MARC FELDMANN FESTSCHRIFT: FROM THE LABORATORY TO THE CLINIC: CYTOKINES, AUTOIMMUNITY AND IMMUNOTHERAPY University of Oxford’s Museum of Natural History and Trinity College, Oxford WEDNESDAY 2nd SEPTEMBER SESSION 1. CYTOKINES/MATRIX THURSDAY 3rd SEPTEMBER SESSION 2. IMMUNITY/AUTOIMMUNITY FRIDAY 4th SEPTEMBER SESSION 3. THERAPEUTICS 9.00 REGISTRATION at Natural History Museum SESSION 1A: Chair: SESSION 2A: Chair: 9.00 Anne Cooke Analysing type I diabetes 9.30 Larry Steinman Antigen specific tolerance for certain autoimmune diseases - diabetes, neuromyelitis optica- and after gene therapy 10.00 Mark Davis Concerted T cell activity in autoimmunity and reading the alpha beta TCR repertoire 10.30 Dan Littman SESSION 3A: Chair: 9.00 Bali Pulendran Systems based approach to vaccine design 9.30 Tracy Hussell Discovery of new therapeutic targets for acute and chronic airway disease. 11.00 Tea/coffee break SESSION 2B: Chair: 11.30 Anne O’Garra The use of transcriptomics to uncover the immune response to pathogens: from mouse models to human disease 12.00 Irina Udalova Myeloid cells in acute and chronic inflammation: search for novel therapeutics 12.30 Jeff Ravetch Structural and functional diversity of immunoglobulin Fc and its receptors 1.00 LUNCH SESSION 2C: Chair: 2.00 Mike Dustin New interactions in the immunological synapse 2.30 Vanda Lennon Neuromyelitis optica: an IgG-mediated inflammatory synapthopathy targeting astrocytes 3.00 Tada Taniguchi Regulation of inflammation and innate immunity by self-derived molecules 3.30 Tea/coffee break SESSION 2D: Chair: 4.00 Kasia Hawrylowicz Immune mechanisms by which vitamin D promotes respiratory health 4.30. Tak Mak Beyond immune checkpoint blockade: emerging strategies 5.00 Alain Fischer The human immune system viewed from its inherited defaults 11.00 Tea/coffee break SESSION 3B: Chair: 11.30 Carl June 9.30 Richard Flavell 10.00 Jagdeep Nanchahal From the lab to the clinic for localised fibrosis 10.30 Mike Brennner Targeting fibroblasts to treat rheumatoid arthritis and type II diabetes 11.00 Tea/coffee break SESSION 1B: Chair: 11.30 Kim Midwood The extracellular matrix: a pro-inflammatory microenvironment during tissue injury and infection 12.00 12.30 Nicole Horwood Cells of the innate immune system in entheseal bone formation Eddy Liew IL-33 1.00 LUNCH SESSION 1C: Chair: Joost Oppenheim 2.00 Claudia Monaco 2.30 Tonia Vincent Sequestered molecules of the pericellular matrix; their role in sterile injury and disease 3.00 Martin Turner Regulation of lymphocyte development and activation by RNA binding proteins 3.30 Tea/coffee break SESSION 1D: Chair: 4.00 Vijay Kuchroo Identification of lymphocyte development and activation by RNA binding proteins 4.30 Paul Bowness Type-17 immunity in Ankylosing Spondylitis 5.00 Andreas Radbruch A pathogenic immunological memory can drive chronic inflammation 10.00 10.30 Mike Shepard Breaching the castle walls: Hyaluronan-Depletion as a therapeutic approach to cancer therapy Andrew McMichael HIV vaccine design for prevention and therapy 12.00 Miriam Merad Myeloid cell control of tissue inflammation 12.30 Andy Cope “Less of your Lyp” is not such a good thing 1.00 LUNCH SESSION 3C: Chair: 2.00 Greg Winter Antibody technologies 2.30 John O’Shea 3.00 Chris Buckley Why does chronic inflammation persist: a key role for the stroma? 3.30 Tea/coffee break SESSION 3D: Chair: 4.00 Lars Klareskog Understanding of specificity of adaptive immunity in RA reveals new targets for therapy 4.30 Ashok Venkitaraman