First Name
Matthew
Middle Initial
J
Last Name
Goette
Degree
PhD
Address
6701 Fannin Street Suite 470
Houston, TX 77030
United States
Phone Number
(832) 822-1356
Fax
(832) 825-0300
Email
mjgoette@texaschildrens.org
Upload Cover Letter
goette_pilot_coverletter.pdf 69.15 KB · PDF
Investigator/Applican
Matthew
t First Name
Investigator/Applican
J
t Name MI
Investigator/Applican
Goette
t Last Name
Investigator/Applican
PhD
t Degree
Investigator/Applican
t Name Address
6701 Fannin Street Suite 470
Houston, TX 77030
United States
Investigator/Applican
(832) 822-1356
t Name Phone
Number
Investigator/Applican
mjgoette@texaschildrens.org
t Name Email
Title
Integrated PET/MR in Pediatric Hodgkin Lymphoma
Abstract of Proposed Research Plan (300 words)
The overall goal of our prospective research project is to compare the diagnostic and prognostic efficacy
of standard 18F-FDG PET/CT to alternative radiation-sparing imaging strategies including novel
integrated 18F-FDG PET/MR and diffusion weighted (DW) MR scans in pediatric patients with Hodgkin
lymphoma. 18F-FDG PET/CT has been established for staging of most types of malignant lymphoma in
pediatric patients, but 18F-FDG PET/CT staging tests have been associated with risk of secondary cancer
development later in life, especially for pediatric patients. Recently, integrated 18F-FDG PET/MR and
diffusion-weighted MRI (DW MR) imaging have been shown to provide tumor staging with markedly
reduced radiation exposure compared to PET/CT. While these new imaging modalities show a comparable
diagnostic accuracy to 18F-FDG PET/CT for lymphoma staging, it is not known whether the imaging test
can also accurately diagnose tumor therapy response. We prop ose to address the urgent need of a
systematic evaluation of these new imaging tests, in order to define the most accurate and safe “onestop-shop” imaging approach for staging and re-staging of Hodgkin lymphoma in pediatric patients. This
will be accomplished in a prospective non-randomized clinical study of pediatric patients with Hodgkin
lymphoma. The proposed imaging technologies could solve the need for balancing critical diagnostic
testing for tumor assessment with concurrent risk of radiation-induced secondary cancer development
later in life. This one-stop-shop approach to oncologic staging and response assessment using integrated
PET/MRI has the potential to lead to improved diagnostic efficacy, consistency, cost savings, reduced need
for sedation, and reduced radiation exposure. Results of this project will have immense significance for
the care of our pediatric oncology patients by defining the most accurate staging and re-staging exam,
saving a large patient population from excessive radiation exposure associated with diagnostic testing,
and decreasing associated risks of potential long-term secondary tumor development later in life.
Upload: Detailed plan
and bibliography
goette_pilot_detailed_plan.pdf 334.52 KB · PDF
Resources and Environment:
Texas Children’s Hospital Department of Pediatric Radiology:
Texas Children's Hospital (TCH), licensed for 639 beds, is the nation's largest pediatric hospital. Its
physicians treat infants, children, and adolescents, and its units specialize in the diagnosis and treatment
of rare disorders. Almost all of the geographically-based physicians at the hospital are members of the
full-time faculty of Baylor. More than 42 medical and surgical outpatient services are available. Based on
the most recent U.S. News & World Report, Texas Children’s Hospital is one of only eight hospitals to
achieve Honor Roll status and ranks near the top in all of the subspecialty categories. The comprehensive
survey – the most extensive listing of its kind – ranks children’s hospitals across ten major subspecialties.
Texas Children’s was named as a best hospital in every subspecialty surveyed, and was ranked in the top
ten in nine out of ten categories. In earning its position on the Honor Roll, Texas Children’s Hospital was
ranked among America’s best in: Kidney Disorders (4); Respiratory Disorders (4); Heart and Heart Surgery
(3); Cancer (5); Digestive Disorders (4); Neurology and Neurosurgery (4); Neonatal Care (7); Diabetes and
Endocrine Disorders (10); Urology (9); and Orthopedics (12).
With Baylor, Texas Children's participates in approximately 400 research projects and receives more NIH
research funding than any other pediatric hospital in the nation. Current projects include testing of
medications to improve the quality of life for patients with HIV infection and AIDS, diagnostic methods
based on DNA analysis for cystic fibrosis, muscular dystrophy and other genetic disorders, and
development of treatments through human gene therapy and other basic and applied research studies.
The two institutions operate the nation's first Children's Nutrition Research Center, a U.S. Department of
Agriculture facility that conducts research on the nutritional needs of pregnant and nursing women and
their children. Investigators at the CNRC are all BCM faculty.
TCH Pavilion for Women: Expanding upon its premier reputation in fetal and neonatal medicine, TCH
opened the Pavilion for Women in November 2011 to provide a full continuum of family-centered care to
women, mothers, and their babies, beginning before conception and continuing after birth through all the
years of a woman's life. The Pavilion for Women responds to the escalating need for obstetrical research
and treatment and will ensure that mothers and their babies have access to the most advanced
technologies and treatments available. What makes this facility unique is the full range of obstetrical and
gynecological services that are all available in one location, including evaluation and consultation, preterm
birth evaluation, as well as perinatal diagnostic and treatment services and support, childbirth and
parenting classes, lactation support and psychosocial support services. This is coupled with Texas
Children’s expertise in pediatric subspecialty care, inclu ding targeted programs in high-risk obstetrics,
fetal intervention and surgery, multiple pregnancy (with a dedicated unique “Program for Multiples”), fetal
echocardiography, reproductive endocrinology, and neonatal intensive care. The 15-story, 790,000square-foot facility has 90 patient beds with the capacity for more than 5,000 births per year; it also
houses both a Level II and Level III Neonatal Intensive Care Unit with private rooms for families to stay
together while the infant receives care. These NICUs have a combined capacity for over 2,000 infants per
year. A skybridge connects the Pavilion to the main TCH facility to allow rapid access to additional
specialized care. The following relevant clinical services are offered in the Pavilion.
TCH Feigin Research Center: With its Vision 2010 campaign, TCH launched several projects to strengthen
innovative patient care and invest in new translational research. Its major research center, the Feigin
Center, houses 20 floors and half-a-million square feet of lab space that accommodates more than 120
investigators (all BCM faculty) and all the Core facilities needed to image, store, and test biologic, genetic,
and clinical samples of all kinds. The Feigin Center expansion, which concluded in 2008, allows
researchers to intensify their research in areas of fundamental importance in microbiology, immunology,
cell biology and sciences of infection and inflammation.
The Texas Medical Center: Baylor College of Medicine provides the fulcrum for the Texas Medical Center
(TMC) at Houston. It is the largest medical center in the world with 14 hospitals, two specialty institutions,
two level 1 trauma centers, three medical schools, six nursing schools, schools of dentistry, public health,
pharmacy and nearly all health related careers. TMC pioneered the first and still the largest air ambulance
service. Today there are a total of 54 institutions (26 government agencies and 26 private not-for-profit
health related institutions) in the TMC. There are 7.1 million annual patient visits and 92,500 employees,
34,000 students and 4,000 residents and fellows. There are 280 buildings on 1,300 acres of land.
Hospitals Affiliated with Baylor College of Medicine: The educational and research programs at BCM are
highly integrated and amplified through strong affiliations with private and public teaching hospitals. The
school has its own private adult outpatient facility, the Baylor Clinic, designed to provide the highest
quality of care and service in an environment that promotes translational research. BCM has an
international reputation for medical excellence and has long had affiliations with a number of different
Texas Medical Center hospitals. It is ranked as one of the top 20 medical schools for research in US News
and World Report and is 1st in Texas in NIH funding. There are 8 affiliated teaching hospitals: St. Luke’s
Episcopal Hospital, Texas Children’s Hospital, Memorial Herman's The Institute for Rehabilitation and
Research, The Menniger Clinic, The Methodist Hospital, Michael E. DeBakey Veterans Affairs Medical
Center, M.D. Anderson Cancer Center, and th e Ben Taub General Hospital, part of the Harris Health
System. There are an additional 12 cooperating Patient Care Institutions.
Major Equipment:
Major equipment in the clinical pediatric radiology imaging suite include:
1. Philips Ingenuity TF PET/MR Scanner
2. Philips Ingenuity TF PET/CT Scanner
Other equipment in the Imaging Facility is as follows:
1. Siemens Inveon micro-CT/SPECT-micro-PET integrated system small animal imaging system.
2. Aspect M2 1T horizontal bore small animal MRI scanner for low-field imaging in rodents.
3. Bruker 9.4 T BioSpec horizontal bore MRI scanner for performing magnetic resonance and
spectroscopy studies in rodents
4. Xenogen IVIS 100 imaging system for in vitro and in vivo bioluminescence imaging
5. VisualSonics Vevo 770 high frequency, high spatial resolution ultrasound system for in vivo imaging
6. Nikon intravital microscope for bright field and fluorescent in vivo imaging
7. Cyclone Plus Phosphor Scanner for high resolution, quantitative digitized phosphor scanning for
autoradiography
8. 2470 Wizard Automatic Gamma Counter equipped with 51 radionuclide energy window library for
running 550 samples
9. Leica microscope capable of bright field and fluorescent imaging equipped with a motorized XY stage,
monochrome CCD camera
Computational resources:
1. 32-core HP Z-800 workstation running Linux, Matlab
2. 8-core HP Z-400 computers running Windows and Linux (dual boot)
All personnel have personal workstations as well.
Other key computational resources are as follows:
1. Intel Xeon 64-bit Vitrea workstation (v 6.1) with advanced image processing/visualization for clinical
and pre-clinical research – features include Vessel Probe, Cardiac Functional Analysis, Cardiac Calcium
Analysis, SUREPlaque etc.
2. MacPro Xeon dual-core workstation for image processing/analysis (loaded with 64-bit Osirix)
3. 4T image repository with secure FTP access
4. Dell Optiplex 745 computers (x4)
5. Printers, scanners
6. Integrated storage back up (Texas Children’s Hospital)
Additional
In addition to the principal investigator who is a dedicated PET/MRI physicist, the
Information:
study mentor, one of two board-certified nuclear medicine radiologists assigned
to this study (among ~25 board-certified pediatric radiologists on staff in the
department), and the co-investigator who is a dedicated research statistician, the
TCH pediatric radiology department contains experienced research project
coordinators and support staff including imaging technicians specifically trained in
PET/MR acquisition.
Award Payee First
Leanne
Name
Award Payee Middle
Initial
B
Award Payee Last
Scott
Name
Award Payee
PhD
Degree
Award Payee Address
One Baylor Plaza Suite 600D
Houston, TX 77030-3411
United States
Award Payee Phone
(713) 798-1297
Number
Award Payee Email
spo@bcm.edu
Grant Administrator's
Shireen
First Name
Grant Administrator's
E
MI
Grant Administrator's
Hayatghaibi
Last Name
Grant Administrator's
MS
Degree
Grant Administrator's
Address
6701 Fannin Street Suite 470
Houston, TX 77030
United States
Grant Administrator's
(832) 822-1225
Phone Number
Grant Administrator's
Email
sehayatg@texaschildrens.org
Upload Letters of
Recommendation 1
spr_grant_matt_g_03_11_15.pdf 327.85 KB · PDF
Upload Letter of
Recommendation 2
goette_recommendation_letter__krishnamurthy.pdf 37.83 KB · PDF
Upload Budget
goette_pilot_budget.pdf 123.76 KB · PDF
Upload Curriculum
Vitae
goette_pilot_cv.pdf 104.36 KB · PDF
(Upload) Mentor/CoInvestigators
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Upload Research
Assurances
h32322__evaluation_of_clinical_equivalence_of_pet_ct_and_pet_mri_in_children.pd
f 138.73 KB · PDF