Grégory Chatelain
PhD in Chemistry: Specialties in medicinal chemistry, surfaces
functionalization and development of electrochemical diagnostic
systems
Available from December 2011
-
Phosphate Chemistry
Heterocyclic Chemistry
DNA synthesis
Nucleoside Chemistry
- Electrochemistry
- HPLC
- NMR
- MALDI-TOF
- SEM
- AFM
- X-ray reflectivity
- XRD
- TOF-SIMS
- FT-IR
- Raman
- GC
Work Experiences:
2010-
Research scientist (12 month) at the Institute of Separative Chemistry of Marcoule,
Bagnols sur Sèze (France) Synthesis and characterization of bone-like matrixes on surfaces to
study their interaction mechanisms with actinides. Collaboration: Dr Vidaud (CEA/DSV
Marcoule) and Prof. Boivin (INSERM Lyon, France).
2009-2010
Research scientist (15month) at the Rega Institute for Medicinal Chemistry, KU Leuven
(Belgium) Synthesis of some new nucleoside analogues for siRNA applications, nucleosides with
antiviral activity against DENV and heterocyclic molecules against Alzheimer’s disease
2005-2007
PhD thesis (bioMérieux financial support, 39 month) at the University of Lyon
2005-2009
Tutor in organic chemistry (Twice 40h) at ES CPE Lyon (Lyon Superior School of
(Laboratoire des Sciences Analytiques), Synthesis of ferrocene modified oligonucleotides with
stem-loop structure or alpha phosphoramidates: Application for electrochemical detection of
nucleic acids on functionalized surfaces. Collaboration: Drs. Vasseur and Morvan (Montpellier,
France)
Chemistry, Physics and Electronics), Villeurbanne (France).
2004-2005
Master project (6 month) at University of Lyon (Institut de chimie et de Biochimie
moléculaire, France) Synthesis of quinolines and tetrahyquinolines from the benzo[b]thiophene
2003-2004
Year off (12 month) at BASF-AG, Ludwigshafen (Germany) Synthesis of Spiroester
compounds by catalytic processes
Education:
2009
2005
Doctorate in organic chemistry and material chemistry at the University of Lyon
Master degree of organic chemistry and catalysis at the University of Lyon
Main subjects studied: heterocyclic synthesis, carbohydrate synthesis, peptide synthesis
2005
Engineer Diploma in chemistry at ESCPE Lyon (Lyon Superior School of Chemistry,
Physics and Electronics), department of Chemistry and Process Engineering.
1999
Baccalauréat Diploma obtained with honours
Languages:
French: Native
German: middle (1 year in Germany)
English: fluent (First Certificate)
Dutch: scholar (Level 1).
Grégory Chatelain (31 years old, French citizen) - 3 rue des cités Louis Gros - Appart 215- F-84000 –
Avignon (France) - +33 (0) 6 21 40 02 78 gregory.chatelain@cpe.fr
Conferences, presentation and courses attended:
Conferences Jacques Cartier 2006, Grenoble, France.
Transducer 2007-Eurosensors 2007, Lyon, France, Poster Comm.
Summer European University of the Max Mousseron Institute of Biomolecules 2006, training course on new
strategies for bio-active molecule from discovery to applications, Montpellier, France.
Symposium on chemistry of nucleic acid components 2008, Cesky Krumlov, Czech Republic, Poster Comm.
IRT 2010 - XIX International Round Table on Nucleosides, Nucleotides and Nucleic Acids, Lyon, France,
poster comm.
Groupement de recherche Assemblages supramoléculaires et membranes biologiques: Concepts, modèles et
fonctions 2010, L’isle sur la Sorgue, France
Journée Rhône-Alpes des Biomolécules 2011, Villeurbanne, France, poster comm.
AFMBioMed Summer School 2011, Marcoule, France
Euromat 2011, Montpellier, France, oral comm.
Groupement de recherche Assemblages supramoléculaires et membranes biologiques: Concepts, modèles et
fonctions 2011, L’isle sur la Sorgue, France, oral comm.
Publication/conference papers:
J. Fournier Dit Chabert, G. Chatelain, S. Pellet Rostaing, D. Bouchu, M. Lemaire, Benzo[b]thiophene as a
template for substituted quinolines and tetrahydroquinolines, Tet. Lett., 2006, 47, 1015.
G. Chatelain, C. Chaix, H. Brisset, C. Moustrou, F. Fages, B. Mandrand, Synthesis of electrochemical probes
for nucleic acid detection, Sens. Actuators, B, 2008, 132, 439.
G. Chatelain, H. Brisset, C. Chaix, A thermodynamic study of ferrocene modified hairpin oligonucleotides
upon duplex formation: Applications to the electrochemical detection of DNA, New J. Chem., 2009, 33, 1139.
G. Chatelain, A. Meyer, F. Morvan, J.-J. Vasseur, C. Chaix, Electrochemical detection of nucleic acids using
pentaferrocenyl phosphoramidate -oligonucleotides, New J. Chem., 2011, 35, 893-901.
G. Chatelain, S. Ansanay-Alex, C. Farre, C. Chaix, A “four-ferrocene” modified hairpin structure as a probe
for sensitive detection and single-base mismatch discrimination of DNA, submitted to Electrochimica Acta.
G. Chatelain, G. Schepers, J. Rozenski and A. Van Aerschot, Hybrization potential of oligonucleotides
comprising 3’-O-methylated altritol nucleosides, manuscript in preparation.
References:
Dr. Carole Chaix (PhD supervisor), UMR des Sciences Analytiques 5180 - Bât. CPE, RdC - 43, Bd du 11
Novembre 1918 - 69622 Villeurbanne Cedex (France) carole.chaix-bauvais@recherche.univ-lyon1.fr +33 (0) 4 72 44 84 79
Dr Francois Morvan, Institut des Biomolécules Max Mousseron - UMR 5247 CNRS-UM1-UM2 - Universite de
Montpellier 2 CC1704, Place E. Bataillon - 34095 Montpellier Cedex 5 (France) morvan@univ-montp2.fr +33 (0) 4 67 144 961
Prof. Dr. Arthur Van Aerschot - Rega Institute, Medicinal Chemistry - K.U.Leuven P.B. 1030 Minderbroedersstraat 10 - B-3000 Leuven (Belgium) Arthur.VanAerschot@rega.kuleuven.be - +32 (0) 16
33738
Dr Damien Bourgeois, Laboratoire de Chimie et Physicochimie des Actinides - UMR 5257 ICSM - BP 17171 30207 Bagnols sur Cèze Cedex –
damien.bourgeois@cea.fr – + 33 (0)4 66 33 94 92
Grégory Chatelain (31 years old, French citizen) - 3 rue des cités Louis Gros - Appart 215- F-84000 –
Avignon (France) - +33 (0) 6 21 40 02 78 gregory.chatelain@cpe.fr