State Budget Educational Institution of Higher Professional Education
"Stavropol State Medical University"
Ministry of Health of the Russian Federation
(StSMU Russian Ministry of Health)
Department of Microbiology
__________________________________________________________________
310, Mira st., Stavropol, 355000, Russia,
tel.: 8(8652) 35-24-75
08/08/2015
Name of development
Department, Head of Department
Authors of development
Content of development
Development and production of nanodrug external forms
and cosmetics based on silicon nature niosomes.
Department of Microbiology, Nanotechnology Drugs
Laboratory, Head of Department – Professor I.A. Basikov
Professor I.A. Basikov
The idea of applying nanoparticles to improve the
efficiency effects of drugs is based on the fact that the
substances in nanoform have properties different from the
properties of substances in macrodispersed form. High
specific surface of nanostructures multiplies the surface
phenomena (adsorption, adhesion) changing processes
they interact with macromolecules and biological objects.
Nanocapsule containers are shaped so that their use is as
means of delivery to target cells or organs. Specificity of
delivery is determined by the use of receptors to specific
cell types. Small size makes them invisible to the immune
system cells, allowing nanocapsules to circulate in the
bloodstream for a long time. We have proved the
phenomenon of transdermal transport of drug substances
via nanocontainers - silicone nature niosomes (Diploma
number 381 on the scientific discovery number A-478 of
6 August 2009). Niosomes – are nanovesicles, 30-80
nanometers in size, consisting of a shell in the form of
insoluble in water double layer of nonionogenic
emulsifier (BAS), which is a group of dimethicones,
consisting of ethers of polyethylene glycol,
polydimethylsiloxane base and active pharmaceutical
substance contained inside a capsule. Niosome shell
consists of PEG-12 dimethicone having amphiphilic
properties, which allow orientating in dispersion of the
water-soluble part (polyethylene glycol) in water and fatsoluble part (dimethicone) – in lipids. Because of such a
structure microcapsules are easily formed with shaking.
When sonicated, multilamellar microcapsules acquire
monolamellar structure, immobilizing drugs. Their size
becomes less than 100 nanometers.
A thin elastic shell allows them to move through the
intercellular spaces, which is a lipid matrix.
Bond of Si-O 1.6 angstroms (in microcapsules of
organosilicone nature) is longer than the C-C 1.4
angstroms (phospholipids - liposomes), which gives
unique elastic properties of skin penetration and
movement in intercellular spaces, which is a lipid matrix.
The organic part gives biodegradable properties. CH3 (methyl) groups form a "cloud" around the Si atoms and
create reactive sites for interaction with the BAS.
The bond angle Si-O-Si is 130 degrees as it is opposed to
109 degrees of the C-C-C connection, which leads to
increased flexibility and stability.
Si-O-Si bond rotates and therefore also has a high
flexibility.
The presence of PEG (polyethylene glycol part) defines
stability in hydrophilic environments and protection from
attack by cells of the reticuloendothelial system (RES).
Using molecular synthesis phases of niosomes
preparation, and also a composition of transdermal gels
with different drugs are worked out.
Stage of development
Works on the creation of sedative transdermal nanogel are
completed in three state assignments of MH RF; niosomal
gel with doxorubicin for treatment of skin cancer, wound
healing niosomal gel "Regenerin", antiparasitic nanogel
with albendazole are also designed. 10 patents of the
Russian Federation are obtained according to developed
drugs. On the basis of innovative enterprise "Cell
technology" nanocosmetics line is made - 20 titles. All
permits are available.
Development and production of drugs are included in the
Federal plan of medical science development in the
Russian Federation until 2025.
Currently preclinical and clinical trials, at the same time
searching for investors and pharmaceutical companies
that are interested in the production of Russian innovative
drugs developed in StSMU are performing.
Potential application area
Medicine, cosmetology
Advantages
over
analogues Advantages over liposomal formulations: Bond Si-O 1.6
(efficiency, price, resources)
angstroms (in microcapsules of organosilicone nature)
longer than the bond C-C 1.4 angstroms (phospholipids liposomes), which gives unique elastic properties of skin
penetration and movement in intercellular spaces, which
is a lipid matrix.
The organic part gives biodegradable properties. CH3 (methyl) groups form a "cloud" around the Si atoms and
create reactive sites for interaction with the BAS.
The bond angle Si-O-Si is 130 degrees as opposed to 109
degrees of the C-C-C connection, which leads to
increased flexibility and stability.
Contact Si-O-Si rotates and therefore also has a high
flexibility.
Existing partners:
a) in Russia;
b) abroad;
Desired actions:
a) placement of information;
b) searching for investors;
c) others
Professor I.A. Basikov
The presence of PEG (polyethylene glycol part) defines
stability in hydrophilic environments and protection from
attack by cells of the reticuloendothelial system (RES).
In the study of pharmacokinetics of developed drugs, it
was proved effectiveness exceeding 2-3 times the
analogues, and the cost is 80% lower. Psychotropic and
antiparasitic gels are unique; a market niche is not yet
occupied, respectively.
The limited liability company(LLC) "Prospector";
«Fund for support of innovative development of the
Stavropol Regon»;
MediGEN Company, the Czech Republic.
а) placement of information;
б) the search for investors;
в) marketing and organization of production based on
StSMU.