e-Table 1. Systematic review – Characteristics of included trials
First author/trial
Total number of RA
Intervention
Comparator
Primary outcome
Follow up
name (year)
patients
22
SCS
No SCS
Exercise capacity
2-months
30
SCS ON
SCS OFF
Ischemic burden
48-hours
104
SCS
Coronary artery
Exercise capacity,
6-month, 2-years, 5-
bypass graft
angina symptoms
years
Country
De Jongste (1994)
Netherlands
DiPede (2001)
Italy
EBSY (1998)
Sweden
Hauvast (1998)
25
SCS ON
SCS OFF
Exercise capacity
1.5-months
24
SCS ON
SCS OFF
Exercise capacity
1-months
68
SCS
Percutaneous laser
Exercise capacity
3, 6, 12, 14-months
Netherlands
Jessurum (1999)
Netherlands
SpiRiT (2006)
UK
myocardial
revascularisation
Eddicks (2007)
24
SCS ON
SCS OFF
Exercise capacity
1-month
25
SCS ON
SCS OFF
Angina episodes
1,3,6 & 12-months
Germany
Lanza (2011)
Italy
e-Table 2. Systematic review – Risk of bias of included trials
Random
Sequence
sequence
concealment
Blinding
Loss to follow
Methods of
Risk of bias
Funding
up/drop out (%)
data analysis
score+
Open label
8%
Not stated
2/5
Government
Blinded ECG
0%
Not stated
2/5
Not stated
7%*
Intention to
2/5
Government
generation
De Jongste (1994)
Not stated
Independent
telephone
service
DiPede (2001)
Not stated
Not stated
assessment
EBSY (1998)
Not stated
Not stated
Open label
treat
Hauvast (1998)
Not stated
Not stated
Open label
0%
Not stated
1/5
Government
Jessurum (1999)
Not stated
Not stated
Open label
0%
Not stated
1/5
Industry
SpiRiT (2006)
Computer
Independent
Open label
9%
Intention to
4/5
Industry
generated
R&D
treat
department
Eddicks (2007)
Not stated
Not stated
Double blind
0%
Not stated
2/5
Industry
Lanza (2011)
Not stated
Not stated
Single blind -
0%
Intention to
3/5
Industry
patients
*: at 6-months; +: number of criteria fulfilled
treat
eFigure 1a. Systematic review – Between group comparison in exercisecapacity
eFigure 1b. Systematic review – Between group comparison in nitrate drug
consumption
eFigure 1c. Systematic review – Between group comparison in health-related
quality of life
eFigure 2. National survey – Frequency of RA therapy use across UK centres
Acupuncture
As required immediate release opioids
Cognitive behavioural therapy
Education
Enhanced external counterpulsation
Exercise programme
Gene therapy
Implanted subcutaneous stimulation
Intrathecal drug delivery
Multidisciplinary assessments
Percutaneous myocardial laser revascularisation
Regular slow release opioids
Spinal cord stimulation
Thoracic sympathectomy (chemical or radiofrequency)
Thoracic sympathectomy (local anaesthetic)
Transcutaneous electrical nerve stimulation
0
10
20
30
40
50
Percentage of UK centres that provide therapy
60