institute - NCI
Scientific Review Group
Science of Disease Study Section (EPIC)
Disciplines involved in this translational work include Science, Science, oncology,
genetics/genomics, and computational biology.
We are requesting EPIC because the focus of this study is to examine metabolic risk factors,
gene variants, and tumor markers associated with prostate Disease progression in two cohorts
of men with prostate Disease. While several complementary disciplines are involved, including
oncology, computational biology, genetics, genomics, and Science, the main structure and
approach is consistent with an epidemiologic cohort study. Thus, we believe EPIC is the best
fit, is likely the study section that reviewed the first award of this grant; and Dr. Chan has also
served on EPIC as a peer-reviewer in the past 12 months.
Thank you very much for your consideration.
Sincerely,
July M. Manly, ScD
Associate Professor
Institute of Research San Diego (ABCD)
RE: K99/R00 Pathway to Independence Award Application, “Effects of Muscle
Quality, Knee Mechanics, and Exercise on Subchondral Bone”
To the NIH Center for Scientific Review,
I would like to submit a revised application for consideration for a K99/R00 Pathway to
Independence Award (PA-10-063). The proposed training and research plan, entitled “Effects of
Muscle Quality, Knee Mechanics, and Exercise on Subchondral Bone,” has been revised based
on the comments and suggestions provided in the summary statement for the original
submission. The proposed study will produce valuable information about the etiology of
osteoarthritis and the effects of exercise on joint health, and it will provide the training I need to
successfully begin my career as an independent researcher.
Because the project addresses research questions in the area of osteoarthritis and
musculoskeletal health, please assign this application to the following:
National Institute of Arthritis and Musculoskeletal and Skin Diseases-NIAMS
The following referees will submit letters of reference through the eRA Commons:
Gabriel S. Baker, PhD, Career Research Scientist, Bone and Joint Center of
Excellence, Veterans Affairs Palo Alto Health Care System
Eugene R. Carter, PhD, Professor, Divisions of Mechanical Engineering
and Bioengineering, Yale Institute
Beth Manly, MD, Professor, Division of Orthopaedic Surgery,
Institute of Research, San Diego
Thank you very much for considering this proposal for a Pathway to Independence Award.
Sincerely,
Anne Walker, PhD
October 4, 2010
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive,
Room 1040 - MSC 7710
Bethesda, MD 20892-7710
Re: Career Development Award (K07) Application “Breast Disease screening and
outcomes in diverse populations: role of comorbidity”
Submission of application number: 1 K07 CA132918-01
To Whom It May Concern:
Please find attached an electronic application in response to funding opportunity PA-08-152.
Please assign this application to the following:
Institutes/ Centers
National Disease Institute – NCI
Scientific Review Groups
Subcommittee J – Population and Patient-Oriented Training
The goal of this application is to investigate the role of comorbidity (concurrent illnesses)
in screening mammography outcomes and breast Disease survival by race and to supplement
my training in Disease Science with additional training in the design and conduct of
epidemiological studies; content expertise in Disease, aging and comorbidity interactions; and
statistical modeling of comorbidity-related effects.
Thank you for your careful consideration of this application.
Sincerely,
Anne Smith, PhD
Assistant Professor of Disease Science
David Smith Family Comprehensive Disease Center
Division of Science and Biostatistics
Institute of Research, San Diego
1234 Tree Street, Suite 500
San Diego, CA 90207
Phone: 212-234-8019
To Whom It May Concern:
I am writing in reference to my attached R01 grant that I am submitting for the February
deadline. The title of the grant is: Identifying and modulating therapeutic targets in a model
of hepatitis B The Funding Opportunity title of the NIH initiative is:
PA-10-067 Research Project Grant (Parent R01)
I am requesting at this grant be assigned to:
National Institute of Diabetes, Digestive and Kidney Diseases- NIDDK
I believe the most appropriate Scientific Review Group (SRG) is:
Hepatobiliary Pathophysiology Study Section [HBPP]
I believe the assignment to NIDDK is most appropriate because the grant proposes to identify
and modulate potential therapeutic targets to prevent and treat virally induced liver disease.
I believe the believe this grant is most suited to be reviewed by the Hepatobiliary
Pathophysiology Study Section [HBPP] because we are proposing to identify and modulate
therapeutic targets to treat a hepatotrophic virus (HBV), liver inflammation and subsequent liver
disease. We use a mouse model of hepatitis B virus, as well as cells and tissue from patients, to
study liver disease induction, as well as potential interventions to halt this process.
Specifically:
1. We are proposing to study the pathophysiology of virally acquired liver disease, and the role
of liver macrophages, and hepatic expression of various molecules in influencing this immune
mediated disease in the liver.
2. We are proposing the use of isolated parenchymal and non-parenchymal liver cells in the
study of the immunopathogenesis of liver disease.
3. We are proposing to study age-dependent gene regulation in the liver, and investigate how
this gene regulation relates to immunity and immune-mediated liver disease.
4. We are proposing to study treatment of liver disease, e.g. manipulation of liver macrophages
and age-dependent liver gene expression as potential treatments or preventive measures for
immune mediated liver disease.
All of these areas are stated to be covered by the expertise in HBPP.
Please feel free to contact me if you have any questions.
Sincerely,
Mandy L Mahon MD, PhD (currently has an active R01 grant)
August 6th, 2010
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040-MSC 7710
Bethesda, MD 20892-7710
RE: Resubmission of “Kenyan Street Children: HIV/STIs in Social Context” (1 R01
HD058423)
To Whom It May Concern:
On behalf of myself, Dr. Austin Smith, and our co-investigators please accept the attached
resubmission of Research Project Grant (R01) application entitled “Kenyan Street Children:
HIV/STIs in Social Context.” Please note that both Dr. Smith and I are new investigators. The
application has been rewritten to meet the new shorter format for R01s.
We are submitting this resubmission in response to funding opportunity PA-07-070. We would
like to request referral to the National Institute of Child Health and Human Development
(NICHD), as we have worked with program staff there, specifically, Susan Smith, PhD. We
request that the National Institute for Mental Health (NIMH—Program Officer Susannah Paul)
be given secondary assignment. We believe that the appropriate review group is the Behavioral
and Social Science Approaches to Preventing HIV/AIDS (BSPH) Study Section, which reviewed
the original application and resubmission.
Given the complexity of the project, we request reviewers with expertise in the areas of
adolescent health, HIV/STIs in Africa, sociology or social Science, and qualitative methods.
Thank you in advance for your time and thoughtful review of our proposal.
Sincerely,
Sarah L. Towne, MD, MS
Principal Investigator
FUNDED (proposals below)
December 7, 2009
Center for Scientific Review
National Institutes of Health, Suite 1040
6701 Rockledge Drive, MSC 7710
Bethesda, Maryland 20817
Subject: Competitive Renewal
Dear Sir or Madam,
Please find enclosed R01 application entitled “Mechanism of Poliovirus Replication,” as the
competing renewal of grant 5R01AI40085-10, “RNA Protein Interaction in Poliovirus
Replication.”
Overall objective of our application is to investigate the basic molecular mechanism of poliovirus
copy-choice recombination and to critically evaluate the role of recombination in viral diversity,
quasispecies dynamics, evolution and pathogenesis.
I am a permanent member of the NIH VIRB Study Section. This application is being submitted in
accordance with the Extension of Application Submission, NOT-0D-09-155 notice, and my
discussion with Tony Tree, Ph.D., Scientific Review Officer.
Thank you for your consideration.
Sincerely,
Michelle Kwan, Ph.D.
Professor
Science and Medicine
22 July 2009
Travis A. Przywara, Ph.D.
Program Director
National Institute Heart, Lung, and Blood Institute
Center of Cardiovascular Diseases
RKL2- Two Rockledge Center, 8182
6701 Rockledge Dr., Mail Stop 7956
Bethesda, MD 20892
Fax: (301) 480-7404
Re: Competitive Renewal Submission of R01 HL080050 Research
Dear Dr. Przywara,
Please find enclosed first competitive renewal of R01 HL080050 ‘Structure and function
of voltage-gated calcium channels’.
My laboratory is actively pursuing X-ray crystallographic studies of voltage-gated calcium
channel complexes. The importance of voltage-gated calcium channels (CaVs) for
proper cardiovascular function is undeniable. These multiprotein switches are the targets of a
wide range of drugs used to treat cardiovascular disorders such as arrhythmias, hypertension,
and congestive heart failure. Despite their paramount importance to human physiology and
decades of functional study, there is only scant knowledge regarding the fundamental threedimensional architecture of these molecules. In the initial period of support from this award, my
laboratory has contributed a large fraction of the high-resolution crystal structures that constitute
our current knowledge of CaVs. This application outlines a multidisciplinary approach including
biochemistry, molecular biology, structural biology, and electrophysiology that builds on our
initial successes and further develops our research into uncovering the atomic level basis for
CaV function. Our work should have a major impact in helping to develop a detailed
understanding of how normal CaVs function and how deranged CaVs misfunction in human
disease.
I respectfully request that this grant be directed to reviewed by the ESTA (Electrical Signaling,
Ion Transport, and Arrhythmias) study section and have a dual listing for administration with the
NHLBI (National Heart Lung and Blood Institute) as the primary and NINDS (National Institute of
Neurological Disorders and Stroke) as the secondary institutes.
Primary Institute: NHLBI
Secondary Institute: NINDS
Study section: ESTA
Please contact me if you have any questions.
Sincerely,
Jackie Joyner., Ph.D.
Professor of Science
Institute of Science
Faculty Scientist
Some Govt Lab
Phone: (212) 123-1234
Email: address@domain.org
July 4, 2010
Center of Receipt and Referral at the Center for Scientific Review
National Institutes of Health
To Whom It May Concern:
My colleagues and I are pleased to resubmit the attached R01 research project grant
application entitled, “Slow-Paced Respiration for Treatment of Menopausal Hot Flashes” in
response to funding announcement # PA-10-067 (Parent R01).
In this resubmission, we outline our revised plans to conduct a randomized controlled trial of
device-guided slow-paced respiration for treatment of hot flashes in peri- and postmenopausal
women. We believe that our revised proposal is fully responsive to the thoughtful comments
and suggestions that we received.
Please note that in response to a previous request from the project officer to submit Just-InTime materials for our original application, we have already obtained approval for this research
protocol from the Institutional Review Board at the Institute of California San Francisco.
Consistent with the original grant submission (R01 AT005491-01), please assign this
resubmitted application to the following:
Institutes/Centers
National Center for Complementary and Alternative Medicine – NCCAM
Scientific Review Group
Integrative and Clinical Endocrinology and Reproduction Study Section - ICER
Thank you for your consideration.
Sincerely,
Science Investigator, MD
October 13, 2010
NIH Center for Scientific Review
6701 Rockledge Drive
Room 1040-MSC 7710
Bethesda, MD 20817
PI: Science, Investigates MD.
1. Application Title: “Hypopadias Differentiation and Endocrine Disrupters”
2. Funding Opportunity (PA-07-070): Research Project Grant (Parent R01)
3. Please assign this application to the following:
Institutes/Centers:
National Institute of Diabetes and Digestive and Kidney Disease. (NIDDK)
Scientific Review Groups: Urology Study Section
List of individual (e.g. competitors) who should not review your application and why:
None
Disciplines involved: single discipline.
Sincerely,
Investigates Science
Principal Investigator