NIH BIOGRAPHICAL SKETCH
NAME
POSITION TITLE
Sheila T. Angeles-Han
Assistant Professor of Pediatrics and Ophthalmology
eRA COMMONS USER NAME
sangeleshan
EDUCATION/TRAINING
INSTITUTION AND LOCATION
University of the Philippines, Manila, Philippines
University of Santo Tomas, Manila, Philippines
University of Illinois at Chicago, Chicago, IL
Cornell University, New York, NY
Hospital for Special Surgery, New York, NY
DEGREE
BS
MD
Resident
MSc
Fellow
MM/YY
04/94
04/98
06/05
08/08
06/08
FIELD OF STUDY
Psychology
Medicine
General Pediatrics
Clinical Investigation
Pediatric Rheumatology
A. Personal Statement
Uveitis is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA), and JIA is the most
common systemic cause of uveitis. My research focus is on 1) the outcomes of children with JIA-associated uveitis, and
2) the development of a novel instrument, “Effects of Youngsters’ Eyesight on Quality of Life (EYE-Q)”, to measure
visual function and vision related quality of life (QOL) in children with uveitis.
I am an assistant professor of pediatrics and ophthalmology at Emory University. My fellowship in Pediatric
Rheumatology at the Hospital for Special Surgery and my Masters of Science degree in Clinical Investigation provide a
strong foundation for the clinical applications of juvenile idiopathic arthritis and clinical research. I currently have an
NIH K23 from the NEI to study the outcomes and QOL of children with JIA-associated uveitis. My long term research
goals are to prevent vision loss and blindness in children with JIA-associated uveitis through the: 1) determination of the
longitudinal profile of children with JIA-U, 2) identification of clinical and genetic risk markers for disease susceptibility
and severity, and 3) validation of the EYE-Q for use as an outcome measure of uveitis.
I have developed a novel instrument to measure visual function and vision related quality of life in children with uveitis.
This has undergone extensive validation and current studies are ongoing. Validating this instrument will enable
widespread distribution as there has been national and international interest in its’ use. It will likewise allow translation
into other languages. Widespread distribution will enable better measure of outcomes of children with uveitis and help
improve care for these patients and an increased understanding of their daily lives.
B. Research and/or Professional Experience
Employment
1998-1999
Veterans Memorial Medical Center, Post-graduate intern, Manila, Philippines
2000
Veterans Memorial Medical Center, Pediatric pre-resident, Manila Philippines
2001
The Medical City General Hospital, Pediatric resident, Manila, Philippines
Oct 2008- present
Assistant Professor, Department of Pediatrics, Emory University, Atlanta, GA
Honors and Awards
1992-1993
1994
2008
2009-2013
2011
University and College Scholar, University of the Philippines
Cum laude, University of the Philippines
Arthritis Foundation Fellowship Award, New York Chapter
NIH Pediatric Research Loan Repayment Program Award (NEI)
ACR REF/AF Career Development Bridge Funding Award
2012
Rheumatology Research Workshop Outstanding Abstract Award
Other Experience and Professional Memberships
2008Member, American College of Rheumatology
2008Member, American Academy of Pediatrics
2008Member, Childhood Arthritis and Rheumatology Research Alliance
2009Member, Pediatric Rheumatology Collaborative Study Group
2009-
Member, Association for Research in Vision and Ophthalmology
2013 2011- present
Clinical Research Faculty Task Force subcommittee
Children’s Healthcare of Atlanta, Vice Section Chief for Rheumatology
C. Publications
1. Angeles-Han ST, Pelajo CF, Vogler LB, Rouster-Stevens K, Kennedy C, Ponder L, McCracken C, Lopez-Benitez J,
Drews-Botsch C, Prahalad S for the CARRAnet investigators. Race and other risk markers in JIA-associated uveitis in the
Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. Revision under review for Journal of
Rheumatology
2. Jeroudi A, Angeles-Han ST, Yeh S. Efficacy of Adalimumab for Pediatric Vogt-Koyanagi-Harada Syndrome.
Submitted to JAMA Ophthalmology.
3. Ferrell EG, Ponder L, Minor L, Angeles-Han ST, Kennedy CW, Rouster-Stevens KA, Rohani-Pichavant M, Vogler
LB, Prahalad S. Limitations in the classification of childhood onset rheumatoid arthritis. Under revision for Journal of
Rheumatology
4. Pelajo CF, Angeles-Han ST, Prahalad S, Sgarlat CM, Davis TE, Miller LC, Lopez-Benitez JM for the
CARRA Registry Investigators. Evaluation of the association between Hispanic ethnicity and disease activity
and severity in a large cohort of patients with juvenile idiopathic arthritis. Rheumatology International, 2013. IN
PRESS
5. Prahalad S, Conneely KN, Jiang Y, Sudman M, Wallace C, Brown M, Ponder L, Rohani-Pichavant M, Zwick
M, Cutler D, Angeles-Han ST, Vogler LB, Kennedy C, Rouster-Stevens K, Wise C, Punaro M, Reed AM,
Mellins ED, Bohnsack JF, Glass DN, Thompson SD. Susceptibility to childhood onset rheumatoid arthritis:
Investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci.
Arthritis and Rheumatism, 2012 June; 65(6):1663-1667.
6. Angeles-Han ST, Yeh S, Vogler, LB. “Updates on the risk markers and outcomes of severe juvenile
idiopathic arthritis-associated uveitis – A review”. International Journal of Clinical Rheumatology, 2013
Feb:8(1):109-121.
8. DeWitt EM, Kimura Y, Beukelman T, Nigrovic PA, Onel K, Prahalad S, Schneider R, Stoll ML, Angeles-Han S,
Milojevic D, Schikler KN, Vehe R, Weiss JE, Weiss P, Ilowite NT, Wallace CA; members of the Juvenile Idiopathic
Arthritis Disease Specific Research Committee of the Children’s Arthritis and Rheumatology Research Alliance.
Consensus Treatment Plans for New-Onset Systemic Juvenile Idiopathic Arthritis. Arthritis Care and Research; 2012
Jul;64(7):1001-1010.
9. Angeles-Han S, Yeh S. Prevention and management of cataracts in children with juvenile idiopathic arthritis-associated
uveitis. Current Rheumatology Reports. 2012 Apr;14(2):142-9.
10. Prahalad S, Thompson SD, Conneely KN, Jiang Y, Leong T, Prozonic J, Brown MR, Ponder LA, Angeles-Han ST,
Vogler LB, Kennedy C, Wallace CA, Wise CA, Punaro M, Reed A, Park JL, Mellins ED, Zeft AS, Bohnsack JF, Glass
AD. Hierarchy of risk in childhood onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared
epitope. Arthritis and Rheumatism, 2011 Sept; Arthritis and Rheumatism, 2012 March; 64(3):925-930.
11. Angeles-Han S, Griffin K, Harrison M, Robb R, Shainberg M, Fields K, Ponder L, Lenhart P, Hutchinson A,
Srivastava S, Prahalad S, Lambert S, Drews-Botsch C. Development of a vision related quality of life instrument for
children 8-18 years of age with juvenile idiopathic arthritis-associated uveitis. Arthritis Care and Research, 2011 Sept;
63(9):1254-61. PMID: 21953520
12. Angeles-Han S, Griffin K, Lehman T, Rutledge J, Lyman S, Nguyen J, Harrison M. The importance of visual function
in the quality of life of children with juvenile idiopathic arthritis-associated uveitis. Journal of American Association of
Pediatric Ophthalmology and Strabismus, 2010, 14(2):163-168. PMID: 20236847
13. Angeles-Han S, Prahalad S. The genetics of juvenile idiopathic arthritis: What is new in 2010? Current Opinions in
Rheumatology, 2010, 12(2):87-93. PMID: 204250165.
14. Angeles-Han ST, Prahalad S. Juvenile idiopathic arthritis. Invited monograph for BMJ Point of Care, BMJ Publishing
Group Ltd, London. UK. 2009.
15. Angeles-Han ST, Flynn T, Lehman TJA. Abatacept for refractory juvenile idiopathic arthritis-associated uveitis - A
case report. Journal of Rheumatology. 2008, 35(9):1897-7. PMID: 18785302
16. Helin RD, Angeles ST, Bhat R. Octreotide therapy for chylothorax in infants and children: A brief review. Pediatric
Critical Care Medicine. 2006, 7(6):576D. Research Support
Ongoing Research Support
NIH-K23 (NEI)
9/1/11-8/30/16
“Outcomes of children with JIA-associated uveitis”
Angeles-Han (PI)
The goal of this study is determine the outcomes of children with JIA-associated uveitis, discover markers of
susceptibility and severity, and identify children at greatest risk for severe disability and blindness.
Completed Research Support
ACR REF/AF Career Development Bridge Funding Award
Angeles-Han (PI)
05/15/11-9/1/11
“Outcomes of children with JIA-associated uveitis”
The objective of this study is to further develop an instrument to measure vision related quality of life in children
specifically with uveitis - “Effects of Youngsters’ Eyesight on Quality of Life (EYE-Q)”.
Knights Templar Eye Foundation, Inc
Angeles-Han (PI)
07/01/09 – 06/30/10
“Validity and reliability of a visual function questionnaire for children 8-18 years of age”
The goal of this study is to provide further validity and reliability on our questionnaire in a larger population.
Emory Egleston Children’s Research Center Seed Grant
Angeles-Han (PI)
03/01/09 – 02/28/10
“Development of a Visual Function Questionnaire”
The goal of this study is to conduct initial validity studies on our questionnaire for children 8-18 years of age.
Fellowship Grant
Angeles-Han (PI)
07/01/07-06/30/08
Arthritis Foundation (New York Chapter)
“Functionality and quality of life in kids with inflammatory disease-(FunQy KIDs)”
The goal of this pilot study is to determine the contribution of visual and physical dysfunction to overall quality of life in
children with juvenile idiopathic arthritis and uveitis.