School of Medicine Research Symposium 25th & 26th February 2016 Crieff Hydro Hotel Thursday 25th February 08:30-09:00 Registration/Coffee • Ballroom Session 1 • Drawing Room Chair: Professor Keith Matthews 09:00-09:15 Professor Paul Clarke “Welcome and Opening Remarks” 09:15-09:40 Professor John Hayes “Opportunities for translational research around oxidative stress in the Medical School: Therapeutic value of targeting Nrf2” 09:40-10:05 Dr Charis Marwick “Antimicrobial use and resistance: opportunities for collaborative research” 10:05-10:30 Professor Kevin Hiom “Understanding the molecular basis of cancer treatment with Parp inhibitors” 10:30-11:00 Tea and Coffee • Ballroom Session 2 Chair: Professor Steve Keyse 11:00-11:25 Dr Dan Morales “Risk prediction modelling: clinical examples using health care data” 11:25-11:50 Professor Andy Evans “Predicting response to neo-adjuvant chemotherapy for breast cancer” 11:50-12:15 Dr Paul Newey “Modelling hereditary and sporadic endocrine tumours using induced pluripotent stem cells (iPSCs)” 12:15-13:30 Lunch • Meikle Restaurant Session 3 Joint with the School of Dentistry and the School of Nursing & Health Sciences • Drawing Room Chair: Professor Peter Mossey 13:30-13:40 Dr Dilip Nathwani “Academic Health Sciences Partnership” 13:40-13:50 Professor Mary Renfrew “Centre for Health and Related Research” 13:50-14:00 Dr Fiona Williams “Academic Health Sciences Partnership – Research Stream” 14:00 – 14:15 Professor Nicola Innes (School of Dentistry) “Turning FiCTION into Fact; Making Non-adherence to Protocol Useful in a Randomised Trial of Children’s Dentistry” 14:15-14:30 Professor Russell Petty (School of Medicine) “Defining novel biological subgroups of oesophageal cancer to stratify and optimise targeted treatments” 14:30 – 14:45 Professor Tim Croudace (School of Nursing & Health Sciences) “General health questionnaires and general wellbeing factors: understanding instruments from multiple epidemiological perspectives” 14:45-15:20 Tea and Coffee • Ballroom Session 4 Chair: Dr Fiona Williams 15:20-15:35 Dr Mike Macluskey (School of Dentistry) “Early detection of oral cancer using a laser detector (EDOCALD award)” 15:35-15:50 Dr Andrea Rodriguez (School of Dentistry) “Scottish oral health improvement homelessness programme (Smile4life project)” 15:50-16:05 Professor Bruce Guthrie (School of Medicine) “Improving primary care prescribing safety: four trials in 550 general practices” 16:05-16:20 Dr Stuart Schembri (School of Medicine) “Screening for lung cancer - where are we now?" 16:20-16:35 Dr Alison McFadden (School of Nursing & Health Sciences) “Enhancing trust between health services and Gypsy/Travellers: a study funded by the Department of Health Policy Research Programme” 16:35-16:50 Dr Steve MacGillivray (School of Nursing and Health Sciences) “Innovative approaches to evidence synthesis: the work of the Evidence Synthesis Training and Research (STAR) Group” 17:00-17:45 Professor Tim Newman – introduced by Mary Renfrew “University Research Strategy: Culture and Sustainability” 17:45-19:00 Poster Session and Wine Reception • Loggia & Ballroom 19:30 Dinner • Ferntower Suite Friday 26th February 07:30-09:00 Breakfast • Meikle Restaurant Session 5 • Drawing Room Chair: Professor Mike Ashford 09:00-09:15 Dr Mike McMahon “Development of a p21 reporter model for assessing the safety of DNA damage responsetargeted anticancer drugs in vivo” 09:15-09:30 Mr Calum Forteath “A novel mechanism underlying inhibition of mTORC1 by metformin in hepatocytes” 09.30-09:45 Dr Alison McNeilly “Neuronal IL-6 receptor deficiency exacerbates glucose intolerance on high fat feeding” 09:45-10:10 Dr James Chalmers “Eat or explode? Neutrophil choices determine outcome in respiratory infections” 10:10-10:35 Dr Weihua Meng “Genome-wide association studies of pain phenotypes and diabetic eye disorders – making use of e-health linkage and genetic data” 10:35-11:05 Tea and Coffee • Ballroom Session 6 Chair: Professor Sara Brown 11:05-11:30 Dr Victoria Sherwood “Fighting metastatic melanoma with nanomedicine” 11:30-11:55 Professor Jeremy Lambert “The influence of early life stress on addiction and cognition” 11:55-12:10 Dr Paul Meakin “Increased amyloid processing disturbs vascular function in mice” 12:10-12:25 Dr Jonathan Weir-McCall “Assessment of the effects of age on proximal pulmonary arterial and aortic stiffness using magnetic resonance imaging” 12:25-12:40 Dr Sarah Mills “Emergency Care Presentations by Patients with Terminal Cancer” 12:40-14:00 Lunch • Meikle Restaurant Core Facilities • Ballroom Session 7 Chair: Professor Tim Hales 14:00-14:25 Professor Chim Lang “Exploiting the Off-Target Effects of Diabetic Therapies” 14:25-14:50 Professor Colin Palmer “Genomics beyond genetics: Biomarker discovery in the post genomic age ” 14:50-15:15 Dr Albena Dinkova-Kostova “Harnessing natural products from plants to understand mammalian cytoprotective mechanisms” 15:15-15:40 Professor John Dillon “Killing a killer disease” 15:40-16:00 Professor Gary Mires “Closing Remarks”