5Gas measurement REFIDs for partial pressure and concentration Paul Schluter August 5, 2013 Essential Concepts 1. Two top-level vocabulary branches for gas concentration and partial pressure measurements are defined: MDC_CONC_AWAY for measurements obtained at the patient connector port and MDC_CONC_GASDLV for measurements obtained in the system supplying the gas to and from the patient, with or without a mechanical ventilator.1 The vocabulary branch REFID prefix is followed by the gas identifier and measurement phase on the waveform, similar to convention already adopted in ISO/IEEE 11073-10101-2004. 2. For both MDC_CONC_AWAY and MDC_CONC_GASDLV, the gas measurement site may be specified by a separate attribute in cases where greater semantic precision is required, such as OBX-20 in an HL7 V2.6 message. One of the enumerated values is identified as the ‘default’ value is OBX-20 is empty. 3. Since the delineation of the expiratory _EXP and inspiratory _INSP breath phases may be ambiguous, additional precision can be specified by an enumerated value (that also has a specified default value). 4. The units-of-measure are conveyed by a separate attribute, e.g. OBX-6 in an HL7 V2.6 message. This may be either a partial pressure (e.g. kPa or mm[Hg]) or concentration (% or {vol}%). 5. Gas setting identifiers are derived from the corresponding observation identifiers by appending ‘_SETTING’ to the REFID and adding 0x01000000 to the CF_CODE10 (using the ‘über-partition’ method). CH4 Ethanol CO NO NO2 He Ar N2 Air CO2 Sevoflurane O2 Isoflurane Xe Halothane N2O Enflurane Volatile Agents MAC Gas Balance Gas Metabolically Useful Metabolically Consumed Metabolically Produced Unwanted Gas MDC gas and phase MDC_CONC_AWAY_gas MDC_CONC_AWAY_gas_ET MDC_CONC_AWAY_gas_INSP MDC_CONC_AWAY_gas_EXP MDC_CONC_GASDLV_gas MDC_CONC_GASDLV_gas_INSP MDC_CONC_GASDLV_gas_ET MDC_FLOW_gas_FG MDC_VOL_DELIV_gas_CASE MDC_VOL_DELIV_gas_TOTAL MDC_VOL_DELIV_gas_LIQUID_CASE MDC_VOL_DELIV_gas_LIQUID_TOTAL Desflurane Agents/Gases Agent Deployment of gas partial pressure and concentration and consumption information 1 The MDC_CONC_AWAY_ REFID prefix is already defined in ISO/IEEE 11073-10101-2004 and has been extended to support additional gases. The new MDC_CONC_GASDLV_ prefix has been defined as a ‘synonym’ to the existing MDC_VENT_CONC_ REFID prefix. GasREFIDs.5c.docx -1- 2013-08-05T14 The table below lists the REFIDs for the concentration (or partial pressure) and utilization of desflurane: CF_CODE10 REFID 152024 MDC_CONC_AWAY_DESFL 152084 MDC_CONC_AWAY_DESFL_ET 152112 MDC_CONC_AWAY_DESFL_EXP 152168 MDC_CONC_AWAY_DESFL_INSP {152052} MDC_CONC_GASDLV_DESFL {152140} MDC_CONC_GASDLV_DESFL_EXP {152200} MDC_CONC_GASDLV_DESFL_INSP 0 MDC_VOL_DELIV_DESFL_LIQUID_CASE 0 MDC_VOL_DELIV_DESFL_LIQUID_TOTAL SysName Concentration | PartialPressure | Desflurane, Gas | Airway Concentration | PartialPressure, EndTidal | Desflurane, Gas | Airway Concentration | PartialPressure, Expiration | Desflurane, Gas | Airway Concentration | PartialPressure, Inspiration | Desflurane, Gas | Airway Concentration | PartialPressure | Desflurane, Gas | Gas Delivery System Concentration | PartialPressure, Expiration | Desflurane, Gas | Gas Delivery System Concentration | PartialPressure, Inspiration | Desflurane, Gas | Gas Delivery System Volume | Case, Delivered | Desflurane, Liquid Volume | Total, Delivered | Desflurane, Liquid CommonTerm Concentration airway desflurane Description Concentration airway desflurane end tidal Concentration of desflurane in airway gas measured at the end of expiration Concentration airway desflurane expiratory Concentration of desflurane in airway gas measured during expiration Concentration airway desflurane inspiratory Concentration of desflurane in airway gas measured in inspiration Concentration of desflurane in airway gas Concentration of desflurane in airway gas in the system conducting gas to and from the patient Concentration airway Concentration of desflurane in airway gas desflurane expiratory (gas measured during expiration in the system delivery system) conducting gas from the patient Concentration airway Concentration of desflurane in airway gas desflurane inspiratory (gas measured during inspiration in the system delivery system) conducting gas to the patient Volume (liquid) of desflurane delivered x during a case Total volume (liquid) of desflurane x delivered Concentration desflurane (gas delivery system) Notes (informative) 1. The MDC_CONC_AWAY_ REFID prefix is already defined in ISO/IEEE 11073-10101-2004 and has been extended to support additional gases. The new MDC_CONC_GASDLV_ prefix has been defined as a ‘REFID synonym’ to the existing MDC_VENT_CONC_ terms and includes gas measurements obtained from the system supplying the gas to the patient, regardless of whether a ventilator is used or not. The new MDC_CONC_GASDLV_ terms will use the same CODE10 and CF_CODE10 numeric codes. The REFID synonym relationship is indicated by {wavy braces} around either code. Notes (normative) 1. The REFID prefix MDC_CONC_AWAY_ denotes gas concentration and partial pressure measurements obtained at the patient connection port (MDC_GAS_MSMT_SITE_AIRWAY) unless otherwise specified by an optional measurement location attribute, e.g. OBX-20 in an HL7 V2.6 message, using one of the following enumerated values listed below: MDC_GAS_MSMT_SITE_UNKNOWN MDC_GAS_MSMT_SITE_AIRWAY= MDC_GAS_MSMT_SITE_YPIECE MDC_GAS_MSMT_SITE_ENDOTRCH … other breathing circuits::sites unknown airway adaptor (default) Y-piece Endotracheal Listed under the Rosetta _GAS_MEAS_SITE_AWAY enumeration group. 2. The REFID prefix MDC_CONC_GASDLV_ denotes gas concentration and partial pressure measurements in the system conducting the gas to and from the patient obtained at the fresh gas port (MDC_GAS_MSMT_SITE_FRESHGAS) unless otherwise specified by an optional measurement location attribute, e.g. OBX-20 in an HL7 V2.6 message, using one of the following enumerated values listed below: MDC_GAS_MSMT_SITE_UNKNOWN MDC_GAS_MSMT_SITE_FRESHGAS= MDC_GAS_MSMT_SITE_EXHAUST MDC_GAS_MSMT_SITE_INSP MDC_GAS_MSMT_SITE_EXP unknown fresh gas (default) exhaust inspiratory port expiratory port Listed under the Rosetta _GAS_MEAS_SITE_GASDLV enumeration group. GasREFIDs.5c.docx -2- 2013-08-05T14 Notes (normative, continued) 3. The _INSP suffix denotes a numeric value representative of the entire inspiratory phase of a breath and may be further qualified by an optional attribute that specifies the calculation method.2 MDC_METHOD_CALC_UNKNOWN MDC_METHOD_CALC_MAX MDC_METHOD_CALC_MIN MDC_METHOD_CALC_MEAN MDC_METHOD_CALC_MEAN_FLOW_WEIGHTED MDC_METHOD_CALC_MEDIAN MDC_METHOD_CALC_BEGIN_INSPIRATION= not otherwise specified maximum minimum mean value, time-weighted mean value, flow weighted median value beginning of inspiration (default) Listed under the Rosetta _GAS_MEAS_AOI_INSP enumeration group.3 4. The _EXP suffix denotes a numeric value representative of the entire expiratory phase of a breath and may be further qualified by an optional attribute that specifies the calculation method. MDC_METHOD_CALC_UNKNOWN MDC_METHOD_CALC_MAX MDC_METHOD_CALC_MIN MDC_METHOD_CALC_MEAN MDC_METHOD_CALC_MEAN_FLOW_WEIGHTED MDC_METHOD_CALC_MEDIAN MDC_METHOD_CALC_END_EXPIRATION= not otherwise specified maximum minimum mean value, time-weighted mean value, flow weighted median value end of expiration (default) Listed under the Rosetta _GAS_MEAS_AOI_EXP enumeration group. 5. The suffix _ET denotes ‘end tidal’, obtained at the end of the expiratory phase where the observed gas concentration and most closely approximates the alveolar concentration, which, in turn, most closely reflects the anesthetic concentration in the systemic blood. 6. Default values: A single default value may be identified within a list of individual enumerations and/or enumeration groups by appending a ‘=’ after the REFID.4 If a default value is not specified, the enumerated value is considered ‘unknown’ or ‘not otherwise specified’ if the value is not provided or the attribute is missing from the message payload. 2 Most observation identifiers in the SCADA partition support the two-bit discriminator for _MIN, _MAX and _MEAN. ‘AOI’ is the acronym for ‘Area of Interest’, first used in the FDA HL7 V3 aECG and IEEE Std 11073-10102 nomenclature. 4 Rosetta allows enumerated value sets to be constructed from zero-or-more individual enumerated values and zero-or-more enumeration groups (e.g. _GAS_MEAS_AOI_EXP). 3 GasREFIDs.5c.docx -3- 2013-08-05T14 Questions and issues: 1. In the current proposal, the MDC_CONC_GASDLV_ is defined as a ‘REFID synonym’ to the existing corresponding MDC_VENT_CONC_ terms, using the same numeric CODE10 and CF_CODE10. Should we assign new numeric codes for the MDC_CONC_GASDLV terms, at the cost of consuming the remaining few numeric codes currently left in the SCADA partition? Norman Jones, in his 5/8 email, would prefer to see CONC_GASDLV replace VENT_CONC rather than make it a synonym. Paul’s response: Let’s see what others who have had implementation experience using the original VENT_CONC have to say about their semantic equivalence. 2. In the normative notes #1 and #2 above, the measurement site was left as ‘optional’ with a pre-defined default value defined in the standard. An alternative approach would be to make the measurement site location mandatory. Preferences? [If we decide on ‘optional’ with a pre-defined default value, the default value will be specified in the RTMMS.] Norman Jones, in his 5/8 email, prefers using pre-defined default values, i.e. the non-default values are only brought in by an optional attribute such as OBX-20 in an HL7 V2 message. 3. During our discussion on Wednesday, the case of where ‘no gas delivery’ occurs when intravenous anesthetics are used. What is the best way to specify that? Norman Jones, in his 5/8 email, re-expresses this as ‘how do we represent the additional case of ‘no gas measurement module installed’. Paul: IEEE 11073 and PCD-01 allow ‘null-flavors’ to describe why a measurement is not available, such as ‘NAV’ for ‘(temporarily) not available’. Another approach is to omit the entire gas module (OBX VMD and descendants) in the message if the module is not present. GasREFIDs.5c.docx -4- 2013-08-05T14 Change Summary (since 2013-05-20 preliminary distribution) From: Wiley Stan [mailto:Stan.Wiley@draeger.com] Sent: Thursday, July 18, 2013 7:57 AM To: Schluter, Paul (GE Healthcare) Cc: Schlichting, Stefan; Heesch, Ralf Subject: RE: PCD Rosetta Terminology Mapping: Draeger Ventilator/Anesthesia Terms Checking Hello Paul, Please find attached our updates to the terminology spreadsheet for Draeger Medical ventilation and anesthesia products. Here are a few comments regarding our changes: 1. Sections (marked in yellow) of the table that require further explanation from you on the term meaning: O2 and Air as "liquid per case" I will remove both entries. I consulted with the person who originally proposed this and he could not identify anyone who actually did this nor preferred to use the liquid phase as a more convenient expression of O2 and/or Air use. DONE 2. Forward looking updates (marked in green): all gases delivered TO the patient could make sense to be monitored as "delivery per case" AND "delivery total", I will add these terms. DONE 3. Concerns (marked in blue): Ar may also be an unwanted gas (accumulation of Argon when a rebreathing/closed system is used in combination with supply by O2-concentrators that have approx. 93% O2 only and approx. 5% Ar) I will include the “dot” that you added to the chart. DONE 4. Removals (marked in red): Remove "to" for EXP and "from" for INSP in the DES-example table (red mark) to have to explanation precise I will make these corrections. DONE, implemented using XSLT. With these exceptions, all other content appears ok. Summary of specific changes to chart on first page: [changed cells highlighted with light yellow] Indicate that Ar is an ‘Unwanted Gas’. Added all AAs for MDC_VOL_DELIV_gas_CASE and MDC_VOL_DELIV_gas_TOTAL Removed MDC_VOL_DELIV_gas_LIQUID_CASE and MDC_VOL_DELIV_gas_LIQUID_TOTAL for N2O, O2 and Air. Removed He and NO for MDC_VOL_DELIV_gas_CASE and MDC_VOL_DELIV_gas_TOTAL. Also, all Systematic Names for gas concentration now start with “Concentration | PartialPressure, … | … to indicate that they can either express ‘concentration’ (e.g. ‘%’) or ‘partial pressure’ (e.g. ‘kPA’, ‘mm[Hg]’). [See Table on page 2.] GasREFIDs.5c.docx -5- 2013-08-05T14 Column Definitions Column Tbl_ID Tbl_Desc Group CF_CODE10 REFID SysName CommonTerm Acronym Description Vendor_Descriptions Vendor_Mnemonics Notes ID JR Tbl_ID_0 Tbl_Desc_0 ROW Extra GasREFIDs.5c.docx New Exist Column Description IEEE 11073-10101-2004 table identifier Short mnemonic for table identifier Group identifier (required for RTM but not IEEE 11073) Context-free numeric identifier Reference ID Systematic Name Common Term Acronym Description Vendor descriptions (from RTM) Vendor mnemonics (from RTM) Paul’s editorial notes Temporary numeric record id (from Jan’s Dec 2012 NIST table) Original table row number (from Jan’s Dec 2012 NIST table) Original Tbl_ID (from Jan’s Dec 2012 NIST table) Original Tbl_Desc (from Jan’s Dec 2012 NIST table) Original row number from IEEE 11073-10101-2004 Table A.7.4.1 A computed “extra” (indicating measurement source) -6- 2013-08-05T14 Gas Parameter Usage Exhaust Exp Fresh Gas Insp Ken Marks GE Healthcare October 12, 2009 Gas/Agent parameter measurement locations Fresh Gas Exhaust Insp Limb Exp Limb Y-Piece Endotracheal Alveolar Gas/Agent parameter measurement time spans & points Insp Phase Exp Phase End Tidal End Insp Breath Cycle Fresh Gas Ctrl Insp Ctrl Exp Ctrl End Tidal Ctrl Note: Titration mechanisms are dependent upon the capabilities of the gas delivery system. Purely pneumatic delivery systems are only capable of setting the fresh gas and cannot provide closed loop compensation due to the absence of sensing and electronic/electro-mechanical control. Electronic gas delivery systems (i.e. electronic mixers and vaporizers) are capable of all these mechanisms because they have the ability for remote control of gas settings via an electronic interface and can be controlled based on compensation from measurements. GasREFIDs.5c.docx Gas/Agent Delivered CH4 Ethanal CO end start flow conc dt end flow dt Note: Concentrations are measured as partial pressures. Accuracy is affected by barometric pressure, temperature, and humidity. NO2 NO He Ar N2 Isoflurane Air Enflurane CO2 Sevoflurane O2 Halothane M A C Gas B alance Gas M et ab o lically U sef ul M et ab o lically C o nsumed M et ab o lically Pr o d uced U nwant ed Gas start Consumption Production Xe Desflurane V o lat ile A g ent s conc dt Case Delivery Total Delivery Gas Physiological Parameters A g ent / Gasses end start conc flow N2O conctime Gas/Agent Parameter Calculations Mean - time wt - flow wt Min Max Gas/Agent parameter setting mechanisms -7- 2013-08-05T14