Tuesday, December 13, 2011 Name: ____________________________________ Period: ____ Describe heredity as the passage of instructions from one generation Competency to another and recognize that heredity information is contained in 3d – DOK 2 genes, located in the chromosomes of each cell. 8th Grade – I can use information from pedigrees to predict future offspring. Lesson 5.8 Page 8 Unit 5 – Heredity and Genetics: Predicting Offspring from Pedigrees Quick Review 1. In a graph, the independent variable is shown on the x-axis and the dependent variable is shown on the y-axis. 2. In a velocity v. time graph, velocity is the dependent variable and time is the independent variable. Use the four graphs to the right to answer the questions below. 3. Graph that has an acceleration of zero = C 4. Graph with a positive acceleration = B 5. Graph with a negative acceleration = A 6. Graph with a non-constant acceleration = D Key Points on Predicting Offspring from Pedigrees 1. Pedigrees are very useful for predicting the genotypes and phenotypes of offspring. a. Pedigrees CANNOT be used to predict the sex of offspring. There is always a 50% chance that an offspring will be male and a 50% chance that it will be female. 2. To make a prediction using a pedigree, you must be told the inheritance pattern of the trait. a. The two main types of traits are autosomal recessive and autosomal dominant. i. It if is a recessive trait, the offspring will only have the trait if its genotype is homozygous recessive ii. It if is a dominant trait, the offspring will have the trait whenever it has the dominant allele 3. How a. Determine the genotypes of the parents. b. Complete a Punnett square. c. Determine the possible genotypes of the offspring. d. Determine the possible phenotypes of the offspring. 4. Shooting For ADVANCED a. Whether an organism is male or female is determine by its sex chromosome. i. Females have two X sex chromosomes (XX) and males have an X and a Y sex chromosome (XY). b. There are two other types of traits, X-linked dominant and X-linked recessive. X X Y X Tuesday, December 13, 2011 Name: ____________________________________ Period: ____ i. These genes are only found on the X chromosome. c. X-linked recessive i. Trait is only seen in females if both X chromosomes have the allele. ii. Trait is seen in males only if mother is a carrier because they always receive the Y chromosome from their father. d. X-linked dominant i. Trait is seen in females if either X chromosome has the allele. ii. Trait is seen in males only if mother has the mutant allele. Predicting Offspring from Pedigrees: Guided Practice In humans, earlobes can be considered attached or unattached. When the bottom portion of the earlobe is attached directly to head, these are considered attached earlobes. When the bottom portion of earlobe slopes upward before attaching to head these are unattached earlobes. Unattached earlobes (E) are dominant to attached earlobes (e). Use this information to answer the questions below. 1. How many people in this family have unattached earlobes? ________ 2. How many males have attached earlobes? ________ 3. If family members 4 and 5 from the second generation mate, what is the chance that their offspring will have unattached earlobes? ________ 4. What is the chance that they will be carriers for the unattached earlobe allele? ________ Predicting Offspring from Pedigrees: Independent Practice The pedigree at the right shows the inheritance of Huntington’s Disease, an autosomal dominant trait, which causes nerve cells to degenerate. 1. How many males are in the pedigree? 2. How many males have Huntington’s? 3. How many females are in the pedigree? 4. How many females have Huntington’s? 5. If family members 3 and 4 from generation two mate, what is the chance that their children will have Huntington’s? 6. What must the genotype be for family member 2 in the second generation? The pedigree at the right shows the inheritance of color blindness, an X-linked recessive trait. 7. Show the cross between the parents in the first generation. 8. Describe the parents of a colorblind female. Tuesday, December 13, 2011 Name: ____________________________________ Period: ____ Describe heredity as the passage of instructions from one generation Competency to another and recognize that heredity information is contained in 3d – DOK 2 genes, located in the chromosomes of each cell. 8th Grade – I can use information from pedigrees to predict future offspring. Lesson 5.8 Page 8 Unit 5 – Heredity and Genetics: Predicting Offspring from Pedigrees Quick Review 1. In a graph, the independent variable is shown on the variable is shown on the -axis. 2. In a velocity v. time graph, velocity is the variable. Use the four graphs to the right to answer the questions below. 3. Graph that has an acceleration of zero = ___ 4. Graph with a positive acceleration = 5. Graph with a negative acceleration = 6. Graph with a non-constant acceleration = -axis and the dependent variable and time is the Key Points on Predicting Offspring from Pedigrees 1. Pedigrees are very useful for the and of . a. Pedigrees be used to predict the of offspring. There is always a chance that an offspring will be male and a chance that it will be female. 2. To make a prediction using a pedigree, you must be told the of the trait. a. The two main types of traits are and . i. It if is a recessive trait, the offspring will only have the trait if its genotype is ii. It if is a dominant trait, the offspring will have the trait whenever it has the 3. How a. Determine the of the . b. Complete a . c. Determine the possible of the offspring. d. Determine the possible of the offspring. 4. Shooting For ADVANCED a. Whether an organism is male or female is determine by its i. Females have two sex chromosomes ( ) and males have an and a sex chromosome ( ). b. There are two other types of traits, and i. These genes are only found on the . . Tuesday, December 13, 2011 Name: ____________________________________ Period: ____ c. X-linked recessive i. Trait is only seen in females if X chromosomes have the allele. ii. Trait is seen in males only if mother is a because males always receive the chromosome from their . d. X-linked dominant i. Trait is seen in females if X chromosome has the allele. ii. Trait is seen in males only if has the mutant allele. Predicting Offspring from Pedigrees: Guided Practice In humans, earlobes can be considered attached or unattached. When the bottom portion of the earlobe is attached directly to head, these are considered attached earlobes. When the bottom portion of earlobe slopes upward before attaching to head these are unattached earlobes. Unattached earlobes (E) are dominant to attached earlobes (e). Use this information to answer the questions below. 1. How many people in this family have unattached earlobes? ________ 2. How many males have attached earlobes? ________ 3. If family members 4 and 5 from the second generation mate, what is the chance that their offspring will have unattached earlobes? ________ 4. What is the chance that they will be carriers for the unattached earlobe allele? ________ Predicting Offspring from Pedigrees: Independent Practice The pedigree at the right shows the inheritance of Huntington’s Disease, an autosomal dominant trait, which causes nerve cells to degenerate. 1. How many males are in the pedigree? 2. How many males have Huntington’s? 3. How many females are in the pedigree? 4. How many females have Huntington’s? 5. If family members 3 and 4 from generation two mate, what is the chance that their children will have Huntington’s? 6. What must the genotype be for family member 2 in the second generation? The pedigree at the right shows the inheritance of color blindness, an X-linked recessive trait. 7. Show the cross between the parents in the first generation. 8. Describe the parents of a colorblind female. Tuesday, December 13, 2011 Name: ____________________________________ Period: ____ Describe heredity as the passage of instructions from one generation Competency to another and recognize that heredity information is contained in 3d – DOK 2 genes, located in the chromosomes of each cell. 8th Grade – I can use information from pedigrees to predict future offspring. Lesson 5.8 Page 8 Unit 5 – Heredity and Genetics: Predicting Offspring from Pedigrees Quick Review 1. In a graph, the independent variable is shown on the variable is shown on the -axis. 2. In a velocity v. time graph, velocity is the variable. Use the four graphs to the right to answer the questions below. 3. Graph that has an acceleration of zero = ___ 4. Graph with a positive acceleration = 5. Graph with a negative acceleration = 6. Graph with a non-constant acceleration = -axis and the dependent variable and time is the Key Points on Predicting Offspring from Pedigrees 1. Pedigrees are very useful for the and of . a. Pedigrees be used to predict the of offspring. There is always a chance that an offspring will be male and a chance that it will be female. 2. To make a prediction using a pedigree, you must be told the of the trait. a. The two main types of traits are and . i. It if is a recessive trait, the offspring will only have the trait if its genotype is ii. It if is a dominant trait, the offspring will have the trait whenever it has the 3. How a. Determine the of the . b. Complete a . c. Determine the possible of the offspring. d. Determine the possible of the offspring. 4. Shooting For ADVANCED a. Whether an organism is male or female is determine by its i. Females have two sex chromosomes ( ) and males have an and a sex chromosome ( ). . Tuesday, December 13, 2011 Name: ____________________________________ Period: ____ Predicting Offspring from Pedigrees: Guided Practice In humans, earlobes can be considered attached or unattached. When the bottom portion of the earlobe is attached directly to head, these are considered attached earlobes. When the bottom portion of earlobe slopes upward before attaching to head these are unattached earlobes. Unattached earlobes (E) are dominant to attached earlobes (e). Use this information to answer the questions below. 1. How many people in this family have unattached earlobes? ________ 2. How many males have attached earlobes? ________ 3. If family members 4 and 5 from the second generation mate, what is the chance that their offspring will have unattached earlobes? ________ 4. What is the chance that they will be carriers for the unattached earlobe allele? ________ Predicting Offspring from Pedigrees: Independent Practice Use the pedigree below showing a disease called phenylketonuria (PKU) to answer questions 1 – 4. PKU is an autosomal recessive disorder which causes mental retardation and seizures. 1. What is the genotype of an individual with PKU? 2. What must the genotype of family member 1 and 2 have been? 3. The condition of family member 12 and 13 is unknown. Predict their genotype. 4. If family member 5 mates with a homozygous dominant person, what is the chance their offspring will be a carrier for PKU? The pedigree at the right shows the inheritance of Huntington’s Disease, an autosomal dominant trait, which causes nerve cells to degenerate. 5. How many males are in the pedigree? 6. How many males have Huntington’s? 7. How many females are in the pedigree? 8. How many females have Huntington’s? 9. If family members 3 and 4 from generation two mate, what is the chance that their children will have Huntington’s? 10. What must the genotype be for family member 2 in the second generation?